PIK3CD
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Official Full Name
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
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Overview
Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010] -
Synonyms
PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; APDS; PI3K; IMD14; p110D; P110DELTA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3Kdelta; phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta; ptdIns-3-kinase subunit p110-delta; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Zebrafish
- E.coli
- HEK293
- Insect (sf21)
- Mammalian Cell
- Sf9 Insect Cell
- DDK
- GST
- His
- His|T7
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PIK3CD-1687HF | Active Recombinant Full Length Human PIK3CD Protein, DDK-tagged, Biotinylated | Insect (sf21) | DDK | 1-1044(end) |
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| Human | PIK3CD-8212HF | Active Recombinant Full Length Human PIK3CD Protein, GST-tagged | Insect (sf21) | GST | 1-1044(end) |
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| Human | PIK3CD-1896H | Recombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged | Sf9 Insect Cell | His |
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| Human | PIK3CD-29587TH | Recombinant Human PIK3CD | N/A |
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| Human | PIK3CD-52H | Recombinant Human PIK3CD, GST-tagged | Sf9 Insect Cell | GST |
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| Human | PIK3CD-3187HCL | Recombinant Human PIK3CD 293 Cell Lysate | HEK293 | N/A |
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| Human | PIK3CD-4900H | Recombinant Human PIK3CD Protein (Val774-Gln1044), N-His tagged | E.coli | N-His | Val774-Gln1044 |
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| Human | PIK3CD-1727H | Recombinant Human PIK3CD protein, His & T7-tagged | E.coli | His/T7 | Val774~Gln1044 (Accession # O00329) |
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| Human | PIK3CD-301404H | Recombinant Human PIK3CD protein, GST-tagged | E.coli | GST | Tyr395-Leu580 |
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| Zebrafish | PIK3CD-11416Z | Recombinant Zebrafish PIK3CD | Mammalian Cell | His |
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| Chicken | PIK3CD-1989C | Recombinant Chicken PIK3CD | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- PIK3CD Related Signal Pathway
PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | NUDT4A;MTMR14;PLCG2;INPPL1A;SYNJ2;PIP5K2;IP6K3;TPI1A;PIP4K2C |
| ErbB signaling pathway | SHC4;ERBB4;PRKCA;RAF1;MAPK8B;ABL1;KRAS;BTC;AKT2 |
| Ras signaling pathway | GNB4;CSF1;VEGFC;PAK7;FIGF;BAD;NFKB1;LOC608458;TBK1 |
| Rap signaling pathway | PLCB1;FGFR2;FGF3;PIK3R5;GNAQ;INSR;RASSF5;SKAP1;FLT4 |
| cGMP-PKG signaling pathway | GATA4;MEF2A;FXYD2;ATP1A2;NFATC4;PIK3CG;ATF4;CALM4;AGTR1A |
| cAMP signaling pathway | GRIN3A;VAV2;AKT2;PIK3CD;FSHR;RYR2;NFKB1;RAF1;CALM3 |
| Chemokine signaling pathway | JAK3;SHC3;SOS1;GNG13;GNG5;CXCR4;MAPK3;CCL4L2;AKT1 |
| HIF- signaling pathway | CAMK2G;PRKCA;NOS2;LDHA;PDHA1;TEK;STAT3;EIF4E2;RPS6 |
| FoxO signaling pathway | GRB2B;GADD45AA;ATG12;RAF1;MAPK8A;SIRT1;TGFBR1B;MAPK12;SOD2 |
| Phosphatidylinositol signaling system | PLCD3;IP6K2;IMPA2;PLCB2;PIK3CG;CALM1B;CALML3;IP6K1;PPIP5K1 |
| Sphingolipid signaling pathway | CERS5;MAPK8;DEGS1;LASS4;SPTLC1;NRAS;PLD1;PPP2R3C;FYN |
| Phospholipase D signaling pathway | MAPK3;PLD1;PLCB1;PIP5K1A;PRKCA;INS1;ARF6;PIK3R5;MS4A2 |
| mTOR signaling pathway | PRKAA2;EIF4EA;PIK3R5;INS2;PIK3R3;PDPK1B;RPS6KA1;INSB;RRAGC |
| PIK-Akt signaling pathway | PCK2;IFNA2;FLT1;FGF4;BCL2;SOS1;SPP1;ITGA7;PKN2 |
| AMPK signaling pathway | PIK3CG;TBC1D1;IRS4;G6PC3;INS;PRKAG2;PFKFB3;MTOR;INS2 |
| Apoptosis | CAPN1A;HDR;DSG1;OCLN;TNFRSF10C;IRF4;ADD1;HELLS;STK24A |
| Adrenergic signaling in cardiomyocytes | GNAI3;ATP2B2;GNAI1;AKT1;PIK3R3B;PLCB2;CACNG3;PPP2R2B;MAPK12 |
| VEGF signaling pathway | AKT1;RAC2;PLA2G4A;PPP3CCA;RAC1;PTK2AA;PTGS2A;CDC42;PTGS2B |
| Osteoclast differentiation | MAP3K14;SQSTM1;NFATC1;FOS;IFNGR1;NFKB1;NCF1;cgr2b;SYK |
| Focal adhesion | PARVB;BAD;PTK2AB;RAP1A;ITGA4;ACTB;PIK3CA;COL2A1B;THBS4B |
| Signaling pathways regulating pluripotency of stem cells | ESX1;PAX6;ID4;LIFR;FGFR1;INHBE;FGFR2;MAPK11;SETDB1 |
| Platelet activation | ITGB3;PRKCI;PLA2G4A;P2RY12;PTGIR;GP6;RAP1B;GUCY1B3;ACTB |
| Toll-like receptor signaling pathway | IRF7;CD40;IL-8;MAPK12B;CXCL10;TAB2;PIK3R3;IFNA8;IFNA17 |
| Jak-STAT signaling pathway | IFNB1;TYK2;IL2RB;SOCS1;RAF1B;STAT6;GRB2;MYCB;THPO |
| Natural killer cell mediated cytotoxicity | KLRC3;NCR3;GRB2;HLA-A;IFNA2;HLA-E;PIK3CB;PIK3CA;FCGR3A |
| T cell receptor signaling pathway | PAK1;AKT2;CD40LG;CD3E; CD3D;PIK3CD;PPP3CC;DEF6A;ZAP70;NFATC1 |
| B cell receptor signaling pathway | ITK;GRB2;VAV1;BCL2L11;SLA2;NFATC3;PIK3CB;CD79B;MALT1 |
| Fc epsilon RI signaling pathway | PLCG2;INPP5D;PIK3CG;IL3;AKT2;MAP2K6;LCP2;FCER1A;SOS1 |
| Fc gamma R-mediated phagocytosis | MARCKS;HCK;PRKCE;LAT;WASL;PLA2G4A;PRKCA;VAV1;DOCK2 |
| TNF signaling pathway | DNM1L;PIK3CB;CXCL1;AKT2;MAGI2;IL6;CX3CL1;TNF;CREB3L2 |
| Leukocyte transendothelial migration | PRKCB;MMP9;NOX1;CLDN18;ACTN4;ARHGAP35;CDH5;GNAI1;GNAI3 |
| Neurotrophin signaling pathway | PDPK1;NTRK2;RAC1;IRAK4;KIDINS220;CDC42;PSEN2;BDNF;SH2B1 |
| Cholinergic synapse | GNG8;ITPR3;KCNJ12;GNB2;FYN;GNAQ;GNAI3;PRKACG;GNG4 |
| Inflammatory mediator regulation of TRP channels | CALM4;HRH1;PRKACB;PRKCG;PIK3R2;MAP2K3;GNAQ;Adcy4;PIK3R3 |
| Regulation of actin cytoskeleton | VAV3;FGFR1;RAF1A;PIP4K2B;RAF1;FGF11A;FGF1B;VCL;ITGB2L |
| Insulin signaling pathway | TSC1;PDPK1;FOXO1B;PPP1R3CB;PIK3R1;PIK3R3B;AKT3A;HK1;G6PCA.1 |
| Progesterone-mediated oocyte maturation | BRAF;AKT1;PIK3CB;HSP90AB1;RPS6KA2;MAPK1;RAF1A;CPEB4;ANAPC5 |
| Estrogen signaling pathway | GRM1;KCNJ9;CALM2;PIK3R5;SP1;NRAS;CALM4;SHC1;HSP90AB1 |
| Prolactin signaling pathway | GSK3B;INS2;MAP2K1;SOCS7;SIRPA;SHC4;SLC2A2;SOCS2;INS |
| Thyroid hormone signaling pathway | NOTCH3;MED13;SLC16A2;NCOA1;PLCZ1;BAD;ITGB3;MED12;ATP2A2 |
| Oxytocin signaling pathway | CAMK4;PPP1R12C;NPR1;CALM2;PRKACA;PRKAB2;PRKACG;CACNA2D2;RCAN1 |
| Regulation of lipolysis in adipocytes | PDE3B;INSR;TSHR;PRKG2;PIK3CA;PRKACB;Adcy4;INS1;PRKG1 |
| Type II diabetes mellitus | TNF;HKDC1;PIK3R3;ADIPOQ;MAPK8;IKBKB;PKM;IRS1;PIK3R5 |
| Insulin resistance | CREB3L3A;GYS2;PPARA;RPS6KA3;CREB5;INSB;PRKCE;ACACB;SOCS3 |
| Non-alcoholic fatty liver disease (NAFLD) | NDUFA12;NDUFA4L2;DDIT3;NDUFB9;NFKB1;BID;IL1B;NDUFS5;LEPR |
| Aldosterone-regulated sodium reabsorption | ATP1A1;PRKCA;PIK3R5;ALPHA-ENAC;PIK3CA;ATP1A4;INS1;IGF1;PIK3CG |
| Carbohydrate digestion and absorption | AMY2A5;ATP1B1;AMY2B;HK2;PIK3CA;SLC37A4;AMY2A3;PIK3R2;ATP1B4 |
| Bacterial invasion of epithelial cells | CD2AP;ARPC5L;CRK;SEPT1;CLTC;CBLB;HCLS1;ILK;PTK2 |
| Chagas disease (American trypanosomiasis) | LOC100033925;PPP2R2D;PPP2CA;IL12B;PIK3CA;PPP2R1A;TNFRSF1A;CASP8;CD3E; CD3D |
| Toxoplasmosis | PIK3CD;TYK2;LAMA4;IRGM;BIRC7;PDPK1;STAT3;MAPK11;IKBKB |
| Amoebiasis | PLCB4;PIK3R2;IL12B;C8G;LAMB2;ACTN1;RAB7;NFKB1;TGFB2 |
| Hepatitis C | ARAF;CLDN9;TRP53;OCLN;PPP2CA;PIK3R5;RAF1;PPP2R1A;CLDN15 |
| Hepatitis B | TBK1;IRF7;IFNA5;TIRAP;NFKB1;PRKCA;YWHAB;TRP53;MAP2K4 |
| Measles | CD3E; CD3D;IL1A;CLEC4M;STAT3;OAS3;CBLB;PIK3CD;CCNE1;CD209 |
| Influenza A | KPNA1;PIK3CA;HLA-DQA2;TMPRSS2;Ifna15;NXF2;LOC780933;HLA-DMA;TNFRSF10A |
| HTLV-I infection | TLN1;TRP53INP1;PIK3R5;BUB1B;CDC23;WNT10B;HLA-G;XIAP;IL2RG |
| Epstein-Barr virus infection | TAB1;CCNA2;HSPB1;TP53;HLA-A;POLR3GL;PSMD4;SFPI1;HDAC2 |
| Pathways in cancer | PTGER4;FGFR3;FZD8;WNT1;GNGT2;CXCR4;TCEB2;TRAF1;MAP2K2 |
| Viral carcinogenesis | GTF2H2;PRKACB;CASP8;UBE3A;RBPJ;RBL2;HIST2H2BB;SYK;ATP6V0D1 |
| Proteoglycans in cancer | PTPN11;FZD3;PRKCB;IGF2;CAMK2G;SLC9A1;PLAU;CD44;MMP9 |
| Colorectal cancer | TCF7;MAPK10;MAPK1;TGFBR2;PIK3R5;KRAS;DCC;SMAD3;GSK3B |
| Renal cell carcinoma | FH1;EGLN1;AHA-1;CUL2;MAPK1;PAK3;PAK7;ARNT2;PIK3R5 |
| Pancreatic cancer | STAT1;TRP53;MAPK3;RAC1;BAD;PIK3CA;KRAS;TGFB1;PIK3CG |
| Endometrial cancer | TCF7;PIK3CG;PTEN;CCND1;ELK1;AKT1;APC;MAP2K1;AXIN2 |
| Glioma | MAPK3;NRAS;CAMK2D;BRAF;PDGFB;RAF1;SHC1;CALM2;PDGFA |
| Prostate cancer | SMARCD1;FGFR1;PTEN;IGF1;PDGFA;NOXA1;INS1;CCND1;INSRR |
| Melanoma | PDGFRA;FGF22;PIK3CG;NRAS;FGF6;PIK3R2;Pdgfa&Pdgfb;FGF1;RB1 |
| Chronic myeloid leukemia | AKT1;RAF1;IKBKG;PIK3CB;PIK3R5;MECOM;TP53;TGFB1;STAT5B |
| Acute myeloid leukemia | RUNX1;PPARD;CEBPA;RUNX1T1;CCNA1;PIK3CG;STAT5A;CHUK;RAF1 |
| Small cell lung cancer | CCNE1;PTEN;RXRB;SKP2;FN1;LAMA2;ITGA2;TRAF6;PIK3CB |
| Non-small cell lung cancer | RARB;BAD;PIK3CD;PRKCA;BRAF;RASSF1;RXRA;TGFA;PIK3CG |
| Central carbon metabolism in cancer | G6PD;C12orf5;PFKL;FGFR1;PFKP;GLS2;SIRT6;PKM;PDHA1 |
| Choline metabolism in cancer | CHKB;PLD1;PDGFC;PDGFA;RALGDS;HRAS;PIK3CB;PDPK1;DGKD |
PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | PIK3C2B;PIK3CG;PIK3C2G;ATM;PIK3C3;PIK3CB;PIK3CD;PIK3R3;PIK3C2A |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3CG;PIK3C2B;PIK3C2A;PIK3CD;PIK3C2G;PIK3CA;PIK3CB |
| ATP binding | KCNJ10;HSPA1A;NME2A;NARS2;PLK2;PAICS;KIF15;TYRO3;TNIK |
| phosphatidylinositol 3-kinase activity | PIK3C2A;PIK3CA;PIK3CD;PIK3CB;PIK3CG |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | PIK3CG;PIK3CB;PIK3CD;PIK3CA |
| protein binding | HOXD12;C22orf39;LINGO1;NUPL1;TXNIP;BCAS2;GABPA;AGER;IKZF1 |
PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.
PIK3R1; 1-phosphatidyl-1d-myo-inositol; pi3kr1_cerae_protein; HRAS; CD37; NCK1; TNPO2; FAM195A; ASCC2; RALY
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