pik3cd

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pik3cd

Official Full Name phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Background Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Synonyms PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; APDS; PI3K; IMD14; p110D; P110DELTA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; PI3Kdelta; phosphoinositide-3-kinase C; PI3-kinase p110 subunit delta; ptdIns-3-kinase subunit p110-delta; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform;
    • Type:
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PIK3CD-1727H Recombinant Human PIK3CD protein, His & T7-tagged E.coli His/T7
    Human PIK3CD-1896H Recombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged Sf9 Insect Cell His
    Human PIK3CD-29587TH Recombinant Human PIK3CD N/A
    Human PIK3CD-3187HCL Recombinant Human PIK3CD 293 Cell Lysate HEK293 N/A
    Human PIK3CD-52H Recombinant Human PIK3CD, GST-tagged Sf9 Insect Cell GST
    Chicken PIK3CD-1989C Recombinant Chicken PIK3CD Mammalian Cell His
    Zebrafish PIK3CD-11416Z Recombinant Zebrafish PIK3CD Mammalian Cell His

    pik3cd involved in several pathways and played different roles in them. We selected most pathways pik3cd participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with pik3cd were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism PLCG1; INPP4AB; SYNJ1; PIK3C2G; IMPA1; PIK3CB; ITPKB; MTMR2; ALDH6A1; INPP4B
    ErbB signaling pathway PRKCB; ERBB4; STAT5B; CBL; CAMK2A; PIK3R3; BAD; MAP2K4A; MAPK8A; CAMK2B1
    Ras signaling pathway FGFR3; ABL2; RAF1; TBK1; MAP2K1; PLA2G2F; PDGFB; SHC2; PIK3CG; RAC3
    Rap signaling pathway KRIT1; PRKCI; PLCE1; HRAS; RAC1; FGFR3; FGF14; FGF9; KITLG; RAPGEF5
    cGMP-PKG signaling pathway ATP1B4; SLC25A5; BNP; SLC8A1; PDE5A; KCNJ8; BAD; ATP2A2; PPP3CC; GUCY1B3
    cAMP signaling pathway GRIN2A; ATP2B1; GPR81; ACOX1; MC2R; Adcy4; CNGA4; PDE3A; PIK3R5; PIK3CD
    Chemokine signaling pathway BRAF; SOS1; CCL3L1; CXCL9; XCL2; PRKACG; PARD3; PRKCZ; MAPK1; CCL13
    HIF- signaling pathway SLC2A1; NOX3; ENO3; MAP2K1; VEGFA; HIF1A; CAMK2B; PIK3R1; MKNK2; NOS3
    FoxO signaling pathway SGK1; CDKN1BA; PRKAB2; SMAD3A; FOXO1A; SETD7; HOMER3; SGK2; MAP2K2; SMAD3
    Phosphatidylinositol signaling system MTMR2; PI4K2A; INPP5K; PIK3CB; PLCE1; PLCZ1; CALM2; PIK3R2; PIK3R1; CALM1A
    Sphingolipid signaling pathway PPP2R3A; ABCC1; ACER1; MAPK12; LASS4; NRAS; SMPD2; DEGS1; LASS5; MAPK3
    Phospholipase D signaling pathway FCER1G; PLCB4; PLD2; PLCB1; PIP5K1A; PIK3R3; DGKZ; DGKD; RHOA; LPAR5
    mTOR signaling pathway AKT1; RPS6KB1B; RICTOR; TSC1; PDPK1B; RRAGCA; VEGFAB; TSC1B; AKT2; TSC1A
    PIK-Akt signaling pathway Fgf15; SPP1; COL27A1; GNB3; IGF1; HRAS; KLK1B4; ANGPT4; KIT; IFNA2
    AMPK signaling pathway PIK3CD; IRS2; PRKAG1; PPP2R5A; CREB3; CREB3L2; PRKAA2; CREB5; PFKFB1; G6PC2
    Apoptosis IRF6; CASP6L1; HIST1H1D; IRF1B; CYCS; BCL2A; NFKBIAA; CTNNB2; BMX; CYCSB
    Adrenergic signaling in cardiomyocytes CREB3L1; PPP2R2C; PLCB1; SLC8A1; VMHC; PPP2R5D; PPP2R2CA; ADRB3B; ATP1B1; CAMK2B
    VEGF signaling pathway PPP3R1B; RAF1A; NOS3; NFATC2; PPP3CCA; PPP3CC; MAPKAPK2; PPP3R1; MAPK12B; CDC42L
    Osteoclast differentiation TRAF6; STAT2; MAP2K7; LILRB1; SYK; NOX3; NFKB2; PIK3R1; IL1R1; LILRA1
    Focal adhesion RHOAD; COL27A1B; VEGFA; PTK2; PDPK1; PAK6; ELK1; SHC2; LAMA3; PDGFRB
    Signaling pathways regulating pluripotency of stem cells WNT9B; HESX1; WNT11; WNT5B; PAX6; IGF1; PIK3R2; WNT4; AXIN1; ID2
    Platelet activation ROCK2; ITGA2; GP1BA; MAPK3; P2RY12; FCER1G; ACTG1; PRKCZ; PIK3R5; PIK3CB
    Toll-like receptor signaling pathway MAPK14A; MYD88; TLR9; PIK3R3A; IFNPHI1; TICAM2; NFKBIA; FADD; CCL4L1; IL6
    Jak-STAT signaling pathway RAF1B; PTPN11; IFNA8; IL2RA; GRB2; PIK3R2; PRLRA; GM2002; IFNA7; IL11RA
    Natural killer cell mediated cytotoxicity MAPK3; SHC1; IFNAR1; NRAS; KIR3DL1; IFNA14; ZAP70; TNFRSF10D; IFNA6; CD48
    T cell receptor signaling pathway NFKBIB; CD4; MAPK13; RHOA; KRAS; PIK3R2; IKBKB; PIK3CG; DEF6A; MAP3K14
    B cell receptor signaling pathway PPP3CB; GRB2; RAP2A; LCP2A; RAC1; PIK3CG; CR2; BANK1; PLCG2; MAP2K2
    Fc epsilon RI signaling pathway PLCG1; INPP5D; LYN; PIK3CG; GRB2; LCP2; MAPK8; MAPK9; NRAS; MAPK3
    Fc gamma R-mediated phagocytosis MARCKSL1; PLA2G6; RAF1; PLD2; ASAP1; RAC2; RPS6KB2; LYN; RPS6KB1; ARF6
    TNF signaling pathway PIK3CD; SOCS3; PIK3CB; RPS6KA4; CXCL5; CX3CL1; BIRC2; MAPK11; MAPK3; ATF4
    Leukocyte transendothelial migration VAV1; ITGB2; ARHGAP5; NCF1; CLDN18; MYLPF; MMP2; GNAI1; CLDN5; MAPK12
    Neurotrophin signaling pathway NFKBIB; SHC1; MAPK7; TRP53; SH2B1; SH2B3; MAPK13; CAMK4; NTRK3; NTF3
    Cholinergic synapse CREB5; GNG11; GNA11; CAMK2D; AKT1; KCNJ12; HRAS; CHRNA6; PIK3R5; PRKCA
    Inflammatory mediator regulation of TRP channels CYP2C54; CALML3; ASIC4; PPP1CB; SRC; PIK3CD; PIK3R3; CAMK2D; KLK1B4; ACCN3
    Regulation of actin cytoskeleton FGF19; PDGFB; ITGAV; ITGB2; CYFIP1; PAK2B; ACTN3B; ITGAL; INS; HRASA
    Insulin signaling pathway PPP1CB; PRKAR1B; PDPK1; PRKAB1A; SOCS1; PRKAG3; RPS6; PPP1CAB; MAP2K1; PCK1
    Progesterone-mediated oocyte maturation ANAPC13; CDC23; PIK3CD; ANAPC1; IGF1RB; CCNA2; HSP90AA1.1; RPS6KA3A; MOS; GNAI3
    Estrogen signaling pathway ATF6B; PIK3R5; HSPA1B; KCNJ9; HSP90AB1; PIK3R3; PRKCD; PIK3CA; PRKACG; PIK3CB
    Prolactin signaling pathway MAPK13; AKT2; MAPK1; ESR2; SOS1; PIK3CA; SOCS4; MAP2K2; NRAS; FOS
    Thyroid hormone signaling pathway TRP53; HDAC1; NOTCH3; MAP2K2; SLCO1C1; MED1; PLCG2; RHEB; KRAS; PRKACB
    Oxytocin signaling pathway PIK3R3; CAMKK1; PRKAB1; CAMK4; CACNB1; PRKAG2; MYL6B; PIK3CD; CACNB3; PLA2G4C
    Regulation of lipolysis in adipocytes PIK3CA; PRKG2; GNAS; GNAI3; PIK3R2; PLIN1; PIK3CB; Adcy4; INS1; AQP7
    Type II diabetes mellitus SLC2A2; PIK3CG; IRS2; INS1; PDX1; MAPK8; PIK3R3; INS-IGF2; HK3; PIK3R5
    Insulin resistance PTPRF; SLC27A4; G6PC3; PTPN1; TBC1D4; SLC27A1B; RPS6KA3A; OGT.1; PRKCB; IRS2
    Non-alcoholic fatty liver disease (NAFLD) AKT1; NDUFA8; NDUFV1; PPARA; UQCRFS1; SOCS3; ADIPOR2; NDUFA9; RAC1; NDUFA4L2
    Aldosterone-regulated sodium reabsorption ATP1B2; MAPK3; ATP1A1; PIK3R3; SCNN1G; PIK3CG; PDPK1; ATP1B4; SGK1; SCNN1B
    Carbohydrate digestion and absorption AMY1A; ATP1B1; AMY1B; HK2; ATP1A1; PIK3CG; HK3; PIK3CD; TAS1R2; G6PC
    Bacterial invasion of epithelial cells ACTB; DOCK1; ACTG1; RHOG; CLTA; SEPT6; CLTC; PIK3R1; DNM1; ELMO1
    Chagas disease (American trypanosomiasis) CASP8; Ccl12; TGFBR1; Fasl; IL1B; GNAQ; CFLAR; IL-8; PIK3CG; TGFB3
    Toxoplasmosis LAMA3; LAMA1; STAT3; IFNGR1; BCL2; RELA; MAPK11; MYD88; HLA-DPA1; IKBKB
    Amoebiasis HSPB1; PIK3CG; IL10; GNA11; ARG1; NOS2; COL1A2; SERPINB6; GNAQ; PLCB1
    Hepatitis C TYK2; OAS3; MAPK1; PPP2CA; PDPK1; AKT2; TRAF2; PIK3R2; TRP53; DDX58
    Hepatitis B GRB2; PIK3CG; IL-8; IFNA8; IRF3; AKT2; IFNA1; CCNE1; MAPK8; IFN-a
    Measles Fasl; IFNA10; STAT3; IFNB1; IRF3; TAB2; IFNA5; CCND1; HSPA1L; TNFRSF10C
    Influenza A DNAJB1; MAP2K4; IFNA16; HSPA6; IFNAR1; MAPK10; IFNA7; FAS; DDX58; HLA-DQB1
    HTLV-I infection ZFP36; SMAD2; TGFBR2; HLA-DRA; SLC2A1; RB1; PRKACB; TRP53; TNFRSF1A; LTBR
    Epstein-Barr virus infection MAPK13; POLR1C; XPO1; YWHAH; POLR3E; PSMD6; SPI1; TRAF5; HLA-C; NEDD4
    Pathways in cancer TCEB1; FGF4; GLI2; TGFBR1; PDGFB; MAP2K2; ITGA3; GNAQ; TPR; MMP2
    Viral carcinogenesis MAD1L1; HIST1H2BL; ACTN1; PMAIP1; HDAC7; VAC14; TTC6; HIST1H2BO; HIST1H2BA; GRB2
    Proteoglycans in cancer VAV2; HPSE2; NANOG; MAP2K2; CBL; TLR4; FZD9; ITGA5; WNT16; ACTB
    Colorectal cancer BIRC5; SMAD4; TGFB1; PIK3CG; BRAF; AKT1; PIK3R3; CYCS; BAX; FOS
    Renal cell carcinoma PIK3R1; ETS1; AKT1; MET; PDGFB; AHA-1; HGF; EPAS1; FH1; VHL
    Pancreatic cancer RB1; MAPK9; ARHGEF6; RELA; TGFBR1; ERBB2; ARAF; RAC1; TGFB1; SMAD4
    Endometrial cancer ILK; PIK3R5; CTNNA3; LEF1; PIK3CD; AXIN1; RAF1; PIK3R1; ARAF; BAD
    Glioma PIK3R5; BRAF; MTOR; PIK3R3; CALM1; KRAS; SHC1; TP53; CALML5; PDGFA
    Prostate cancer NOXA1; GRB2; NDRG1; FGFR2; IKBKG; CPN1; PDGFD; FOXA1; PIK3R5; PTEN
    Melanoma CCND1; FGF7; FGF6; RAF1; AKT1; PIK3CD; PDGFC; TRP53; MAPK1; MAPK3
    Chronic myeloid leukemia MAP2K1; SHC2; CBL; IKBKB; SHC3; TGFB1; RELA; CCND1; STAT5B; CTBP2
    Acute myeloid leukemia CHUK; PIK3R2; MAP2K2; IKBKB; FLT3; LEF1; MYC; IKBKG; KIT; EIF4EBP1
    Small cell lung cancer RB1; PIK3R1; NFKB1; XIAP; TRP53; LAMB4; TP53; CCNE1; CYCS; CASP9
    Non-small cell lung cancer RAF1; ARAF; PDPK1; NRAS; PIK3R3; PIK3CG; MAPK1; ERBB2; RXRG; CCND1
    Central carbon metabolism in cancer SLC7A5; SIRT3; PFKM; PIK3CA; MTOR; RAF1; G6PDX; FGFR3; SCO2; GLS
    Choline metabolism in cancer SLC5A7; PIP5K1A; RAC2; MAPK3; SOS1; DGKQ; DGKB; RAC1; RAC3; MAPK1

    pik3cd has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pik3cd itself. We selected most functions pik3cd had, and list some proteins which have the same functions with pik3cd. You can find most of the proteins on our site.

    Function Related Protein
    1-phosphatidylinositol-3-kinase activity PIK3C2B; PIK3CB; PIK3CG; PIK3CD; PIK3C2A; PIK3CA; ATM; PIK3C2G; PIK3C3; PIK3R3
    1-phosphatidylinositol-4-phosphate 3-kinase activity PIK3C2G; PIK3CG; PIK3CB; PIK3C2B; PIK3CD; PIK3C2A; PIK3CA
    ATP binding DDX51; PTK7A; RPS6KB2; PIP4K2B; BMPR1AA; MAP4K4; EPHA5; MTHFD1L; FUK; UBE2D3
    phosphatidylinositol 3-kinase activity PIK3C2A; PIK3CD; PIK3CG; PIK3CA; PIK3CB
    phosphatidylinositol-4,5-bisphosphate 3-kinase activity PIK3CB; PIK3CG; PIK3CA; PIK3CD
    protein binding SPATA7; HNRNPH2; COL6A5; CDH23; STAM2; CHCHD2; AXL; ATG13; PDXP; NASP

    pik3cd has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pik3cd here. Most of them are supplied by our site. Hope this information will be useful for your research of pik3cd.

    PIK3R1; 1-phosphatidyl-1d-myo-inositol; pi3kr1_cerae_protein; HRAS; CD37; NCK1; TNPO2; FAM195A; ASCC2; RALY

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