PIK3CD

Official Full Name

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Overview

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I PI3K found primarily in leukocytes. Like other class I PI3Ks (p110-alpha p110-beta, and p110-gamma), the encoded protein binds p85 adapter proteins and GTP-bound RAS. However, unlike the other class I PI3Ks, this protein phosphorylates itself, not p85 protein.[provided by RefSeq, Jul 2010]
Synonyms

PIK3CD;phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta;APDS;PI3K;IMD14;p110D;P110DELTA;phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform;PI3Kdelta;phosphoinositide-3-kinase C;PI3-kinase p110 subunit delta;ptdIns-3-kinase subunit p110-delta;phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta;phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Recombinant Proteins

Type:

Recombinant Proteins

Cell & Tissue Lysates

Filters:

Species

Human
Zebrafish
Chicken

Source

Sf21 Cells
Mammalian Cells
Sf9 Cells
HEK293
E.coli
E. coli

Tag

Flag
GST
His
Non
T7

Cat.#	Product name	Source (Host)	Species	Tag	Protein Length	Price
PIK3CD-1687HF	Active Recombinant Full Length Human PIK3CD Protein, DDK-tagged, Biotinylated	Sf21 Cells	Human	Flag	Full L. 1-1044(end)	Inquiry
PIK3CD-8212HF	Active Recombinant Full Length Human PIK3CD Protein, GST-tagged	Sf21 Cells	Human	GST	Full L. 1-1044(end)	Inquiry
PIK3CD-11416Z	Recombinant Zebrafish PIK3CD	Mammalian Cells	Zebrafish	His		Inquiry
PIK3CD-1896H	Recombinant Human Phosphoinositide-3-Kinase, Catalytic, Delta Polypeptide, His-tagged	Sf9 Cells	Human	His		Inquiry
PIK3CD-1989C	Recombinant Chicken PIK3CD	Mammalian Cells	Chicken	His		Inquiry
PIK3CD-29587TH	Recombinant Human PIK3CD		Human	Non	Full L.	Inquiry
PIK3CD-52H	Recombinant Human PIK3CD, GST-tagged	Sf9 Cells	Human	GST		Inquiry
PIK3CD-3187HCL	Recombinant Human PIK3CD 293 Cell Lysate	HEK293	Human	Non		Inquiry
PIK3CD-1727H	Recombinant Human PIK3CD protein, His & T7-tagged	E.coli	Human	His&T7	Val774~Gln1044	Inquiry
PIK3CD-301404H	Recombinant Human PIK3CD protein, GST-tagged	E.coli	Human	GST	Tyr395-Leu580	Inquiry
PIK3CD-4900H	Recombinant Human PIK3CD Protein (Val774-Gln1044), N-His tagged	E.coli	Human	His	Val774-Gln1044	Inquiry
PIK3CD-8555H	Recombinant Human PIK3CD protein, His-tagged	E. coli	Human	His		Inquiry

Involved Pathway

PIK3CD involved in several pathways and played different roles in them. We selected most pathways PIK3CD participated on our site, such as Inositol phosphate metabolism,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CD were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Small cell lung cancer	RXRG,APAF1,LAMC2,BIRC2,IKBKB,IKBKG,PIK3R5,CCNE1,LAMA4,CASP9
Acute myeloid leukemia	RPS6KB1,AKT2,MAPK3,STAT5A,RPS6KB2,MAPK1,ARAF,CCNA1,RARA,STAT3
TNF signaling pathway	CXCL1,ITCH,CXCL10,CASP8,PTGS2,RIPK1,PIK3R2,CASP7,IL18R1,MAP3K7IP3
T cell receptor signaling pathway	CD3D,GSK3B,CBLC,KRAS,NFKBIE,CD4,PRKCQ,SHB,OXSR1A,CD8B
Chronic myeloid leukemia	BRAF,AKT1,IKBKG,KRAS,NFKBIA,MAPK1,CTBP2,HRAS,STAT5A,PIK3CB
ErbB signaling pathway	NCK1,CBLB,PAK2A,PRKCA,MAP2K1,PAK4,ERBB3,PAK3,PIK3R3,RPS6KB1
Insulin resistance	PTENA,G6PCA.1,RPS6KA1,INSRA,MAPK8A,PRKCD,PTPN11B,TNFRSF1A,GSK3AA,RPS6KA3B
Hepatitis C	OAS1,IRF9,RELA,IFNA10,CLDN10,PPP2R1A,PIAS1,NRAS,MAPK1,PPP2CA
Chemokine signaling pathway	CCL4,CCL1,GNG3,CCL3L1,GRK1,Ccl27a,CCL19,PIK3CG,SHC4,CCL8

Protein Function

PIK3CD has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity,1-phosphatidylinositol-4-phosphate 3-kinase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CD itself. We selected most functions PIK3CD had, and list some proteins which have the same functions with PIK3CD. You can find most of the proteins on our site.

Function	Related Protein
1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3CB,PIK3CG,PIK3C2G,PIK3C2A,PIK3C2B,PIK3CA
protein binding	PARP4,SLC38A2,TAF9,TBCB,PPP6R3,CALD1,KRT18,CTLA2B,AVPI1,GPR50
ATP binding	DQX1,ZAP70,VRK3,EIF2B2,DCK,DHX34,CAMKVB,FIGN,SIK3,PSMC6
phosphatidylinositol-4,5-bisphosphate 3-kinase activity	PIK3CB,PIK3CA,PIK3CG
phosphatidylinositol 3-kinase activity	PIK3CG,PIK3CB,PIK3C2A,PIK3CA
1-phosphatidylinositol-3-kinase activity	PIK3C2A,PIK3C2B,PIK3CG,PIK3CA,PIK3R3,ATM,PIK3C3,PIK3C2G,PIK3CB

Interacting Protein

PIK3CD has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CD here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CD.

PIK3R1;1-phosphatidyl-1d-myo-inositol;pi3kr1_cerae_protein;HRAS;CD37;NCK1;TNPO2;FAM195A;ASCC2;RALY