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PIK3R5

Official Full Name

phosphoinositide-3-kinase, regulatory subunit 5
Overview

Phosphatidylinositol 3-kinases (PI3Ks) phosphorylate the inositol ring of phosphatidylinositol at the 3-prime position, and play important roles in cell growth, proliferation, differentiation, motility, survival and intracellular trafficking. The PI3Ks are divided into three classes: I, II and III, and only the class I PI3Ks are involved in oncogenesis. This gene encodes the 101 kD regulatory subunit of the class I PI3K gamma complex, which is a dimeric enzyme, consisting of a 110 kD catalytic subunit gamma and a regulatory subunit of either 55, 87 or 101 kD. This protein recruits the catalytic subunit from the cytosol to the plasma membrane through high-affinity interaction with G-beta-gamma proteins. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found.
Synonyms

PIK3R5; phosphoinositide-3-kinase, regulatory subunit 5; phosphoinositide 3-kinase regulatory subunit 5; p101; P101 PI3K; F730038I15Rik; FOAP2; OTTHUMP00000135339; Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit; Phosphoinositide 3 kinase, regulatory subunit 5; Phosphoinositide 3 kinase, regulatory subunit 5, p101; Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101; PI3 kinase p101 subunit; PI3 kinase regulatory subunit 5; PIK3 R5; Protein FOAP 2; PtdIns 3 kinase p101; PtdIns 3 kinase regulatory subunit; protein FOAP-2; ptdIns-3-kinase p101; PI3-kinase p101 subunit; phosphatidylinositol-4,5-bisphosphate 3-kinase regulatory subunit; FOAP-2; P101-PI3K;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PIK3R5-31760TH	Recombinant Human Human PIK3CG, His-tagged		His		Inquiry
Human	PIK3R5-3182HCL	Recombinant Human PIK3R5 293 Cell Lysate	HEK293	Non		Inquiry
Human	PIK3R5-1084H	Recombinant Human PIK3R5 Protein (1-494 aa), His-SUMO-tagged	E.coli	His&SUMO	1-494 aa	Inquiry
Chicken	PIK3R5-2400C	Recombinant Chicken PIK3R5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PIK3R5 involved in several pathways and played different roles in them. We selected most pathways PIK3R5 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ErbB signaling pathway	MAP2K4B;CBL;MAPK1;KRAS;AKT2L;GSK3AA;MYCB;MAP2K1;AKT3A
Ras signaling pathway	CALML3;TEK;KITLG;ABL1;RAP1A;INS;VEGFC;MAP2K1;PLA2G4A
Rap signaling pathway	ITGB3;FGF20;PDGFRA;AKT2;RALGDS;LPAR5;FGF6;PDGFA;MAP2K3
cGMP-PKG signaling pathway	TRPC6;MYH7;VASP;PPP1CA;SRF;PIK3R2;ATP2B4;ATP1B2;MEF2A
cAMP signaling pathway	PIK3R2;FSHB;CREB3L1;MAPK3;ATP1A2;PIK3CA;GPR81;VAV1;GNAS
Chemokine signaling pathway	ITK;CCR1;CXCR3;CXCL14;STAT3;GNAI3;NCF1;STAT2;PPBP
HIF- signaling pathway	NOX3;BCL2;EP300;LDHA;PIK3CB;ENO3;CAMK2A;HIF1A;PIK3CG
FoxO signaling pathway	RAF1B;AKT2L;G6PCA.2;PIK3CG;INSRA;RAG1;SGK2A;IRS1;PIK3CD
Phosphatidylinositol signaling system	PIK3C2G;MTMR6;PRKCB;INPP5A;PIP5K1AB;INPP4B;INPPL1A;IP6K3;CALM
Sphingolipid signaling pathway	GNAI3;LASS2;HRAS;GAB2;PIK3R1;PIK3CB;PIK3CG;PIK3CD;PPP2R2D
Phospholipase D signaling pathway	AGTR1B;INS;Adcy4;DGKD;SOS1;PIP5K1B;TSC2;CYTH2;GRM2
mTOR signaling pathway	TSC2;PRKCBB;RRAGD;MAPK3;PTENA;RICTOR;PIK3R5;RPS6KB2;TSC1B
PIK-Akt signaling pathway	KITLG;ANGPT1;FGF10;GRB2;FGF20;PPP2R5A;TCL1A;ITGB6;RPS6
AMPK signaling pathway	PPP2R2A;CFTR;AKT1S1;PIK3CD;AKT1;EEF2K;CCNA2;CREB3L3;PPP2R5C
Apoptosis	BAX;DYNLL2;PRKACB;TRADD;RIPK1;STK24A;PKP1;HIST1H1C;CASP6L1
Adrenergic signaling in cardiomyocytes	PPP1CBL;CREB1A;CACNB3;PIK3CG;ATP2B1;AKT3A;ACTC1B;PRKACAA;ADCY7
VEGF signaling pathway	MAPKAPK3;SRC;RAC3B;PPP3CC;RAF1A;PTGS2A;PIK3CB;BADB;SH2D2A
Osteoclast differentiation	FOSB;PPP3CC;SIRPG;GRB2;PIK3CB;LILRB1;IFNAR1;MAP2K7;CSF1R
Focal adhesion	CAPN2B;CCND1;RAP1B;PPP1R12B;GSK3AA;RAC1;ELK1;VCLA;CHAD
Signaling pathways regulating pluripotency of stem cells	NODAL;GSK3B;WNT3;ACVR1;WNT8A;FZD7;ACVR2B;INHBC;PCGF5
Platelet activation	ROCK1;PIK3CA;GNAI1;MAPK12;MYLK3;PIK3R1;ARHGEF1;PPP1CA;F2RL3
Toll-like receptor signaling pathway	TRAF6;PIK3R2;IRAK4;CD80;IL12BA;TLR1;MAPK14A;IFNA1;IKBKB
Jak-STAT signaling pathway	PRLR;IL23;PTPN11;BCL2A;PIAS4;IFNA16;EPOR;IL29;IL7
Natural killer cell mediated cytotoxicity	ULBP2;HRAS;KLRC1;RAC3;IFNA7;RAF1;NRAS;RAET1E;NCR2
T cell receptor signaling pathway	Il2;EVLB;VAV3;CD8B;PLCG1;MAPK1;PIK3R2;AKT2;VAV2
B cell receptor signaling pathway	BTK;PLCG2;PPP3CA;CRKL;MAP4K1;NFATC2;BLK;PIK3CA;CARD11
Fc epsilon RI signaling pathway	AKT1;RAC1;PLCG2;MAP2K3;MAPK12;PIK3R5;RAF1;AKT2;PIK3CA
Fc gamma R-mediated phagocytosis	PRKCG;RAF1;PIK3CD;ASAP1;ASAP3;FCGR1A;FCGR2B;SYK;MYO10
TNF signaling pathway	PGAM5;PIK3R3;MAP3K7;PIK3R5;CCL2;CXCL3;CCL5;MAPK12;PIK3R1
Leukocyte transendothelial migration	CLDN14;ESAM;RAP1A;PIK3R3;MYL9;MAPK12;ITGAL;MYL7;CLDN4
Neurotrophin signaling pathway	MAPK10;CALM2;MAP3K5;RPS6KA5;AKT1;IRAK2;NFKBIB;RAP1A;MAP2K1
Cholinergic synapse	CAMK4;GNG13;GNGT2;GNG3;GNAI1;GNB4;CAMK2G;GNAI2;GNAO1
Inflammatory mediator regulation of TRP channels	PIK3R1;PIK3R5;PRKACG;PRKCB;TRPV3;PRKACB;ASIC3;BDKRB2;ACCN5
Regulation of actin cytoskeleton	ARHGEF6;ABI2A;ARPC5B;ARPC5LA;FGF13B;HRASB;APC;MYL2B;FGF8
Insulin signaling pathway	PRKAG2;PRKAB2;IRS4;INS;PRKACAA;CALM3A;GRB2;SHC1;PIK3R1
Progesterone-mediated oocyte maturation	RPS6KA3;PIK3CD;GNAI1;MAD2L1;INS1;Adcy4;ADCY2B;IGF1;CDC25A
Estrogen signaling pathway	MAP2K2;CREB3L3;ITPR1;PIK3CG;FKBP5;KCNJ9;SRC;AKT1;PRKACB
Prolactin signaling pathway	KRAS;SOCS4;GRB2;PIK3CG;AKT2;INS;ESR1;ESR2;AKT1
Thyroid hormone signaling pathway	HDAC2;KAT2A;STAT1;SLC2A1;PRKACB;PLCE1;MED30;MED27;FXYD2
Oxytocin signaling pathway	GUCY1A3;MYLK4;CACNA2D2;PTGS2;CAMK2A;CAMK2D;MAP2K1;PRKACA;PRKCB
Regulation of lipolysis in adipocytes	PRKACB;NPY;GNAS;IRS2;FABP4;GNAI2;PTGS1;TSHR;AKT1
Type II diabetes mellitus	PIK3R3;PRKCD;PKLR;HK2;IKBKB;IRS1;PIK3R5;PIK3R2;INS-IGF2
Insulin resistance	RPS6KB1B;PPP1CC;GYS1;PRKCD;CREB3L2;PTENA;CREB3L3;PPARGC1B;ACACB
Non-alcoholic fatty liver disease (NAFLD)	COX4I2;INSR;PIK3R1;IKBKB;Fasl;BAX;ADIPOQ;UQCR10;PIK3R5
Aldosterone-regulated sodium reabsorption	PIK3CG;SFN;ALPHA-ENAC;PIK3R2;ATP1A3;SLC9A3R2;ATP1A2;ATP1B4;PIK3CB
Carbohydrate digestion and absorption	GNAT3;SLC37A4;PIK3CB;PLCB2;ATP1B1;SLC2A5;AMY2B;ATP1B3;ATP1A4
Bacterial invasion of epithelial cells	ARPC1B;SEPT11;PIK3R2;CAV1;ILK;SEPT1;DNM2;SHC2;SEPT12
Chagas disease (American trypanosomiasis)	TLR4;TLR9;FASLG;IL1B;GNA15;MYD88;CD3E;CCL2;IL6
Toxoplasmosis	BIRC7;LAMA4;ALOX5;NFKBIA;NOS2;IKBKB;MAP2K3;BCL2L1;PIK3CG
Amoebiasis	IFNG;IL-8;CD1D;PIK3R3;RAB5B;COL1A1;IL12B;TLR4;TNF
Hepatitis C	IFNA5;TRAF2;STAT1;PIK3R5;NFKB1;CLDN3;TNFRSF1A;CLDN15;IFIT1
Hepatitis B	APAF1;TIRAP;NRAS;BCL2;STAT1;IL6;PIK3R5;PIK3R3;IFNA16
Measles	DDX58;TP53;CD28;RAB9B;PIK3R1;Ifna11;HSPA8;IL1B;IL12A
Influenza A	Fasl;MAP2K4;IFNG;LOC100686744;IFNA6;HSPA8;EIF2AK3;IFNAR1;IL33
HTLV-I infection	MAP3K14;FZD5;H2-AB1;ANAPC5;PPP3CA;MSX1;CCND2;FZD9;RELB
Epstein-Barr virus infection	HLA-G;PSMD4;H2-Q10;PSMD8;PSMC6;PSMC1;GTF2B;POLR3F;AKT1
Pathways in cancer	FZD10;STAT1;LAMC1;PDGFRB;BIRC3;NOS2;BIRC2;RAC1;FGF12
Viral carcinogenesis	REL;PIK3R3;GTF2A1L;HLA-A;HIST1H2BK;RHOA;PRKACA;PRKACG;HIST1H2BB
Proteoglycans in cancer	Casp3;IGF2;ANK1;EZR;MMP9;PIK3CB;SDC4;WNT8A;TIMP3
Colorectal cancer	FOS;PIK3CB;PIK3CA;TRP53;TGFBR1;MSH2;SMAD4;MAP2K1;AXIN1
Renal cell carcinoma	SOS1;HRAS;KRAS;TGFA;EPAS1;NRAS;PIK3R2;PIK3CD;ARNT
Pancreatic cancer	TGFA;MAPK3;TGFBR1;MAPK9;RAC2;RALB;MAPK10;BAD;RAF1
Endometrial cancer	APC;MAP2K1;PIK3R2;LEF1;PIK3R5;CCND1;ELK1;AKT1;ILK
Glioma	AKT1;MAPK3;SHC1;CALML5;PIK3CD;TP53;PIK3CG;CALM3;PDGFA
Prostate cancer	RB1;PDGFRA;LEF1;MAPK1;MDM2;BRAF;PIK3CA;NKX3-1;SPINK1
Melanoma	RAF1;FGFR1;MAP2K2;FGF19;Fgf15;FGF18;PIK3R2;PIK3CA;PDGFD
Chronic myeloid leukemia	TGFB2;STAT5B;RUNX1;RAF1;PIK3R2;SMAD3;SHC3;PIK3CB;NFKB1
Acute myeloid leukemia	KRAS;SFPI1;CEBPA;PIK3CD;MAP2K2;MYC;NRAS;PIK3CB;MAPK3
Small cell lung cancer	BIRC3;LAMB4;TRAF2;PTGS2;SKP2;BIRC2;BIRC7;PIK3CD;BCL2
Non-small cell lung cancer	RXRA;RASSF1;PIK3CG;MAP2K1;PIK3R5;AKT1;PIK3CB;CCND1;PDPK1
Central carbon metabolism in cancer	GLS;SLC2A2;PGAM1;MAP2K1;PIK3R3;HIF1A;PDGFRA;HKDC1;PKM2
Choline metabolism in cancer	PDGFC;HRAS;PIK3CB;RHEB;WASF1;PPAP2C;RAC1;PRKCB;MAPK1

PIK3R5 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, G-protein beta/gamma-subunit complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R5 itself. We selected most functions PIK3R5 had, and list some proteins which have the same functions with PIK3R5. You can find most of the proteins on our site.

Function	Related Protein
1-phosphatidylinositol-3-kinase regulator activity	PIK3R3;CCKBR;PIK3R1;PIK3R2;PIK3R3A;PIK3R5;PIK3R3B;PIK3R6
G-protein beta/gamma-subunit complex binding	GNA15.4;GNA11B;ADORA1;GNA15.1;GNAI1;GNAQ;CETN2;PIK3R5;CETN4

PIK3R5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R5.

PIK3CG; ADAMTS2; TTR; CXCL2; SDHB; CYP4A11; acnA

Research Area

Apoptosis Intracellular Kinases

Apical-basal Polarity Effectors

Diabetic Peripheral Neuropathy

PI 3-Kinases (Phosphoinositide 3-Kinases)

Ni, Y; Sinnett-Smith, J; et al. PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors. PLOS ONE 8:-(2013).

Feola, A; Cimini, A; et al. The Inhibition of p85 alpha PI3KSer83 Phosphorylation Prevents Cell Proliferation and Invasion in Prostate Cancer Cells. JOURNAL OF CELLULAR BIOCHEMISTRY 114:2114-2119(2013).