PIK3CG
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Official Full Name
phosphoinositide-3-kinase, catalytic, gamma polypeptide -
Overview
This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. -
Synonyms
PIK3CG;phosphoinositide-3-kinase, catalytic, gamma polypeptide;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform;p110gamma;p120-PI3K;PI3K-gamma;p110-gamma;PI3-kinase subunit gamma;ptdIns-3-kinase subunit gamma;1-phosp
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- HEK293
- Insect Cells
- Sf21 Cells
- Sf9 Cells
- Mammalian Cells
- E.coli
- Avi
- Fc
- His
- Non
- Flag
- GST
- Myc
- DDK
Involved Pathway
PIK3CG involved in several pathways and played different roles in them. We selected most pathways PIK3CG participated on our site, such as Inositol phosphate metabolism,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphatidylinositol signaling system | ITPR1,IP6K3,PIP5K1A,PIP4K2A,IP6K2,PPIP5K2,PIP5K1BB,MTMR7A,PIK3CA,PIP5K1B |
| Adrenergic signaling in cardiomyocytes | CREB3,FXYD2,ATP2B4,PPP2R5C,TPM4,ATP2A2,CACNB2A,ATF2,PPP2R1B,ATP1B1B |
| Apoptosis | STK24B,APAF1,PRKACB,CFLARA,LMNB1,OCLN,IRF2,IRF4A,HIST1H1A,CASP6 |
| Endometrial cancer | APC2,ILK,NRAS,TCF7,PIK3R2,CDH1,KRAS,PIK3CB,TCF7L2,TP53 |
| Cholinergic synapse | KRAS,JAK2,FYN,CREB3L2,CHAT,GNGT1,SLC5A7,GNG2,CHRM1,KCNQ2 |
| Central carbon metabolism in cancer | SLC1A5,MAPK1,PIK3R2,PDHA2,ERBB2,GLS2,AKT1,PFKL,PGAM1,HK2 |
| Prolactin signaling pathway | NFKB1,PIK3R2,MAPK13,SOCS5,NRAS,INS,KRAS,TNFRSF11A,STAT3,TH |
| Osteoclast differentiation | SOCS3,CYBB,FOS,LILRB2,PPP3CB,NCF1,PLCG2,NFATC1,MAPK8,NCF4 |
| T cell receptor signaling pathway | PAK1,MAP3K14,Il2,GRAPA,MAPK11,AKT2,VAV3,PTPRC,PIK3R2,IL4 |
Protein Function
PIK3CG has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity,1-phosphatidylinositol-4-phosphate 3-kinase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CG itself. We selected most functions PIK3CG had, and list some proteins which have the same functions with PIK3CG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PTK2AB,SMCHD1,CLCN6,ROCK2,NLRP4E,INSR,ADCK3,PPP2R4,MCCC2,HELZ |
| phosphatidylinositol 3-kinase activity | PIK3CA,PIK3CD,PIK3C2A,PIK3CB |
| 1-phosphatidylinositol-3-kinase activity | PIK3CA,ATM,PIK3C3,PIK3C2A,PIK3CB,PIK3CD,PIK3C2B,PIK3R3,PIK3C2G |
| protein serine/threonine kinase activity | IKBKB,ACVR1L,HIPK2,TESK2,WNK2,DCLK2,MAPKAPK5,ACVR1,MAP3K11,PSKH1 |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3CB,PIK3CA,PIK3C2G,PIK3C2A,PIK3C2B,PIK3CD |
| protein kinase activity | LMTK3,RASSF2,PTK2,PRKCDA,TBCK,AKT3,BRAF,STK26,CDC42BPB,EPHB2B |
| protein binding | ID4,A2M,SETBP1,TUT1,PTPRS,IL7R,KLHL12,ABCG2,LSM3,SRPK1 |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | PIK3CD,PIK3CB,PIK3CA |
| ephrin receptor binding | EFNA2,EFNA5B,FYN,NTRK1,EPHA7,EFNA3,CBL,CRK,EFNA5,SHC1 |
Interacting Protein
PIK3CG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CG here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CG.
PIK3R5;PDE3B;HRAS;KIT;CD37;BCR;UTRN;PRKAA2;USP45;PIK3R5;GABARAPL1;PRMT7
PIK3CG Related Signal Pathway
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