PIK3R2
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
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Overview
The PI3Kb isoform can be activated by insulin via the insulin receptor to initiate a cascade of events that control cell growth and metabolism. The activation of PI3Kb is mediated by the p85 regulatory subunit binding to tyrosine phosphorylated insulin r -
Synonyms
PIK3R2; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphatidylinositol 3-kinase regulatory subunit beta; p85; P85B; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; PI3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory sub;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Sf9 Insect Cell
- His
- His (Fc)
- Avi
- His|MBP
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- PIK3R2 Related Research Area
PIK3R2 involved in several pathways and played different roles in them. We selected most pathways PIK3R2 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | ERBB4;ABL1;RPS6KB2;PTK2AB;BTC;NRG2;PRKCA;HRASB;ERBB2 |
| Ras signaling pathway | FGF19;FGFR1;RRAS2;RAP1A;FLT1;ZAP70;PAK3;CSF1;FIGF |
| Rap signaling pathway | FLT4;AKT2;IGF1R;PARD6B;SRC;Itgam&Itgb2;RAPGEF5;FGF22;INS1 |
| cGMP-PKG signaling pathway | MYLK;GATA4;CALM1;PPP1CB;NPPB;PIK3CB;ATP1A3;MYLK4;NPR2 |
| cAMP signaling pathway | NPY;PIK3R3;VAV2;PDE3A;PPARA;HTR1E;ATP1B2;PDE4D;CALML5 |
| Chemokine signaling pathway | Ccl21c;CXCL3;CCL23;RHOA;AKT2;WAS;GNG4;WASL;SRC |
| HIF- signaling pathway | MAP2K2;AKT2;RPS6KB1;STAT3;IFNG;RBX1;PIK3R3;IL6R;CAMK2B |
| FoxO signaling pathway | RAG2;GABARAPA;PRKAB1A;ARAF;INSR;RAG1;CAT;PRKAG2A;PIK3CB |
| Phosphatidylinositol signaling system | PLCG1;CALM3A;MTMR1B;INPP5A;DGKAA;PIP5K1AB;ITPR3;PIP5K1B;INPP5E |
| Sphingolipid signaling pathway | S1PR4;MAPK8;BDKRB2;MAPK11;PIK3R2;NRAS;ROCK2;LASS1;GNAI1 |
| Phospholipase D signaling pathway | PLD1;PIP5K1A;INS2;PRKCA;PTK2B;TSC2;PDGFC;MRAS;PDGFA |
| mTOR signaling pathway | EIF4EA;PIK3R5;CAB39;BRAF;RPS6KB1;RPS6KAL;IGF1;PRR5;MAPK3 |
| PIK-Akt signaling pathway | CCNE1;IGF1;GH1;INS;FGF11;GNG12;INS1;FGFR4;KRAS |
| AMPK signaling pathway | PPP2R3C;ADIPOR2;RAB14;RAB11B;LEP;CPT1B;CD36;CREB3L2;PPP2R3A |
| Apoptosis | BADB;PIK3CD;CASP8L1;GAS2;BIRC5A;TRADD;APAF1;YWHAQ;Gzmg |
| Adrenergic signaling in cardiomyocytes | TNNT2A;CALM1A;PIK3R3B;CACNG7;MAPK11;MYL3;CACNA1DA;AGTR1;PLCB4 |
| VEGF signaling pathway | VEGFAA;RAC3B;PIK3CD;PIK3R1;VEGFA;NOS3;AKT2L;NRAS;MAPK14B |
| Osteoclast differentiation | TGFB2;LILRA4;IKBKB;CAMK4;OSCAR;FOSL1;NFATC1;AKT1;LILRA1 |
| Focal adhesion | MYL9;FYN;RHOAC;SRMS;ACTG1;RAC3A;VEGFA;MYL10;MAPK3 |
| Signaling pathways regulating pluripotency of stem cells | WNT8A;INHBA;PIK3R5;WNT10B;FGFR2;FGFR3;JARID2;MYF5;DLX5 |
| Platelet activation | FCER1G;GP5;PRKACG;PLCB2;MYLK;P2RX1;GP1BA;GP6;ACTB |
| Toll-like receptor signaling pathway | CCL3L1;NFKBIAB;IRAK4;CASP8;RAC1B;MAPK13;IFNAR2;PIK3CG;IKBKB |
| Jak-STAT signaling pathway | STAT6;GH1;PIK3CD;IL23;IFNA1;IFNE;STAT1B;OSMR;IL15RA |
| Natural killer cell mediated cytotoxicity | PPP3R1;NRAS;IFNA10;CD247;HLA-C;PPP3CC;SHC2;RAET1L;FCGR3B |
| T cell receptor signaling pathway | PAK7;MAP2K1;PPP3CB;MAPK13;MUC1;CD8B1;VAV3;NCK2;FYN |
| B cell receptor signaling pathway | PLEKHA1;DOK3;ARPC3;CDK4;INPP5D;FOS;BANK1;LIME1;AKT1 |
| Fc epsilon RI signaling pathway | MAPK10;MAP2K1;MS4A2;RAF1;MAPK3;FCER1A;GM-CSF;MAP2K7;PIK3R1 |
| Fc gamma R-mediated phagocytosis | VASP;CFL1;MAPK3;PLA2G6;ASAP1;MARCKSL1;PLA2G4F;ARPC5L;MARCKS |
| TNF signaling pathway | MMP9;CCL2;IL18R1;PIK3CA;MAPK13;MAGI2;PIK3CD;IL1B;MLKL |
| Leukocyte transendothelial migration | PXN;ITGB1;NOX3;RAP1B;ACTG1;CLDN8;VAV1;MYL12A;PTK2 |
| Neurotrophin signaling pathway | RAF1;SH2B3;RIPK2;SHC4;RPS6KA2;MAPK8;GSK3B;NFKB1;MATK |
| Cholinergic synapse | ATF4;KCNJ6;ACHE;CREB3L3;SLC5A7;PIK3R2;PRKACB;GNB4;KCNJ3 |
| Inflammatory mediator regulation of TRP channels | ALOX12;MAPK11;ALOX12E;SRC;IL1RAP;IL1R1;KLK1B4;CALML3;CALM2 |
| Regulation of actin cytoskeleton | FGF1B;ITGB2;RRAS2;CYFIP1;SCINLA;HRASA;MAP2K2B;PDGFRA;FGF12 |
| Insulin signaling pathway | PIK3CG;LIPE;SOS1;CBLC;MKNK2;EIF4EA;FLOT2B;MAPK8B;CALM3A |
| Progesterone-mediated oocyte maturation | PIK3R1;PRKACG;MAPK12B;CCNA1;ANAPC11;PGR;RPS6KA3B;CDC27;CDC16 |
| Estrogen signaling pathway | HSPA2;HSPA8;GNAI2;HSPA1L;RAF1;PIK3R5;PIK3R2;ESR1;KCNJ5 |
| Prolactin signaling pathway | PRP2;MAPK3;MAPK11;NRAS;NEK3;SOCS1;MAPK8;ELF5;SOCS3 |
| Thyroid hormone signaling pathway | ACTB;MAP2K2;ACTG1;SRC;PLCD1;AKT1;RCAN1;HRAS;MTOR |
| Oxytocin signaling pathway | PIK3R3;NPR1;CAMKK1;MAPK3;PLA2G4D;CD38;PRKAG2;ROCK1;MYLK4 |
| Regulation of lipolysis in adipocytes | IRS4;INSR;AQP7;PIK3R2;PIK3CD;PIK3R1;FABP4;PRKACA;INS2 |
| Type II diabetes mellitus | ADIPOQ;SOCS2;PIK3CB;MTOR;IRS1;PIK3R2;PKM2;INS1;MAPK10 |
| Insulin resistance | PIK3CB;SLC2A4;IRS1;FOXO1B;PPP1CA;PPARAB;RPS6KA6;PPP1R3DA;PTPN11 |
| Non-alcoholic fatty liver disease (NAFLD) | RAC1;CASP8;MAPK9;SDHD;IL6;NDUFV3;COX4I2;IL-8;Il6ra |
| Aldosterone-regulated sodium reabsorption | PIK3R5;INS;PIK3CD;SFN;INS2;ATP1B4;SLC9A3R2;INSR;PRKCA |
| Carbohydrate digestion and absorption | SLC2A5;AMY2A4;PIK3CB;AMY2B;PRKCB;AMY2A3;AMY1A;ATP1A4;AKT2 |
| Bacterial invasion of epithelial cells | ARPC3;DNM1;PXN;CRKL;GAB1;CAV3;ITGB1;SRC;RHOG |
| Chagas disease (American trypanosomiasis) | PPP2R2C;TNF;C1QA;TLR4;IFNG;PPP2R1A;PIK3R3;IL1B2;AKT1 |
| Toxoplasmosis | LAMB4;H2-AA;PIK3R1;PPIF;IFNGR2;LAMB2;TGFB3;MAPK13;IL10RB |
| Amoebiasis | GNA15;CD1D;Itgam&Itgb2;Casp3;IL6;PRKACB;RAB5C;PLCB2;SERPINB9 |
| Hepatitis C | PPP2R2B;MAPK13;PDPK1;IKBKB;HRAS;CLDN10;CLDN9;IFNA6;PPP2CB |
| Hepatitis B | TICAM2;IFNA6;CCNE1;BAD;IKBKE;RELA;TLR2;IFN-a;IFNA10 |
| Measles | IFNGR2;IKBKE;TRAF6;HSPA8;TNFSF10;TLR7;FASLG;MSN;RELA |
| Influenza A | HLA-DRB4;PRKCA;IVNS1ABP;IFN-a;BCL2L2-PABPN1;IL1B;NXF1;IL-8;PRSS2 |
| HTLV-I infection | CRTC1;PTTG2;WNT9B;HLA-DQA2;SMAD4;POLB;FZD2;VCAM1;WNT9A |
| Epstein-Barr virus infection | CR2;IRAK1;EIF2AK1;MAP3K14;TBK1;NFKBIE;ITGAL;NEDD4;CD44 |
| Pathways in cancer | PLCB2;GNG3;HIF1A;STAT3;MITF;PLCB3;NKX3;WNT5B;LAMB4 |
| Viral carcinogenesis | SCRIB;ATP6V0D2;TRP53;CDK1;MRPS18B;GTF2A1L;YWHAB;STAT5B;SND1 |
| Proteoglycans in cancer | ARHGEF12;WNT2B;CAV2;HRAS;RAF1;PLCE1;PPP1R12C;WNT10B;ITGB1 |
| MicroRNAs in cancer | BCL2;SLC45A3;RASSF1;ABCC1;KIF23;RPTOR;STMN1;CCNE2;MAP2K1 |
| Colorectal cancer | AKT2;LEF1;AKT1;MLH1;PIK3CB;TGFBR2;RAC2;TP53;AXIN2 |
| Renal cell carcinoma | HIF1A;GAB1;MAPK1;TGFB2;ARNT;HRAS;PIK3CB;VEGFA;PIK3R1 |
| Pancreatic cancer | TRP53;TGFA;SMAD2;SMAD4;PIK3CD;RAC3;BCL2L1;RAC1;RALB |
| Endometrial cancer | PIK3CG;TCF7;ARAF;RAF1;ELK1;TRP53;BAD;SOS1;PIK3R3 |
| Glioma | GRB2;CALM4;CALML5;IGF1R;PIK3CD;TRP53;MAPK3;PRKCG;PDGFA |
| Prostate cancer | SRD5A2;INS;ACTL6B;Pdgfa&Pdgfb;MDM2;SMARCA4;FOXA1;ATF4;HSP90AB1 |
| Melanoma | HGF;BAD;AKT2;FGF5;FGF20;FGF14;PIK3R3;RB1;PDGFRB |
| Chronic myeloid leukemia | AKT1;PTPN11;TGFB3;CRKL;NFKB1;PIK3CA;RAF1;BAD;CBL |
| Acute myeloid leukemia | GRB2;TCF7;RARA;KIT;MTOR;RUNX1;SOS1;AKT2;MYC |
| Small cell lung cancer | RXRG;LAMC1;PIK3R2;BIRC2;PTEN;TRAF2;CKS2;LAMA2;RELA |
| Non-small cell lung cancer | EML4;PLCG2;TRP53;PIK3CD;SOS1;RASSF1;PIK3CB;ALK;PRKCG |
| Central carbon metabolism in cancer | FGFR2;PGAM1;HRAS;PDHA2;HKDC1;SLC1A5;PIK3CA;PGAM2;NTRK3 |
| Choline metabolism in cancer | FOS;WASF3;PLA2G4F;TSC1;PIK3CA;MAPK10;PLA2G4D;PDGFRA;PIK3R3 |
PIK3R2 has several biochemical functions, for example, contributes_to 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-3-kinase regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R2 itself. We selected most functions PIK3R2 had, and list some proteins which have the same functions with PIK3R2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to 1-phosphatidylinositol-3-kinase activity | |
| 1-phosphatidylinositol-3-kinase regulator activity | PIK3R5;PIK3R2;PIK3R3B;PIK3R6;PIK3R1;PIK3R3A;CCKBR;PIK3R3 |
| protein binding | RFC3;PDLIM3;ACAN;LAT2;GAGE5;CLEC18A;APAF1;CKB;EIF3C |
| protein heterodimerization activity | H2AFY2;PANX2;CEBPB;CA;LIMK2;DMBX1;H3F3B;HIST2H4A;NOTCH1 |
| protein phosphatase binding | EGFR;SNX3;ANAPC7;DRD1A;CTNNB1;LCK;PARD3;PPP6R1;DLG4 |
| receptor tyrosine kinase binding | SOCS5;HYAL2;NCK1;ANGPT2A;TP53;SHC4;PCNA;ANGPT1;FNTA |
PIK3R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R2.
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