PIK3CA
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Official Full Name
phosphoinositide-3-kinase, catalytic, alpha polypeptide
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Overview
Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. -
Synonyms
PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3K; PI3K-alpha; PI3-kinase p110 subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Mouse, Human
- Rhesus Macaque
- E.coli
- HEK293
- Insect (sf21)
- Insect Cell
- Mammalian Cell
- Sf9 Insect Cell
- DDK
- Flag
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PIK3CA Related Articles
- PIK3CA Related Research Area
- PIK3CA Related Signal Pathway
PIK3CA involved in several pathways and played different roles in them. We selected most pathways PIK3CA participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | INPPL1;NUDT4B;PIP5K2;PI4KAA;TPI1;ITPKA;PIK3CD;ITPK1;PIP4K2A |
| ErbB signaling pathway | CAMK2D;ERBB3;NRG2;PIK3CG;ERBB4;AREGB;NRG2B;PLCG1;CAMK2G1 |
| Ras signaling pathway | PAK1;RAPGEF5;SHC3;MET;FIGF;MAPK9;PLA2G5;IKBKG;RELA |
| Rap signaling pathway | THBS1;AKT1;MAPK11;BCAR1;SKAP1;MET;FGFR4;IGF1R;MAPK13 |
| cGMP-PKG signaling pathway | VDAC1;ATF4;IRS2;CREB3L3;PPP1CA;AKT2;MYLK4;PPP3CA;GNAI3 |
| cAMP signaling pathway | GRIN2B;PRKACG;HCAR2;CALM3;NFKBIA;GPR81;CALM2;ATP1A3;PDE3A |
| Chemokine signaling pathway | PRKACA;CXCL3;CCR8;NCF1;GNG4;STAT2;NFKB1;CCR7;CCR5 |
| HIF- signaling pathway | BCL2;Trf;TCEB1;TF;ARNT;NOX3;CUL2;ENO2;NOS3 |
| FoxO signaling pathway | MAPK1;PRKAB1;HOMER3;AKT2;GRB2;STK4;PRKAG1;IGF1;TGFB1 |
| Phosphatidylinositol signaling system | MTMR4;SYNJ1;IPPK;PIK3R5;ITPR3;PIP5K1BA;INPP5D;OCRL;CALM |
| Sphingolipid signaling pathway | PLD2;GNAI3;SGPP1;PIK3CB;PTEN;PPP2CA;SPTLC2;PLD1;BDKRB2 |
| Phospholipase D signaling pathway | PIK3R1;PDGFD;Adcy4;F2R;LPAR2;GRM8;CYTH4;DNM3;DGKD |
| mTOR signaling pathway | PIK3CB;ULK2;PRKAA2;AKT2L;INSB;AKT1S1;PTENB;TSC1A;MTOR |
| PIK-Akt signaling pathway | PIK3R5;DDIT4;PHLPP1;EIF4E2;PRKAA2;ITGA9;NGFR;MTCP1;GYS1 |
| AMPK signaling pathway | PRKAB2;RPTOR;PRKAA1;PCK1;INSR;PFKM;CAMKK2;RAB8A;MTOR |
| Apoptosis | DFFB;TRADD;BIRC8;XIAP;PRKACAB;NFKBIAB;NMT1;PIK3CB;NGF |
| Adrenergic signaling in cardiomyocytes | PIK3R3A;CALM1A;CAMK2A;MAPK12A;ATF6B;CALML5;MYL4;TPM4B;CACNA2D4 |
| VEGF signaling pathway | PRKCBA;RAF1B;MAP2K2A;MAPKAPK2A;CDC42L2;PIK3R2;SH2D2A;PIK3R1;MAPK3 |
| Osteoclast differentiation | PLCG2;NFKB1;MAPK3;MAPK11;LILRB3;TGFBR1;STAT1;STAT2;IFNB1 |
| Focal adhesion | VASP;ACTG1;CDC42L2;VEGFB;VAV2;RHOA;LAMB1;ACTN3;TNW |
| Signaling pathways regulating pluripotency of stem cells | BMP4;INHBA;ACVR1B;WNT3;MAPK12;FZD8;HRAS;SMARCAD1;MYF5 |
| Platelet activation | PLA2G4D;COL24A1;F2R;MAPK1;VAMP8;PLCB4;PIK3R1;PPP1CC;MYL12A |
| Toll-like receptor signaling pathway | AKT2L;Ifna11;IFNA16;LBP;CRFB2;IFNB;RAC1;CXCL11;PIK3CD |
| Jak-STAT signaling pathway | RAF1B;AKT1;CRLF2;Ifna15;AKT2;CNTF;IL12B;IFNA3;NT5C3 |
| Natural killer cell mediated cytotoxicity | PIK3CB;KIR2DL1;TNFRSF10A;SYK;ITGAL;PTK2B;TNFRSF10C;KLRD1;IFNA12 |
| T cell receptor signaling pathway | AKT1;DEF6A;PPP3CB;GRAP2;PIK3CD;MAPK11;CD28;PTPN6;MAP2K7 |
| B cell receptor signaling pathway | NFKB1;ARPC2;IGHM;PPP3R2;LYN;DOK1;NFATC3;SLA2;CD79A |
| Fc epsilon RI signaling pathway | PLCG1;RAC2;PLA2G4D;IL4;LAT;LYN;IL5;IL3;PIK3CG |
| Fc gamma R-mediated phagocytosis | PRKCE;AMPH;LIMK2;WASF3;PLCG1;FCGR1;VAV2;MARCKSL1;PIP5K1C |
| TNF signaling pathway | RPS6KA5;NFKBIA;IL18R1;TNFAIP3;TRADD;MAPK13;TRAF2;MLKL;CASP8 |
| Leukocyte transendothelial migration | TXK;CLDN15;PTK2B;CLDN22;PRKCB;RAP1B;RHOH;CLDN8;AASS |
| Neurotrophin signaling pathway | PLCG2;MAPK10;PSEN2;CAMK2G;RPS6KA1;CALM2;ARHGDIB;BCL2;MAP2K7 |
| Cholinergic synapse | CHRNA3;FYN;GNG10;KCNJ2;CHRM1;GNG8;CAMK2B;KCNQ3;CREB3L1 |
| Inflammatory mediator regulation of TRP channels | TRPM8;IGF1;ACCN4;SRC;GNAQ;MAP2K6;CAMK2A;CYP2J6;PLA2G4F |
| Regulation of actin cytoskeleton | ARAF;SCIN;ITGAE;SLC9A1;PDGFAA;MAP2K2A;NCKAP1L;BRAF;ITGA1 |
| Insulin signaling pathway | INSB;SOCS2;SHC4;ACACB;RPS6;MTOR;PRKAA1;TSC1;PPP1CAB |
| Progesterone-mediated oocyte maturation | MAPK10;BUB1;PIK3R3A;ADCY2B;GNAIA;CDC23;INS;PIK3R3B;PKMYT1 |
| Estrogen signaling pathway | PIK3CA;CALML5;GNAI3;HSPA1A;HSPA1L;KCNJ3;PIK3R3;ATF6B;CALM1 |
| Prolactin signaling pathway | SOS1;SOCS6;ESR1;SOCS7;NFKB1;SOCS3;STAT3;PRL;SOCS1 |
| Thyroid hormone signaling pathway | KAT2A;ACTG1;CASP9;DIO1;MED24;ATP1B3;MAP2K2;PIK3R2;ATP1A3 |
| Oxytocin signaling pathway | PIK3CG;GUCY1A3;RYR1;PPP3CA;GNAI3;PLCB3;MYL9;CAMK2B;PPP3R1 |
| Regulation of lipolysis in adipocytes | INS1;PTGS1;PTGS2;INS;PTGER3;PIK3CG;INSR;PNPLA2;PRKG2 |
| Type II diabetes mellitus | IRS1;HK3;PIK3R2;PIK3R1;PKLR;MAPK1;INSR;SLC2A2;INS2 |
| Insulin resistance | GYS1;SLC2A4;INSB;RELA;CRTC2;PIK3R1;PIK3CD;MAPK8A;PTPN11B |
| Non-alcoholic fatty liver disease (NAFLD) | COX8C;UQCRH;CASP8;IRS2;TRAF2;CDC42;UQCR11;COX7B2;COX7A2 |
| Aldosterone-regulated sodium reabsorption | PIK3R5;ATP1A4;PIK3R1;PRKCG;KRAS;NEDD4L;INSR;ATP1A1;ATP1B3 |
| Carbohydrate digestion and absorption | ATP1B4;PIK3R3;PIK3CD;AKT1;PIK3R2;AMY2A2;PIK3R1;SI;G6PC |
| Bacterial invasion of epithelial cells | ITGB1;PIK3CB;ELMO2;ITGA5;MAD2L2;ILK;RAC1;MET;CAV3 |
| Chagas disease (American trypanosomiasis) | MAPK8;TGFBR1;MYD88;IRAK1;TNF;GNAS;MAPK3;GNA14;RELA |
| Toxoplasmosis | CD40LG;BAD;LAMB1;HSPA8;MAP3K7;IRAK4;TGFB1;TNFRSF1A;AKT1 |
| Amoebiasis | PIK3CD;PRKCG;VCL;PRKACB;SERPINB10;RAB5B;NFKB1;TGFB1;COL4A5 |
| Hepatitis C | CLDN23;STAT2;MAPK3;OAS2;HRAS;MAPK11;PPARA;IFNA7;EIF2AK3 |
| Hepatitis B | KRAS;STAT6;IKBKE;IFNA21;BAD;MAP2K1;PTEN;MAPK8;IFNA16 |
| Measles | HSPA1B;HSPA1L;IL2RB;CD3E;TYK2;CBLB;IFNA6;CD3E; CD3D;FYN |
| Influenza A | IL8L2;IKBKE;Ccl12;TNFRSF10D;RAF1;TNFSF10;IFNA21;IL18;HLA-DOB |
| HTLV-I infection | VDAC2;HLA-E;RB1;WNT6;HLA-DOB;APC2;TGFBR1;PPP3CB;ANAPC4 |
| Epstein-Barr virus infection | PIK3R2;PSMC4;GTF2E1;NUP214;GTF2E2;RAN;POLR2A;PIK3R3;HLA-C |
| Pathways in cancer | Adcy4;VEGFB;GNGT1;GNG11;PLD1;ARNT;PML;MAP2K2;KRAS |
| Viral carcinogenesis | GTF2H1;CCNA1;IKBKG;HDAC9;GTF2H4;PRKACG;RHOA;NFKB2;PIK3R5 |
| Proteoglycans in cancer | CAMK2D;WNT10B;TP53;Casp3;STAT3;KRAS;TWIST1;ARHGEF1;HPSE |
| MicroRNAs in cancer | MAP2K2;STAT3;ABCC1;ERBB2;CCND2;PRKCE;ATM;PDGFB;TNXB |
| Colorectal cancer | AKT1;MSH3;TCF7L2;BCL2;MAPK10;GSK3B;BAD;LEF1;BIRC5 |
| Renal cell carcinoma | EGLN2;TGFB1;HRAS;EPAS1;AHA-1;SLC2A1;SOS1;FH1;EP300 |
| Pancreatic cancer | RAC1;RAF1;PIK3R5;BCL2L1;RALGDS;KRAS;VEGFA;ERBB2;TP53 |
| Endometrial cancer | PDPK1;SOS1;TP53;ILK;PIK3R2;CTNNA3;NRAS;TCF7;APC |
| Glioma | BRAF;PTEN;MAP2K2;MTOR;ARAF;PIK3CA;MAPK1;PDGFRB;PDGFB |
| Prostate cancer | MDM2;LEF1;FGFR2;SMARCC2;NDRG1;HSP90AB1;SPINK1;FOXO1;NRAS |
| Melanoma | FGF13;MITF;FGF10;PDGFRB;MAPK3;HRAS;FGF4;FGF16;FGF2 |
| Chronic myeloid leukemia | CBL;IKBKB;PIK3R5;SHC3;GAB2;AKT2;RB1;CRK;CBLC |
| Acute myeloid leukemia | PIK3CG;MAP2K2;PIK3R2;KIT;MAPK1;PIK3R1;MTOR;PIK3R5;CCND1 |
| Small cell lung cancer | BIRC8;FHIT;LAMC2;LAMA3;IKBKG;FN1;LAMC1;TRAF6;PIK3R3 |
| Non-small cell lung cancer | PIK3CD;ALK;RXRA;NRAS;TRP53;MAPK3;PRKCG;ARAF;PIK3CB |
| Central carbon metabolism in cancer | PIK3R2;HIF1A;SLC7A5;HK1;PIK3CG;SIRT3;PDGFRA;SLC1A5;HK2 |
| Choline metabolism in cancer | SLC22A1;PLCG1;PIK3CD;TSC2;HIF1A;PLD2;HRAS;SLC44A1;SOS1 |
PIK3CA has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CA itself. We selected most functions PIK3CA had, and list some proteins which have the same functions with PIK3CA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | PIK3C2A;PIK3C3;PIK3CB;PIK3C2B;PIK3CA;PIK3R3;PIK3CG;PIK3CD;PIK3C2G |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3C2G;PIK3CG;PIK3C2B;PIK3CA;PIK3CB;PIK3C2A;PIK3CD |
| ATP binding | PFKP;DDX58;MKNK2A;NOL9;PRKG2;CAMK4;PIK3CA;CDK3;EIF4A1 |
| insulin receptor substrate binding | PRKCZ;INSRR;IGF1RA;PIK3CB;PIK3CA;PTPN11;PIK3R1;PRKCD;INSRB |
| kinase activity | Fert2;JAK2A;MAPK8B;PRPS2;GSK3B;NUCKS1A;CAMK2D2;CKMT1;PTK2AA |
| phosphatidylinositol 3-kinase activity | PIK3CB;PIK3CD;PIK3C2A;PIK3CG;PIK3CA |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | PIK3CB;PIK3CG;PIK3CD;PIK3CA |
| protein binding | LSM6;LDHA;VEGFA;GCKR;PSMD7;MATN1;IGF2BP2;PLK1S1;ABCD2 |
| protein kinase activator activity | NKX3-1;MT3;AGAP2;PRKAG2;MAPK8IP2;STK11;NCKAP1L;STRADA;FGF13 |
| protein serine/threonine kinase activity | ADCK4;MAP4K4;NLK2;CLK3;CDK12;EIF2AK4;SGK2;MAP2K2;STK25 |
PIK3CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CA.
PIK3R1; IRS1
Ciombor, KK; Wu, C; et al. Recent Therapeutic Advances in the Treatment of Colorectal Cancer. ANNUAL REVIEW OF MEDICINE, VOL 66 66:83-95(2015).
Treilleux, I; Arnedos, M; et al. Translational studies within the TAMRAD randomized GINECO trial: evidence for mTORC1 activation marker as a predictive factor for everolimus efficacy in advanced breast cancer. ANNALS OF ONCOLOGY 26:120-125(2015).
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