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PIK3CA

  • Official Full Name

    phosphoinositide-3-kinase, catalytic, alpha polypeptide

  • Overview

    Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers.
  • Synonyms

    PIK3CA; phosphoinositide-3-kinase, catalytic, alpha polypeptide; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; PI3K; PI3K-alpha; PI3-kinase p110 subunit alpha; ptdIns-3-kinase subunit p110-alpha; serine/threonine protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Mouse, Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIK3CA&PIK3R1-152H Active Recombinant Human PIK3CA(E542K)/PIK3R1 protein, His-tagged Insect Cell His
Human PIK3CA&PIK3R1-151H Active Recombinant Human PIK3CA(N345K)/PIK3R1 protein, His-tagged Insect Cell His
Human PIK3CA-1894H Active Recombinant Human PI3 kinase (p110α/p85α) protein, GST-tagged Insect Cell GST
Human PIK3CA&PIK3R3-152H Active Recombinant Human PIK3CA/PIK3R3 protein, His-tagged Insect Cell His
Human PIK3CA&PIK3R1-150H Active Recombinant Human PIK3CA(E545K)/PIK3R1 protein, His-tagged Insect Cell His
Human PIK3CA&PIK3R1-153H Active Recombinant Human PIK3CA/PIK3R1 protein, GST-tagged Insect Cell GST
Human PIK3CA&PIK3R1-154H Active Recombinant Human PIK3CA/PIK3R1 protein, His-tagged Insect Cell His
Human PIK3CA-2690HF Active Recombinant Full Length Human PIK3CA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-1068(end)
Human PIK3CA-2229HF Active Recombinant Full Length Human PIK3CA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-1068(end)
Human PIK3CA-9713HF Active Recombinant Full Length Human PIK3CA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-1068(end)
Human PIK3CA-4827HF Active Recombinant Full Length Human PIK3CA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-1068(end)
Human PIK3CA-2941HF Active Recombinant Full Length Human PIK3CA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-1068(end)
Human PIK3CA-7972HF Active Recombinant Full Length Human PIK3CA Protein, GST-tagged Insect (sf21) GST 1-1068(end)
Human PIK3CA-8555HF Active Recombinant Full Length Human PIK3CA Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-1068(end)
Human PIK3CA-29687TH Recombinant Human Human PIK3CA, His-tagged His
Human PIK3CA-1078H Recombinant Human Phosphoinositide-3-kinase, Catalytic, Alpha Polypeptide, His-tagged Sf9 Insect Cell His
Human PIK3CA/PIK3R1-631H Recombinant Human PIK3CA/PIK3R1, FLAG-tagged Sf9 Insect Cell Flag
Human PIK3CA/PIK3R1-641H Recombinant Human PIK3CA/PIK3R1 Insect Cell N/A
Human PIK3CA-331H Recombinant Human PIK3CA Mammalian Cell His
Human PIK3CA/PIK3R1-389H Recombinant Human PIK3CA/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Human PIK3CA-70H Recombinant Human PIK3CA protein, Flag-tagged, Biotinylated Insect Cell Flag
Human PIK3CA-3189HCL Recombinant Human PIK3CA 293 Cell Lysate HEK293 N/A
Human PIK3CA-3860H Recombinant Human PIK3CA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PIK3CA-2591H Recombinant Human PIK3CA Protein, His-tagged E.coli N-His Ile330-Pro487
Human PIK3CA-3860H-B Recombinant Human PIK3CA Protein Pre-coupled Magnetic Beads HEK293
Human PIK3CA-4896H Recombinant Human PIK3CA Protein (Asn345-Phe550), N-His tagged E.coli N-His Asn345-Phe550
Mouse Pik3ca-1079H Recombinant Mouse Phosphatidylinositol 3-Kinase, Catalytic, Alpha Polypeptide, His-tagged Sf9 Insect Cell His
Mouse PIK3CA-12801M Recombinant Mouse PIK3CA Protein Mammalian Cell His
Mouse PIK3CA-6737M-B Recombinant Mouse PIK3CA Protein Pre-coupled Magnetic Beads HEK293
Mouse PIK3CA-6737M Recombinant Mouse PIK3CA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine PIK3CA-208B Active Recombinant Bovine PIK3CA Sf9 Insect Cell N/A
Bovine PIK3CA-610B Recombinant Bovine Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, His-tagged Sf9 Insect Cell His
Bovine PIK3CA-1864B Recombinant Bovine Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, GST-tagged Sf9 Insect Cell GST
Mouse, Human Pik3ca/PIK3R1-390H Recombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Rhesus Macaque PIK3CA-3432R Recombinant Rhesus monkey PIK3CA Protein, His-tagged Mammalian Cell His
Rhesus Macaque PIK3CA-3250R Recombinant Rhesus Macaque PIK3CA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PIK3CA-3250R-B Recombinant Rhesus Macaque PIK3CA Protein Pre-coupled Magnetic Beads HEK293
Chicken PIK3CA-1228C Recombinant Chicken PIK3CA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • PIK3CA Related Signal Pathway

PIK3CA involved in several pathways and played different roles in them. We selected most pathways PIK3CA participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inositol phosphate metabolismPIP4K2AA;ITPKC;MTMR1;PIK3CA;PIK3C2B;MINPP1B;IMPA2;CDIPT;PTENA
ErbB signaling pathwayPAK2A;EREG;PAK2;CAMK2D2;MAPK3;PIK3R2;PIK3CG;HRASA;PRKCBA
Ras signaling pathwayPLA2G4C;INSR;GAB1;CALM3;GNGT2;INS2;GNG10;PRKACB;RHOA
Rap signaling pathwayFGFR4;IGF1;RAP1GAP;TEK;ITGB2;PIK3CD;RALGDS;P2RY1;CALM4
cGMP-PKG signaling pathwayBNP;CALML3;PIK3R3;NPPB;MAPK1;ATP2B1;RHOA;GNAI2;NPR2
cAMP signaling pathwayMAPK10;GHRL;PLN;GNAS;PIK3R5;VIPR2;MAPK9;PDE3B;RRAS2
Chemokine signaling pathwayVAV1;CCR3;PIK3R2;ELMO1;IKBKB;VAV3;ARRB2;CCR8;AKT1
HIF- signaling pathwayCUL2;CAMK2A;VHL;MTOR;PIK3R1;MAP2K1;PRKCA;NPPA;STAT3
FoxO signaling pathwayPRKAG1;IRS2;MAPK12B;TNFSF10;PLK1;PCK2;FOXG1A;PLK4;CCNB1
Phosphatidylinositol signaling systemMTMR3;MTMR6;PIP5K1C;SYNJ1;PTEN;PPIP5K1;CALM;PLCB2;IMPA1
Sphingolipid signaling pathwayNRAS;S1PR5;TNFRSF1A;MAPK9;SGMS2;MAPK3;TNF;SGPP2;LOC100328615
Phospholipase D signaling pathwayGRB2;PIK3R2;GNAS;CYTH2;Kitl;SPHK1;PIK3CD;PLD1;PLCB1
mTOR signaling pathwayPOLDIP3;PRKAA1;PIK3R2;RICTOR;BRAF;AKT2L;TNF;PRR5;EIF4BA
PIK-Akt signaling pathwayTCL1B4;STK11;PPP2R1A;Ifna15;PCK2;NGF;PHLPP2;FGF4;IL2RB
AMPK signaling pathwayCREB3L1;SCD;ADIPOR2;PIK3R3;SCD5;RPS6KB1;FASN;PRKAA2;SLC2A4
ApoptosisPRKACBB;TNFRSF10C;STK24A;CASP7;MYC;IRAK2;HIST1H1B;BCL2L1;TNF
Adrenergic signaling in cardiomyocytesCALML5;GNA15.4;ADRB1;ACTC1A;ATP2B3B;MAPK12;ATP2A2;CAMK2B;ATP1A3A
VEGF signaling pathwayVEGFA;MAP2K2B;SHC2;SPHK1;PRKCA;CASP9;AKT3A;MAPK12A;MAP2K2
Osteoclast differentiationRELB;PPP3CC;LILRA4;NOX3;BTK;LILRB4;LILRA3;LILRB2;PIK3R5
Focal adhesionACTN2;MYLK3;FLNA;RAP1A;PTENB;PIP5K1C;FYN;MYL7;HRASA
Signaling pathways regulating pluripotency of stem cellsFZD6;FGFR3;ISL1;FZD8;FZD9;ESX1;ACVR1C;ZIC3;MAPK1
Platelet activationMYL12B;FGB;SRC;GUCY1A3;PRKCI;GNAI2;RAP1B;GNAQ;ACTG1
Toll-like receptor signaling pathwayCXCL9;MAPK12;IRF5;IRF3;IFNA1;NFKB1;IFNA13;IFNAR1;MAP2K2A
Jak-STAT signaling pathwaySTAT1A;IL20;IL11RA2;IFNA6;PIM1;MYCB;STAT6;IL10RA;SOCS5B
Natural killer cell mediated cytotoxicityIFNA13;NFATC1;KIR2DL3;FYN;H60a;CD247;Ifna15;IFNA4;SAMD3
T cell receptor signaling pathwayPIK3CA;CD28;PPP3CC;NFKBIE;PRKCQ;GRAP2;CBL;NFATC2;CD40LG
B cell receptor signaling pathwayITPR2;RAP2A;NFKBIA;CD22;HDAC5;RASGRP3;ACTR3;CDK6;PIK3AP1
Fc epsilon RI signaling pathwayMAP2K3;PLA2G4B;GM-CSF;PIK3CD;PIK3CG;PIK3CB;LAT;IL5;RAF1
Fc gamma R-mediated phagocytosisPIK3CA;PLA2G6;GAB2;SPHK2;PPAP2B;PRKCA;SPHK1;VASP;PPAP2A
TNF signaling pathwayDNM1L;PIK3CG;CREB5;IL6;PIK3R3;IKBKG;TNFAIP3;MAPK11;VEGFC
Leukocyte transendothelial migrationPIK3CB;CLDN6;MYL12B;ROCK2;ACTG1;ITGA4;CLDN18;MYL7;PIK3CD
Neurotrophin signaling pathwayNTRK2;BAD;KRAS;ARHGDIA;RHOA;SORT1;MAPK10;CAMK2G;CDC42
Cholinergic synapseKCNQ5;PIK3R2;MAPK3;PIK3R3;MAP2K1;GNB3;GNAI1;CREB3L2;JAK2
Inflammatory mediator regulation of TRP channelsPLA2G6;PRKCD;CALM4;PLA2G4F;CYP2C54;PPP1CC;PRKCA;TRPV4;Adcy4
Regulation of actin cytoskeletonDIAPH1;HRASA;PAK7;SSH3;CFL2L;PIK3CG;RHOA;ROCK2A;ITGAX
Insulin signaling pathwayG6PC2;PIK3CA;CALM2A;FOXO1;HK2;AKT2L;FOXO1B;SOCS3B;PHKA1
Progesterone-mediated oocyte maturationCDC25C;PIK3R3;RAF1B;MAD2L2;PIK3CB;MAPK11;GNAI1;PIK3R3B;PIK3CG
Estrogen signaling pathwayPIK3CA;MAPK1;KCNJ9;FOS;HSPA1B;ITPR1;SHC4;PLCB2;PIK3R2
Prolactin signaling pathwayPIK3CA;RELA;PIK3R5;SOCS4;STAT5A;SHC4;KRAS;NRAS;TNFRSF11A
Thyroid hormone signaling pathwayMED17;HDAC3;ATP1A4;RXRB;KAT2A;EP300;TBC1D4;HDAC1;PIK3R5
Oxytocin signaling pathwayPPP1CC;PIK3CD;CALM2;PRKCB;PRKACA;Adcy4;CACNB4;ROCK2;CAMK1D
Regulation of lipolysis in adipocytesPRKACB;PNPLA2;AKT1;ABHD5;PIK3CD;GNAI2;PRKG1;AQP7;PRKACG
Type II diabetes mellitusMAPK9;MAPK10;MTOR;PIK3R1;PKM2;SLC2A2;INSR;PRKCE;HK3
Insulin resistanceOGT;NFKBIAB;PTPRFB;PPARA;MAPK8A;CRTC2;PRKCZ;IRS2;TRIB3
Non-alcoholic fatty liver disease (NAFLD)SDHA;PPARA;PIK3CA;SREBF1;MAPK9;INS;COX6B2;TNFRSF1A;SDHB
Aldosterone-regulated sodium reabsorptionFXYD4;FXYD2;PIK3R2;PIK3CD;ATP1B4;MAPK1;PRKCA;IRS1;PIK3CB
Carbohydrate digestion and absorptionSLC2A5;AMY2B;ATP1B1;G6PC;Amy1;SLC37A4;AMY2A3;HKDC1;AMY1A
Bacterial invasion of epithelial cellsDNM2;DNM3;ACTG1;CBLC;CLTA;CD2AP;GAB1;CTNNA3;CBL
Chagas disease (American trypanosomiasis)PLCB3;IRAK1;TNFRSF1A;TGFB2;AKT2;MAP2K4;SMAD2;MAPK3;MAPK1
ToxoplasmosisPDPK1;IL12B;ALOX5;GNAI3;IFNGR1;HLA-DMB;MAPK9;HLA-DMA;Casp3
AmoebiasisCTSG;CXCL1;LAMB4;Casp3;ITGB2L;GNA15;PTK2;C8G;TGFB2
Hepatitis CTNFRSF1A;NFKBIA;PIK3CG;PIK3R2;MAPK13;EIF2AK2;IFNA17;DDX58;IRF1
Hepatitis BPIK3CG;IFNA16;Fasl;TIRAP;PTEN;EP300;MMP9;YWHAB;CREB3L1
MeaslesPRKCQ;PIK3CD;IFNA14;CD3E; CD3D;MSN;IKBKE;BBC3;FCGR2B;IL1A
Influenza AHSPA6;MAP2K4;RSAD2;SOCS3;IFNA10;IL-8;HLA-DRA;IFNA1;RAF1
HTLV-I infectionNFKB1;HLA-DQA1;CDC26;CCND2;WNT5B;XBP1;SMAD4;ITGAL;BAX
Epstein-Barr virus infectionPRKACB;TRP53;YWHAB;TRAF6;PSMD2;FGR;HLA-DRA;NFKB2;MAPK8
Pathways in cancerCXCR4;ERBB2;PTGS2;NCOA4;WNT5B;TRAF6;ROCK1;PIK3R3;FGF14
Viral carcinogenesisHIST1H2BI;TRAF1;TRAF2;HDAC7A;DDX3X;ACTN4;HIST1H2BO;HLA-B;CREB3L1
Proteoglycans in cancerSRC;ITGA5;FZD3;PLAU;CAV1;FASLG;FN1;TWIST1;MDM2
MicroRNAs in cancerTNXB;PIK3CA;TIMP3;RDX;MCL1;RHOA;PDGFRA;NFKB1;BMF
Colorectal cancerPIK3R5;GSK3B;TRP53;RAC3;RHOA;LEF1;MAPK9;MAPK10;MSH2
Renal cell carcinomaPAK6;MAPK1;FLCN;ETS1;HGF;HRAS;HIF1A;CUL2;PAK3
Pancreatic cancerPIK3R2;MAPK8;PIK3R5;CASP9;VEGFA;PIK3R1;MAP2K1;ARAF;PIK3CD
Endometrial cancerSOS1;TCF7;LEF1;MAP2K1;MAP2K2;BAD;MAPK3;PIK3R5;RAF1
GliomaKRAS;PIK3CA;CAMK2A;MAP2K2;PIK3R5;MAPK3;PLCG2;AKT1;TGFA
Prostate cancerMTOR;AKT1;FGFR1;HSP90AB1;TGFA;MAP2K1;HSP90AA1;ARID1A;PDGFC
MelanomaBRAF;PIK3R2;FGF12;FGF7;FGF8;MET;RAF1;FGF14;PDGFB
Chronic myeloid leukemiaCBLB;RAF1;PIK3R1;IKBKB;BCR;STAT5A;SMAD3;MAP2K2;GRB2
Acute myeloid leukemiaPIK3R1;STAT5A;MAP2K1;KIT;JUP;PIK3R5;NFKB1;SFPI1;PIK3CD
Small cell lung cancerCCNE1;ITGAV;RXRG;ITGB1;PTK2;PIK3R3;ITGA3;PIK3R5;PIK3CB
Non-small cell lung cancerFOXO3;CCND1;TP53;MAPK1;PIK3R3;MAPK3;PRKCA;KRAS;ERBB2
Central carbon metabolism in cancerSLC2A1;IDH1;PIK3R3;HIF1A;PTEN;PKM;PGAM1;PDHA2;PIK3R5
Choline metabolism in cancerPIK3CB;MAPK3;DGKD;RPS6KB1;RPS6KB2;DGKG;PLA2G4D;MAPK10;WASF3

PIK3CA has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CA itself. We selected most functions PIK3CA had, and list some proteins which have the same functions with PIK3CA. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol-3-kinase activityPIK3C2G;PIK3CG;PIK3CA;ATM;PIK3C3;PIK3C2B;PIK3R3;PIK3CD;PIK3C2A
1-phosphatidylinositol-4-phosphate 3-kinase activityPIK3CB;PIK3CA;PIK3C2B;PIK3CD;PIK3C2A;PIK3CG;PIK3C2G
ATP bindingSMARCA4;TMEM38A;PI4K2A;CTPS2;MKKS;ATAD5;ABCB1A;ABCA7;DHX38
insulin receptor substrate bindingJAK2;INSR;PIK3CA;GRB2;PTPN11;IGF1R;INSRA;IGF1RB;INSRR
kinase activityTSSK1;PFKFB2A;BMPR1BA;DCLK1A;PTK2AB;SGMS1;BAIAP2L1A;CCNE1;PAK2A
phosphatidylinositol 3-kinase activityPIK3CD;PIK3CA;PIK3C2A;PIK3CB;PIK3CG
phosphatidylinositol-4,5-bisphosphate 3-kinase activityPIK3CD;PIK3CA;PIK3CB;PIK3CG
protein bindingYY1AP1;GZMB;HES1;CAV1;SERTAD1;C9orf86;HSD17B14;CDC25A;NGF
protein kinase activator activityEPO;MARK2;TOM1L1;WNT11;DBF4B;FGF13;DUSP19;MT3;NKX3-1
protein serine/threonine kinase activityDSTYK;DCKL1B;SMG1;PIK3R4;TP53RK;SLKA;MAP2K3;TLK1B;AAK1

PIK3CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CA.

PIK3R1; IRS1

Research Area

Related articles

Ciombor, KK; Wu, C; et al. Recent Therapeutic Advances in the Treatment of Colorectal Cancer. ANNUAL REVIEW OF MEDICINE, VOL 66 66:83-95(2015).
Treilleux, I; Arnedos, M; et al. Translational studies within the TAMRAD randomized GINECO trial: evidence for mTORC1 activation marker as a predictive factor for everolimus efficacy in advanced breast cancer. ANNALS OF ONCOLOGY 26:120-125(2015).
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