• Official Full Name

    phosphoinositide-3-kinase, class 2, alpha polypeptide

  • Overview

    The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
  • Synonyms

    PIK3C2A; phosphoinositide-3-kinase, class 2, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; PI3K C2alpha; PI3K-C2alpha; PI3K-C2-alpha; ptdIns-3-kinase C2 subunit alpha; phosphoinositide 3-kinase-C2-alpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Sf21
  • Sf9 Insect Cell
  • GST
  • His
  • His|GST
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIK3C2A-1452H Active Recombinant Human PIK3C2A, GST-tagged Sf9 Insect Cell GST 299 aa-end
Human PIK3C2A-191H Active Recombinant Human PIK3C2A(299-end) Protein, N-His-tagged Sf21 His 299–end
Human PIK3C2A-1715H Recombinant Human PIK3C2A, His-tagged E.coli His 1-338aa
Human PIK3C2A-551H Recombinant Human PIK3C2A Protein, His-tagged E.coli His Phe172~Asn403
Human PIK3C2A-3191HCL Recombinant Human PIK3C2A 293 Cell Lysate HEK293 N/A
Human PIK3C2A-3165H Recombinant Human PIK3C2A Protein (Phe172-Asn403), His tagged E.coli His Phe172-Asn403
Mouse Pik3c2a-552M Recombinant Mouse Pik3c2a Protein, His/GST-tagged E.coli His/GST Lys349~Pro611
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PIK3C2A involved in several pathways and played different roles in them. We selected most pathways PIK3C2A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3C2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inositol phosphate metabolismPI4KB;MINPP1B;IPMK;PLCH1;MTMR1;PIK3CG;ITPKC;PLCD3;IMPAD1
Metabolic pathwaysG6PC3;NDUFB2;ADH2-2;ADH2-1;MT-ATP6;HPSE;OGDH;NDUFB7;SLC33A1
Phosphatidylinositol signaling systemPI4KB;PIK3R3A;PIK3R3;PIP4K2AA;PIK3R5;PIP4K2A;IP6K3;PLCD4;ITPK1A

PIK3C2A has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3C2A itself. We selected most functions PIK3C2A had, and list some proteins which have the same functions with PIK3C2A. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol-3-kinase activityPIK3CB;PIK3C2G;PIK3CA;PIK3C3;PIK3R3;PIK3CG;PIK3CD;PIK3C2A;ATM
1-phosphatidylinositol-4-phosphate 3-kinase activityPIK3CD;PIK3CG;PIK3C2G;PIK3C2A;PIK3CA;PIK3CB;PIK3C2B
phosphatidylinositol 3-kinase activityPIK3C2A;PIK3CB;PIK3CA;PIK3CD;PIK3CG
phosphatidylinositol bindingSNX10A;SNX17;MYO1E;ARHGAP32;TULP4A;NISCH;SNX6;PASK;ZCCHC2

PIK3C2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3C2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3C2A.

Dlg4; ATG7; STAMBP; PGK1; TARS; FKBP4; MAP1LC3A; ANKFY1; PA2G4; AMOT; phoA; purvalanol b; Sec24c; GAK; SEC16A; EGFR; ERBB2; CLTB; FLNA

Research Area

Related articles

Muffak-Granero, K; Olmedo, C; et al. Gene Network Profiling Before and After Transplantation in Alcoholic Cirrhosis Liver Transplant Recipients. TRANSPLANTATION PROCEEDINGS 44:1493-1495(2012).
Huang, WS; Wang, TB; et al. Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948. WORLD JOURNAL OF GASTROENTEROLOGY 18:3458-3464(2012).
  • Reviews
  • Q&As

Customer Reviews (3)

Write a review

    The PIK3C2A protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.


      Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.


        Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.

        Q&As (5)

        Ask a question
        Can targeting PIK3C2A have potential applications in immunotherapy? 07/30/2022

        PIK3C2A inhibitors may enhance the efficacy of immunotherapy by modulating immune cell function and overcoming resistance to immune checkpoint inhibitors in cancer.

        What strategies are being explored to target PIK3C2A for the treatment of insulin resistance and diabetes? 11/27/2020

        Research is focusing on developing small molecule inhibitors and gene therapy approaches to modulate PIK3C2A activity as a potential therapeutic strategy for diabetes.

        What role does PIK3C2A play in the development of neurological disorders? 10/25/2019

        PIK3C2A has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting its potential as a target for disease-modifying therapies.

        What are the potential therapeutic applications of targeting PIK3C2A in cancer treatment? 03/18/2019

        Targeting PIK3C2A may lead to the development of novel anticancer therapies, including small molecule inhibitors and monoclonal antibodies.

        How does PIK3C2A protein contribute to cell signaling pathways? 10/15/2017

        PIK3C2A is involved in the PI3K/Akt/mTOR signaling pathway, which regulates cell growth, proliferation, and survival, making it an attractive target for therapeutic intervention.

        Ask a Question for All PIK3C2A Products

        Required fields are marked with *

        My Review for All PIK3C2A Products

        Required fields are marked with *


        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends