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Official Full Name phosphoinositide-3-kinase, class 2, alpha polypeptide
Background The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
Synonyms PIK3C2A; phosphoinositide-3-kinase, class 2, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; PI3K C2alpha; PI3K-C2alpha; PI3K-C2-alpha; ptdIns-3-kinase C2 subunit alpha; phosphoinositide 3-kinase-C2-alpha
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PIK3C2A-1452H Recombinant Human PIK3C2A (Active), GST-tagged Sf9 Insect Cell GST
    Human PIK3C2A-1715H Recombinant Human PIK3C2A, His-tagged E.coli His
    Human PIK3C2A-3191HCL Recombinant Human PIK3C2A 293 Cell Lysate HEK293 N/A
    Human PIK3C2A-551H Recombinant Human PIK3C2A Protein, His-tagged E.coli His
    Mouse Pik3c2a-552M Recombinant Mouse Pik3c2a Protein, His/GST-tagged E.coli His/GST

    pik3c2a involved in several pathways and played different roles in them. We selected most pathways pik3c2a participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with pik3c2a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Inositol phosphate metabolism MTMR8; PLCD1; PIP4K2A; IMPA1; MTMR1A; MTMR3; PIP4K2B; NUDT3; MTMR1B; PIP5K1AB
    Metabolic pathways ATP5F1; POLE2; HSD17B8; FDPS; MOCS2; PTGDSB; FOLH1; DHRS13L1; HSD17B12; PKM
    Phosphatidylinositol signaling system INPP4A; PI4KB; ITPKA; PI4K2A; IPMKB; IP6K3; PTENB; MTMR7A; MTMR1B; CALM2A

    pik3c2a has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by pik3c2a itself. We selected most functions pik3c2a had, and list some proteins which have the same functions with pik3c2a. You can find most of the proteins on our site.

    Function Related Protein
    1-phosphatidylinositol-3-kinase activity PIK3CB; PIK3C3; PIK3C2A; PIK3CA; PIK3CG; PIK3CD; ATM; PIK3C2G; PIK3R3; PIK3C2B
    1-phosphatidylinositol-4-phosphate 3-kinase activity PIK3CG; PIK3CB; PIK3C2A; PIK3CD; PIK3C2B; PIK3C2G; PIK3CA
    ATP binding FKBP4; SIK2; ULK2; NLRC3; MCCC1; SYN2; UBE2D4; DDX39A; PANK4; DHX16
    phosphatidylinositol 3-kinase activity PIK3CG; PIK3CA; PIK3CD; PIK3CB; PIK3C2A
    phosphatidylinositol binding SEPT12; ITPR3; PLD2; SH3PXD2AA; SNX5; NOXO1A; HIP1; SNX27; NISCH; SNX15

    pik3c2a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with pik3c2a here. Most of them are supplied by our site. Hope this information will be useful for your research of pik3c2a.

    Dlg4; ATG7; STAMBP; PGK1; TARS; FKBP4; MAP1LC3A; ANKFY1; PA2G4; AMOT; phoA; purvalanol b; Sec24c; GAK; SEC16A; EGFR; ERBB2; CLTB; FLNA

    Muffak-Granero, K; Olmedo, C; et al. Gene Network Profiling Before and After Transplantation in Alcoholic Cirrhosis Liver Transplant Recipients. TRANSPLANTATION PROCEEDINGS 44:1493-1495(2012).
    Huang, WS; Wang, TB; et al. Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948. WORLD JOURNAL OF GASTROENTEROLOGY 18:3458-3464(2012).

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