PIK3C2A
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Official Full Name
phosphoinositide-3-kinase, class 2, alpha polypeptide
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Overview
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. -
Synonyms
PIK3C2A; phosphoinositide-3-kinase, class 2, alpha polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha; PI3K C2alpha; PI3K-C2alpha; PI3K-C2-alpha; ptdIns-3-kinase C2 subunit alpha; phosphoinositide 3-kinase-C2-alpha;
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- Human
- Mouse
- E.coli
- HEK293
- Sf21
- Sf9 Insect Cell
- GST
- His
- Non
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | PIK3C2A-1452H | Active Recombinant Human PIK3C2A, GST-tagged | Sf9 Insect Cell | GST | 299 aa-end | |
Human | PIK3C2A-191H | Active Recombinant Human PIK3C2A(299-end) Protein, N-His-tagged | Sf21 | His | 299–end | |
Human | PIK3C2A-1715H | Recombinant Human PIK3C2A, His-tagged | E.coli | His | 1-338aa | |
Human | PIK3C2A-551H | Recombinant Human PIK3C2A Protein, His-tagged | E.coli | His | Phe172~Asn403 | |
Human | PIK3C2A-3191HCL | Recombinant Human PIK3C2A 293 Cell Lysate | HEK293 | Non | ||
Human | PIK3C2A-3165H | Recombinant Human PIK3C2A Protein (Phe172-Asn403), His tagged | E.coli | His | Phe172-Asn403 | |
Mouse | Pik3c2a-552M | Recombinant Mouse Pik3c2a Protein, His/GST-tagged | E.coli | His&GST | Lys349~Pro611 |
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PIK3C2A involved in several pathways and played different roles in them. We selected most pathways PIK3C2A participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3C2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Inositol phosphate metabolism | PLCE1;INPP1;PLCD4;PLCG2;PLCD3A;PLCH2;PIP5K1C;NUDT4B;SYNJ2 |
Metabolic pathways | IVD;GATM;ZNF408;EXTL1;ALAS1;NT5C;MTMR4;CERS1;HSD3B2 |
Phosphatidylinositol signaling system | TMEM55B;DGKD;INPP4AB;PPIP5K2;CALM1A;ITPR3;INPP4B;CALM1;MTMR7 |
PIK3C2A has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3C2A itself. We selected most functions PIK3C2A had, and list some proteins which have the same functions with PIK3C2A. You can find most of the proteins on our site.
Function | Related Protein |
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1-phosphatidylinositol-3-kinase activity | PIK3C2G;PIK3R3;ATM;PIK3CD;PIK3C3;PIK3CA;PIK3C2A;PIK3C2B;PIK3CG |
1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3C2A;PIK3CG;PIK3C2G;PIK3CB;PIK3CA;PIK3C2B;PIK3CD |
ATP binding | EPHB3A;KIF3CB;ABCB5;LIG1;H1FNT;CSNK1DB;JAK1;DDX11;PDK2 |
phosphatidylinositol 3-kinase activity | PIK3CA;PIK3C2A;PIK3CB;PIK3CG;PIK3CD |
phosphatidylinositol binding | WDR35;SNX25;SNX12;ESYT2;SNX6;SNX22;TNFAIP8L3;ZCCHC2;TULP4A |
PIK3C2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3C2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3C2A.
Dlg4; ATG7; STAMBP; PGK1; TARS; FKBP4; MAP1LC3A; ANKFY1; PA2G4; AMOT; phoA; purvalanol b; Sec24c; GAK; SEC16A; EGFR; ERBB2; CLTB; FLNA
Research Area
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Customer Reviews (3)
Write a reviewThe PIK3C2A protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.
Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.
Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.
Q&As (5)
Ask a questionPIK3C2A inhibitors may enhance the efficacy of immunotherapy by modulating immune cell function and overcoming resistance to immune checkpoint inhibitors in cancer.
Research is focusing on developing small molecule inhibitors and gene therapy approaches to modulate PIK3C2A activity as a potential therapeutic strategy for diabetes.
PIK3C2A has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, suggesting its potential as a target for disease-modifying therapies.
Targeting PIK3C2A may lead to the development of novel anticancer therapies, including small molecule inhibitors and monoclonal antibodies.
PIK3C2A is involved in the PI3K/Akt/mTOR signaling pathway, which regulates cell growth, proliferation, and survival, making it an attractive target for therapeutic intervention.
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