PIK3CB
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Official Full Name
phosphoinositide-3-kinase, catalytic, beta polypeptide
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Overview
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important;in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic;subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the;activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative;splicing results in multiple transcript variants. -
Synonyms
PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide; PIK3C1; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3K-beta; PtdIns-3-kinase p110; PI3-kinase subunit beta; PI3-kinase p110 subunit beta; ptdIns-3-kinase;
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- PIK3CB Related Signal Pathway
PIK3CB involved in several pathways and played different roles in them. We selected most pathways PIK3CB participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | MTMR1A;NUDT4A;PLCD1A;PTENA;PIK3CG;PIKFYVE;PIP4K2AA;PIP4K2C;PLCB4 |
| ErbB signaling pathway | ERBB3B;MTOR;ERBB4A;MAPK8;ABL1;NCK2A;ELK1;KRAS;CAMK2D1 |
| Ras signaling pathway | SHOC2;FGFR3;GNG5;GNG4;PLCE1;ETS1;NRAS;SHC3;RASA3 |
| Rap signaling pathway | KLK1B4;PFN3;FGF14;SRC;ITGA2B;PARD3;GNAI2;RAP1GAP;APBB1IP |
| cGMP-PKG signaling pathway | GNAI1;NOS3;ATF4;GNA12;NPPB;VASP;INS2;MYLK3;CALM2 |
| cAMP signaling pathway | ATP1B1;PDE3B;GRIN2D;ATP1A2;CALM3;FXYD1;FSHR;GRIA2;TSHR |
| Chemokine signaling pathway | PIK3R1;PPBP;STAT1;GNB3;CXCR1;FGR;GNG10;PF4;GNGT1 |
| HIF- signaling pathway | PIK3CD;INS1;IGF1;TFRC;EPO;CAMK2G;SERPINE1;LTBR;AKT1 |
| FoxO signaling pathway | TGFB1A;EP300;FOXG1;STK11;CAT;IGF1R;PIK3R3;CCNB2;SGK2B |
| Phosphatidylinositol signaling system | CALM1B;PI4K2B;MTMR4;CDS2;PTEN;PIP5K1A;CALML3;PIK3C2B;PTENA |
| Sphingolipid signaling pathway | GNAI1;RELA;PIK3CG;MAPK12;OPRD1;MAPK13;PTEN;PLCB2;DEGS1 |
| Phospholipase D signaling pathway | SPHK1;AVPR1A;DGKD;GAB2;GRM7;AGPAT4;SHC4;LPAR4;GRM2 |
| mTOR signaling pathway | POLDIP3;BRAF;RRN3;PRKCBA;MAPK3;PIK3R1;RPS6KA3;EIF4BB;PIK3R2 |
| PIK-Akt signaling pathway | FGF9;Fgf15;FGF13;INS2;OSM;GH2;YWHAE;RPTOR;IFNA5 |
| AMPK signaling pathway | PPP2R2B;G6PC3;SLC2A4;FOXO1;CFTR;LIPE;Scd2;CAB39;ULK1 |
| Apoptosis | PPP3CCB;CASP8;HIST1H1B;FADD;PRKACAB;CASP4;E2F1;PANK1A;BIRC3 |
| Adrenergic signaling in cardiomyocytes | ADRa1A;PIK3CG;PIK3R3A;PPP2R2CA;ATP1A3B;CACNG3;ATP2B2;PPP1CAA;PRKACB |
| VEGF signaling pathway | PTGS2B;RAF1;BADB;RAF1B;PIK3R3A;AKT1;CDC42L2;PLA2G4AA;PIK3R3 |
| Osteoclast differentiation | MAP2K1;FCGR1;TGFB2;NFKB2;OSCAR;MAPK8;MAP3K14;FYN;TRAF6 |
| Focal adhesion | VAV2;TNW;PRKCB;TNXB;FLNA;ITGA5;BIRC3;PIK3R2;COL6A4 |
| Signaling pathways regulating pluripotency of stem cells | FGFR4;WNT3A;SMAD3;WNT5A;WNT16;FZD6;INHBC;PIK3CG;FZD2 |
| Platelet activation | PIK3R1;RAP1A;MYLK;PIK3R3;NOS3;P2RX1;PRKACB;GNAI1;RHOA |
| Toll-like receptor signaling pathway | MAP3K7;MAPK11;CD80;TAB2;IFNA5;TLR8;PIK3R5;PIK3CB;TNF |
| Jak-STAT signaling pathway | IL2RGA;SOCS9;PIK3R5;IFNA5;IL4R;PIAS1;IL13RA2;JAK2A;LEPA |
| Natural killer cell mediated cytotoxicity | ICAM1;ICAM2;PTK2B;FCGR3;KIR2DS5;SAMD3;PRKCG;FCGR4;TNF |
| T cell receptor signaling pathway | MAP3K7;NFKBIE;EVLB;LCK;GRB2;PTPRC;CD8B1;RHOA;CD3G |
| B cell receptor signaling pathway | GSK3B;PLEKHA1;INPP5D;NFATC2;BCL2L11;MAPK3;ACTR2;PLCG2;PTPN18 |
| Fc epsilon RI signaling pathway | VAV3;MAPK12;PIK3CA;FCER1G;PRKCA;FYN;PIK3R5;MAP2K6;PLA2G4C |
| Fc gamma R-mediated phagocytosis | PLA2G6;WASF2;FCGR2A;BIN1;PIP5K1C;FCGR2B;VAV1;PIK3R1;ASAP3 |
| TNF signaling pathway | CREB3L3;TNFRSF1B;RPS6KA5;CXCL10;CCL5;AKT2;CXCL2;MAPK10;TAB2 |
| Leukocyte transendothelial migration | PTK2B;CLDN17;PRKCA;AASS;CLDN7;TXK;PIK3R2;CDC42;CLDN1 |
| Neurotrophin signaling pathway | IRAK4;BCL2;NTF3;MAP3K5;CDC42;SHC1;MAPK10;BAX;GSK3B |
| Cholinergic synapse | CHRM1;JAK2;PRKCG;ITPR1;CREB3L3;PLCB4;GNG13;FYN;KCNJ3 |
| Inflammatory mediator regulation of TRP channels | TRPV3;KLK1B4;PLA2G4A;CYP2C38;PIK3CB;CAMK2A;PIK3R2;PTGER4;IL1B |
| Regulation of actin cytoskeleton | SSH3;PPP1CA;CD14;MYL2B;FGF7;MSN;FGF5;RAC1;FGFR2 |
| Insulin signaling pathway | AKT2L;PRKACG;INS;RPTOR;RPS6KB2;SOCS4;LIPE;FBP1A;HRASA |
| Progesterone-mediated oocyte maturation | INSB;PIK3R5;CDC16;ANAPC11;CCNB1;ANAPC7;PRKACBA;BRAF;HSP90AA1 |
| Estrogen signaling pathway | GRM1;SHC1;SOS1;ESR1;MAP2K1;HSPA1L;PRKACG;RAF1;MMP2 |
| Prolactin signaling pathway | SHC1;CSN2;MAPK3;AKT2;NRAS;HRAS;SIRPA;MAPK13;MAPK11 |
| Thyroid hormone signaling pathway | PRKACB;PIK3CD;NOTCH3;SLC9A1;KAT2B;RXRG;TBC1D4;MAP2K1;PRKCB |
| Oxytocin signaling pathway | RYR1;PPP3CC;FOS;NRAS;PPP1R12C;CAMK2B;MAP2K5;CAMKK1;CCND1 |
| Regulation of lipolysis in adipocytes | PIK3CG;PRKACB;IRS1;PNPLA2;IRS4;PTGER3;PRKACG;INSR;TSHB |
| Type II diabetes mellitus | PIK3R2;SOCS3;PIK3CD;HK3;IKBKB;PKM2;SOCS1;PIK3R5;ADIPOQ |
| Insulin resistance | NOS3;IRS1;GSK3B;PRKAA2;NR1H2;CREB3L1;PRKAB2;INSRA;RPS6KB1B |
| Non-alcoholic fatty liver disease (NAFLD) | CEBPA;EIF2AK3;NDUFB8;COX7B;PIK3CG;NDUFB5;LEP;NDUFC1;PIK3R1 |
| Aldosterone-regulated sodium reabsorption | ATP1B3;PIK3CG;SGK1;KCNJ1;IRS1;IGF1;PRKCA;FXYD2;PIK3R5 |
| Carbohydrate digestion and absorption | SLC2A5;AMY2A4;AMY2B;AMY2A2;TAS1R3;AMY2A5;SLC37A4;PIK3R3;PRKCB |
| Bacterial invasion of epithelial cells | PIK3CA;BCAR1;CD2AP;CAV3;PIK3CG;ACTG1;PIK3CD;SEPT6;CTNNA3 |
| Chagas disease (American trypanosomiasis) | C1QA;SERPINE1;FOS;PIK3CA;GNA14;NFKBIA;IRAK4;CCL3;CASP8 |
| Toxoplasmosis | IKBKG;IFNGR2;IKBKB;GNAI3;HLA-DQA2;AKT1;BIRC7;HSPA1B;HLA-DQB1 |
| Amoebiasis | RELA;IL1R1;COL4A4;ADCY1;CXCL1;Casp3;ACTN3;LAMB2;PRKACG |
| Hepatitis C | TRAF6;MAPK12;PPP2R2D;CLDN18;RAF1;MAPK8;PIK3R3;AKT1;STAT3 |
| Hepatitis B | VDAC3;IFNA5;PRKCG;STAT2;RELA;SMAD3;EP300;PIK3R1;CREB3L1 |
| Measles | PIK3CA;TNFRSF10B;OAS1A;HSPA2;IFNA12;CCNE2;IFNA2;STAT3;CD209 |
| Influenza A | EIF2AK3;PIK3R1;MAPK10;FASLG;IRAK4;HLA-DMB;IKBKE;Ifna11;MAP2K2 |
| HTLV-I infection | ELK4;TCF3;H2-AB1;NRAS;MAP2K4;TNFRSF13C;ATM;PPP3CB;SMAD2 |
| Epstein-Barr virus infection | IL10RB;HLA-DRA;POLR1C;HDAC1;HLA-DPA1;POLR2G;HSPA6;TP53;HDAC2 |
| Pathways in cancer | LAMB2;FGFR1;RALB;FGFR2;MAX;FZD2;TRAF3;SUFU;GLI3 |
| Viral carcinogenesis | HIST2H4;PXN;HDAC1;HPN;NFKB1;HIST1H4I;UBE3A;PMAIP1;C3 |
| Proteoglycans in cancer | PXN;GPC1;PTPN11;HCLS1;TGFB1;HIF1A;PTPN6;FGF2;DROSHA |
| Colorectal cancer | BRAF;RAF1;TGFBR2;PIK3CA;RAC2;MSH3;PIK3CG;ARAF;RHOA |
| Renal cell carcinoma | MAP2K1;TGFA;FLCN;SLC2A1;PDGFB;RAPGEF1;AKT1;PIK3R1;AKT2 |
| Pancreatic cancer | RAC3;PLD1;TGFBR1;CASP9;MAP2K1;STAT1;SMAD4;TGFB1;ERBB2 |
| Endometrial cancer | PIK3R3;APC;BRAF;ELK1;APC2;CCND1;PIK3CD;MLH1;MAP2K2 |
| Glioma | PRKCA;PDGFRA;AKT1;IGF1R;PIK3CA;RAF1;SHC4;CAMK2B;PIK3R3 |
| Prostate cancer | NDRG1;TP53;MAP4K1;AKT2;SOS1;INSRR;IGF1R;CCNE1;GSK3B |
| Melanoma | PIK3R2;MAP2K2;CDH1;ARAF;FGF13;PDGFRB;FGF8;FGF18;FGF22 |
| Chronic myeloid leukemia | PTPN11;TGFB3;TGFB2;PIK3R1;CCND1;CTBP1;TGFB1;GAB2;KRAS |
| Acute myeloid leukemia | STAT3;PIM1;PIK3CD;JUP;MAP2K1;PIK3CB;RELA;RPS6KB2;AKT2 |
| Small cell lung cancer | CCNE2;PIK3CG;FHIT;TRAF4;BIRC2;LAMA2;LAMB1;RXRB;TRP53 |
| Non-small cell lung cancer | GRB2;BAD;EML4;PIK3R3;MAP2K1;ARAF;PLCG2;FHIT;PIK3CB |
| Central carbon metabolism in cancer | MAP2K2;NRAS;PKM;PKM2;HK2;SLC2A2;PDHB;MAPK1;HRAS |
| Choline metabolism in cancer | RALGDS;RAF1;RAC3;CHKB;DGKZ;GRB2;MAPK3;GPCPD1;DGKQ |
PIK3CB has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CB itself. We selected most functions PIK3CB had, and list some proteins which have the same functions with PIK3CB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | PIK3CG;PIK3C2A;PIK3C2B;PIK3CA;ATM;PIK3C2G;PIK3CD;PIK3R3;PIK3C3 |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3CD;PIK3C2G;PIK3C2B;PIK3CB;PIK3C2A;PIK3CA;PIK3CG |
| ATP binding | SNRK;MYHZ2;ABL2;ROCK1;UBE2J1;ERBB2;OXSR1A;ABCD4;UBA6 |
| insulin receptor substrate binding | INSR;IGF1RA;GRB2;PIK3CA;IGF1RB;PRKCD;PTPN11;IGF1R;INSRA |
| phosphatidylinositol 3-kinase activity | PIK3CG;PIK3C2A;PIK3CA;PIK3CD;PIK3CB |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | PIK3CA;PIK3CG;PIK3CD;PIK3CB |
| protein binding | CCDC120;C1QTNF6;ZNF32;APEH;PPIL3;SCG2;FBXO17;MEA1;HSPB7 |
PIK3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CB.
PIK3R2; PIK3R1; PIK3R3; YWHAQ; HCK; TFCP2; ALAS1; HPS6; DVL3; NS; NS; ERBB3
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