PIK3CB

  • Official Full Name

    phosphoinositide-3-kinase, catalytic, beta polypeptide

  • Overview

    This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important;in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic;subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the;activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative;splicing results in multiple transcript variants.
  • Synonyms

    PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide; PIK3C1; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3K-beta; PtdIns-3-kinase p110; PI3-kinase subunit beta; PI3-kinase p110 subunit beta; ptdIns-3-kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Chicken
  • E.coli
  • HEK293
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIK3CB&PIK3R1-155H Active Recombinant Human PIK3CB/PIK3R1 protein, His-tagged Insect Cell His
Human PIK3CB&PIK3R2-156H Active Recombinant Human PIK3CB/PIK3R2 protein, His-tagged Insect Cell His
Human PIK3CB-31095TH Recombinant Human Human PIK3CB, His-tagged His
Human PIK3CB-620H Recombinant Human PIK3CB Mammalian Cell His
Human PIK3CB-214H Recombinant Human PIK3CB Sf9 Insect Cell N/A
Human PIK3CB-31766TH Recombinant Human Human PIK3CB, His-tagged His
Human PIK3CB/PIK3R1-632H Recombinant Human PIK3CB/PIK3R1, FLAG-tagged Sf9 Insect Cell Flag
Human PIK3CB/PIK3R1-391H Recombinant Human PIK3CB/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Human PIK3CB-3188HCL Recombinant Human PIK3CB 293 Cell Lysate HEK293 N/A
Human CPBTT-30929CH Chicken Anti-Human PI3K Polyclonal Antibody Chicken N/A
Human PIK3CB-3861H Recombinant Human PIK3CB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PIK3CB-1810HF Active Recombinant Full Length Human PIK3CB Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-1070(end)
Human PIK3CB-1724H Recombinant Human PIK3CB protein, His-tagged E.coli His Ala524~Val703 (Accession # P42338)
Human PIK3CB-2278HF Active Recombinant Full Length Human PIK3CB Protein, GST-tagged Insect (sf21) GST 1-1070(end)
Human PIK3CB-3991H Recombinant Human PIK3CB protein, His-tagged E.coli His 139-373 aa
Human PIK3CB-01H Recombinant Human PIK3CB/PIK3R2 Protein, His-tagged Insect Cell His
Human PIK3CB-3861H-B Recombinant Human PIK3CB Protein Pre-coupled Magnetic Beads HEK293
Human PIK3CB-4897H Recombinant Human PIK3CB Protein (Met152-Val349), N-His tagged E.coli N-His Met152-Val349
Mouse PIK3CB-12802M Recombinant Mouse PIK3CB Protein Mammalian Cell His
Mouse PIK3CB-6738M-B Recombinant Mouse PIK3CB Protein Pre-coupled Magnetic Beads HEK293
Mouse PIK3CB-6738M Recombinant Mouse PIK3CB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PIK3CB-4461R Recombinant Rat PIK3CB Protein Mammalian Cell His
Rat PIK3CB-4121R-B Recombinant Rat PIK3CB Protein Pre-coupled Magnetic Beads HEK293
Rat PIK3CB-4121R Recombinant Rat PIK3CB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken PIK3CB-2965C Recombinant Chicken PIK3CB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PIK3CB Related Research Area
  • PIK3CB Related Signal Pathway

PIK3CB involved in several pathways and played different roles in them. We selected most pathways PIK3CB participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Inositol phosphate metabolismNUDT4;INPP4A;PLCB2;INPP1;MINPP1A;PIK3CB;MINPP1;PIK3C3;PIP4K2AA
ErbB signaling pathwayMAPK9;ARAF;GRB2B;PAK3;MAP2K2A;RPS6KB1B;NRG1;AKT2;ABL1
Ras signaling pathwayPLA2G12B;RALGDS;GRIN2B;MRAS;ANGPT4;FGF5;FGF11;PLD2;BAD
Rap signaling pathwayCALM1;PLCB1;CALML5;MAGI1;SKAP1;PLCG1;APBB1IP;PLCB2;RAF1
cGMP-PKG signaling pathwayNOS3;MAPK1;PLCB4;NFATC4;INS2;ATP1B1;PIK3CG;GNAI2;ATP2B4
cAMP signaling pathwayFFAR2;PDE3A;MAPK10;ACOX3;ATP1A2;PPP1CC;ATP2A2;GRIN1;CREB3L3
Chemokine signaling pathwayRAF1;ARRB1;CXCL3;AMCF-II;FOXO3;GM13304;WAS;GNB1;CCL11
HIF- signaling pathwayIGF1R;Trf;VHL;CAMK2A;MKNK1;ERBB2;PLCG2;ENO1;PIK3CB
FoxO signaling pathwayIL6;PDPK1B;FOXO3A;EP300;CCND2;IRS4;GABARAPL2;PRKAB2;SKP2
Phosphatidylinositol signaling systemDGKAA;INPPL1;INPP5B;OCRL;CDS2;INPP4A;CALM3A;INPP5E;INPPL1A
Sphingolipid signaling pathwayNOS3;CERS5;DEGS1;PRKCA;TNF;PPP2CB;S1PR5;PRKCB;PPP2R5A
Phospholipase D signaling pathwayMAP2K1;DGKE;RALB;PDGFRA;PLA2G4A;GRM7;ARF6;Pdgfa&Pdgfb;PLA2G4D
mTOR signaling pathwayPIK3R3;RPS6KB1B;RPS6KA3B;TSC1A;ULK2;MAPK3;INS1;EIF4BB;PTENA
PIK-Akt signaling pathwayBCL2;YWHAB;F2R;PPP2R5B;Il6ra;Reln;LPAR4;EPOR;HRAS
AMPK signaling pathwayTSC2;PRKAG1;PFKP;IRS4;PPP2R2A;INS;ADIPOR1;IGF1;PPP2R2D
ApoptosisCSF2RB;PPP3R2;AIFM1;CASP8L1;IL1R1;TNFRSF10A;IRAK4;Casp3;CASP7
Adrenergic signaling in cardiomyocytesPPP2R2D;CREB1A;ATP1B1A;ATF4B1;PPP1CAB;PIK3R3A;CACNA1DA;ATP2B3B;CAMK2D2
VEGF signaling pathwayPLCG2;MAPK12;MAPKAPK3;PXN;PPP3CCA;SPHK1;MAPK13;VEGFA;HRAS
Osteoclast differentiationPIK3CA;LILRB5;TNF;MAPK10;TYK2;FCGR1;TRAF2;MAPK1;SFPI1
Focal adhesionAASS;RAPGEF1B;COL27A1B;PRKCG;RHOAB;THBS4B;MYL7;VEGFAA;PARVB
Signaling pathways regulating pluripotency of stem cellsSOX2;ZFHX3;HAND1;FGFR4;PIK3CG;SKIL;INHBE;WNT3A;HESX1
Platelet activationPIK3CB;PLCB2;COL27A1;MYLK3;PLCB1;GNAI1;MAPK1;VWF;GNAI3
Toll-like receptor signaling pathwayTLR4BB;PIK3R1;CXCL9;CCL4;AKT2;IFNA3;CCL3L3;TLR5;TOLLIP
Jak-STAT signaling pathwayFHL1;IL11RA2;AKT3A;PIK3CA;IL13RA1;PTPN2A;RAF1;SOCS4;OSMR
Natural killer cell mediated cytotoxicityHLA-B;PPP3R2;NCR3;TNFRSF10D;H60a;BID;RAF1;KLRD1;HLA-C
T cell receptor signaling pathwayGRAP2;PDCD1;DBNLB;CABIN1;MAPK11;MAPK12;NFKBIE;MAPK1;CD3E; CD3D
B cell receptor signaling pathwayFOS;NFKBIE;MALT1;MAPK3;BANK1;HDAC5;BTK;ARPC1B;CTNNB2
Fc epsilon RI signaling pathwayMAP2K2;MAP2K3;PLA2G4D;PLCG1;PLA2G4A;LAT;AKT1;BTK;PLCG2
Fc gamma R-mediated phagocytosisWASF2;FCGR1;PLA2G4F;FCGR1A;FCGR2A;AKT1;DOCK2;MAP2K1;PIK3R5
TNF signaling pathwayIL18R1;MAP3K7IP3;TRAF5;TRAF1;NFKBIA;TNF;CFLAR;FADD;TAB2
Leukocyte transendothelial migrationCLDN1;MLLT4;JAM2;RASSF5;PRKCG;NCF2;MYLPF;ICAM1;JAM3
Neurotrophin signaling pathwayCALML5;CAMK2G;RHOA;BAD;CALM3;MAPK12;MAPK10;RAC1;BDNF
Cholinergic synapseGNG10;FYN;GNAI1;GNAI3;GNG7;KCNJ4;AKR1C1;GNB1;ITPR1
Inflammatory mediator regulation of TRP channelsACCN4;ACCN5;CYP2C50;CAMK2D;CYP2C37;Adcy4;CYP2C38;PRKCQ;CYP2J5
Regulation of actin cytoskeletonGNG12;PIP5K1BA;MYL12.1;PIK3R2;PIK3R3A;ARHGEF7A;FGF11A;Fgf15;RAF1
Insulin signaling pathwayMTOR;PRKAB1A;INPPL1A;INPPL1;PRKCI;CALM1B;HKDC1;PRKACBA;GRB2A
Progesterone-mediated oocyte maturationANAPC5;RAF1;AKT2L;INS1;MAPK11;RPS6KA2;CDH1-A;IGF1RB;PIK3R2
Estrogen signaling pathwaySHC4;PIK3CD;ATF4;FOS;CREB5;ATF6B;HSPA2;PLCB1;HSP90B1
Prolactin signaling pathwayMAPK11;SOCS7;SHC4;INS2;CCND1;SOCS6;NEK3;SHC1;STAT3
Thyroid hormone signaling pathwayAKT2;NCOR1;PRKCA;NRAS;ATP1B2;PRKCG;WNT4;ATP2A2;NOTCH1
Oxytocin signaling pathwayPLCB4;PRKAA1;ITPR3;MYL9;TRPM2;EEF2K;CAMK2G;RGS2;PLCB3
Regulation of lipolysis in adipocytesGNAS;NPY1R;PLIN1;Adcy4;PRKACA;PTGS1;PTGS2;FABP4;IRS2
Type II diabetes mellitusMAPK8;SOCS1;INS-IGF2;PKLR;PRKCZ;PIK3CD;PDX1;PKM;MAPK3
Insulin resistancePPARGC1A;PRKCBB;MTOR;PTEN;SOCS3;RPS6KA6;RPS6KAL;PCK2;IL6
Non-alcoholic fatty liver disease (NAFLD)NDUFA5;TRAF2;PIK3CD;GSK3A;PRKAB1;NDUFS4;COX7B2;NDUFB11;MAP3K5
Aldosterone-regulated sodium reabsorptionPIK3CG;SLC9A3R2;PRKCB;IRS1;ATP1B4;ATP1B1;PIK3CD;PRKCA;PIK3CB
Carbohydrate digestion and absorptionATP1B4;AKT1;PIK3CD;FXYD2;TAS1R2;PIK3R2;ATP1A2;SI;AKT2
Bacterial invasion of epithelial cellsPIK3CB;GAB1;ARPC5;CAV3;CLTB;RHOA;DNM1;PIK3CA;SHC4
Chagas disease (American trypanosomiasis)PIK3CB;GNAI2;TGFBR1;CD3D;BDKRB2;GNA15;FASLG;TNFRSF1A;FAS
ToxoplasmosisHSPA1B;TLR4;LAMB2;GNAO1;BIRC7;IRGM;ITGB1;PPIF;MAP3K7
AmoebiasisHSPB1;IL1B2;COL5A1;IL12B;RAB7;COL3A1;ACTN3;COL2A1;ARG1
Hepatitis CPPARA;TNF;EIF2AK4;CLDN6;TYK2;CLDN23;RNASEL;NFKB1;Ifna11
Hepatitis BAPAF1;TP53;YWHAB;PTK2B;IFNA13;Ifna11;IFNA7;MAPK3;IFNA12
MeaslesIL4;IFNA7;CD209A;BBC3;Ifna11;IFNG;FAS;IL1B;IL2RB
Influenza AFasl;BLB2;LOC100686744;HNRNPUL1;BMA2;XPO1;PRKCA;IFNA16;FAS
HTLV-I infectionSLC25A31;POLE;CD3G;PDGFB;IL2RA;Fzd4;EP300;SFPI1;FZD10
Epstein-Barr virus infectionHLA-DQA2;PSMD11;DDX58;XPO1;POLR2J;NFKBIE;TRAF1;POLR3F;PSMD2
Pathways in cancerBDKRB2;WNT3A;CXCR4;MMP1;ROCK2;FZD1;GNG13;WNT8A;HSP90AA1
Viral carcinogenesisHIST1H2BI;IRF7;PIK3R3;HPN;HIST2H2BB;YWHAH;HIST1H4F;HIST1H2BK;HDAC7
Proteoglycans in cancerPIK3CA;Casp3;CTTN;PIK3R1;SDC4;ELK1;IGF2;MAPK11;RPS6KB1
Colorectal cancerPIK3CB;SMAD3;TP53;RHOA;AKT1;TGFBR1;MAPK9;MSH6;BIRC5
Renal cell carcinomaRBX1;RAF1;RAP1B;ARAF;AKT2;VHL;SLC2A1;ARNT2;GRB2
Pancreatic cancerPIK3CD;PIK3CB;PLD1;SMAD2;BCL2L1;MAPK1;TP53;SMAD3;TGFBR1
Endometrial cancerMLH1;ELK1;AKT1;TP53;BRAF;AXIN2;GRB2;PIK3R5;GSK3B
GliomaCALM3;PDGFA;NRAS;SHC3;MAPK3;CCND1;PIK3CD;PIK3CG;PDGFB
Prostate cancerHSP90AA1;GSK3B;CCNE2;MAP2K2;CREB5;CREB3L1;BRAF;CREB3L3;ERBB2
MelanomaKRAS;FGF18;FGF10;MAPK1;FGF19;PIK3R1;RB1;ARAF;AKT2
Chronic myeloid leukemiaTP53;SHC2;HDAC1;SHC1;CCND1;PIK3CB;CBLC;SMAD4;PIK3R3
Acute myeloid leukemiaPIK3R1;PML;JUP;KIT;STAT5B;PIK3CD;ARAF;GRB2;TCF7
Small cell lung cancerPIK3CD;LAMA4;PIAS2;LAMB2;TRP53;BIRC7;CYCS;LAMA5;TP53
Non-small cell lung cancerFHIT;PIK3R2;RASSF5;STK4;PLCG1;ARAF;BAD;MAPK3;TGFA
Central carbon metabolism in cancerAKT1;TRP53;GLS;PIK3R2;RAF1;PKM;LDHA;IDH1;SIRT3
Choline metabolism in cancerSLC22A1;PDPK1;PDGFD;PIK3R3;DGKZ;PPAP2A;PLD2;SLC5A7;EGF

PIK3CB has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CB itself. We selected most functions PIK3CB had, and list some proteins which have the same functions with PIK3CB. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol-3-kinase activityPIK3CA;PIK3C2A;PIK3CG;PIK3C3;PIK3CD;PIK3R3;PIK3C2G;PIK3CB;PIK3C2B
1-phosphatidylinositol-4-phosphate 3-kinase activityPIK3CA;PIK3CB;PIK3CG;PIK3CD;PIK3C2B;PIK3C2A;PIK3C2G
ATP bindingABCG5;ERCC6L2;AURKB;KCNJ11;ROR1;DYNC2H1;KIF13B;Fert2;LIG1
insulin receptor substrate bindingPIK3CA;PIK3R1;IGF1RB;INSRA;INSR;PRKCZ;INSRR;IGF1RA;PIK3CB
phosphatidylinositol 3-kinase activityPIK3CB;PIK3CA;PIK3CD;PIK3CG;PIK3C2A
phosphatidylinositol-4,5-bisphosphate 3-kinase activityPIK3CB;PIK3CD;PIK3CG;PIK3CA
protein bindingTBX22;CLEC18A;GSDMD;CRABP1;CEP152;CKMT1;TMEM30A;ROS1;S100A2

PIK3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CB.

PIK3R2; PIK3R1; PIK3R3; YWHAQ; HCK; TFCP2; ALAS1; HPS6; DVL3; NS; NS; ERBB3

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