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PIK3R6

Official Full Name

phosphoinositide-3-kinase, regulatory subunit 6
Synonyms

RGD1560850;

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	PIK3R6-1059H	Recombinant Human PIK3R6	Mammalian Cell	His	Inquiry
Human	PIK3R6-3863H-B	Recombinant Human PIK3R6 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	PIK3R6-3863H	Recombinant Human PIK3R6 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PIK3R6 involved in several pathways and played different roles in them. We selected most pathways PIK3R6 participated on our site, such as 3-phosphoinositide biosynthesis, G beta:gamma signalling through PI3Kgamma, G-protein beta:gamma signalling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
3-phosphoinositide biosynthesis	FIG4;PIP5KL1;CDIPT;PIK3R6
G beta:gamma signalling through PI3Kgamma
G-protein beta:gamma signalling
GPCR downstream signaling	NPFF;NPS;RHOC;PENKB;OPN4B;GNA13;PTGDR2;PNOC;TAS2R7
GPVI-mediated activation cascade	G6b;CLEC1B;C6orf25;RHOB;PDPN;FCER1GL;RHOGA;LCP2A;PIK3R6
Hemostasis	KIF4;BA1L;TRPC6A;CFHL1;CEACAM8;PROCR;HBBE3;VPS45;GAS6
Metabolism	GLYAT;PDP2;SLC4A1B;B3GNT2;PNP5B;CDK19;SLC25A13;ARSH;UPP2
Metabolism of lipids and lipoproteins	ARSE;PITPNB;ACOT13;CPTP;GLTPD1;CYP4F22;CYP46A1;VAPB;ACSF3

PIK3R6 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, contributes_to phosphatidylinositol-4,5-bisphosphate 3-kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R6 itself. We selected most functions PIK3R6 had, and list some proteins which have the same functions with PIK3R6. You can find most of the proteins on our site.

Function	Related Protein
1-phosphatidylinositol-3-kinase regulator activity	PIK3R2;PIK3R3;PIK3R6;CCKBR;PIK3R3B;PIK3R1;PIK3R5;PIK3R3A
contributes_to phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein binding	AGO3;DTX3;NCK2;SP140;DDX23;EML1;C12orf40;KRTAP19-7;CD200R3

PIK3R6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R6.

PDE3B; RAPGEF3

Research Area

Folgiero, V; Di Carlo, SE; et al. Inhibition of p85, the non-catalytic subunit of phosphatidylinositol 3-kinase, exerts potent antitumor activity in human breast cancer cells. CELL DEATH & DISEASE 3:-(2012).

Weinger, JG; Gohari, P; et al. In brain, Axl recruits Grb2 and the p85 regulatory subunit of PI3 kinase; in vitro mutagenesis defines the requisite binding sites for downstream Akt activation. JOURNAL OF NEUROCHEMISTRY 106:134-146(2008).