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PIK3C2B

Official Full Name

phosphoinositide-3-kinase, class 2, beta polypeptide
Overview

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.
Synonyms

PIK3C2B; phosphoinositide-3-kinase, class 2, beta polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta; C2 PI3K; PI3K C2beta; PI3K-C2beta; PI3K-C2-beta; PTDINS-3-kinase C2 beta; ptdIns-3-kinase C2 subunit beta; phosphoi;

Type

Recombinant Proteins

Species

Human
Mouse
Rat

Source

E.coli
HEK293T
Insect Cell
Sf9 Insect Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PIK3C2B-164H	Active Recombinant Human PIK3C2B protein, GST-tagged	Insect Cell	GST	850-end	Inquiry
Human	PIK3C2B-1716H	Recombinant Human PIK3C2B, His-tagged	E.coli	His	1-350aa	$319 / 25μg
Human	PIK3C2B-118H	Recombinant Human PIK3C2B, GST-tagged	Sf9 Insect Cell	GST	850-end	Inquiry
Human	PIK3C2B-1871H	Recombinant Human PIK3C2B protein, GST-tagged	E.coli	GST	1-350 aa	$319 / 25μg
Mouse	Pik3c2b-4862M	Recombinant Mouse Pik3c2b Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Rat	Pik3c2b-1722R	Recombinant Rat Pik3c2b protein, His & T7-tagged	E.coli	His&T7	Ser790~Leu1025	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PIK3C2B involved in several pathways and played different roles in them. We selected most pathways PIK3C2B participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3C2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Inositol phosphate metabolism	PTENA;MTMR8;NUDT11;PLCE1;MINPP1B;PIP4K2AA;PLCD4;NUDT4A;INPP1
Metabolic pathways	ACSL5;BST1;ATP5E;GOT1;NAMPT;NADSYN1;SCP2A;SLC33A1;CERS2
Phosphatidylinositol signaling system	IMPA2;PIKFYVE;INPP4B;PLCG2;MTMR4;PIK3R5;PLCD3;PIP5K1A;ITPKB

PIK3C2B has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3C2B itself. We selected most functions PIK3C2B had, and list some proteins which have the same functions with PIK3C2B. You can find most of the proteins on our site.

Function	Related Protein
1-phosphatidylinositol-3-kinase activity	PIK3C2B;PIK3CA;PIK3CD;PIK3C2A;PIK3CG;PIK3CB;PIK3R3;ATM;PIK3C3
1-phosphatidylinositol-4-phosphate 3-kinase activity	PIK3CB;PIK3CG;PIK3CA;PIK3C2B;PIK3C2A;PIK3CD;PIK3C2G
ATP binding	PFAS;AKT2;NEK5;RENBP;MADD;KIF19;EPHB4;MYO18A;ENTPD2
lipid kinase activity	PIK3C2B;TAE1;DGKZ
phosphatidylinositol binding	SNX9;ARHGAP33;TULP4;SNX31;AKR1C1;TULP3;P2RX2;FES;RPS6KC1
protein binding	PTPRS;PELO;BHLHE40;ATP5A1;RAB6B;CPSF7;TPD52L1;RAB5B;RCC1

PIK3C2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3C2B here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3C2B.

EGFR; TRIM27; GRB2; ERBB2; PDGFRB; NCK1