PIK3R1

  • Official Full Name

    phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

  • Overview

    Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms.
  • Synonyms

    PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Mouse, Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect cells
  • Leishmania Tarentolae
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIK3R1&PIK3CD-157H Active Recombinant Human PIK3R1/PIK3CD protein, His-tagged Insect Cell His
Human PIK3R1&Pik3ca-155H Active Recombinant Human PIK3CA and Mouse Pik3ca protein, His-tagged Insect Cell His
Human PIK3R1-29688TH Recombinant Human Human PIK3CA, His-tagged His
Human PIK3R1-31767TH Recombinant Human Human PIK3CB, His-tagged His
Human PIK3R1-31096TH Recombinant Human Human PIK3CB, His-tagged His
Human PIK3CA/PIK3R1-641H Recombinant Human PIK3CA/PIK3R1 Insect Cell N/A
Human PIK3R1-4864H Recombinant Human Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), His-tagged Sf9 Insect Cell His
Human PIK3R1-4934H Recombinant Human PIK3R1 Protein, His-tagged Insect cells His
Human PIK3CA/PIK3R1-631H Recombinant Human PIK3CA/PIK3R1, FLAG-tagged Sf9 Insect Cell Flag
Human PIK3CA/PIK3R1-389H Recombinant Human PIK3CA/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Human PIK3R1-29588TH Recombinant Human PIK3R1, His-tagged His
Human PIK3CB/PIK3R1-632H Recombinant Human PIK3CB/PIK3R1, FLAG-tagged Sf9 Insect Cell Flag
Human PIK3CB/PIK3R1-391H Recombinant Human PIK3CB/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Human PIK3R1-1079H Recombinant Human PIK3R1, His-tagged Sf9 Insect Cell His Full Length
Human PIK3R1-315H Recombinant Human PIK3R1 protein, His/MBP-tagged E.coli His/MBP 1-110 aa
Human PIK3R1-316H Recombinant Human PIK3R2 protein, His/MBP-tagged E.coli His/MBP 296-397 aa
Human PIK3R1-3185HCL Recombinant Human PIK3R1 293 Cell Lysate HEK293 N/A
Human PIK3R1-4904H Recombinant Human PIK3R1 Protein (Trp624-Val718), N-His tagged E.coli N-His Trp624-Val718
Human PIK3R1-2925H Recombinant Human PIK3R1 protein, His-tagged E.coli His 319-372 aa
Human PIK3R1-670H Recombinant Human PIK3R1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PIK3R1-2931H Recombinant Human PIK3R1 Protein E.coli Tag Free
Human PIK3R1-4903H Recombinant Human PIK3R1 Protein (Trp624-Val718), C-His tagged E.coli C-His Trp624-Val718
Mouse Pik3r1-4865M Recombinant Mouse Pik3r1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PIK3R1-4463R Recombinant Rat PIK3R1 Protein Mammalian Cell His
Rat PIK3R1-4123R Recombinant Rat PIK3R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PIK3R1-4123R-B Recombinant Rat PIK3R1 Protein Pre-coupled Magnetic Beads HEK293
Bovine PIK3R1-05B Recombinant Bovine PIK3R1 Leishmania Tarentolae N/A
Bovine PIK3R1-06B Recombinant Bovine PIK3R1 Sf9 Insect Cell N/A
Mouse, Human Pik3ca/PIK3R1-390H Recombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Rhesus Macaque PIK3R1-3434R Recombinant Rhesus monkey PIK3R1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PIK3R1-3252R Recombinant Rhesus Macaque PIK3R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PIK3R1-3252R-B Recombinant Rhesus Macaque PIK3R1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PIK3R1-8346Z Recombinant Zebrafish PIK3R1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • PIK3R1 Related Signal Pathway

PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayAKT2L;SHC3;ERBB4;RAF1B;ERBB2;HRASB;PIK3CA;PAK2A;MAP2K7
Ras signaling pathwayPDGFD;RASGRF2;KRAS;RAC2;PRKACA;MAPK9;FGF5;SOS1;BAD
Rap signaling pathwayNRAS;LPAR2;F2RL3;ARAP3;PFN3;RAC1;PRKCZ;VASP;IGF1R
cGMP-PKG signaling pathwayMYLK4;GNAQ;INS2;ATP2A3;BDKRB2;NFATC4;ATP1B1;PPP3CA;CALM2
cAMP signaling pathwaySUCNR1;PLCE1;VAV2;F2R;PTGER2;CAMK2A;PRKACB;ACOX3;CNGA3
Chemokine signaling pathwayLOC100033925;CCL22;CCL18;CCR8;CXCL10;CXCL5;GRK6;Ccl27a;JAK2
HIF- signaling pathwayIL6R;ANGPT1;PLCG1;INS;EIF4E2;ANGPT4;PIK3R5;RPS6;AKT2
FoxO signaling pathwayRAF1A;TGFBR1B;IGF1RA;G6PC;STK4;PTEN;MAPK13;SOS1;PRKAG1
Phosphatidylinositol signaling systemMTMR3;INPP5K;MTMR7B;MTMR14;PRKCA;ITPR1;PIK3R3B;IPMK;CALM
Sphingolipid signaling pathwaySGMS2;MAPK12;MAPK13;PPP2R2A;SGPP2;CERS4;AKT2;SMPD2;PLD1
Phospholipase D signaling pathwayGNAS;Adcy4;PLA2G4A;MAP2K2;PDGFA;ARF6;PLCG1;PLCB3;NRAS
mTOR signaling pathwayMAPK1;AKT2L;PIK3R2;VEGFAA;EIF4E1B;PTEN;RPS6KA3A;MTOR;RPS6KAL
PIK-Akt signaling pathwayBRCA1;PRKCA;FGF17;FGF3;EPO;FGF13;IFNA7;GNG3;FGF18
AMPK signaling pathwayAKT2;PDPK1;Scd2;ADRa1A;RPS6KB2;SCD5;PIK3CD;INS2;RPTOR
ApoptosisHIST1H1D;MAP3K14;CYCSB;CYCS;CASP10;BIRC5A;PPP3CCB;TNFRSF10C;BOK
Adrenergic signaling in cardiomyocytesCALM2;SLC14A2;RAPGEF3;VMHCL;PPP2R3C;MAPK12B;CREM;CACNB2A;MYL2
VEGF signaling pathwayCDC42;PTK2;PXN;PTK2AB;RAF1;PPP3CCB;MAPKAPK2A;PIK3R2;RAF1A
Osteoclast differentiationLILRB2;ACP5;TGFBR1;SIRPB1;PIK3R3;BTK;MAP2K7;IL1A;TRAF6
Focal adhesionCOL6A5;VEGFB;AKT2;RAC3A;LAMB2;ACTN3B;CAV2;ROCK2;ITGB1B.2
Signaling pathways regulating pluripotency of stem cellsSMARCAD1;JARID2;SMAD1;ID2;FZD9;GRB2;ESRRB;SMAD5;PIK3R5
Platelet activationGP5;PLCB3;PRKG2;ARHGAP35;GP1BB;PRKACB;GP6;RAP1B;ITGB1
Toll-like receptor signaling pathwayIFNA3;IRF5;TLR1;MAPK13;TLR5B;NFKBIAB;IL6;PIK3R5;AKT3A
Jak-STAT signaling pathwayIL5;IFNPHI3;GHRA;IL12RB1;CSH;IL11;IL-15RA;IFNAR1;STAT1A
Natural killer cell mediated cytotoxicityIfna15;PIK3CA;KLRC4-KLRK1;PRKCG;KLRC1;MICA;NFATC2;PIK3CB;RAET1G
T cell receptor signaling pathwayPRKCQ;IL4;DEF6A;IKBKG;DBNLB;CABIN1;VAV1;PPP3CC;NFKBIE
B cell receptor signaling pathwaySLA2;MALT1;PIK3R2;Cd79a, Cd79b;CDK4;PPP3R1;ITK;NFATC3;DOK1B
Fc epsilon RI signaling pathwayVAV2;MS4A2;INPP5D;GRB2;PIK3R2;PDPK1;LYN;TNF;PIK3CD
Fc gamma R-mediated phagocytosisFCGR1A;PIK3R2;AKT1;ARF6;PLA2G4F;GSN;MARCKSL1;INPPL1;PRKCA
TNF signaling pathwayLIF;SELE;SOCS3;MAPK8;IL15;PIK3R2;FOS;CCL20;TRAF1
Leukocyte transendothelial migrationTXK;CLDN5;THY1;ROCK1;JAM3;VCL;PECAM1;CLDN17;NCF2
Neurotrophin signaling pathwayNTRK3;TP73;PSEN1;RAP1A;PIK3CB;SHC4;MAPK12;KIDINS220;CALML3
Cholinergic synapseGNG3;GNG2;CAMK2B;KCNQ2;KCNQ5;CHRM1;PIK3R1;PLCB4;PRKACA
Inflammatory mediator regulation of TRP channelsTRPM8;SRC;GNAS;PRKCA;PRKACG;PTGER2;PTGER4;MAPK12;CYP4A10
Regulation of actin cytoskeletonPPP1R12A;SCIN;GSNA;INSB;ITGA3;MYL7;ITGB2L;FGF8A;F2R
Insulin signaling pathwayPRKACBA;PPARGC1A;PRKAA2;PRKACA;CALM;FOXO1B;FBP1A;SOCS2;PRKAB1A
Progesterone-mediated oocyte maturationPGR;FZR1A;SPDYA;KRAS;CDK1;INS1;IGF1R;PIK3CA;RPS6KA2
Estrogen signaling pathwayESR2;HSPA2;KRAS;GABBR2;KCNJ6;HSP90AB1;FOS;PRKCD;PLCB4
Prolactin signaling pathwaySOCS1;NEK3;MAPK9;LHB;TNFRSF11A;CSN2;PRP2;SHC4;MAPK12
Thyroid hormone signaling pathwayPLCZ1;PLCE1;FXYD2;MAP2K2;HDAC2;PIK3R1;NOTCH2;PIK3CB;RXRA
Oxytocin signaling pathwayPIK3R2;NPR2;ACTG1;MAPK3;NRAS;PLCB3;PIK3CB;CACNG4;PPP3R1
Regulation of lipolysis in adipocytesPIK3CB;GNAI2;PTGER3;IRS1;NPY1R;PRKACA;PRKACG;AKT2;TSHB
Type II diabetes mellitusPRKCE;SLC2A2;IRS2;SOCS4;PDX1;PIK3R5;PIK3CD;PRKCD;INS-IGF2
Insulin resistanceNOS3;NFKBIAB;PIK3R3;PIK3R2;PPARGC1B;PRKAG3B;IRS1;MLXIPL;G6PC3
Non-alcoholic fatty liver disease (NAFLD)AKT1;INS;NDUFC2-KCTD14;PIK3CB;NDUFB2;NDUFB11;CDC42;SDHA;NDUFB5
Aldosterone-regulated sodium reabsorptionATP1A1;IRS1;PIK3CA;ALPHA-ENAC;PIK3R3;KCNJ1;ATP1B1;PDPK1;SCNN1G
Carbohydrate digestion and absorptionSLC2A5;PIK3R1;AMY2B;AKT2;SI;PLCB2;G6PC2;SLC37A4;G6PC
Bacterial invasion of epithelial cellsCDH1;PIK3R1;MAD2L2;ACTG1;ARPC2;CLTC;BCAR1;SEPT11;CBL
Chagas disease (American trypanosomiasis)CD3G;CXCL8;TGFBR2;PIK3R1;CASP8;SMAD2;TICAM1;IL1B;IKBKG
ToxoplasmosisCasp3;HLA-DMA;MAPK11;H2-AB1;BCL2;LAMB4;Toxoplasma Gondii Major Surface Antigen P30;MAPK10;MAPK8
AmoebiasisGNAS;CD1D;SERPINB3;IL12B;TGFB2;GM-CSF;PIK3CG;IL1R2;SERPINB1A
Hepatitis CCXCL8;RXRA;TRAF2;Ifna11;EIF2AK1;ARAF;CLDN16;TRAF6;PIAS1
Hepatitis BVDAC3;BCL2;IFNA10;CCNA2;PIK3R1;PIK3R3;FAS;OSTN;NFATC4
MeaslesHSPA2;CD209;TLR7;IFNA17;CD46;IL12B;IL1A;OAS1;EIF3H
Influenza APIK3R1;Fasl;PABPN1;IKBKE;PYCARD;HSPA6;BLB1;IL12B;BCL2L2-PABPN1
HTLV-I infectionICAM1;WNT8B;IKBKG;SLC25A4;WNT5B;RANBP1;ITGB2;BUB1B;TBP
Epstein-Barr virus infectionPOLR2J;AKT1;Fcer2a;PSMD8;PIK3R5;MAP2K3;POLR3E;TRAF5;PSMC6
Pathways in cancerSLC2A1;HHIP;HSP90B1;ETS1;GNAI3;PTGER3;STAT3;GLI3;SMAD3
Viral carcinogenesisSNW1;HIST1H2BB;HDAC9;BAX;H2BFWT;HDAC7;CDC42;HIST1H4B;SYK
Proteoglycans in cancerMET;SLC9A1;ROCK1;PIK3CA;ITGB1;WNT4;WNT3;IGF1R;IL12B
Colorectal cancerRAC2;PIK3CD;RHOA;CCND1;BAX;APC;AXIN2;AXIN1;TRP53
Renal cell carcinomaVHL;PIK3R1;ARNT2;NRAS;PIK3R5;PIK3CG;ETS1;RBX1;EGLN1
Pancreatic cancerPLD1;PIK3R5;CCND1;MAPK8;IKBKB;PIK3R2;NFKB1;PIK3CD;KRAS
Endometrial cancerAXIN2;TCF7;PIK3R1;ILK;SOS1;ARAF;APC2;PIK3R3;BAD
GliomaMAPK3;PLCG1;AKT2;TP53;PIK3CG;PRKCB;CCND1;CAMK2D;GRB2
Prostate cancerIGF1;NOXA1;RB1;ACTL6B;PDPK1;PDGFA;BAD;NFKBIA;SRD5A2
MelanomaPIK3CA;BRAF;MAPK3;MAPK1;FGF14;PIK3R5;FGF8;IGF1;PDGFD
Chronic myeloid leukemiaPIK3CB;CCND1;PIK3CG;CBL;BCL2L1;NFKB1;MDM2;HDAC1;BCR
Acute myeloid leukemiaCHUK;IKBKG;MAP2K1;PIK3R5;PIK3CA;RARA;MTOR;EIF4EBP1;SPI1
Small cell lung cancerLAMA1;PIK3R1;IKBKG;CASP9;TRAF5;LAMB2;TRAF6;PIK3CG;LAMB1
Non-small cell lung cancerPLCG1;RARB;PIK3CD;RASSF1;AKT1;GRB2;MAP2K1;CCND1;PIK3CB
Central carbon metabolism in cancerFGFR1;SIRT6;AKT2;PIK3R5;SLC16A3;PDGFRA;PGAM1;HK2;PIK3CA
Choline metabolism in cancerRAF1;PIK3CG;NRAS;MAPK9;WASF2;PDPK1;PDGFB;TSC1;PIP5K1C

PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, ErbB-3 class receptor binding, insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol-3-kinase regulator activityPIK3R2;CCKBR;PIK3R3;PIK3R3A;PIK3R3B;PIK3R6;PIK3R1;PIK3R5
ErbB-3 class receptor bindingERBB2;PIK3R1;NRG1;CDK5
insulin bindingIGF1R;C2CD2L;INSR;HSPD1;PIK3R1;IDE
insulin receptor bindingINS;IRS1;INS1;DOK1;DOK1B;IGF2;PTPN11;INSL3;PDPK1
insulin receptor substrate bindingPIK3CA;PRKCD;PIK3R1;IGF1R;INSRR;INSRB;IGF1RB;INSR;PRKCZ
insulin-like growth factor receptor bindingRen1;PIK3R1;INS;IGF3;REN;YWHAH;INS2;SOCS1;GNAS
neurotrophin TRKA receptor bindingPLCG1;PIK3R1;FRS2;SHC1;EFNA5;GRB2;NGFR
phosphatidylinositol 3-kinase bindingATP1A1;INSR;PDGFRB;DAB1;PIK3R1;LCK;FYN;IRS2;IRS4
phosphatidylinositol 3-kinase regulator activityPIK3R3B;AGAP2;KLF4;PIK3R1;PIK3R3A
phosphatidylinositol 3-kinase regulatory subunit bindingPIK3AP1;FAM83B;DNM2;XBP1;FAM83A;PTPN13;PIK3R1
protein bindingMNDA;AIDA;PIF1;WWP2;ARHGAP4;RASSF3;RFPL3;C16orf53;SEC31A
protein heterodimerization activityTLR1;HIF1A;TIRAP;IKZF1;HIST1H2BH;P4HB;HEYL;TAF9B;TAF6
protein phosphatase bindingRPA2;ITGA1;ITPR1;ERBB2;STAT3;JAK3;MAP2K7;AP3B1;JAK1
transcription factor bindingRNF19A;HES6;IGHMBP2;KCNA3;HDAC3;NFYC;TBL1X;TRAPPC2;PPP1R13BA
transmembrane receptor protein tyrosine kinase adaptor activityPIK3R1;FRS2;DOK2;SHC1;GAB2;SH2B2;BLNK;TRAT1;STAP1

PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.

PDGFRB; CBL

Research Area

Related articles

Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).
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