PIK3R1

  • Official Full Name

    phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

  • Overview

    Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms.
  • Synonyms

    PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Mouse, Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect cells
  • Leishmania Tarentolae
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • His
  • Flag
  • His (Fc)
  • Avi
  • His|MBP
  • Myc
  • DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PIK3R1&PIK3CD-157H Active Recombinant Human PIK3R1/PIK3CD protein, His-tagged Insect Cell His
Human PIK3R1&Pik3ca-155H Active Recombinant Human PIK3CA and Mouse Pik3ca protein, His-tagged Insect Cell His
Human PIK3R1-29688TH Recombinant Human Human PIK3CA, His-tagged His
Human PIK3R1-31767TH Recombinant Human Human PIK3CB, His-tagged His
Human PIK3R1-31096TH Recombinant Human Human PIK3CB, His-tagged His
Human PIK3CA/PIK3R1-641H Recombinant Human PIK3CA/PIK3R1 Insect Cell N/A
Human PIK3R1-4864H Recombinant Human Phosphoinositide-3-Kinase, Regulatory Subunit 1 (Alpha), His-tagged Sf9 Insect Cell His
Human PIK3R1-4934H Recombinant Human PIK3R1 Protein, His-tagged Insect cells His
Human PIK3CA/PIK3R1-631H Recombinant Human PIK3CA/PIK3R1, FLAG-tagged Sf9 Insect Cell Flag
Human PIK3CA/PIK3R1-389H Recombinant Human PIK3CA/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Human PIK3R1-29588TH Recombinant Human PIK3R1, His-tagged His
Human PIK3CB/PIK3R1-632H Recombinant Human PIK3CB/PIK3R1, FLAG-tagged Sf9 Insect Cell Flag
Human PIK3CB/PIK3R1-391H Recombinant Human PIK3CB/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Human PIK3R1-1079H Recombinant Human PIK3R1, His-tagged Sf9 Insect Cell His
Human PIK3R1-315H Recombinant Human PIK3R1 protein, His/MBP-tagged E.coli His/MBP
Human PIK3R1-316H Recombinant Human PIK3R2 protein, His/MBP-tagged E.coli His/MBP
Human PIK3R1-3185HCL Recombinant Human PIK3R1 293 Cell Lysate HEK293 N/A
Human PIK3R1-4904H Recombinant Human PIK3R1 Protein (Trp624-Val718), N-His tagged E.coli N-His
Human PIK3R1-2925H Recombinant Human PIK3R1 protein, His-tagged E.coli His
Human PIK3R1-670H Recombinant Human PIK3R1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PIK3R1-2931H Recombinant Human PIK3R1 Protein E.coli Tag Free
Human PIK3R1-4903H Recombinant Human PIK3R1 Protein (Trp624-Val718), C-His tagged E.coli C-His
Mouse Pik3r1-4865M Recombinant Mouse Pik3r1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PIK3R1-4463R Recombinant Rat PIK3R1 Protein Mammalian Cell His
Rat PIK3R1-4123R Recombinant Rat PIK3R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PIK3R1-4123R-B Recombinant Rat PIK3R1 Protein Pre-coupled Magnetic Beads HEK293
Bovine PIK3R1-05B Recombinant Bovine PIK3R1 Leishmania Tarentolae N/A
Bovine PIK3R1-06B Recombinant Bovine PIK3R1 Sf9 Insect Cell N/A
Mouse, Human Pik3ca/PIK3R1-390H Recombinant Mouse and Human Pik3ca/PIK3R1, His-tagged, Active Sf9 Insect Cell His
Rhesus Macaque PIK3R1-3434R Recombinant Rhesus monkey PIK3R1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PIK3R1-3252R Recombinant Rhesus Macaque PIK3R1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PIK3R1-3252R-B Recombinant Rhesus Macaque PIK3R1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PIK3R1-8346Z Recombinant Zebrafish PIK3R1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PIK3R1 Related Articles
  • PIK3R1 Related Research Area
  • PIK3R1 Related Signal Pathway

PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ErbB signaling pathwayGSK3AA;CAMK2G1;PIK3R2;CAMK2B1;SHC1;AREG;EREG;MAP2K1;PAK2B
Ras signaling pathwayPLCG1;BRAP;HTR7;GNGT2;FGF16;FLT1;RASSF5;ABL2;HGF
Rap signaling pathwayFGF3;MAP2K3;PDGFA;ID1;KRIT1;ITGAL;TLN1;CALM3;FGF19
cGMP-PKG signaling pathwayPPP1R12A;LOC100328615;BDKRB2;CALM1;PIK3R1;BAD;KCNJ8;MAP2K2;GNA11
cAMP signaling pathwayPIK3R1;GHRL;GNAI3;MAPK8;PDE4C;HTR4;FXYD1;CALML3;HTR1F
Chemokine signaling pathwayCCL19;CCL4L2;GNAI1;CXCR5;ARRB2;GNAI2;CXCL8;CCL21B;ROCK1
HIF- signaling pathwayVHL;MAPK3;RPS6KB2;TCEB1;STAT3;EGLN1;SERPINE1;NOX1;AKT2
FoxO signaling pathwayFOXO1;MAP2K1;SOS1;MAPK3;CDKN2B;MAPK12;STK11;FASLG;PDPK1B
Phosphatidylinositol signaling systemPI4K2A;IPPK;PI4KAA;PLCD4;PLCD1;PLCD3;CDS2;MTMR1A;PLCD1B
Sphingolipid signaling pathwaySPHK1;FCER1G;SPHK2;GNAI3;PPP2R3C;PPP2R1A;MAPK9;S1PR4;NOS3
Phospholipase D signaling pathwayPIP5K1C;GRB2;TSC2;PDGFRB;RRAS;Kitl;LPAR3;LPAR4;AVP
mTOR signaling pathwayEIF4E2;CAB39L;VEGFAA;PIK3R5;TNF;INS1;EIF4E1B;TSC2;RRAGCA
PIK-Akt signaling pathwayINSR;IL7R;CCNE2;GNB2;IKBKG;ITGB7;LAMA4;FLT4;FGF5
AMPK signaling pathwayULK1;MTOR;PIK3CD;PPP2CA;RAB11B;CCNA2;PPP2R3C;PFKFB3;LEP
ApoptosisIRF2;CDK5RAP2;DBNLB;IRAK4;NFKBIAA;MYC;HIST1H1A;TP53;BAXB
Adrenergic signaling in cardiomyocytesGNA11A;ATP1B2B;ACTC1A;CACNA2D3;ADCY3;PIK3CD;CACNG1A;PIK3R1;ATP1B4
VEGF signaling pathwayPRKCBB;PIK3R3B;MAPK14B;MAP2K2B;PIK3CB;PXNA;PRKCG;PIK3R2;PLCG1
Osteoclast differentiationSIRPB1;TAB2;TREM2;CYLD;SPI1;IFNB1;TNFRSF1A;TGFBR2;AKT1
Focal adhesionPIK3R3B;PDGFA;ILK;VWF;ROCK2B;CHAD;MYL10;ACTN2;MAPK3
Signaling pathways regulating pluripotency of stem cellsMAPK13;ID4;IL6ST;WNT8A;PCGF3;Fzd4;POU5F1;INHBC;SMAD9
Platelet activationAPBB1IP;PIK3CG;BTK;PIK3CA;PPP1R12A;RAP1A;PLA2G4D;PLA2G4C;ARHGEF12
Toll-like receptor signaling pathwayTLR4BB;CCL3;CCL4;IRAK4;IFNB1;AKT1;TLR3;MAP2K3;PIK3R3B
Jak-STAT signaling pathwayIL19;IL10RB;CCND2;PIAS1;LIFRA;CISH;PIAS4B;STAT1;CSH
Natural killer cell mediated cytotoxicityIFNA13;LCK;ULBP3;PRKCG;HLA-E;KIR3DL1;PIK3R3;SHC3;LAT
T cell receptor signaling pathwayNFKBIA;DEF6A;NRAS;GRAP2;PIK3CA;PDPK1;PAK6;CD3G;CD247
B cell receptor signaling pathwayPLCG2;IKBKB;PRKCB;MAP2K2;PILRB;PDK2B;BANK1;TTC6;VAV1
Fc epsilon RI signaling pathwayGAB2;MAPK3;PRKCA;INPP5D;GM-CSF;KRAS;FCER1G;AKT1;MAP2K2
Fc gamma R-mediated phagocytosisPRKCB;PIK3R2;PPAP2B;PRKCG;INPP5D;FCGR2A;PIK3CA;ARF6;PPAP2C
TNF signaling pathwayPIK3CG;MAP2K7;MAPK9;CXCL3;BIRC3;MMP3;MAGI2;MAPK10;LTA
Leukocyte transendothelial migrationMYL5;ICAM1;CLDN2;MYL10;PIK3R5;GNAI3;PIK3CG;RAC2;CLDN18
Neurotrophin signaling pathwayTP73;IKBKB;CAMK2B;TP53;RAC1;PIK3R1;PIK3R2;ABL1;CAMK2G
Cholinergic synapseMAP2K1;PIK3R3;MAPK1;GNB1;CAMK2A;CREB3L3;GNAO1;KCNQ1;ATF4
Inflammatory mediator regulation of TRP channelsACCN5;PIK3R3;PIK3CG;PLA2G4A;IL1R1;CALM3;CALM2;CYP2C54;TRPV3
Regulation of actin cytoskeletonWASB;PDGFRB;PIK3CA;FGF2;ARHGEF1;RAC1B;CYFIP2;MYL9A;PDGFAB
Insulin signaling pathwayPRKAR2B;RPS6KB1B;EIF4EA;HRASA;ACACA;MAP2K2;CALM3;IRS1;INPP5K
Progesterone-mediated oocyte maturationPRKACG;KRAS;MAP2K1;PIK3CG;CPEB1;INS2;INSB;GNAI2A;MAD2L2
Estrogen signaling pathwayFKBP5;PRKCD;ATF6B;KCNJ6;KCNJ9;MMP9;ESR2;RAF1;SHC1
Prolactin signaling pathwayINS;PRLR;SOCS2;SOCS3;TH;SHC3;PIK3R2;FOS;INS2
Thyroid hormone signaling pathwayPIK3R3;MTOR;PLCB3;PIK3CA;MED27;RHEB;PRKACG;MED30;MED13
Oxytocin signaling pathwayCACNB1;PLCB1;PTGS2;SRC;CCND1;PPP1CA;FOS;CAMK2D;PPP3CA
Regulation of lipolysis in adipocytesLIPE;PIK3R2;PRKACA;PLIN1;AKT2;Adcy4;IRS4;GNAS;NPR1
Type II diabetes mellitusINS1;IRS2;INS-IGF2;TNF;PIK3CA;IRS4;PKM;INSR;PIK3R2
Insulin resistancePCK2;CREB3L3L;INSB;PPARGC1A;MGEA5;CD36;PCK1;AKT2L;PPP1R3D
Non-alcoholic fatty liver disease (NAFLD)ADIPOR2;NDUFA10;RAC1;PIK3R5;INSR;SDHD;CDC42;NDUFV3;NDUFV1
Aldosterone-regulated sodium reabsorptionSGK1;PIK3R2;PIK3R1;KRAS;FXYD2;SCNN1B;PIK3CD;FXYD4;ATP1A3
Carbohydrate digestion and absorptionATP1B1;ATP1B3;HK1;AMY2A4;ATP1B4;TAS1R2;ATP1A1;PIK3R1;AMY2A5
Bacterial invasion of epithelial cellsDNM2;CD2AP;VCL;SEPT11;CBL;DOCK1;ARPC5;FN1;ITGA5
Chagas disease (American trypanosomiasis)MYD88;C1QA;PIK3R3;SMAD2;IFNGR1;PIK3CA;Ccl12;AKT2;IFNGR2
ToxoplasmosisPIK3R2;CASP9;NOS2;HSPA8;IL10RA;STAT1;CD40LG;TRAF6;BAD
AmoebiasisCOL2A1;IFNG;C8B;PLCB3;LAMA3;GNAL;PIK3CG;SERPINB2;PIK3R5
Hepatitis CMAPK11;LDLR;MAPK8;CLDN3;PIK3CD;BRAF;IFIT1;CLDN8;NFKB1
Hepatitis BPIK3R1;HSPG2;NFATC2;FOS;CCNE1;TGFBR1;Ifna11;CASP12;ELK1
MeaslesIRAK4;IL13;IFNA1;Ifna11;NFKBIB;IFNA4;CD3D;HSPA1L;TNFRSF10A
Influenza APIK3R1;FDPS;EIF2AK1;CYCS;Ifna15;IFNA16;IRAK4;IFIH1;PYCARD
HTLV-I infectionKAT2A;TGFBR1;TRP53;RANBP1;WNT9B;RRAS;MRAS;HLA-DOA;EP300
Epstein-Barr virus infectionPOLR2J;HSPA1L;PSMD2;TBP;POLR2E;ENTPD3;PSMC3;MAPK9;MAPK13
Pathways in cancerAKT2;BIRC2;TPR;MAX;TPM3;RAF1;CCNE2;GLI3;FLT3LG
Viral carcinogenesisBAD;HIST1H4N;GTF2H2C_2;HIST1H2BB;ACTN3;YWHAZ;LYN;UBR4;HLA-F
Proteoglycans in cancerITGB1;RRAS;ARHGEF12;TWIST2;MAPK12;EZR;IGF2;PPP1CA;GPC3
Colorectal cancerBAD;BIRC5;LEF1;CYCS;RAC3;TCF7;BAX;RAC1;TGFB1
Renal cell carcinomaPAK3;MAP2K1;TCEB2;TGFA;PIK3CA;PTPN11;MAPK1;PIK3CD;HIF1A
Pancreatic cancerPIK3CB;RAF1;RAC1;BRAF;ARAF;STAT3;TRP53;PIK3CG;RAC2
Endometrial cancerPTEN;BAD;TRP53;KRAS;AKT1;ELK1;BRAF;PIK3R1;CDH1
GliomaCAMK2G;TGFA;PRKCB;PRKCA;PIK3CG;KRAS;MAPK1;Pdgfa&Pdgfb;CALML5
Prostate cancerHRAS;SRD5A2;ATF4;ARID1A;ARAF;IKBKB;NFKBIA;CREB3L3;ERBB2
MelanomaMAPK3;HRAS;MAPK1;PIK3R2;PDGFB;MITF;KRAS;BRAF;FGF11
Chronic myeloid leukemiaMECOM;SOS1;TGFB1;PIK3CB;MAP2K1;SHC2;PIK3R2;SMAD3;IKBKG
Acute myeloid leukemiaKIT;SFPI1;JUP;PIK3CD;MAPK3;IKBKB;PIK3R5;CHUK;CCND1
Small cell lung cancerTRAF3;BCL2;SKP2;CKS2;PTEN;RARB;PIK3CA;TRP53;PIK3CB
Non-small cell lung cancerBRAF;RXRG;RXRA;PRKCB;ALK;RB1;GRB2;AKT1;FHIT
Central carbon metabolism in cancerSLC2A1;PDGFRB;FGFR3;SIRT6;FGFR2;PFKM;PGAM1;ERBB2;HKDC1
Choline metabolism in cancerPDPK1;HRAS;PIP5K1C;RAC3;PLA2G4C;RAC1;DGKZ;SLC44A1;PPAP2C

PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, ErbB-3 class receptor binding, insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.

Function Related Protein
1-phosphatidylinositol-3-kinase regulator activityPIK3R2;PIK3R1;PIK3R3A;CCKBR;PIK3R3B;PIK3R3;PIK3R6;PIK3R5
ErbB-3 class receptor bindingPIK3R1;CDK5;NRG1;ERBB2
insulin bindingC2CD2L;HSPD1;PIK3R1;INSR;IGF1R;IDE
insulin receptor bindingPHIP;FRS2;SNX4;INSL3;PTPN11;INS2;FRS3;FRS2A;IRS2
insulin receptor substrate bindingINSRA;PRKCZ;INSRB;PIK3CB;IGF1R;PTPN11;PIK3CA;IGF1RA;PRKCD
insulin-like growth factor receptor bindingIGF2A;IGF2;IGF2B;IGF3;YWHAG;INS;IRS1;ARRB1;GNAS
neurotrophin TRKA receptor bindingFRS2;SHC1;PLCG1;GRB2;NGFR;PIK3R1;EFNA5
phosphatidylinositol 3-kinase bindingPDGFRB;IRS2;IGF1RA;CORO1A;IRS1;HCST;CALM1;CALM3;CALM2
phosphatidylinositol 3-kinase regulator activityPIK3R1;KLF4;PIK3R3B;AGAP2;PIK3R3A
phosphatidylinositol 3-kinase regulatory subunit bindingPIK3R1;PIK3AP1;PTPN13;XBP1;DNM2;FAM83A;FAM83B
protein bindingOSTC;LRP2;NAP1L4;LZTFL1;SPATC1;POLE4;GPR85;RAB1B;RABL2
protein heterodimerization activityNKX2-5;HIST1H2BN;SOX6;TCF3B;INHA;DRD2;SDCBP2;MAFG;SRI
protein phosphatase bindingCTNNB1;TRAF2;AP3B1;VRK3;KAT2A;PPP6R1;GNB2L1;JAK3;ANAPC7
transcription factor bindingTBP;ENPP2;MAPK9;LCOR;HTT;SOX17;NIF3L1;SNF8;GTF2F1
transmembrane receptor protein tyrosine kinase adaptor activityTRAT1;PIK3R1;SH2B2;IRS1;DOK2;SHC1;STAP1;BLNK;FRS2

PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.

PDGFRB; CBL

Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).
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