PIK3R1
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Official Full Name
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
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Overview
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The;enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the;85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin,;and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in;four transcript variants encoding different isoforms. -
Synonyms
PIK3R1; phosphoinositide-3-kinase, regulatory subunit 1 (alpha); phosphatidylinositol 3-kinase regulatory subunit alpha; GRB1; p85; p85 ALPHA; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; phosphati;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Human
- Mouse
- Mouse, Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Insect cells
- Leishmania Tarentolae
- Mammalian Cell
- Sf9 Insect Cell
- Flag
- His
- Fc
- Avi
- MBP
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- PIK3R1 Related Signal Pathway
PIK3R1 involved in several pathways and played different roles in them. We selected most pathways PIK3R1 participated on our site, such as ErbB signaling pathway, Ras signaling pathway, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ErbB signaling pathway | KRAS;PLCG2;CAMK2D;MAPK8A;NRG1;HRASA;RAF1A;ERBB3A;ARAF |
| Ras signaling pathway | GNB2;PIK3R1;CALM1;RAF1;RASA3;GRB2;PIK3CG;FLT4;AKT1 |
| Rap signaling pathway | KRIT1;RRAS;NGF;GNAQ;MAP2K6;INS2;CALM1;PFN1;THBS1 |
| cGMP-PKG signaling pathway | ATP2A3;MAPK3;PPP1CB;GUCY1A3;PPP3R1;MEF2D;GNA11;AKT1;BDKRB2 |
| cAMP signaling pathway | GLP1R;NFKB1;RAP1A;NFKBIA;ATP1B4;GABBR1;CALML5;MAP2K2;BAD |
| Chemokine signaling pathway | CCL3;NCF1;CCL4;CCL19;CCL16;SHC1;SRC;GNAI2;RAF1 |
| HIF- signaling pathway | AKT2;TIMP1;ARNT;NOX3;PIK3CD;MKNK2;TFRC;CAMK2D;RBX1 |
| FoxO signaling pathway | IRS4;RBL2;PRKAG3;STK11;CCNB3;FOXO3A;RAF1;CDKN1BA;GRB2A |
| Phosphatidylinositol signaling system | OCRL;PIP4K2A;INPP5D;ITPK1A;MTMR6;PIKFYVE;PLCB3;PRKCBB;PLCB4 |
| Sphingolipid signaling pathway | CERS2;GNAI2;TRP53;PPP2R5C;BAX;PLCB1;RAC1;RHOA;MAP2K1 |
| Phospholipase D signaling pathway | DNM3;PLCB4;PLCB1;PIK3R2;CYTH1;CXCR2;PIP5K1A;PPAP2C;PLA2G4D |
| mTOR signaling pathway | HIF1AB;RRAGC;EIF4BA;STRADA;RPS6KA3B;RHEB;PRKCA;PIK3CD;DDIT4 |
| PIK-Akt signaling pathway | EPO;GNG5;ITGA4;TEK;AKT1;FGF22;CREB3L3;FGF21;FGF7 |
| AMPK signaling pathway | MTOR;ULK1;PFKP;GYS2;PPP2R1A;CRTC2;IGF1R;PPP2R2A;Scd1 |
| Apoptosis | PRKAR2AB;BIRC5A;BAXB;DAPK3;HIST1H1A;NFKBIAB;PRKACAB;TNFSF10;IRAK4 |
| Adrenergic signaling in cardiomyocytes | PPP2R5EB;MYH7;ADCY8;ATP2B1;ACTC1;VMHC;PPP2R5C;CREB3L1;MAPK12B |
| VEGF signaling pathway | MAPK12A;RAC1A;PRKCBB;RAC3A;PTGS2B;PXN;MAPK12B;PLA2G4F;RAC1 |
| Osteoclast differentiation | TGFB2;BTK;MAP2K6;IFNB1;MAP2K7;AKT2;FCGR2A;FCGR3B;TNFRSF11A |
| Focal adhesion | PAK1;PTK6;PTENA;PXN;CDC42;ACTN4;MYL5;VAV3;PAK6B |
| Signaling pathways regulating pluripotency of stem cells | FGFR3;AKT2;Fzd4;NANOG;PIK3R5;BMPR2;WNT5A;PCGF1;POU5F1 |
| Platelet activation | LYN;PLCB3;MYLK2;FGB;ITGB3;SRC;P2RX1;ARHGEF1;PIK3R1 |
| Toll-like receptor signaling pathway | MAPK8B;TLR3;MAPK12B;TLR2-2;LBP;PIK3R5;RIPK1;PIK3R1;CCL4 |
| Jak-STAT signaling pathway | IL4;IL24;FHL1A;RNF207B;IL12B;LEPR;IFNE;IFNAR2;PIK3CB |
| Natural killer cell mediated cytotoxicity | KLRD1;PPP3R1;SH2D1A;MAP2K2;FCGR4;GRB2;ITGB2L;KLRK1;SAMD3 |
| T cell receptor signaling pathway | PAK6;PIK3R2;NFATC3;AKT2;MAP2K1;NFKB1;RAF1;VAV2;KRAS |
| B cell receptor signaling pathway | CDK4;ARPC4;CDK7;PDK2B;AKT2;NFATC3;PIK3CD;PPP3R2;VAV3 |
| Fc epsilon RI signaling pathway | MAPK8;MAP2K7;GRB2;PLA2G4D;GAB2;LCP2;MAPK13;RAF1;MAPK1 |
| Fc gamma R-mediated phagocytosis | GAB2;LIMK1;RPS6KB1;FCGR1A;VASP;GSN;LIMK2;PIK3R2;WASF3 |
| TNF signaling pathway | BAG4;MAP2K3;FAS;PTGS2;BIRC2;CCL2;BCL3;TNFRSF1A;PIK3R2 |
| Leukocyte transendothelial migration | PIK3CB;RAC2;CLDN2;PLCG1;OCLN;JAM2;PTK2;JAM3;CXCL12 |
| Neurotrophin signaling pathway | NFKBIE;GRB2;MAP2K1;MAPK8;NFKB1;IRAK4;CALM2;CALML5;PIK3CG |
| Cholinergic synapse | CHRNA6;PIK3CA;GNG13;HRAS;PIK3R1;GNG4;GNAI1;ITPR3;NRAS |
| Inflammatory mediator regulation of TRP channels | ASIC1;PRKACG;IL1R1;PLCG2;PLA2G4D;MAPK13;TRPV2;MAPK12;PRKCD |
| Regulation of actin cytoskeleton | PPP1CA;ITGA2B;FGF13A;MAP2K2A;PIP5K1A;PIP5KL1;PIK3R3A;ITGB7;FGF10 |
| Insulin signaling pathway | G6PCA.2;PHKA2;HK2;SHC1;AKT2L;TSC2;CALM2;PRKAG2A;PRKAG2 |
| Progesterone-mediated oocyte maturation | MAPK11;GNAI2B;IGF1RB;IGF1RA;INS;PRKACG;CPEB1B;CCNB2;AKT2 |
| Estrogen signaling pathway | CREB3L1;ITPR3;SHC3;ESR2;ESR1;CALML3;CALM1;SHC4;SRC |
| Prolactin signaling pathway | MAPK3;NRAS;AKT2;SIRPA;TH;PIK3R2;SLC2A2;PRLR;PIK3CA |
| Thyroid hormone signaling pathway | PLCD4;ITGB3;PIK3CD;MDM2;SLC2A1;MED4;MED17;TSC2;PIK3R1 |
| Oxytocin signaling pathway | CAMK1G;RAF1;PRKCB;CAMKK2;CACNB1;PIK3R3;MYLK4;GUCY1B3;NPR2 |
| Regulation of lipolysis in adipocytes | NPY;IRS2;Adcy4;PTGER3;PRKACB;LIPE;AKT1;AKT2;INSR |
| Type II diabetes mellitus | PIK3R5;MAPK1;IRS4;PRKCD;PRKCE;PDX1;HK3;MAFA;SLC2A2 |
| Insulin resistance | PIK3R1;NFKBIAB;CRTC2;PIK3R3A;RPS6KA1;SLC2A2;PPP1CAA;INS;NOS3 |
| Non-alcoholic fatty liver disease (NAFLD) | INSR;SDHD;RELA;COX7A1;ERN1;COX7B;MAPK10;NDUFS4;NDUFB3 |
| Aldosterone-regulated sodium reabsorption | FXYD2;ATP1A4;PRKCA;INS2;SCNN1G;INSR;PIK3CG;KCNJ1;IRS1 |
| Carbohydrate digestion and absorption | AMY2A;PIK3CA;FXYD2;ATP1A4;ATP1B3;AMY2A2;PIK3CG;ATP1A3;HK3 |
| Bacterial invasion of epithelial cells | WASF1;ELMO2;CTTN;CLTC;PIK3R5;DNM2;CDC42;SEPT6;ARPC1B |
| Chagas disease (American trypanosomiasis) | CCL2;GNAI2;TGFB3;IRAK4;PIK3R1;Fasl;NFKBIA;PIK3CA;FASLG |
| Toxoplasmosis | Toxoplasma Gondii Dense Granule Protein 7;Toxoplasma Gondii Profilin Family Protein;TRAF6;BCL2L1;HLA-DQB1;MAPK13;GNAO1;IRAK4;BAD |
| Amoebiasis | PRKACG;COL5A1;LAMC3;C8G;PIK3CB;GNA14;ACTN2;RAB7;NFKB1 |
| Hepatitis C | Ifna15;IFNA5;PPP2R2B;IFNA14;NR1H3;IFNA21;TRAF2;KRAS;IKBKE |
| Hepatitis B | IFNA14;TNF;NFATC4;PIK3CD;NRAS;SRC;BAX;FASLG;IFNA12 |
| Measles | PIK3CG;CD46;TLR2;AKT2;IRAK4;IFNA14;PIK3R2;TNFRSF10B;NFKBIB |
| Influenza A | TBK1;MAP2K2;MAPK11;NFKB1;TMPRSS13;NXF1;IFNA1;IFNA10;Fasl |
| HTLV-I infection | SFPI1;TP53;WNT7B;IL2RA;SLC25A4;KAT2B;LCK;FOSL1;DVL2 |
| Epstein-Barr virus infection | TAB2;TRAF6;YWHAZ;NFKB2;PSMD1;PIK3CD;HSPA6;IKBKB;SNW1 |
| Pathways in cancer | FH1;MDM2;APC2;CCND1;WNT7B;NKX3-1;EGLN2;XIAP;RARA |
| Viral carcinogenesis | VAC14;GTF2A2;HLA-C;H2-Q10;GTF2H1;PIK3CG;HDAC4;CDC42;YWHAB |
| Proteoglycans in cancer | PLAUR;WNT2;ANK2;ITPR1;ARHGEF12;CAMK2A;WNT10B;PRKACA;ITGA5 |
| Colorectal cancer | SMAD4;MAPK8;MSH6;PIK3CG;MSH3;CYCS;RAC2;RAC1;APC2 |
| Renal cell carcinoma | TGFA;SLC2A1;RAC1;VHL;PAK6;EGLN1;ETS1;RAP1A;AKT2 |
| Pancreatic cancer | KRAS;CASP9;RAC1;RAC3;STAT3;CCND1;MAPK1;CDC42;TRP53 |
| Endometrial cancer | PIK3R2;AXIN2;NRAS;ARAF;PDPK1;PIK3R5;AXIN1;TP53;KRAS |
| Glioma | MDM2;PIK3CB;CAMK2A;ARAF;AKT1;AKT2;SHC2;RAF1;SOS1 |
| Prostate cancer | SOS1;GSK3B;PIK3R3;RAF1;RB1;PDGFC;INS;TRP53;PDGFRB |
| Melanoma | PIK3R3;PTEN;FGF20;Pdgfa&Pdgfb;Fgf15;KRAS;FGF17;MET;NRAS |
| Chronic myeloid leukemia | GAB2;TRP53;PIK3R3;CTBP1;BAD;KRAS;SHC4;RUNX1;STAT5A |
| Acute myeloid leukemia | RPS6KB2;PIK3R2;EIF4EBP1;RPS6KB1;STAT5B;RUNX1T1;RELA;PIK3CD;MAP2K1 |
| Small cell lung cancer | CKS2;TRAF5;BIRC2;SKP2;LAMC2;BIRC7;RELA;CYCS;AKT2 |
| Non-small cell lung cancer | HRAS;MAP2K2;PLCG2;EML4;RASSF1;MAP2K1;KRAS;RAF1;PIK3CA |
| Central carbon metabolism in cancer | AKT1;PIK3CG;NTRK3;PIK3CA;C12orf5;FGFR3;SCO2;MAP2K1;G6PD |
| Choline metabolism in cancer | PPAP2B;PIP5K1C;GRB2;PRKCA;TSC1;KRAS;HIF1A;WASF2;PIK3R1 |
PIK3R1 has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase regulator activity, ErbB-3 class receptor binding, insulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R1 itself. We selected most functions PIK3R1 had, and list some proteins which have the same functions with PIK3R1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase regulator activity | PIK3R3;PIK3R3A;PIK3R3B;CCKBR;PIK3R2;PIK3R1;PIK3R6;PIK3R5 |
| ErbB-3 class receptor binding | PIK3R1;NRG1;ERBB2;CDK5 |
| insulin binding | HSPD1;IDE;IGF1R;C2CD2L;INSR;PIK3R1 |
| insulin receptor binding | DOK4;LMBRD1;IGF1;IGF2;GRB10;IGF1R;FRS2;IRS1;DOK6 |
| insulin receptor substrate binding | INSRA;PRKCZ;PRKCD;PIK3R1;INSR;PTPN11;IGF1R;IGF1RB;PIK3CA |
| insulin-like growth factor receptor binding | IGF2;YWHAH;IGF2B;INSL4;REN;IGF2A;Ren1;IGF1;IRS1 |
| neurotrophin TRKA receptor binding | FRS2;PLCG1;PIK3R1;GRB2;EFNA5;NGFR;SHC1 |
| phosphatidylinositol 3-kinase binding | INSRR;INSRB;CALM3;BECN1;TYRO3;IRS4;PDGFRB;ATP1A1;PIK3R1 |
| phosphatidylinositol 3-kinase regulator activity | AGAP2;PIK3R3A;PIK3R3B;PIK3R1;KLF4 |
| phosphatidylinositol 3-kinase regulatory subunit binding | PIK3R1;FAM83A;PTPN13;XBP1;FAM83B;PIK3AP1;DNM2 |
| protein binding | RNF139;HIST2H4;CUEDC2;ANKRD10;PLEKHG2;SOCS5;TAX1BP1;USP25;PDHX |
| protein heterodimerization activity | GABPB1;VAPA;HIST3H2A;TRP53;DMBX1;PAFAH1B2;Defa-rs7;BCL2L2;H3F3B.1 |
| protein phosphatase binding | ITGA1;VCAN;JUP;DLG3;MVP;PPP6R3;CDC27;PPARG;TRAF3 |
| transcription factor binding | HDAC11;HES6;PAX6;KDM1A;AHR;GNPTAB;NFYC;KAT6B;SMARCA4 |
| transmembrane receptor protein tyrosine kinase adaptor activity | BLNK;STAP1;FRS2;DOK2;PIK3R1;SH2B2;IRS1;SHC1;TRAT1 |
PIK3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R1.
PDGFRB; CBL
Research Area
Related articles
Deau, MC; Heurtier, L; et al. A human immunodeficiency caused by mutations in the PIK3R1 gene. JOURNAL OF CLINICAL INVESTIGATION 124:3923-3928(2014).
Sood, A; McClain, D; et al. PTEN Gene Expression and Mutations in the PIK3CA Gene as Predictors of Clinical Benefit to Anti-Epidermal Growth Factor Receptor Antibody Therapy in Patients With KRAS Wild-Type Metastatic Colorectal Cancer. CLINICAL COLORECTAL CANCER 11:143-150(2012).
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