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PIK3R4

Official Full Name

phosphoinositide-3-kinase, regulatory subunit 4
Overview

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.
Synonyms

PIK3R4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide 3-kinase regulatory subunit 4; p150; VPS15; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; phosphoinositide 3-kinase adaptor protein; phosphatidylinositol 3-kinase-associ;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PIK3R4-1719H	Recombinant Human PIK3R4, His-tagged	E.coli	His	1-330aa	$319 / 25μg
Human	PIK3R4-3183HCL	Recombinant Human PIK3R4 293 Cell Lysate	HEK293	Non		Inquiry
Human	PIK3R4-1245H	Recombinant Human PIK3R4 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Mouse	PIK3R4-12809M	Recombinant Mouse PIK3R4 Protein	Mammalian Cell	His		Inquiry
Mouse	PIK3R4-6741M	Recombinant Mouse PIK3R4 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	PIK3R4-6741M-B	Recombinant Mouse PIK3R4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

PIK3R4 involved in several pathways and played different roles in them. We selected most pathways PIK3R4 participated on our site, such as Regulation of autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3R4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Regulation of autophagy	IFNA17;ATG4B;INS2;IFNA13;IFNA5;INS1;GABARAP;PIK3C3;ATG12

PIK3R4 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3R4 itself. We selected most functions PIK3R4 had, and list some proteins which have the same functions with PIK3R4. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	EHD1;PSMC1;TPX2;NLRP2;TGFBR1B;DDX46;KIF7;KDRL;ATP11A
protein binding	GZMA;EHMT2;SULT1C2;B4GALT7;MFAP4;CDR2;NUMA1;MAPK7;NARG2
protein kinase activity	MYO3A;MAP2K1;BMPR1AA;PHKG1B;CLK4B;MAPK12A;GRK1;STK24A;NEK5
protein serine/threonine kinase activity	TSSK1;VPRBP;SIK2A;SMG1;EIF2AK2;STK16;MASTL;MAP4K3;ADCK5

PIK3R4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3R4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3R4.

ATG14; NRBF2; BECN1

Research Area

Apoptosis Intracellular Kinases

Apical-basal Polarity Effectors

Diabetic Peripheral Neuropathy

Intracellular Kinases in the Akt Pathway

PI 3-Kinases (Phosphoinositide 3-Kinases)

Ni, Y; Sinnett-Smith, J; et al. PKD1 Mediates Negative Feedback of PI3K/Akt Activation in Response to G Protein-Coupled Receptors. PLOS ONE 8:-(2013).

Feola, A; Cimini, A; et al. The Inhibition of p85 alpha PI3KSer83 Phosphorylation Prevents Cell Proliferation and Invasion in Prostate Cancer Cells. JOURNAL OF CELLULAR BIOCHEMISTRY 114:2114-2119(2013).