Recombinant Zebrafish PTPN13

• Cat.No.: PTPN13-5628Z
• Product Overview: Recombinant Zebrafish PTPN13 full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ptpn13 protein tyrosine phosphatase, non-receptor type 13 [ Danio rerio (zebrafish) ]
• Official Symbol: PTPN13
• Gene ID: 560883
• mRNA Refseq: NM_001089543
• Protein Refseq: NP_001083012

Reviews

05/13/2020

The performance of this reagent during the experiment is remarkable, providing the optimal sample preparation conditions.

12/26/2016

I am truly grateful for this product as it has successfully resolved protein interference issues that I encountered.

06/05/2016

Utilizing this protein reagent, my gel electrophoresis results for experimental samples are clearer, enabling better comparison and analysis.

Q&As

How is the expression of PTPN13 regulated in cells?

The expression of PTPN13 can be regulated at the transcriptional level by various factors, including transcription factors, epigenetic modifications, and signaling pathways. For example, the tumor suppressor p53 can transcriptionally upregulate PTPN13 expression. Additionally, growth factors, cytokines, and oncogenic signals can modulate PTPN13 expression through their downstream effectors.

Are there any specific inhibitors or activators targeting PTPN13?

There are no specific inhibitors or activators targeting PTPN13 available. However, further research is underway to identify small molecules or compounds that can modulate PTPN13 activity selectively.

How does PTPN13 interact with its substrates and regulate their activities?

PTPN13 binds to its substrates through its phosphatase domain and regulates their activities by dephosphorylation. It acts as a negative regulator of signaling pathways by dephosphorylating tyrosine residues on target proteins, thereby modulating their enzymatic activity, protein-protein interactions, and subcellular localization.

Can PTPN13 serve as a prognostic marker or therapeutic target in specific cancer types?

PTPN13 shows diverse expression patterns in different cancer types, and its potential as a prognostic marker or therapeutic target remains to be fully elucidated. Further studies are needed to determine its clinical significance in specific cancer types and its potential for personalized treatment approaches.

Are there any potential therapeutic strategies targeting PTPN13 for cancer treatment?

As PTPN13 functions as a tumor suppressor, restoring its activity or expression could be a potential therapeutic strategy. However, direct targeting of PTPN13 is challenging. Alternatively, targeting downstream signaling pathways that are dysregulated in PTPN13-deficient tumors, such as the PI3K/AKT pathway, may provide potential therapeutic opportunities.

What is the role of PTPN13 in cancer development and progression?

PTPN13 acts as a tumor suppressor in various cancers. Its loss or inactivation is associated with increased cell proliferation, survival, and metastasis. PTPN13 regulates key signaling pathways involved in cancer progression, such as the PI3K/AKT and MAPK pathways, and its dysregulation contributes to tumor growth, invasion, and resistance to therapies.

What are the cellular functions of PTPN13 and its related signaling pathways?

PTPN13, also known as Fas-associated phosphatase-1 (FAP-1), plays critical roles in various cellular processes, including cell adhesion, migration, proliferation, and survival. It is involved in regulating multiple signaling pathways such as the PI3K/AKT, MAPK, and Wnt pathways.