Recombinant Human PTPN13,GST-tagged,Active

• Cat.No.: PTPN13-463H
• Product Overview: Recombinant human PTPN13 (2169-2485) was expressed inE.colicells using a N-terminal GST tag. MW=61kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 2169-2485 a.a.
• Description: PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPN13 is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. PTPN13 binds to a negative regulatory domain in Fas that inhibits Fas-induced apoptosis.
• Sequence: 2169-2485.
• Applications: Phosphatase Assay, Western Blot.
• Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Gene Information

• Gene Name: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) [ Homo sapiens ]
• Synonyms: PTPN13; protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); PNP1; FAP-1; PTP1E; PTPL1; PTPLE; PTP-BL; PTP-BAS; DKFZp686J1497; Tyrosine-protein phosphatase non-receptor type 13; EC 3.1.3.48; Protein-tyrosine phosphatase 1E; PTP-E1; hPTPE1; Protein-tyrosine phosphatase PTPL1; Fas-associated protein-tyrosine phosphatase 1
• Gene ID: 5783
• mRNA Refseq: NM_006264
• Protein Refseq: NP_006255
• UniProt ID: Q12923
• Chromosome Location: 4q21.3
• MIM: 600267
• Function: hydrolase activity; protein binding; protein tyrosine phosphatase activity