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Recombinant Rat Ptpn13 protein, His & T7-tagged

Cat.No. : Ptpn13-8099R
Product Overview : Recombinant Rat Ptpn13 aa. (Met1~Asn161 (Accession # G3V9S3)) fused with N-terminal His & T7 tag was produced in E. coli cells.
  • Specification
  • Gene Information
  • Related Products
Source : E. coli
Species : Rat
Tag : His & T7
Form : Freeze-dried powder
Molecular Mass : Predicted Molecular Mass: 21.4kDa.
Protein length : Met1~Asn161 (Accession # G3V9S3)
Endotoxin : <1.0EU per 1ug (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 4.8.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage Buffer : Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
Reconstitution : Reconstitute in sterile ddH2O.
Gene Name : Ptpn13 protein tyrosine phosphatase, non-receptor type 13 [ Rattus norvegicus (Norway rat) ]
Official Symbol : Ptpn13
Synonyms : Ptpn13; protein tyrosine phosphatase, non-receptor type 13; ptp; Ptp-bl; tyrosine-protein phosphatase non-receptor type 13; protein Tyr phosphatase
Gene ID : 498331
mRNA Refseq : NM_001100789.1
Protein Refseq : NP_001094259.1
UniProt ID : G3V9S3

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How is the expression of PTPN13 regulated in cells? 04/09/2023

The expression of PTPN13 can be regulated at the transcriptional level by various factors, including transcription factors, epigenetic modifications, and signaling pathways. For example, the tumor suppressor p53 can transcriptionally upregulate PTPN13 expression. Additionally, growth factors, cytokines, and oncogenic signals can modulate PTPN13 expression through their downstream effectors.

Are there any specific inhibitors or activators targeting PTPN13? 04/04/2023

There are no specific inhibitors or activators targeting PTPN13 available. However, further research is underway to identify small molecules or compounds that can modulate PTPN13 activity selectively.

How does PTPN13 interact with its substrates and regulate their activities? 05/20/2021

PTPN13 binds to its substrates through its phosphatase domain and regulates their activities by dephosphorylation. It acts as a negative regulator of signaling pathways by dephosphorylating tyrosine residues on target proteins, thereby modulating their enzymatic activity, protein-protein interactions, and subcellular localization.

Can PTPN13 serve as a prognostic marker or therapeutic target in specific cancer types? 07/23/2020

PTPN13 shows diverse expression patterns in different cancer types, and its potential as a prognostic marker or therapeutic target remains to be fully elucidated. Further studies are needed to determine its clinical significance in specific cancer types and its potential for personalized treatment approaches.

Are there any potential therapeutic strategies targeting PTPN13 for cancer treatment? 07/21/2020

As PTPN13 functions as a tumor suppressor, restoring its activity or expression could be a potential therapeutic strategy. However, direct targeting of PTPN13 is challenging. Alternatively, targeting downstream signaling pathways that are dysregulated in PTPN13-deficient tumors, such as the PI3K/AKT pathway, may provide potential therapeutic opportunities.

What is the role of PTPN13 in cancer development and progression? 04/27/2017

PTPN13 acts as a tumor suppressor in various cancers. Its loss or inactivation is associated with increased cell proliferation, survival, and metastasis. PTPN13 regulates key signaling pathways involved in cancer progression, such as the PI3K/AKT and MAPK pathways, and its dysregulation contributes to tumor growth, invasion, and resistance to therapies.

What are the cellular functions of PTPN13 and its related signaling pathways? 03/18/2017

PTPN13, also known as Fas-associated phosphatase-1 (FAP-1), plays critical roles in various cellular processes, including cell adhesion, migration, proliferation, and survival. It is involved in regulating multiple signaling pathways such as the PI3K/AKT, MAPK, and Wnt pathways.

Customer Reviews (3)

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Reviews
05/13/2020

    The performance of this reagent during the experiment is remarkable, providing the optimal sample preparation conditions.

    12/26/2016

      I am truly grateful for this product as it has successfully resolved protein interference issues that I encountered.

      06/05/2016

        Utilizing this protein reagent, my gel electrophoresis results for experimental samples are clearer, enabling better comparison and analysis.

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