| Description : |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
96.3 kDa |
| AA Sequence : |
MLPAPAAPRWPPLLLLLLLLPLARG APARPAAGGQASELVVPTRLPGSAG ELALHLSAFGKGFVLRLAPDDSFLA PDFKIERLGGSGRATGGERGLRGCF FSGTVNGEPESLAAVSLCRGLSGSF LLDGEEFTIQPQGAGGSLAQPHRLQ RWGPAGARPLPRGPEWEVETGEGQR QERGDHQEDSEEESQEEEAEGASEP PPPLGATSRTKRFVSEARFVETLLV ADASMAAFYGADLQNHILTLMSVAA RIYKHPSIKNSINLMVVKVLIVEDE KWGPEVSDNGGLTLRNFCNWQRRFN QPSDRHPEHYDTAILLTRQNFCGQE GLCDTLGVADIGTICDPNKSCSVIE DEGLQAAHTLAHELGHVLSMPHDDS KPCTRLFGPMGKHHVMAPLFVHLNQ TLPWSPCSAMYLTELLDGGHGDCLL DAPAAALPLPTGLPGRMALYQLDQQ CRQIFGPDFRHCPNTSAQDVCAQLW CHTDGAEPLCHTKNGSLPWADGTPC GPGHLCSEGSCLPEEEVERPKPVVD GGWAPWGPWGECSRTCGGGVQFSHR ECKDPEPQNGGRYCLGRRAKYQSCH TEECPPDGKSFREQQCEKYNAYNYT DMDGNLLQWVPKYAGVSPRDRCKLF CRARGRSEFKVFEAKVIDGTLCGPE TLAICVRGQCVKAGCDHVVDSPRKL DKCGVCGGKGNSCRKVSGSLTPTNY GYNDIVTIPAGATNIDVKQRSHPGV QNDGNYLALKTADGQYLLNGNLAIS AIEQDILVKGTILKYSGSIATLERL QSFRPLPEPLTVQLLTVPGEVFPPK VKYTFFVPNDVDFSMQSSKERATTN IIQPLLHAQWVLGDWSECSSTCGAG WQRRTVECRDPSGQASATCNKALKP EDAKPCESQLCPLTRTRPLEQKLIS EEDLAANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
