adamts8

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adamts8

Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif, 8
Background This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
Synonyms ADAMTS8; ADAM metallopeptidase with thrombospondin type 1 motif, 8; METH2; ADAM-TS8; A disintegrin and metalloproteinase with thrombospondin motifs 8; METH-2; METH-8; ADAMTS-8; ADAM-TS 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8;
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAMTS8-1511H Recombinant Human ADAMTS8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ADAMTS8-29H Recombinant Human ADAMTS8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ADAMTS8-3009H Recombinant Human ADAMTS8, His-tagged E.coli His
    Human ADAMTS8-309H Recombinant Human ADAMTS8 Protein, GST-tagged Wheat Germ GST
    Human ADAMTS8-9027HCL Recombinant Human ADAMTS8 293 Cell Lysate HEK293 N/A
    Mouse Adamts8-1531M Recombinant Mouse Adamts8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Adamts8-3016M Recombinant Mouse Adamts8, His-tagged E.Coli or Yeast His

    adamts8 involved in several pathways and played different roles in them. We selected most pathways adamts8 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with adamts8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of the extracellular matrix CTSS; CTSD; CTSL2; CTSK; CTSL1; BMP1; COL17A1; MMP17; MMP24; CMA1
    Extracellular matrix organization COL8A1; COL8A1A; FBN1; MFAP4; COL10A1; FBN2; LRP4; CTSK; FAM49BA; ADAM8A
    Metabolism of proteins SUMF2; B3GNT6; MBOAT4; TBCC; DNAJC19; EIF5A; TIMM50; IGFBP1A; ST6GALNAC2; PFDN5
    O-glycosylation of TSR domain-containing proteins ADAMTSL4; ADAMTS8; SPON1A; ADAMTS3; ADAMTS1; ADAMTSL5; SPON1B; THSD7A; ADAMTSL3; ADAMTS20
    O-linked glycosylation MUC21; THSD1; ADAMTS18; ADAMTSL3; B3GNT2A; ADAMTS15; ADAMTS13; GALNT6; GALNT13; GALNTL2
    Post-translational protein modification TRAPPC1; WDR85; ADAMTS10; SAE1; MIA3; PHC3; NAPB; GALNTL2; NAPAB; GALNT6

    adamts8 has several biochemical functions, for example, heparin binding, integrin binding, low-affinity phosphate transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by adamts8 itself. We selected most functions adamts8 had, and list some proteins which have the same functions with adamts8. You can find most of the proteins on our site.

    Function Related Protein
    heparin binding ECM2; WISP1A; ELANE; MMP7; FGF7; CTGFA; MSTN; WISP1B; APOB; RSPO2
    integrin binding CIB2; ADAM22; ITGA5; ICAM2; ANGPTL3; CTGFA; ADAM25; PTPN2; ANXA7; SYK
    low-affinity phosphate transmembrane transporter activity ADAMTS8
    metalloendopeptidase activity ADAMTSL4; KEL; MMP15; ADAMDEC1; ADAMTS7; ADAMTS4; MMP9; C6AST3; PAPPAB; MMP13A
    metallopeptidase activity CNDP1; MMP13A; PAPPAA; CHMP1A; GM5136; MMP14B; HE2; PAPPA2; MEP1A.2; ADAMTS8
    zinc ion binding MYNN; RNF212; ZFAND2B; RNF175; HERC2; NRD1B; LANCL1; CHMP1A; CBLB; PGLYRP3

    adamts8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adamts8 here. Most of them are supplied by our site. Hope this information will be useful for your research of adamts8.

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