adamts8
Share
  • Official Full Name
  • ADAM metallopeptidase with thrombospondin type 1 motif, 8
  • Background
  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADAMTS8; ADAM metallopeptidase with thrombospondin type 1 motif, 8; METH2; ADAM-TS8; A disintegrin and metalloproteinase with thrombospondin motifs 8; METH-2; METH-8; ADAMTS-8; ADAM-TS 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8;
Cat.#:ADAMTS8-29HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAMTS8 Protein, MYC/DDK-tagged
+Inquiry
Cat.#:ADAMTS8-3009HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS8, His-tagged
+Inquiry
Cat.#:ADAMTS8-309HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAMTS8 Protein, GST-tagged
+Inquiry
Cat.#:Adamts8-3016MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Adamts8, His-tagged
+Inquiry
Cat.#:ADAMTS8-9027HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ADAMTS8 293 Cell Lysate
+Inquiry

Involved Pathway

ADAMTS8 involved in several pathways and played different roles in them. We selected most pathways ADAMTS8 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Degradation of the extracellular matrix
MMP15; COL9A3; MMP11; COL15A1B; ADAMTS8; MGC174152; FURINB; TLL2; ADAM8A; MMP12
Extracellular matrix organization
MFAP3; PPIB; COL17A1A; DDR2; F11R.2; TRAPPC4; ABHD1; EMID2; MFAP5; COL3A1
Metabolism of proteins
TOMM22; SSPO; SFTPC; DDX11; IGFBP5B; TIMM17A; IGFBP6A; GPR120; GALNT5; PFDN5
O-glycosylation of TSR domain-containing proteins
ADAMTSL4; ADAMTS13; ADAMTSL1; SPON1; ADAMTSL5; THSD1; ADAMTS8; SSPO; ADAMTS18; SPON1A
O-linked glycosylation
ADAMTS10; ADAMTS5; MUC1; ADAMTSL5; ADAMTS20; SPON1A; GALNT13; THSD1; ADAMTSL3; ADAMTSL1
Post-translational protein modification
NANP; NAPB; SUMF2; MGAT4B; SPON1B; ARSJ; ALG10B; MAGT1; ADAMTSL1; CTAGE5

Protein Function

ADAMTS8 has several biochemical functions, for example, heparin binding, integrin binding, low-affinity phosphate transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS8 itself. We selected most functions ADAMTS8 had, and list some proteins which have the same functions with ADAMTS8. You can find most of the proteins on our site.
Function
Related Protein
Function heparin binding
Related Protein FGF2; SERPINE2; FGFBP1; FGF10; THBS2; CCDC80; PTPRFB; PTCH1; VEGFAB; COMP
Function integrin binding
Related Protein WISP1B; FBN1; IGF1; CALR; ICAM2; PPAP2B; GPNMB; EMP2; Tcam1; KDR
Function low-affinity phosphate transmembrane transporter activity
Related Protein ADAMTS8
Function metalloendopeptidase activity
Related Protein C6AST3; MBTPS2; YME1L1B; ASTL; ZMPSTE24; TLL1; MMP25; PAPPAB; MMEL1; SPG7
Function metallopeptidase activity
Related Protein STAMBPL1; MMP23BB; C6AST4; ADAM28; ADAMTS9; HE2; DNPEP; ADAMTS7; BMP1A; ADAMTS8
Function zinc ion binding
Related Protein NANOS2; BMI1; APOBEC3C; TRIM16; RFPL3; SH3RF3; TRIM55B; MKRN2; COP1; ZDHHC15