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ADAMTS8

  • Official Full Name

    ADAM metallopeptidase with thrombospondin type 1 motif, 8

  • Overview

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADAMTS8; ADAM metallopeptidase with thrombospondin type 1 motif, 8; METH2; ADAM-TS8; A disintegrin and metalloproteinase with thrombospondin motifs 8; METH-2; METH-8; ADAMTS-8; ADAM-TS 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAMTS8-3009H Recombinant Human ADAMTS8, His-tagged E.coli His 889
Human ADAMTS8-309H Recombinant Human ADAMTS8 Protein, GST-tagged Wheat Germ GST
Human ADAMTS8-9027HCL Recombinant Human ADAMTS8 293 Cell Lysate HEK293 N/A
Human ADAMTS8-0160H Recombinant Human ADAMTS8 Protein (Leu832-Leu889), N-His-tagged E.coli N-His Leu832-Leu889
Human ADAMTS8-29H Recombinant Human ADAMTS8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ADAMTS8-605HFL Recombinant Full Length Human ADAMTS8 Protein, C-Flag-tagged Mammalian cells Flag
Human ADAMTS8-1511H Recombinant Human ADAMTS8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ADAMTS8-281H Recombinant Human ADAMTS8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ADAMTS8-281H-B Recombinant Human ADAMTS8 Protein Pre-coupled Magnetic Beads HEK293
Mouse Adamts8-3016M Recombinant Mouse Adamts8, His-tagged E.Coli or Yeast His 905
Mouse Adamts8-1531M Recombinant Mouse Adamts8 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAMTS8 Related Research Area

ADAMTS8 involved in several pathways and played different roles in them. We selected most pathways ADAMTS8 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of the extracellular matrixCTSD;TLL1;ADAM8A;TIMP2B;TLL2;FURINB;CTSG;ADAMTS5;ADAM9
Extracellular matrix organizationMATN3;MATN1;MATN3B;TIMP2;PCOLCEB;ADAMTS1;MMP19;KLK7;ITGB3A
Metabolism of proteinsMUC4;ADAMTSL1;FKBP9;ARL2;CBX4;CCDC59;TBCE;CEACAM21;FBXW4
O-glycosylation of TSR domain-containing proteinsADAMTS13;ADAMTSL3;SPON1B;THSD1;ADAMTSL4;SSPO;B3GALTL;ADAMTS20;ADAMTSL5
O-linked glycosylationGALNTL2;ST6GALNAC2;ADAMTS5;A4GNT;MUCL1;ADAMTS20;C8orf84;ADAMTSL5;SSPO
Post-translational protein modificationGNE;PPP6C;MPDU1;ANKRD28;SEC23IP;ADAMTS13;MAN1B1;A4GNT;B3GNT8

ADAMTS8 has several biochemical functions, for example, heparin binding, integrin binding, low-affinity phosphate transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS8 itself. We selected most functions ADAMTS8 had, and list some proteins which have the same functions with ADAMTS8. You can find most of the proteins on our site.

Function Related Protein
heparin bindingCOL20A1;PLA2G2D;WISP1A;SFRP1;ABI3BP;SLIT1A;HBEGF;SMOC2;LIPG
integrin bindingLAMB2;ADAM17;FBLN1;ICAM1;ILK;GPNMB;FBN1;THBS4;ICAM2
low-affinity phosphate transmembrane transporter activity
metalloendopeptidase activityADAM9;MMP19;PAPPAB;FAP;MMP24;ADAMTS2;ADAMTS18;ADAMTS8;MMP1A
metallopeptidase activityPAPPAA;ADAMTS16;AMZ2;ADAMTS12;STAMBPL1;ADAM25;BMP1;STAMBPA;MMP14B
zinc ion bindingTRIM35-35;ISL2A;L3MBTL2;S100A7;TRIM60;DMD;TRIM24;ZCCHC10;RNF44

ADAMTS8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS8.

  • Q&As
  • Reviews

Q&As (5)

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What is the biological function of ADAMTS8? 07/06/2022

ADAMTS8 shows anti-angiogenesis and inhibition of endothelial cell production

What diseases is ADAMTS8 used to study? 04/07/2022

ADAMTS8 is used in more studies of heart and cardiovascular diseases

What is ADAMTS8 also called? 05/05/2021

ADAMTS8 used to be called METH-2.

Where is ADAMTS8 mainly expressed? 04/10/2021

ADAMTS8 is predominantly expressed in the lungs and heart

What is the structure domain of ADAMTS8? 10/19/2020

Pre-structural domains, metalloproteinase structural domains, disintegrin-like structural domains, central thrombospondin-like motifs, cysteine-rich structural domains, spacer region structural domains and C-terminal motifs

Customer Reviews (3)

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Reviews
06/02/2022

    The technician modified my experimental protocol so that my experiment went smoothly.

    06/15/2021

      Very good after-sales service to get my experiments going!

      01/05/2021

        The protein composition was stable and concentrated, allowing me to obtain satisfactory experimental results.

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