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Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif, 4
Background This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
Synonyms ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAMTS4-1028H Recombinant Human ADAMTS4 Protein, His-tagged CHO His
    Human ADAMTS4-1754H Recombinant Human ADAMTS4 protein, His-tagged E.coli His
    Human ADAMTS4-533H Recombinant Human ADAMTS4, His-tagged Insect Cell His
    Human ADAMTS4-534H Recombinant Human ADAMTS4, His-tagged CHO N/A
    Human ADAMTS4-535H Recombinant Human ADAMTS4, GST-tagged Wheat Germ GST
    Human ADAMTS4-536H Recombinant Human ADAMTS4, GST-tagged Wheat Germ GST
    Human ADAMTS4-537H Recombinant Human ADAMTS4, MYC/DDK-tagged HEK293 Myc/DDK
    Human ADAMTS4-538H Recombinant Human ADAMTS4, MYC/DDK-tagged HEK293 N/A
    Human ADAMTS4-9029HCL Recombinant Human ADAMTS4 293 Cell Lysate HEK293 N/A
    Mouse Adamts4-1530M Recombinant Mouse Adamts4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat ADAMTS4-506R Recombinant Rat ADAMTS4 Protein Mammalian Cell His

    adamts4 involved in several pathways and played different roles in them. We selected most pathways adamts4 participated on our site, such as Degradation of the extracellular matrix, Endochondral Ossification, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with adamts4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of the extracellular matrix ADAM8A; ADAMTS18; ADAM15; FURINA; COL25A1; ADAM9; MMP11; MMP10; CTSS; TLL2
    Endochondral Ossification KIF3A; MGP; PTH; IFT88; CTSL2; NKX3-2; CDKN1C; DDR2; MMP13; COL2A1
    Extracellular matrix organization LEPREL1; MATN4; COL19A1; COL17A1A; MATN3; FN1B; LEPREL2; TIMP2B; TLDC2; PCOLCE2
    Metabolism of proteins ADAMTSL4; CPB2; DPH3; TBCB; SLC25A13; ST6GALNAC1.2; FURINB; NAPG; ST3GAL3A; SCMH1
    O-glycosylation of TSR domain-containing proteins ADAMTSL4; ADAMTSL3; THSD7A; B3GALTL; ADAMTS3; THSD1; ADAMTS13; C8orf84; ADAMTS20; ADAMTS5
    O-linked glycosylation MUC15; ADAMTS18; GALNT6; GALNT5; SPON1B; ADAMTSL5; B3GALTL; ADAMTS4; ADAMTSL3; SSPO
    Post-translational protein modification PHC3; TRAPPC2L; DPH1; LMAN2; MUC20; MUC21; ST6GALNAC1.2; ARSI; CNIH; SEC16B

    adamts4 has several biochemical functions, for example, metalloendopeptidase activity, metallopeptidase activity, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by adamts4 itself. We selected most functions adamts4 had, and list some proteins which have the same functions with adamts4. You can find most of the proteins on our site.

    Function Related Protein
    metalloendopeptidase activity BMP1B; MMP11; MMP14; MMP14A; PHEX; ADAMTS3; YBEY; ADAMTS2; MMP1A; ADAM25
    metallopeptidase activity ADAMTSL1; ADAM28; CLCA4; LNPEP; GM5136; CNDP2; NAALAD2; PAPPA2; TMEM27; ADAM20
    peptidase activity BMP1A; CAPN2L; KLK1B3; CTSL1B; ELA2L; TMPRSS13A; lon; MMP1A; ZMPSTE24; NPEPPS
    protease binding ANXA2; SERPINA1A; SELL; ADAMTS4; UBC; ITGAV; RFFL; BRCA2; VWF; Serpina1b
    protein binding CD58; MAPKBP1; IRAK1; ODF2; MED7; SPRR2A; NOXA1; SUMO3; CPT1C; MBL2
    zinc ion binding OAS1A; DNPEP; RNF214; MAN2B2; ADAMTS15; NPLOC4; AKT1S1; ADAM22; DRL; ADAMTSL1

    adamts4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adamts4 here. Most of them are supplied by our site. Hope this information will be useful for your research of adamts4.

    ZBTB16; YTHDC1

    Valenzuela, JC; Heise, C; et al. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369:-(2014).
    Wainwright, SD; Bondeson, J; et al. ADAMTS-4_v1 Is a Splice Variant of ADAMTS-4 That Is Expressed as a Protein in Human Synovium and Cleaves Aggrecan at the Interglobular Domain. ARTHRITIS AND RHEUMATISM 65:2866-2875(2013).

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