adamts4
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  • Official Full Name
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4
  • Background
  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4;
Cat.#:ADAMTS4-1028HTag:His
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human ADAMTS4 Protein, His-tagged
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Cat.#:ADAMTS4-1754HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS4 protein, His-tagged
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Cat.#:ADAMTS4-533HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADAMTS4, His-tagged
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Cat.#:ADAMTS4-534HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ADAMTS4, His-tagged
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Cat.#:ADAMTS4-535HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ADAMTS4, GST-tagged
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Cat.#:ADAMTS4-536HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ADAMTS4, GST-tagged
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Cat.#:ADAMTS4-537HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAMTS4, MYC/DDK-tagged
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Cat.#:ADAMTS4-538HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAMTS4, MYC/DDK-tagged
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Cat.#:ADAMTS4-506RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADAMTS4 Protein
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Cat.#:ADAMTS4-9029HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ADAMTS4 293 Cell Lysate
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Involved Pathway

ADAMTS4 involved in several pathways and played different roles in them. We selected most pathways ADAMTS4 participated on our site, such as Degradation of the extracellular matrix, Endochondral Ossification, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Degradation of the extracellular matrix
ELANE; COL19A1; ADAMTS18; ADAM8; KLK7; MMP10; LOC100686744; TIMP2B; CTSD; ADAM15
Endochondral Ossification
KIF3A; COL10A1A; CST5; FRZB; PTH; NKX3-2; MGP; SOX9A; NKX3.2; SOX5
Extracellular matrix organization
COL5A3B; COL5A2; COL4A6; DST; COL8A1; ICAM4; COL10A1A; MGC174155; CAPNS1; COL6A3
Metabolism of proteins
TOMM7; BCS1L; NSMCE4A; ADAMTS20; GZMH; GRP; SAE1; CXXC1; ARSE; TFG
O-glycosylation of TSR domain-containing proteins
ADAMTS15; SPON1A; ADAMTS1; ADAMTSL4; ADAMTS20; SPON2; ADAMTS18; ADAMTSL1; THSD1; ADAMTS4
O-linked glycosylation
B3GNT6; MUCL1; SPON1B; MUC20; ADAMTS4; ST6GALNAC2; C8orf84; MUC12; ADAMTS13; SSPO
Post-translational protein modification
ADAMTSL1; PHC1; PHC3; TMED2; MUC4; ARSJ; KCNA6; PPP6R1; NANP; MPDU1

Protein Function

ADAMTS4 has several biochemical functions, for example, metalloendopeptidase activity, metallopeptidase activity, peptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS4 itself. We selected most functions ADAMTS4 had, and list some proteins which have the same functions with ADAMTS4. You can find most of the proteins on our site.
Function
Related Protein
Function metalloendopeptidase activity
Related Protein ADAM9; OSGEPL1; MMP14B; MMP23B; ADAMTS15; BMP1A; C6AST1; ADAM17; ADAM18; MEP1A.1
Function metallopeptidase activity
Related Protein PSMD14; PGCP; MMP23B; MMP23BB; CPD; ADAM10; NPSN; NAALAD2; AGBL4; STAMBP
Function peptidase activity
Related Protein C6AST1; AGBL4; MMP23BB; PROCA; MMP13A; MMP1A; HE1A; SPPL3; CAPN8; CAPN12
Function protease binding
Related Protein A2M; SERPINA1A; ADAM8A; DVL3; HSPA6; ITGB1; FAP; INSL3; FLOT2; ADAMTS4
Function protein binding
Related Protein TAF7L; TFPT; KRTAP9-4; ELF1; CANX; FAM108A1; MYH7B; UBE2B; TIMM8A; RPS6KA2
Function zinc ion binding
Related Protein RXRG; ZRANB1B; ZFYVE1; ZDHHC22; CTCF; QPCT; ABLIM1B; ANPEPA; PHF23B; NR6A1B

Interacting Protein

ADAMTS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS4.
ZBTB16; YTHDC1

ADAMTS4 Related Articles

Valenzuela, JC; Heise, C; et al. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369:-(2014).
Wainwright, SD; Bondeson, J; et al. ADAMTS-4_v1 Is a Splice Variant of ADAMTS-4 That Is Expressed as a Protein in Human Synovium and Cleaves Aggrecan at the Interglobular Domain. ARTHRITIS AND RHEUMATISM 65:2866-2875(2013).