adamts4
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  • Official Full Name
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4
  • Background
  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif, 4; ADMP-1; ADAMTS-2; ADAMTS-4; A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4;
Cat.#:ADAMTS4-1028HTag:His
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human ADAMTS4 Protein, His-tagged
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Cat.#:ADAMTS4-1754HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS4 protein, His-tagged
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Cat.#:ADAMTS4-533HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADAMTS4, His-tagged
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Cat.#:ADAMTS4-534HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human ADAMTS4, His-tagged
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Cat.#:ADAMTS4-535HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ADAMTS4, GST-tagged
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Cat.#:ADAMTS4-536HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human ADAMTS4, GST-tagged
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Cat.#:ADAMTS4-537HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAMTS4, MYC/DDK-tagged
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Cat.#:ADAMTS4-538HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADAMTS4, MYC/DDK-tagged
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Cat.#:ADAMTS4-506RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADAMTS4 Protein
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Cat.#:ADAMTS4-9029HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ADAMTS4 293 Cell Lysate
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ADAMTS4 Related Articles

Valenzuela, JC; Heise, C; et al. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 369:-(2014).
Wainwright, SD; Bondeson, J; et al. ADAMTS-4_v1 Is a Splice Variant of ADAMTS-4 That Is Expressed as a Protein in Human Synovium and Cleaves Aggrecan at the Interglobular Domain. ARTHRITIS AND RHEUMATISM 65:2866-2875(2013).