ADAMTS2
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 2
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Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010] -
Synonyms
ADAMTS2; ADAM metallopeptidase with thrombospondin type 1 motif, 2; NPI; PNPI; PCINP; PCPNI; PCI-NP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAMTS-3; A disintegrin and metalloproteinase with thrombospondin motifs 2; procollagen I N-proteinase; procollagen N-endopeptidase; procollagen I/II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | ADAMTS2-304H | Recombinant Human ADAMTS2 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ADAMTS2-1778H | Recombinant Human ADAMTS2 protein, His & SUMO-tagged | E.coli | His/SUMO | Gln23~Pro161 |
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| Human | ADAMTS2-1779H | Recombinant Human ADAMTS2 Protein, His&Myc-tagged | E. coli | His&Myc | 254-492aa |
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| Mouse | Adamts2-1757M | Recombinant Mouse Adamts2 protein, His-tagged | E.coli | His | Val855~Pro1030 (Accession # Q8C9W3) |
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| Cattle | ADAMTS2-3007C | Recombinant Cattle ADAMTS2, His-tagged | E.coli | His | 1205 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ADAMTS2 Related Articles
ADAMTS2 involved in several pathways and played different roles in them. We selected most pathways ADAMTS2 participated on our site, such as Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collagen biosynthesis and modifying enzymes | COL5A1;COL1A2;COL4A4;COL5A3A;SERPINH1B;COL8A1;PCOLCE2B;COL9A3;COL8A2 |
| Collagen formation | BMP1B;COL3A1;P3H2;COL5A2;TLL2;COL10A1;COL4A4;COL11A1B;COL2A1 |
| Extracellular matrix organization | COL9A1B;FAM49BA;LOX;CAPNS1;ELANE;CTRB1;ADAMTS3;PCOLCE;LOXL1 |
ADAMTS2 has several biochemical functions, for example, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS2 itself. We selected most functions ADAMTS2 had, and list some proteins which have the same functions with ADAMTS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | ADAMTSL4;PAPPAB;IDE;MEP1A;MMP11;ADAM20;ADAMTS10;ADAMTS5;MMP7 |
| zinc ion binding | TRIM59;MARCH3;RBM14B;NSMCE1;MICALL2A;RNF24;PDLIM7;CAD;TAF2 |
ADAMTS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS2.
- Q&As
- Reviews
Q&As (10)
Ask a questionADAMTS2 has high sequence homology with ADAMTS14 and ADAMTS3.
Overexpression of ADAMTS2 significantly improves cardiac function and inhibits the development of myocardial hypertrophy, meaning that ADAMTS2 plays a protective role in the development of cardiac hypertrophy.
Yes, we are able to provide custom manufactured ADAMTS2 according to your needs.
ADAMTS2 affects the pathogenesis of cardiovascular disease and regulates myocardial hypertrophy.
We can custom produce ADAMTS2 (GST-tagged) for you.
ADAMTS2 is mainly expressed in connective tissues extending from the lymphatic network.
Mutations in the ADAMTS2 gene cause abnormal skin development in animals and congenital connective tissue dysplasia syndrome in humans.
Both cytokines TNF-α and TGF-β promote the secretion of ADAMTS2.
ADAMTS2 is widely used in cardiovascular disease research.
Due to the small molecular weight of the His tag, it generally does not affect the downstream application of the protein.
Customer Reviews (5)
Write a reviewThe protein received was tailored to my needs, allowing me to move forward with my research.
Technicians are able to provide helpful advice on product use.
High protein concentrations were received and the desired experimental results were obtained.
Smooth communication and timely shipment, allowing my experiment to be implemented as soon as possible.
The sales staff gave me good advice and allowed me to purchase products that met my research needs.
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