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Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif, 2
Background This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Synonyms ADAMTS2; ADAM metallopeptidase with thrombospondin type 1 motif, 2; NPI; PNPI; PCINP; PCPNI; PCI-NP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAMTS-3; A disintegrin and metalloproteinase with thrombospondin motifs 2; procollagen I N-proteinase; procollagen N-endopeptidase; procollagen I/II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2;
    • Species :
    • Cattle
    • Human
    • Mouse
    • Source :
    • E.coli
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAMTS2-1778H Recombinant Human ADAMTS2 protein, His & SUMO-tagged E.coli His/SUMO
    Human ADAMTS2-304H Recombinant Human ADAMTS2 Protein, GST-tagged Wheat Germ GST
    Mouse Adamts2-1757M Recombinant Mouse Adamts2 protein, His-tagged E.coli His
    Cattle ADAMTS2-3007C Recombinant Cattle ADAMTS2, His-tagged E.coli His

    adamts2 involved in several pathways and played different roles in them. We selected most pathways adamts2 participated on our site, such as Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with adamts2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Collagen biosynthesis and modifying enzymes COL5A3A; COL15A1B; COL8A1; COL5A1; BMP1B; COL3A1; COL4A6; SERPINH1; TLL1; LEPREL1
    Collagen formation COL15A1B; COL25A1; CD151; CTSS; LOXL3; PCOLCEA; COL8A1; COL28A1; BMP1B; COL9A1A
    Extracellular matrix organization COL9A3; TIMP2; BGNB; PCOLCE2B; ADAMTS1; FN1B; TTR; TLL2; MATN4; FBN2

    adamts2 has several biochemical functions, for example, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by adamts2 itself. We selected most functions adamts2 had, and list some proteins which have the same functions with adamts2. You can find most of the proteins on our site.

    Function Related Protein
    metalloendopeptidase activity C6AST1; ADAM5; MMP14A; BMP1B; ADAM28; MMP26; ADAMTS15A; ADAMTS16; YME1L1B; MMEL1
    zinc ion binding CPE; PDLIM3A; TRIM105; RING1; SETDB2; NR1H5; BSPRY; TRIM32; SF1; ZFR

    adamts2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adamts2 here. Most of them are supplied by our site. Hope this information will be useful for your research of adamts2.

    Pyun, JA; Kim, S; et al. Epistasis between polymorphisms in ACVR2B and ADAMTS19 is associated with premature ovarian failure. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 22:212-216(2015).
    Monteagudo, LV; Ferrer, LM; et al. In silico identification and three-dimensional modelling of the missense mutation in ADAMTS2 in a sheep flock with dermatosparaxis. VETERINARY DERMATOLOGY 26:49-+(2015).

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