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ADAMTS18

  • Official Full Name

    ADAM metallopeptidase with thrombospondin type 1 motif, 18

  • Overview

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
  • Synonyms

    ADAMTS18; ADAM metallopeptidase with thrombospondin type 1 motif, 18; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 , ADAMTS21; A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAMTS 18; ADAMTS21; EC 3.4.24.; ADAM-TS18; ADAMTS-18; ADAM-TS 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21; KNO2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAMTS18-303H Recombinant Human ADAMTS18 Protein, GST-tagged Wheat Germ GST
Human ADAMTS18-26H Recombinant Human ADAMTS18 protein, GST-tagged E.coli GST
Human ADAMTS18-302H Recombinant Human ADAMTS18 Protein, GST-tagged Wheat Germ GST
Human ADAMTS18-26HCL Recombinant Human ADAMTS18 cell lysate N/A
Human ADAMTS18-4728H Recombinant Human ADAMTS18 protein, His-tagged E.coli His 942-1047aa
Human ADAMTS18-918HF Recombinant Full Length Human ADAMTS18 Protein, GST-tagged In Vitro Cell Free System GST 415 amino acids
Mouse ADAMTS18-1315M Recombinant Mouse ADAMTS18 Protein Mammalian Cell His
Mouse ADAMTS18-326M Recombinant Mouse ADAMTS18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ADAMTS18-326M-B Recombinant Mouse ADAMTS18 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ADAMTS18 involved in several pathways and played different roles in them. We selected most pathways ADAMTS18 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Degradation of the extracellular matrixADAMTS1;MMP20;NID1;MMP15;CTS7;TLDC2;ADAMTS5;ELANE;COL19A1
Extracellular matrix organizationCOL3A1;COL5A2;TRAPPC4;FBN1;MFAP2;ASPN;CTSD;ADAM15;CEACAM6
Metabolism of proteinsTHSD7A;DPH5;F9B;CXXC1;LDHD;TRAPPC4;GPR116;PMPCB;O3far1
O-glycosylation of TSR domain-containing proteinsB3GALTL;ADAMTS1;ADAMTSL5;SPON1B;ADAMTSL1;ADAMTS13;ADAMTSL4;THSD7A;ADAMTS4
O-linked glycosylationADAMTS15;GALNT5;GALNTL5;MUC4;SSPO;B3GALTL;ADAMTSL4;ADAMTS10;MUCL1
Post-translational protein modificationTRAPPC6B;GALNT5;NAPB;EIF5A2;TRAPPC10;ARSI;ADAMTS10;MUC21;B3GNT8

ADAMTS18 has several biochemical functions, for example, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS18 itself. We selected most functions ADAMTS18 had, and list some proteins which have the same functions with ADAMTS18. You can find most of the proteins on our site.

Function Related Protein
metalloendopeptidase activityMMP1;NLN;ADAM12;PHEX;ADAMTS15A;ADAMTS20;ADAM23;MMP28;ADAMTS18
zinc ion bindingMAN2A1;RNF217;RNF170;DNLZ;ADAM1B;MMP17;ADAM2;BTR06;S100A7

ADAMTS18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS18 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS18.

  • Q&As
  • Reviews

Q&As (8)

Ask a question
Do you provide technical guidance on the use of recombinant proteins? 09/12/2022

We will provide customers with relevant technical support.

Can the Tag and tag location of human ADAMTS18 be customized according to my requirements? 09/21/2021

Yes, we will provide custom-manufactured recombinant proteins according to your requirements.

What is the structure domain of ADAMTS18? 08/22/2021

The structure of ADAMTS18 includes a signal peptide, a prodomain, a metalloproteinase domain, a disintegrin-like domain, a TSP1, a cysrich domain, a spacer and a TSP1-like repeat.

Is ADAMTS18 widely used in disease research? 08/14/2021

ADAMTS18 has been more frequently studied in esophageal cancer, osteosarcoma and endometrial cancer.

In which tissues is ADAMTS18 abundantly expressed? 04/14/2021

ADAMTS18 is mainly expressed in adult brain, prostate and retina tissues.

How do you purify the protein? 10/25/2020

We have adopted multiple purification methods, including hydrophobic chromatography, affinity chromatography, ion exchange chromatography, salting out, molecular sieve, etc.

What is the biological function of ADAMTS18? 06/18/2020

Expression of ADAMTS18 reduced cancer cell replication and growth, suggesting that it has a tumor-suppressive effect.

Where is the cellular localization of ADAMTS18? 06/18/2020

ADAMTS18 is mainly localized in the cytoplasm.

Customer Reviews (4)

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Reviews
11/19/2022

    The delivery was fast, which solved my urgent needs.

    05/09/2021

      The ADAMTS18 proteins purchased from your company is suitable for ELISA.

      05/05/2021

        Purchased the right product at the right price and with the best quality.

        08/13/2020

          The technicians understand the customer's experimental needs and have helped me to solve many of the problems that have arisen during the experiments.

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