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Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif, 18
Background This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
Synonyms ADAMTS18; ADAM metallopeptidase with thrombospondin type 1 motif, 18; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18 , ADAMTS21; A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAMTS 18; ADAMTS21; EC 3.4.24.; ADAM-TS18; ADAMTS-18; ADAM-TS 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21; KNO2
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAMTS18-26H Recombinant Human ADAMTS18 protein, GST-tagged E.coli GST
    Human ADAMTS18-26HCL Recombinant Human ADAMTS18 cell lysate N/A
    Human ADAMTS18-302H Recombinant Human ADAMTS18 Protein, GST-tagged Wheat Germ GST
    Human ADAMTS18-303H Recombinant Human ADAMTS18 Protein, GST-tagged Wheat Germ GST
    Mouse ADAMTS18-1315M Recombinant Mouse ADAMTS18 Protein Mammalian Cell His

    adamts18 involved in several pathways and played different roles in them. We selected most pathways adamts18 participated on our site, such as Degradation of the extracellular matrix, Extracellular matrix organization, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with adamts18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of the extracellular matrix ADAM8A; EMID2; BMP1B; CTSL2; CTSK; BSG; MMP19; ADAM8; MMP10; CTSD
    Extracellular matrix organization MATN4; LTBP2; COL17A1; PCOLCE; CTSB; VCANB; COL17A1A; ASPN; SERPINH1A; TLL2
    Metabolism of proteins SFTPBB; EXOC5; IGFBP4; NSMCE2; FBXW5; TIMM8A; CEACAM21; GPR116; ADAMTS15; EXOSC8
    O-glycosylation of TSR domain-containing proteins SSPO; SPON1A; ADAMTS10; ADAMTS3; ADAMTS1; ADAMTSL5; ADAMTS15; SPON2; ADAMTS4; ADAMTS18
    O-linked glycosylation ADAMTSL1; MUC1; GALNT6; GALNT5; MUC5AC; ADAMTS10; GALNT13; THSD1; ADAMTS5; ADAMTS18
    Post-translational protein modification SEC22A; NSMCE4A; GALNTL2; GALNT5; TRAPPC5; NAPAB; OTOP2; NEU3; PHC3; MUC20

    adamts18 has several biochemical functions, for example, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by adamts18 itself. We selected most functions adamts18 had, and list some proteins which have the same functions with adamts18. You can find most of the proteins on our site.

    Function Related Protein
    metalloendopeptidase activity ADAMTS1; MMP1; ADAMTS7; MEP1A; BMP1; ADAM22; YME1L1; MMP15; MMP9; BMP1A
    zinc ion binding GFI1; ZDHHC5A; ZDHHC3A; KMT2E; BTR18; CPDB; PCGF5B; ANPEP; ZNF346; TRIM27

    adamts18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adamts18 here. Most of them are supplied by our site. Hope this information will be useful for your research of adamts18.

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