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ADAMTS12

  • Official Full Name

    ADAM metallopeptidase with thrombospondin type 1 motif, 12

  • Overview

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADAMTS12; ADAM metallopeptidase with thrombospondin type 1 motif, 12; PRO4389; A disintegrin and metalloproteinase with thrombospondin motifs 12; ADAM-TS12; ADAMTS-12; ADAM-TS 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAMTS12-298H Recombinant Human ADAMTS12 Protein, GST-tagged Wheat Germ GST
Human ADAMTS12-1485H Recombinant Human ADAMTS12 protein, His-tagged E.coli His Gln823~Pro997 (Accession # P58397)
Human ADAMTS12-916HF Recombinant Full Length Human ADAMTS12 Protein, GST-tagged In Vitro Cell Free System GST 229 amino acids
Mouse ADAMTS12-3006M Recombinant Mouse ADAMTS12, His-tagged E.coli His 34350
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ADAMTS12 involved in several pathways and played different roles in them. We selected most pathways ADAMTS12 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ADAMTS12 has several biochemical functions, for example, hydrolase activity, metal ion binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS12 itself. We selected most functions ADAMTS12 had, and list some proteins which have the same functions with ADAMTS12. You can find most of the proteins on our site.

Function Related Protein
hydrolase activityLCTLB;ABHD13;DQX1;KLK1B3;PPEF2;LACTB2;YDJC;HE1B;Reln
metal ion bindingCYP51;DPEP2;ZNF397;ZNF484;MGAT1;ZNF83;HDHD2;ZFYVE28;ZHX3
metalloendopeptidase activityPAPPAA;C6AST4;ADAM12;MMP14B;MEP1A.2;BMP1A;ADAM30;MMP7;MME
metallopeptidase activityACY1;NPSN;TAF2;ADAMTS8;ADAMTS1;XPNPEP2;ADAMTSL1;AGBL1;ADAM25
peptidase activityPRSS40;CTRC;MPND;CAPN1B;NPEPPS;FURINA;IWS1;TMPRSS4B;CAPN11
zinc ion bindingMARCH11;ADAM5P;TLL1;RSPRY1;MUL1;TRIM3;RNF149;RFPL1;APOBEC3D

ADAMTS12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS12 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS12.

  • Q&As
  • Reviews

Q&As (8)

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How long will it take to ship? 11/09/2022

We will ship as soon as possible after your purchase.

Is ADAMTS12 involved in the mitogen activated protein kinases signaling pathway? 10/18/2022

ADAMTS12 blocked the mitogen activated protein kinase signaling pathway and prevented the tumorigenic effect of hepatocyte growth factor.

What diseases is ADAMTS12 currently used in research? 08/12/2022

ADAMTS12 is more frequently studied in pancreatic and liver cancers.

Can the labeling of the full-length protein be changed? 12/03/2021

We can customize the production products according to your needs.

Is ADAMTS12 expressed in normal tissues? 05/09/2021

Not expressed, ADAMTS12 protein is only widely expressed in malignant digestive system tumor tissues.

Does ADAMTS12 affect epithelial-mesenchymal transition(EMT)? 03/01/2021

Yes, reducing the expression of ADAMTS12 interferes with the EMT process.

What are the biological functions of ADAMTS12? 11/21/2020

ADAMTS12 has the capabilities of tissue remodeling and cell migration and may work during normal inflammatory response.

I want to buy ADAMTS12 for western blotting, can you recommend it? 07/05/2019

You can contact our experts directly, and they will recommend suitable products for you according to your research purpose.

Customer Reviews (4)

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Reviews
01/16/2023

    I got this product at a discounted price, with some discounted prices. It also works well for ELISA.

    05/05/2021

      Fast shipping, quality product, right price, worth buying!

      03/01/2021

        Customer service patiently communicated with me and helped me to determine the experimental matters.

        02/24/2021

          The purchased ADAMTS12 protein is suitable for WB experiments and I am satisfied with the results.

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