ADAMTS5

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ADAMTS5

Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif, 5
Background This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]
Synonyms ADAMTS5; ADAM metallopeptidase with thrombospondin type 1 motif, 5; ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11; A disintegrin and metalloproteinase with thrombospondin motifs 5; aggrecanase-2; a disintegrin and metalloproteinase with thrombospondin motifs 11; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2);
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAMTS5-144H Recombinant Human ADAMTS5 Protein, His-tagged CHO His
    Human ADAMTS5-1755H Recombinant Human ADAMTS5 protein, His & T7-tagged E.coli His/T7
    Human ADAMTS5-306H Recombinant Human ADAMTS5 Protein, His-tagged Insect Cell His
    Human ADAMTS5-307H Recombinant Human ADAMTS5 Protein, GST-tagged Wheat Germ GST
    Human ADAMTS5-534H Recombinant Human ADAMTS5, His-tagged Insect Cell His
    Human ADAMTS5-535H Recombinant Human ADAMTS5 Mammalian cells His
    Human ADAMTS5-9028HCL Recombinant Human ADAMTS5 293 Cell Lysate HEK293 N/A
    Mouse ADAMTS5-2037M Recombinant Mouse ADAMTS5 Protein (262-930 aa), His-tagged E.coli His
    Rat Adamts5-1756R Recombinant Rat Adamts5 protein, His & T7-tagged E.coli His/T7
    Zebrafish ADAMTS5-8483Z Recombinant Zebrafish ADAMTS5 Mammalian Cell His

    ADAMTS5 involved in several pathways and played different roles in them. We selected most pathways ADAMTS5 participated on our site, such as Degradation of the extracellular matrix, Endochondral Ossification, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of the extracellular matrix CTSL2; COL19A1; ADAM9; COL17A1; ADAM15; BMP1; CTSD; CAPNS1; CMA1; COL13A1
    Endochondral Ossification COL10A1; ADAMTS1; CDKN1C; CTSL2; KIF3A; COL2A1; IFT88; PTHLH; ADAMTS4; PTH
    Extracellular matrix organization MMP10; MATN3; LAMB1B; COL28A1A; COL5A3B; MFAP1B; LOC100686744; COL9A3; CTSK; COL25A1
    Metabolism of proteins PHC3; CNIH2; NSFB; PAM16; CPN1; IGFBP6A; TMED2; A4GNT; GALNT13; ACE
    O-glycosylation of TSR domain-containing proteins ADAMTSL1; SSPO; SPON2; ADAMTS15; THSD7A; ADAMTS4; ADAMTSL4; ADAMTS18; SPON1A; ADAMTS5
    O-linked glycosylation MUC20; SPON1A; SPON2; ADAMTS1; ADAMTS8; MUC13; SPON1; MUC5AC; A4GNT; C8orf84
    Post-translational protein modification ADAMTSL5; NSMCE2; NAPAB; PHC1; MUC1; SCMH1; ARSH; ZNF408; TRAPPC10; PHC2

    ADAMTS5 has several biochemical functions, for example, integrin binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS5 itself. We selected most functions ADAMTS5 had, and list some proteins which have the same functions with ADAMTS5. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding ITGA3; ITGB5; NIPAL1; ITGB6; CYR61L1; ILK; FCER2; DMP1; FN1A; ACTN3
    metalloendopeptidase activity MMP8; MMP14B; ADAM22; ADAMDEC1; YME1L1B; ADAM21; PAPPA; Adamts19; ADAMTS13; ADAM5
    metallopeptidase activity C6AST4; ADAM18; HE1B; ADAMTS13; CLCA1; ADAM17A; C6AST1; STAMBPL1; GM5136; CLCA5
    protein binding PDE1B; CNO; PDCL; ACY1; MKL1; AGR2; RPS26; NCOR1; ZBTB25; C1GALT1C1
    zinc ion binding MT1F; RNF181; CA5A; DBF4B; CIZ1; MDM2; SF1; RFWD2; LTA4H; DPYS

    ADAMTS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS5.

    ACAN; TIMP3; q5ni35_fratt

    Akyol, S; Ugurcu, V; et al. Evidence for the Control of Aggrecanases by Insulin and Glucose in Alzheimer's Disease. KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY 24:323-332(2014).
    Foulcer, SJ; Nelson, CM; et al. Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27859-27873(2014).

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