ADAMTS5
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 5 -
Overview
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008] -
Synonyms
ADAMTS5;ADAM metallopeptidase with thrombospondin type 1 motif, 5;ADMP-2;ADAM-TS5;ADAMTS-5;ADAMTS11;ADAM-TS 5;ADAMTS-11;ADAM-TS 11;A disintegrin and metalloproteinase with thrombospondin motifs 5;aggrecanase-2;a disintegrin and metalloproteinase with thrombospondin motifs 11;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Mouse
- E.coli
- Insect Cells
- CHO
- Wheat Germ
- Mammalian Cells
- HEK293
- His
- T7
- GST
- Non
- Avi
- Fc
Involved Pathway
ADAMTS5 involved in several pathways and played different roles in them. We selected most pathways ADAMTS5 participated on our site, such as Degradation of the extracellular matrix,Endochondral Ossification,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of the extracellular matrix | LOC100686744,MMP15,MMP10,TLL2,ADAM15,COL25A1,MGC174155,FURINB,CTSLL,CTSL2 |
| O-glycosylation of TSR domain-containing proteins | C8orf84,SPON1B,ADAMTS10,THSD7A,SSPO,ADAMTS3,SPON1A,ADAMTSL3,THSD1,ADAMTSL5 |
| Post-translational protein modification | MPDU1B,ADAMTS10,SEC22C,ST8SIA3,GCNT3,OTOP2,MLEC,ARSE,MCFD2,DPH3 |
| Extracellular matrix organization | MATN3B,FURINA,FMOD,ADAMTS4,EFEMP1,BMP1A,PCOLCE2B,SPARC,BGNA,EFEMP2 |
| Metabolism of proteins | TBCC,SENP1,TIMM17A,TOMM7,MIA3,FXC1,APCS,LMAN2,IGFBP6,PHC3 |
| Endochondral Ossification | COL10A1A,PTHLHA,CTSL2,MMP13,KIF3A,RUNX3,SOX6,SOX9A,CST5,COL2A1 |
| O-linked glycosylation | B3GALTL,MUC12,ST6GALNAC2,GALNT6,MUCL1,ADAMTS13,A4GNT,THSD7A,ADAMTS1,ADAMTS18 |
Protein Function
ADAMTS5 has several biochemical functions, for example, integrin binding,metalloendopeptidase activity,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS5 itself. We selected most functions ADAMTS5 had, and list some proteins which have the same functions with ADAMTS5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metalloendopeptidase activity | MMP14A,ADAMTS7,ADAM10,PAPPAB,MMP1,Adam6,MME,ADAM22,SPG7,MMP14 |
| protein binding | IFT172,GLI2,ITGB1,PRUNE,PDE4A,TMEM93,ZC3H18,ROPN1L,FHL1,RPUSD4 |
| zinc ion binding | TRIM108,RING1,RNF34A,CPA1,MARCH11,TRIM64C,PCGF3,ZNF212,RNF34B,ADAMTS15 |
| integrin binding | FAP,IGF1,MFGE8,LAMA5,CTGF,ITGB6,CYR61L1,SEMA7A,ADAM17,COL16A1 |
| metallopeptidase activity | ANPEPA,MMP1A,MMP14A,PGCP,DPEP3,AQPEP,MMP9,NAALAD2,XPNPEP2,TMEM27 |
Interacting Protein
ADAMTS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS5.
ACAN;TIMP3;q5ni35_fratt
Resources
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References
- Foulcer, SJ; Nelson, CM; et al. Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27859-27873(2014).
- Akyol, S; Ugurcu, V; et al. Evidence for the Control of Aggrecanases by Insulin and Glucose in Alzheimer's Disease. KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY 24:323-332(2014).
