ADAMTS5

  • Official Full Name

    ADAM metallopeptidase with thrombospondin type 1 motif, 5
  • Overview

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADAMTS5;ADAM metallopeptidase with thrombospondin type 1 motif, 5;ADMP-2;ADAM-TS5;ADAMTS-5;ADAMTS11;ADAM-TS 5;ADAMTS-11;ADAM-TS 11;A disintegrin and metalloproteinase with thrombospondin motifs 5;aggrecanase-2;a disintegrin and metalloproteinase with thrombospondin motifs 11;a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)

Recombinant Proteins

  • Rat
  • Human
  • Zebrafish
  • Mouse
  • E.coli
  • Insect Cells
  • CHO
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • His
  • T7
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
Adamts5-1756R Recombinant Rat Adamts5 protein, His & T7-tagged E.coli Rat His&T7 Arg267~Asn622
ADAMTS5-306H Active Recombinant Human ADAMTS5 Protein, His-tagged Insect Cells Human His 625-930 a.a.
ADAMTS5-534H Active Recombinant Human ADAMTS5, His-tagged Insect Cells Human His
ADAMTS5-144H Active Recombinant Human ADAMTS5 Protein, His-tagged CHO Human His
ADAMTS5-307H Recombinant Human ADAMTS5 Protein, GST-tagged Wheat Germ Human GST
ADAMTS5-535H Recombinant Human ADAMTS5 Mammalian Cells Human His
ADAMTS5-8483Z Recombinant Zebrafish ADAMTS5 Mammalian Cells Zebrafish His
ADAMTS5-9028HCL Recombinant Human ADAMTS5 293 Cell Lysate HEK293 Human Non
ADAMTS5-0159H Recombinant Human ADAMTS5 Protein (Glu485-Pro622), N-His-tagged E.coli Human His Glu485-Pro622
ADAMTS5-1755H Recombinant Human ADAMTS5 protein, His & T7-tagged E.coli Human His&T7 Glu485~Pro622
ADAMTS5-2037M Recombinant Mouse ADAMTS5 Protein (262-930 aa), His-tagged E.coli Mouse His 262-930 aa
ADAMTS5-2425H Recombinant Human ADAMTS5 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
ADAMTS5-2425H-B Recombinant Human ADAMTS5 Protein Pre-coupled Magnetic Beads HEK293 Human
ADAMTS5-3533H Recombinant Human ADAMTS5 protein, His-tagged E.coli Human His 417-558 aa
ADAMTS5-3632H Recombinant Human ADAMTS5 protein, GST-tagged E.coli Human GST 417-558 aa

    Involved Pathway

    ADAMTS5 involved in several pathways and played different roles in them. We selected most pathways ADAMTS5 participated on our site, such as Degradation of the extracellular matrix,Endochondral Ossification,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    O-glycosylation of TSR domain-containing proteins ADAMTS18,SPON1B,THSD1,ADAMTS10,ADAMTSL4,ADAMTS20,ADAMTS3,C8orf84,SPON2,SPON1A
    O-linked glycosylation B3GNT8,C8orf84,ADAMTSL3,ADAMTS3,ADAMTS10,SPON1A,GALNTL5,GCNT3,MUCL1,ADAMTS8
    Degradation of the extracellular matrix ADAM15,EMID2,COL9A1,TIMP2B,FURINB,TIMP2A,COL23A1,CTSD,CTSL1,TIMP2
    Extracellular matrix organization PCOLCE2B,MFAP1,P3H2,MMP15,PCOLCEA,MGC174155,MFAP3,COL9A3,SERPINH1B,FMOD
    Post-translational protein modification CNIH,WDR85,ADAMTSL1,CNIH3,RING1,PHC2,GALNTL5,EID3,SPON1A,MAN1A2
    Endochondral Ossification COL2A1,SOX5,ADAMTS4,MMP13,ADAMTS1,DDR2,SOX6,RUNX2A,NKX3-2,RUNX3
    Metabolism of proteins GPR116,CBX8,DPH3,KCNA3,BET1,LMAN2,SLC30A5,MUC4,TOMM22,COX17

    Protein Function

    ADAMTS5 has several biochemical functions, for example, integrin binding,metalloendopeptidase activity,metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS5 itself. We selected most functions ADAMTS5 had, and list some proteins which have the same functions with ADAMTS5. You can find most of the proteins on our site.

    Function Related Protein
    integrin binding L1CAM,PTPN2,PPAP2B,ADAM9,CTGFB,EDIL3,ACTN4,LAMA5,FBLN1,ADAM17
    metallopeptidase activity ADAM30,ADAM8A,ADAM17A,COPS5,ACE,MMP30,ADAM23,ANPEPB,C6AST3,ANPEP
    protein binding KCP,NFATC2,RAD1,EXOSC8,DYSFIP1,RARA,FGFR1OP2,PYGO1,DDIT3,KLK15
    zinc ion binding ZDHHC15B,GATAD2AB,ZNF212,AFG3L2,ING2,VAT1L,PTPN1,ZMAT3,PHF7,CAHZ
    metalloendopeptidase activity TLL2,YME1L1B,NRD1B,UQCRC2A,ADAM7,MMP8,MMP1,MMP23B,PAPPAB,ADAMTS15A

    Interacting Protein

    ADAMTS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS5.

    ACAN;TIMP3;q5ni35_fratt

    Resources

    References

    • Foulcer, SJ; Nelson, CM; et al. Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27859-27873(2014).
    • Akyol, S; Ugurcu, V; et al. Evidence for the Control of Aggrecanases by Insulin and Glucose in Alzheimer's Disease. KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY 24:323-332(2014).

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