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Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif, 1
Background This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
Synonyms ADAMTS1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; C3-C5; METH1; A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1;
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAMTS1-105H Recombinant Human ADAMTS1, GST-tagged E.coli GST
    Human ADAMTS1-2048H Recombinant Human ADAMTS1 protein, His-tagged E.coli His
    Human ADAMTS1-295H Recombinant Human ADAMTS1 Protein, His-tagged Insect Cell His
    Human ADAMTS1-296H Recombinant Human ADAMTS1 Protein, GST-tagged Wheat Germ GST
    Human ADAMTS1-531H Recombinant Human ADAMTS1, His-tagged NS0 His
    Human ADAMTS1-532H Recombinant Human ADAMTS1, His-tagged Insect Cell His
    Mouse ADAMTS1-1307M Recombinant Mouse ADAMTS1 Protein Mammalian Cell His
    Mouse Adamts1-2049M Recombinant Mouse Adamts1 protein, His-tagged E.coli His
    Mouse Adamts1-441M Recombinant Mouse A Disintegrin-Like And Metallopeptidase (reprolysin type) With Thrombospondin Type 1 Motif, 1, His-tagged CHO His
    Rat Adamts1-2050R Recombinant Rat Adamts1 protein, His-tagged E.coli His
    Rhesus Macaque ADAMTS1-234R Recombinant Rhesus monkey ADAMTS1 Protein, His-tagged Mammalian Cell His

    adamts1 involved in several pathways and played different roles in them. We selected most pathways adamts1 participated on our site, such as Degradation of the extracellular matrix, Endochondral Ossification, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with adamts1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Degradation of the extracellular matrix ADAMTS8; MMP15; EMID2; KLK7; LOC100686744; CMA1; MGC174857; MMP8; ADAM8A; NID1
    Endochondral Ossification CDKN1C; RUNX2A; PTH; FRZB; NKX3-2; RUNX3; CTSL2; MMP13; MGP; COL10A1
    Extracellular matrix organization MGC174152; ADAMTS5; MUSK; ADAM8; MGC174155; COL3A1; PCOLCE2B; COL5A3A; JAM2B; PTPRS
    Metabolism of proteins HYOU1; GPR116; NEU4; DDIT3; EEF1A1; NSMCE4A; TRAPPC10; KLK13; MBOAT4; THSD7A
    O-glycosylation of TSR domain-containing proteins ADAMTSL3; ADAMTS1; SSPO; B3GALTL; SPON1B; ADAMTS4; ADAMTS8; ADAMTS18; ADAMTS5; THSD1
    O-linked glycosylation ST6GALNAC2; GALNT5; ADAMTS8; MUCL1; KCNA6; MUC12; MUC20; ADAMTS20; ADAMTSL3; THSD1
    Post-translational protein modification ST6GALNAC2; ADAMTS18; MUC12; ADAMTS10; SSPO; BET1; NAPAB; PROZ; ALG2; SEC23IP

    adamts1 has several biochemical functions, for example, heparin binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by adamts1 itself. We selected most functions adamts1 had, and list some proteins which have the same functions with adamts1. You can find most of the proteins on our site.

    Function Related Protein
    heparin binding FGFBP3; PTN; KNG1; ZFP207; CYR61; HDGF; APOB; CXCL13; CRISPLD2; PTPRFB
    metalloendopeptidase activity MME; BMP1; AFG3L2; MMP20; MMP16; YME1L1B; ADAM33; TLL2; UQCRC1; MMP15
    metallopeptidase activity CLCA5; DPP3; NPEPPS; AGBL4; ADAM9; C6AST1; ANPEPA; CNDP2; MEP1A.1; ERMP1
    zinc ion binding PAPLN; ZNRF2A; C6AST1; CPXM2; ADAMTSL3; NEURL1AB; UBR7; VPS41; ZNRF3; KDM1B

    adamts1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adamts1 here. Most of them are supplied by our site. Hope this information will be useful for your research of adamts1.

    USP17L24; trpE

    Foulcer, SJ; Nelson, CM; et al. Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27859-27873(2014).
    Dallaglio, K; Bruno, A; et al. Paradoxic effects of metformin on endothelial cells and angiogenesis. CARCINOGENESIS 35:1055-1066(2014).

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