|Official Full Name||ADAM metallopeptidase with thrombospondin type 1 motif, 1|
|Background||This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]|
|Synonyms||ADAMTS1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; C3-C5; METH1; A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
adamts1 involved in several pathways and played different roles in them. We selected most pathways adamts1 participated on our site, such as Degradation of the extracellular matrix, Endochondral Ossification, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with adamts1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Degradation of the extracellular matrix||ADAMTS8; MMP15; EMID2; KLK7; LOC100686744; CMA1; MGC174857; MMP8; ADAM8A; NID1|
|Endochondral Ossification||CDKN1C; RUNX2A; PTH; FRZB; NKX3-2; RUNX3; CTSL2; MMP13; MGP; COL10A1|
|Extracellular matrix organization||MGC174152; ADAMTS5; MUSK; ADAM8; MGC174155; COL3A1; PCOLCE2B; COL5A3A; JAM2B; PTPRS|
|Metabolism of proteins||HYOU1; GPR116; NEU4; DDIT3; EEF1A1; NSMCE4A; TRAPPC10; KLK13; MBOAT4; THSD7A|
|O-glycosylation of TSR domain-containing proteins||ADAMTSL3; ADAMTS1; SSPO; B3GALTL; SPON1B; ADAMTS4; ADAMTS8; ADAMTS18; ADAMTS5; THSD1|
|O-linked glycosylation||ST6GALNAC2; GALNT5; ADAMTS8; MUCL1; KCNA6; MUC12; MUC20; ADAMTS20; ADAMTSL3; THSD1|
|Post-translational protein modification||ST6GALNAC2; ADAMTS18; MUC12; ADAMTS10; SSPO; BET1; NAPAB; PROZ; ALG2; SEC23IP|
adamts1 has several biochemical functions, for example, heparin binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by adamts1 itself. We selected most functions adamts1 had, and list some proteins which have the same functions with adamts1. You can find most of the proteins on our site.
|heparin binding||FGFBP3; PTN; KNG1; ZFP207; CYR61; HDGF; APOB; CXCL13; CRISPLD2; PTPRFB|
|metalloendopeptidase activity||MME; BMP1; AFG3L2; MMP20; MMP16; YME1L1B; ADAM33; TLL2; UQCRC1; MMP15|
|metallopeptidase activity||CLCA5; DPP3; NPEPPS; AGBL4; ADAM9; C6AST1; ANPEPA; CNDP2; MEP1A.1; ERMP1|
|zinc ion binding||PAPLN; ZNRF2A; C6AST1; CPXM2; ADAMTSL3; NEURL1AB; UBR7; VPS41; ZNRF3; KDM1B|
adamts1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adamts1 here. Most of them are supplied by our site. Hope this information will be useful for your research of adamts1.