adamts13

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adamts13

Official Full Name ADAM metallopeptidase with thrombospondin type 1 motif, 13
Background This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Synonyms ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13; A disintegrin and metalloproteinase with thrombospondin motifs 13; vWF-cleaving protease; von Willebrand factor-cleaving protease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13;
    • Species :
    • Human
    • Mouse
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • T7
    • Myc/DDK
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ADAMTS13-136H Recombinant Human ADAMTS13 protein, His-tagged CHO His
    Human ADAMTS13-137H Recombinant Human ADAMTS13, MYC/DDK-tagged HEK293 Myc/DDK
    Human ADAMTS13-1432H Recombinant Human ADAMTS13 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ADAMTS13-26136TH Recombinant Human ADAMTS13 Wheat Germ N/A
    Human ADAMTS13-299H Recombinant Human ADAMTS13 Protein, GST-tagged Wheat Germ GST
    Human ADAMTS13-5660H Recombinant Human ADAMTS13 protein, His & T7-tagged E.coli His/T7
    Human ADAMTS13-5661H Recombinant Human ADAMTS13 protein, His & GST-tagged E.coli His/GST
    Human ADAMTS13-820H Recombinant Human ADAMTS13 protein, His-tagged CHO His
    Mouse ADAMTS13-1310M Recombinant Mouse ADAMTS13 Protein Mammalian Cell His
    Mouse Adamts13-1528M Recombinant Mouse Adamts13 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse ADAMTS13-2684M Recombinant Mouse ADAMTS13 Protein (904-1137 aa), His-Myc-tagged E.coli His/Myc

    adamts13 involved in several pathways and played different roles in them. We selected most pathways adamts13 participated on our site, such as Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with adamts13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism of proteins TMED10; TIMM21; PPP6R3; CPB1; ARSI; PFDN1; IGFBP2B; SAMM50; SLC30A8; SPON1B
    O-glycosylation of TSR domain-containing proteins SPON1A; THSD1; THSD7A; ADAMTSL1; ADAMTS3; SPON1B; ADAMTS15; SSPO; ADAMTSL4; ADAMTS1
    O-linked glycosylation ST6GALNAC2; GALNTL2; MUC15; ADAMTS4; MUC5AC; ADAMTS13; ADAMTSL5; ADAMTS10; GALNTL5; ADAMTSL3
    Post-translational protein modification ADAMTSL5; SUMF2; ARSD; TRAPPC6A; DPH5; ANKRD28; DPH3; PREB; PPP6R3; NEU3

    adamts13 has several biochemical functions, for example, calcium ion binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by adamts13 itself. We selected most functions adamts13 had, and list some proteins which have the same functions with adamts13. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding SYT1; MYLPFB; PCDH2AB1; EPD; EPDR1; SPTA1; FKBP10; COL4A3BPA; ELTD1; S100A7
    integrin binding VWF; WISP2; ADAM23; TNN; Tcam1; EDIL3; CTGFA; ITGB1BP1; CD9; PPAP2B
    metalloendopeptidase activity MMP16; ADAM10A; MMP12; MMP14B; MEP1A.2; ADAMTS15; ADAM28; ADAMTS1; ADAMTS10; NRD1B
    metallopeptidase activity ADAM18; CLCA3; MMP9; ADAM17; ADAM10A; MMP14A; ERAP2; CLCA5; ADAM10; GM5136
    protein binding RCAN1; LDHD; DNM2; VPS4A; RASSF3; NR2C1; AKR1B10; STXBP4; ERN1; FAM98A
    zinc ion binding RNF150A; SPG7; S100A13; GATA1; KDM2AA; BMP1A; LHX5; ZNF253; MMP8; LIMS1

    adamts13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adamts13 here. Most of them are supplied by our site. Hope this information will be useful for your research of adamts13.

    VWF

    Rossio, R; Lotta, LA; et al. A novel CD46 mutation in a patient with microangiopathy clinically resembling thrombotic thrombocytopenic purpura and normal ADAMTS13 activity. HAEMATOLOGICA 100:E87-E89(2015).
    Becerra, E; Scully, MA; et al. Effect of rituximab on B cell phenotype and serum B cell-activating factor levels in patients with thrombotic thrombocytopenic purpura. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 179:414-425(2015).

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