ADAMTS13
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Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif, 13
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Overview
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] -
Synonyms
ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13; A disintegrin and metalloproteinase with thrombospondin motifs 13; vWF-cleaving protease; von Willebrand factor-cleaving protease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13;
- Recombinant Proteins
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- CHO
- E.coli
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|Myc
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ADAMTS13 Related Articles
ADAMTS13 involved in several pathways and played different roles in them. We selected most pathways ADAMTS13 participated on our site, such as Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of proteins | MGAT4A;TRAPPC5;DPAGT1;IGFBP4;PFDN2;ADAMTS15;B3GNT2A;PAPPAB;NSMCE2 |
| O-glycosylation of TSR domain-containing proteins | THSD1;ADAMTS15;ADAMTSL1;SPON1;SSPO;ADAMTS20;SPON2;ADAMTS8;ADAMTS13 |
| O-linked glycosylation | A4GNT;ADAMTSL1;ADAMTSL4;MUC20;MUC1;ST6GALNAC2;ADAMTS5;ADAMTSL5;GALNT13 |
| Post-translational protein modification | GALNTL5;SCFD1;MGAT4B;TRAPPC6BL;CTAGE5;ADAMTS3;ARSD;TMED10;GALNTL2 |
ADAMTS13 has several biochemical functions, for example, calcium ion binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS13 itself. We selected most functions ADAMTS13 had, and list some proteins which have the same functions with ADAMTS13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | VCAN;GUCA1E;MYL10;PCDHGA5;VIL1;SNED1;LRP1;PCDHGA10;VSNL1 |
| integrin binding | LAMB1;IGF1;GFAP;CD226;ACTN3;EMP2;ADAM9;WISP2;KDR |
| metalloendopeptidase activity | MMP13A;MMP3;MMP1A;PAPLN;NPSN;TLL1;PAPPAA;ZMPSTE24;OSGEPL1 |
| metallopeptidase activity | STAMBPL1;ADAMTSL3;ADAM12;TMEM27;ECEL1;BMP1B;DNPEP;MYSM1;ADAMTS9 |
| protein binding | KHDC3;SLC16A3;EFS;IKZF1;DKK1B;SAP30BP;PUM2;PIANP;LRRC3 |
| zinc ion binding | RNF144B;LIMK2;MMP1;ZDHHC15A;MMP2;XAF1;APOBEC3H;ZNF276;CSRP2 |
ADAMTS13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS13 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS13.
VWF
- Q&As
- Reviews
Q&As (9)
Ask a questionYes, all ADAMTS13 are eligible for this promotion, including proteins that require custom production.
We have multiple expression systems, including bacterial expression systems, baculovirus-insect cell expression systems, cell-free in vitro protein expression systems, mammalian expression systems, yeast expression systems, etc.
ADAMTS13 is mainly synthesized in the liver.
ADAMTS13 consists of signal peptide, leader peptide, metalloproteinase domain, disintegrin-like domain, thrombospondin domain 1, a cysteine-rich domain, a spacer, a TSP motif region and two CUB domains.
Using mCherry fluorescent protein labeling of ADAMTS13, it was found that it was mainly localized to the top of the thrombus.
ADAMTS13 can inhibit the inflammatory response by cleaving vascular hemophilic factors to reduce inflammatory response and thus reduce vascular endothelial function deficits.
ADAMTS13 cleaves the active supervascular hemophilia factor (vWF) and is therefore also known as vWF cleavage protease.
Our experts will recommend suitable products for you based on your research needs.
ADAMTS13 is involved in the study of diseases such as chronic kidney disease and diabetes.
Customer Reviews (3)
Write a reviewThe ADAM6TS13 proteins purchased from your company is suitable for ELISA.
Customer service was patient and careful, solved all kinds of problems for me.
The technician answered my questions in detail and helped me to get the desired results.
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