|Official Full Name||ADAM metallopeptidase with thrombospondin type 1 motif, 13|
|Background||This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]|
|Synonyms||ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13; A disintegrin and metalloproteinase with thrombospondin motifs 13; vWF-cleaving protease; von Willebrand factor-cleaving protease; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
adamts13 involved in several pathways and played different roles in them. We selected most pathways adamts13 participated on our site, such as Metabolism of proteins, O-glycosylation of TSR domain-containing proteins, O-linked glycosylation, which may be useful for your reference. Also, other proteins which involved in the same pathway with adamts13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Metabolism of proteins||TMED10; TIMM21; PPP6R3; CPB1; ARSI; PFDN1; IGFBP2B; SAMM50; SLC30A8; SPON1B|
|O-glycosylation of TSR domain-containing proteins||SPON1A; THSD1; THSD7A; ADAMTSL1; ADAMTS3; SPON1B; ADAMTS15; SSPO; ADAMTSL4; ADAMTS1|
|O-linked glycosylation||ST6GALNAC2; GALNTL2; MUC15; ADAMTS4; MUC5AC; ADAMTS13; ADAMTSL5; ADAMTS10; GALNTL5; ADAMTSL3|
|Post-translational protein modification||ADAMTSL5; SUMF2; ARSD; TRAPPC6A; DPH5; ANKRD28; DPH3; PREB; PPP6R3; NEU3|
adamts13 has several biochemical functions, for example, calcium ion binding, integrin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by adamts13 itself. We selected most functions adamts13 had, and list some proteins which have the same functions with adamts13. You can find most of the proteins on our site.
|calcium ion binding||SYT1; MYLPFB; PCDH2AB1; EPD; EPDR1; SPTA1; FKBP10; COL4A3BPA; ELTD1; S100A7|
|integrin binding||VWF; WISP2; ADAM23; TNN; Tcam1; EDIL3; CTGFA; ITGB1BP1; CD9; PPAP2B|
|metalloendopeptidase activity||MMP16; ADAM10A; MMP12; MMP14B; MEP1A.2; ADAMTS15; ADAM28; ADAMTS1; ADAMTS10; NRD1B|
|metallopeptidase activity||ADAM18; CLCA3; MMP9; ADAM17; ADAM10A; MMP14A; ERAP2; CLCA5; ADAM10; GM5136|
|protein binding||RCAN1; LDHD; DNM2; VPS4A; RASSF3; NR2C1; AKR1B10; STXBP4; ERN1; FAM98A|
|zinc ion binding||RNF150A; SPG7; S100A13; GATA1; KDM2AA; BMP1A; LHX5; ZNF253; MMP8; LIMS1|
adamts13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with adamts13 here. Most of them are supplied by our site. Hope this information will be useful for your research of adamts13.