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ADAMTS3

  • Official Full Name

    ADAM metallopeptidase with thrombospondin type 1 motif, 3

  • Overview

    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible for dermatosparaxis, a genetic defect of connective tissues. [provided by RefSeq, Jul 2008]
  • Synonyms

    ADAMTS3; ADAM metallopeptidase with thrombospondin type 1 motif, 3; ADAMTS-4; A disintegrin and metalloproteinase with thrombospondin motifs 3; ADAM-TS3; ADAMTS-3; PC II-NP; ADAM-TS 3; zinc metalloendopeptidase; procollagen II N-proteinase; procollagen II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • Human cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAMTS3-736H Recombinant Human ADAMTS3 Mammalian Cell His
Human ADAMTS3-305H Recombinant Human ADAMTS3 Protein, GST-tagged Wheat Germ GST
Human ADAMTS3-9389H Recombinant Human ADAMTS3, His-tagged E.coli His C-term-160a.a.
Human ADAMTS3-3015H Recombinant Human ADAMTS3, His-tagged E.Coli or Yeast His 1205
Human ADAMTS3-9030HCL Recombinant Human ADAMTS3 293 Cell Lysate HEK293 N/A
Human ADAMTS3-1965H Recombinant Human ADAMTS3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ADAMTS3-280H-B Recombinant Human ADAMTS3 Protein Pre-coupled Magnetic Beads HEK293
Human ADAMTS3-01H Recombinant Human ADAMTS3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human ADAMTS3-02H Recombinant Human ADAMTS3 Protein, Flag-tagged Human cells Flag
Human ADAMTS3-280H Recombinant Human ADAMTS3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ADAMTS3-1829HFL Recombinant Full Length Human ADAMTS3 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Adamts3-1529M Recombinant Mouse Adamts3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish ADAMTS3-8392Z Recombinant Zebrafish ADAMTS3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAMTS3 Related Articles
  • ADAMTS3 Related Research Area

ADAMTS3 involved in several pathways and played different roles in them. We selected most pathways ADAMTS3 participated on our site, such as Collagen biosynthesis and modifying enzymes, Collagen formation, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Collagen biosynthesis and modifying enzymesCOL25A1;ADAMTS2;TLL1;COL9A1;COL5A3B;COL1A1;COL28A1D;COL8A1;LEPREL1
Collagen formationCOL25A1;SERPINH1B;ABHD1;PCOLCEB;LOXL3;SERPINH1;LEPRE1;COL4A6;COL6A1
Extracellular matrix organizationCEACAM6;FAM49BA;DAG1;PRP;CTSG;PPIB;COL5A3A;LEPREL2;COL6A3
Metabolism of proteinsAPCS;KLHDC3;ODAM;GALNT13;ADAMTS8;IGFBP1B;DDIT3;F9B;PFDN6
O-glycosylation of TSR domain-containing proteinsC8orf84;THSD7A;ADAMTS8;THSD1;ADAMTS20;ADAMTSL1;ADAMTSL3;ADAMTS5;ADAMTSL4
O-linked glycosylationMUC21;ADAMTS15;SPON2;ADAMTS18;MUC20;A4GNT;THSD7A;C8orf84;ADAMTS10
Post-translational protein modificationSENP5;NSMCE2;PIGK;TRAPPC10;DPH2;ST6GALNAC1.2;SEC22C;MLEC;SMC6

ADAMTS3 has several biochemical functions, for example, endopeptidase activity, heparin binding, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS3 itself. We selected most functions ADAMTS3 had, and list some proteins which have the same functions with ADAMTS3. You can find most of the proteins on our site.

Function Related Protein
endopeptidase activityTPP1;SENP3A;TMEM59;RHBDD1;PSMB8F;MMP3;ATG4B;PSMA7;SENP3
heparin bindingCYR61;VTN;MSTN;GPNMB;APLP1;WISP1A;CRISPLD2;WISP1;GM4980
metalloendopeptidase activityYBEY;MMP30;C6AST3;NLN;MMP24;YME1L1;TLL1;FAP;SPG7
protein bindingTNIP2;ZFP335;PCDH18;HIST1H2AG;C5;MARK2;POLR1C;GMPPB;SEC31A
zinc ion bindingTAB2;NAPEPLD;CHMP1A;RNFT2;AMFR;ABLIM3;HDAC6;RNF150;TRIM16

ADAMTS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS3.

Pyun, JA; Kim, S; et al. Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY 21:522-529(2014).
Chaemsaithong, P; Madan, I; et al. Characterization of the myometrial transcriptome in women with an arrest of dilatation during labor. JOURNAL OF PERINATAL MEDICINE 41:665-681(2013).
  • Q&As
  • Reviews

Q&As (4)

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Which proteins have the highest homology to ADAMTS3? 02/23/2021

ADAMTS2, ADAMTS3 and ADAMTS14 had high homology.

What are the effects of a lack of ADAMTS3? 10/16/2020

ADAMTS3 is required for lymphangiogenesis and its defective function leads to abnormal lymphatic vessel development.

Where is ADAMTS3 mainly expressed? 09/09/2020

ADAMTS3 is widely expressed in connective tissues such as bone and tendon.

What is the function of ADAMTS3? 09/17/2019

ADAMTS3 is a procollagen N-propeptidase that is essential for the maturation of triple-helical collagen fibrils.

Customer Reviews (3)

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Reviews
12/25/2021

    Friendly customer service and detailed answers to all the questions I asked!

    05/15/2020

      Your company offers a one-stop shop and the process from purchase to receipt of the protein was very smooth!

      07/20/2019

        The purchased ADAMTS3 protein is suitable for WB experiments and I am satisfied with the results.

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