"ANXA5" Related Products

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Recombinant Human Annexin A5, APC

Cat. No.: ANXA5-2623H
Product Overview: Recombinant Human Annexin A5-APC is expressed inE. coli.
Description: Annexin 5 is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. In vitro studies have shown that Annexin 5 is a cellular protein which plays a role in the inhibition of blood coagulation by competing for phosphatidylserine binding sites with prothrombin. Through affinity assays Annexin 5 has been localized on cells that expressed phosphatidylserine on the cell surface, a feature found in apoptosis as well as other forms of cell death.
Source: E. coli.
Purity: >98% pure as demonstrated by SDS-gel electrophoresis and reverse phase HPLC.
Molecular Weight: 35.8 kDa.
Presentation: Solution containing 50 mM TRIS, 100 mM NaCl, 1% BSA, 0.02% Sodium Azide, pH 7.4.
Biological Activity: Annexin V exhibits anti-phospholipase activity and binds to phosphatidylserine (PS).
Application: The fluorochrome allophycocyanin (APC) shows an excitation maximum of 650 nm and an emission maximum of 660 nm. Annexin V conjugated to APC is suitable for the detection of PS and allows simple secondary labelling by staining, for example, the membrane surface proteins with a monoclonal antibody for further cellular characterization.
Storage: Stable at 2°-8°C as indicated on the label. Do not freeze!
Gene Name: ANXA5 annexin A5 [ Homo sapiens ]
Synonyms:
ANXA5; annexin A5; PP4; ANX5; ENX2; anchorin CII; endonexin II; lipocortin V; placental anticoagulant protein I; Annexin-5; Annexin V; Lipocortin V; Endonexin II; Calphobindin I; Placental anticoagulant protein I; Placental anticoagulant protein 4; Thromboplastin inhibitor; Vascular anticoagulant-alpha; VAC-alpha; CBP-I; PAP-I
Gene ID: 308
mRNA Refseq: NM_001154
Protein Refseq: NP_001145
MIM: 131230
UniProt ID: P08758
Chromosome Location: 4q27
Function: calcium ion binding; calcium-dependent phospholipid binding; eukaryotic cell surface binding; phospholipase inhibitor activity; protein binding; receptor tyrosine kinase binding

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