• Official Full Name

    annexin A6

  • Overview

    Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described.
  • Synonyms

    ANXA6; annexin A6; ANX6; CBP68; 67 kDa calelectrin; Annexin VI; Annexin-6; Calphobindin-II; CPB-II; Chromobindin-20; Lipocortin VI; Protein III; p68; p70; calelectrin; calphobindin II; annexin VI (p68); OTTHUMP00000226119; OTTHUMP00000226120; OTTHUMP00000226122; calcium-binding protein p68e;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • GST|His
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANXA6-6862H Active Recombinant Human ANXA6 protein, His-tagged E.coli His Met1-Asp673
Human ANXA6-27321TH Recombinant Human ANXA6, His-tagged E.coli His
Human ANXA6-1839H Recombinant Human Annexin A6, His-tagged E.coli His
Human ANXA6-9699H Recombinant Human ANXA, His-tagged E.coli His C-term-350a.a.
Human ANXA6-27320TH Recombinant Human ANXA6, His-tagged E.coli His
Human ANXA6-636H Recombinant Human ANXA6 protein, GST-tagged Wheat Germ GST
Human ANXA6-8829HCL Recombinant Human ANXA6 293 Cell Lysate HEK293 N/A
Human ANXA6-572H Recombinant Human ANXA6 Protein, His-tagged E.coli His Ala2~Ser251
Human ANXA6-001H Recombinant Human ANXA6 Protein, His-tagged E.coli His
Human ANXA6-02H Recombinant Human ANXA6 Protein, Fc/His-tagged HEK293T MYC/DDK
Human ANXA6-2141H Recombinant Human ANXA6 Protein, GST/His-tagged E.coli GST/His
Human ANXA6-1045HF Recombinant Full Length Human ANXA6 Protein, GST-tagged In Vitro Cell Free System GST 673 amino acids
Human ANXA6-3113H Recombinant Human ANXA6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANXA6-0426H Recombinant Human ANXA6 Protein (Ala2-Asp673), C-His-tagged E.coli C-His Ala2-Asp673
Human ANXA6-0427H Recombinant Human ANXA6 Protein (Ala2-Ser251), His-tagged E.coli His Ala2-Ser251
Mouse Anxa6-573M Recombinant Mouse Anxa6 Protein, His-tagged E.coli His Ser251~Leu504
Zebrafish ANXA6-274Z Recombinant Zebrafish ANXA6 Mammalian Cell His
Chicken ANXA6-6295C Recombinant Chicken ANXA6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ANXA6 involved in several pathways and played different roles in them. We selected most pathways ANXA6 participated on our site, such as Calcium Regulation in the Cardiac Cell, Muscle contraction, Prostaglandin Synthesis and Regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Calcium Regulation in the Cardiac CellRGS6;GNG13B;RGS5B;GNB3B;RGS14A;GJB4;RGS5A;RGS17;RGS5
Prostaglandin Synthesis and RegulationS100A10;ANXA5;ANXA3;ANXA6;ANXA2;CC10;ANXA4;S100A6

ANXA6 has several biochemical functions, for example, GTP binding, calcium ion binding, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA6 itself. We selected most functions ANXA6 had, and list some proteins which have the same functions with ANXA6. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingTBC1D9;PGS1;EFHC2;PCDH2AB10;S100A11;FAT3A;UMOD;PROC;CAPS
calcium-dependent phospholipid bindingESYT2;CCDC167;SYT1A;SYT2;RPH3A;ANXA3;ANXA3B;SYT11A;AP1S2
calcium-dependent protein bindingANXA6;MBL1;ALG2;DMBT1;S100A4;STX2;CASQ2;SNAP25;SYT1
cholesterol bindingAPOA4B.2;APOA2;OSBP2;PMP2;OSBPL7;OSBPL8;OSBPL10;ERLIN2;NPC2
ligand-gated ion channel activityTRPA1A;CHRNA4;CHRNA3;CLCA2;TRPA1B;CHRNA5;CHRNB4;ANXA6;CNGA3
protein homodimerization activityXPA;ROPN1B;TRPM8;CD247;CCBL2;ABCB9;RENBP;SP100;TLR13

ANXA6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA6.

ACTB; ERBB2; MLH1; pilB; ruvB; sucA; CDC73; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; MME; CD9; GRB2; TJP1; SF1

  • Q&As
  • Reviews

Q&As (21)

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How is ANXA6 associated with cardiovascular diseases? 03/30/2023

ANXA6 has been implicated in various cardiovascular diseases such as atherosclerosis, myocardial infarction, and heart failure. It has been suggested that altered ANXA6 expression and function may contribute to abnormal lipid metabolism, inflammation, and vascular calcification, which are hallmarks of cardiovascular pathologies.

How is ANXA6 involved in membrane trafficking? 07/17/2022

ANXA6 interacts with intracellular membranes and can play a role in regulating membrane trafficking processes such as endocytosis, exocytosis, and membrane repair. It has been shown to influence the fusion and fission events necessary for proper membrane trafficking.

Is ANXA6 involved in autophagy? 06/15/2021

Yes, ANXA6 has been implicated in autophagy, a cellular process responsible for the degradation and recycling of cellular components. It has been suggested that ANXA6 may play a role in autophagosome formation and maturation by interacting with proteins involved in autophagy regulation.

Are there any pharmacological agents that can modulate ANXA6 expression or activity? 02/22/2021

Some studies have identified pharmacological agents that can modulate ANXA6 expression or activity. For example, certain drugs have been reported to regulate ANXA6 expression levels in cancer cells. Additionally, compounds affecting calcium signaling or phospholipid metabolism can indirectly influence ANXA6 function. However, more research is needed to identify specific pharmacological agents that can selectively target ANXA6.

Can ANXA6 be targeted for therapeutic interventions? 10/09/2020

Modulating ANXA6 expression or function may have potential therapeutic value, especially in diseases where ANXA6 plays a critical role. Developing drugs that selectively target ANXA6 or its interacting partners could potentially lead to novel therapeutic strategies. However, further research is needed to understand the precise mechanisms and validate its therapeutic potential.

Does ANXA6 have any specific binding partners? 03/14/2020

ANXA6 can interact with several proteins and cellular components. It has been reported to interact with various phospholipids, membrane proteins, cytoskeletal proteins, and signaling molecules. Some of its known binding partners include clathrin, caveolin, Rab GTPases, and integrins.

What are the future directions of research on ANXA6? 12/02/2019

Future research on ANXA6 may focus on elucidating its precise molecular mechanisms and functional roles in various cellular processes. Further studies are also needed to understand its involvement in specific diseases to develop targeted therapies and exploit its potential as a diagnostic or prognostic marker.

Can ANXA6 be used as a diagnostic or prognostic marker? 10/19/2019

ANXA6 has been investigated as a potential biomarker in several diseases. Its altered expression and subcellular localization in cancer tissues have shown promise for its diagnostic and prognostic value. However, further research is needed to validate its clinical utility in different diseases.

Are there any known therapeutic strategies targeting ANXA6? 09/30/2019

Currently, there are no specific therapeutic strategies directly targeting ANXA6. However, since ANXA6 plays a role in various diseases, understanding its mechanisms of action may facilitate the development of targeted therapies. Some studies have explored the use of small molecules or inhibitors that indirectly modulate ANXA6 function or its interacting partners as potential therapeutic interventions.

Are there any specific drugs targeting ANXA6? 08/06/2019

Currently, there are no specific drugs targeting ANXA6. However, studies exploring the potential therapeutic value of modulating ANXA6 expression and activity are ongoing, especially in the context of cancer and other diseases where ANXA6 is implicated.

Can ANXA6 interact with other proteins or molecules? 08/03/2019

Yes, ANXA6 can interact with various proteins and molecules. It has been shown to interact with membrane lipids, calcium ions, and other annexin family members. ANXA6 also interacts with proteins involved in intracellular trafficking, such as dynamin, clathrin, and various Rab GTPases. Additionally, ANXA6 can interact with signaling molecules, cytoskeletal proteins, and membrane receptors, suggesting its involvement in diverse cellular processes.

Are there any known genetic mutations or polymorphisms in ANXA6? 06/25/2019

Certain genetic mutations and polymorphisms have been identified in ANXA6. For example, in some cancers, alterations in ANXA6 expression levels and mutations affecting its function have been observed. The significance of other genetic variations in ANXA6 and their association with disease phenotypes require further investigation.

How is ANXA6 involved in cellular signaling? 04/05/2019

ANXA6 can function as a scaffold protein and participate in diverse signaling pathways. It can interact with signaling molecules like protein kinases, phospholipases, and second messengers, modulating their activities and contributing to cellular signaling events, including calcium signaling and receptor trafficking.

Are there any genetic mutations or polymorphisms in ANXA6 associated with diseases? 07/03/2017

While ANXA6 mutations or polymorphisms have not been extensively studied, some studies have reported genetic variants in ANXA6 that are associated with certain diseases. For example, specific ANXA6 polymorphisms have been linked to the risk of developing Parkinson's disease and schizophrenia. However, more research is needed to investigate the association between ANXA6 genetic variations and diseases.

Can ANXA6 be used as a biomarker for diseases? 05/24/2017

ANXA6 has been investigated as a potential biomarker for several diseases. Its expression levels and localization have been analyzed in various conditions, including cancer, cardiovascular diseases, and neurodegenerative disorders. However, further studies are needed to establish its utility as a diagnostic or prognostic biomarker in clinical settings.

Can ANXA6 be used as a drug delivery vehicle? 03/10/2017

As a membrane-binding protein, ANXA6 has been explored for drug delivery applications. Its ability to interact with intracellular membranes and regulate membrane trafficking processes makes it a potential candidate for targeted drug delivery. However, more research is needed to evaluate its efficacy and safety in drug delivery systems.

Does ANXA6 have any role in immune responses? 01/11/2017

Yes, ANXA6 has been reported to have immunomodulatory properties. It can regulate immune cell migration, phagocytosis, and cytokine release. ANXA6 has also been implicated in autoimmune diseases, such as systemic lupus erythematosus, suggesting its involvement in immune dysregulation.

What are the potential roles of ANXA6 in disease? 01/04/2017

ANXA6 has been linked to several pathological conditions. It has been associated with cancers, where its altered expression and subcellular localization have been observed. ANXA6 has also been implicated in metabolic disorders, cardiovascular diseases, and neurodegenerative diseases like Alzheimer's and Parkinson's.

Does ANXA6 have any role in insulin resistance or diabetes? 08/05/2016

ANXA6 has been implicated in metabolic disorders like insulin resistance and diabetes. It has been shown to influence insulin signaling and glucose homeostasis in animal models. Altered ANXA6 expression and localization have been observed in insulin-resistant tissues, suggesting its involvement in insulin sensitivity and glucose metabolism.

Are there any animal models available to study ANXA6 function and its role in diseases? 03/22/2016

Yes, animal models, such as genetically modified mice, have been used to study ANXA6 function and its involvement in disease processes. Knockout or transgenic animal models with altered ANXA6 expression allow researchers to investigate its specific roles in various systems and diseases.

Can ANXA6 play a role in cancer progression? 01/31/2016

Yes, ANXA6 has been implicated in cancer progression. Altered expression levels of ANXA6 have been observed in different types of cancer, and it has been associated with tumor growth, invasion, metastasis, and drug resistance. ANXA6 can modulate various cellular processes in cancer cells, including cell proliferation, migration, and angiogenesis, making it a potential therapeutic target in cancer treatment.

Customer Reviews (4)

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    the manufacturer's support is crucial for researchers using ANXA6 protein in trials.


      These resources can enhance the efficiency and accuracy of experimental workflows and contribute to successful outcomes.


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          Their collaboration, expertise, and customized solutions contribute to the successful execution of experiments, reliable data generation, and the advancement of scientific knowledge in the field.

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