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  • Official Full Name

    annexin A3

  • Overview

    This gene encodes a member of the annexin family.Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways.This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
  • Synonyms

    ANXA3; annexin A3; 1 2 cyclic inositol phosphate phosphodiesterase; 2-cyclic phosphate 2-phosphohydrolase; 35 alpha calcimedin; 35-alpha calcimedin; Annexin III; Annexin-3; AnnexinA3; AnnexinIII; ANX 3; ANX A3; ANX3; ANXA 3; ANXA3_HUMAN; Calcimedin 35 alpha; Inositol 1 2 cyclic phosphate 2 phosphohydrolase; Inositol 1; Lipocortin III; LipocortinIII; OTTHUMP00000160701; OTTHUMP00000219237; OTTHUMP00000219238; PAP III; PAP-III; PAPIII; Placental anticoagulant protein III; calcimedin 35-alpha; Annexin III (lipocortin III); inositol 1,2-cyclic phosphate 2-phosphohydrolase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANXA3-633H Recombinant Human ANXA3 protein, GST-tagged Wheat Germ GST
Human ANXA3-26596TH Recombinant Human ANXA3 E.coli N/A
Human ANXA3-1834H Recombinant Human Annexin A3 E.coli N/A
Human ANXA3-5260H Recombinant Human Annexin A3, His-tagged E.coli His
Human ANXA3-2433H Recombinant Human ANXA3 Protein, MYC/DDK HEK293 Myc/DDK
Human ANXA3-9696H Recombinant Human ANXA3, GST-tagged E.coli GST 1-322a.a.
Human ANXA3-26351TH Recombinant Human ANXA3, His-tagged E.coli His
Human ANXA3-8832HCL Recombinant Human ANXA3 293 Cell Lysate HEK293 N/A
Human ANXA3-2266H Recombinant Human ANXA3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANXA3-001H Recombinant Human ANXA3 Protein, His-tagged E.coli His
Human ANXA3-2191H Recombinant Human ANXA3 Protein (5-322 aa), His-tagged Yeast His 5-322 aa
Human ANXA3-166H Recombinant Human ANXA3 Protein, His-tagged E.coli N-His Ala2-Asp323
Human ANXA3-345H Recombinant Human ANXA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ANXA3-5312H Recombinant Human ANXA3 protein, His-tagged E.coli His 5-322aa
Human ANXA3-345H-B Recombinant Human ANXA3 Protein Pre-coupled Magnetic Beads HEK293
Human ANXA3-1042HF Recombinant Full Length Human ANXA3 Protein, GST-tagged In Vitro Cell Free System GST 323 amino acids
Human ANXA3-0197H Recombinant Human ANXA3 Protein (Ala26-Ala160), N-His-tagged E.coli N-His Ala26-Ala160
Human ANXA3-1379HFL Recombinant Full Length Human ANXA3 Protein, C-Flag-tagged Mammalian cells Flag
Human ANXA3-0198H Recombinant Human ANXA3 Protein (Met1-Asp323), Tag Free E.coli Tag Free Met1-Asp323
Mouse Anxa3-1342M Recombinant Mouse Anxa3 protein, His-tagged E.coli His Asn184~Ile318 (Accession # O35639)
Mouse ANXA3-1715M Recombinant Mouse ANXA3 Protein Mammalian Cell His
Mouse ANXA3-583M Recombinant Mouse ANXA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Anxa3-607M Recombinant Mouse Anxa3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ANXA3-583M-B Recombinant Mouse ANXA3 Protein Pre-coupled Magnetic Beads HEK293
Rat Anxa3-3495R Recombinant Rat Anxa3, His-tagged E.Coli or Yeast His 324
Rat ANXA3-690R Recombinant Rat ANXA3 Protein Mammalian Cell His
Rat Anxa3-1343R Recombinant Rat Anxa3 protein, His-tagged E.coli His Phe19~Arg154 (Accession # P14669)
Rat ANXA3-346R Recombinant Rat ANXA3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ANXA3-346R-B Recombinant Rat ANXA3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANXA3 Related Articles
  • ANXA3 Related Research Area

ANXA3 involved in several pathways and played different roles in them. We selected most pathways ANXA3 participated on our site, such as Prostaglandin Synthesis and Regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Prostaglandin Synthesis and RegulationS100A10;S100A6;ANXA2;ANXA4;ANXA5;ANXA3;CC10;ANXA6

ANXA3 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA3 itself. We selected most functions ANXA3 had, and list some proteins which have the same functions with ANXA3. You can find most of the proteins on our site.

Function Related Protein
calcium-dependent phospholipid bindingANXA7;PCLO;ANXA5A;ANXA11B;ANXA5;CPNE3;ANXA3A;ANXA1;ANXA1A
calcium-dependent protein bindingDDX5;CHP1;MBL2;A2M;ANXA2;ANXA1;MYO1D;S100A11;DMBT1
phospholipase A2 inhibitor activityCC10;ANXA3;ANXA2;ANXA1

ANXA3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA3.

TP53; UNC119; UBR1; EMG1; IGSF21; pi3p; ATF2

Hamelin-Peyron, C; Vlaeminck-Guillem, V; et al. Prostate cancer biomarker annexin A3 detected in urines obtained following digital rectal examination presents antigenic variability. CLINICAL BIOCHEMISTRY 47:901-908(2014).
Suzuki, T; Ikari, K; et al. PADI4 and HLA-DRB1 Are Genetic Risks for Radiographic Progression in RA Patients, Independent of ACPA Status: Results from the IORRA Cohort Study. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (18)

Ask a question
Is ANXA3 involved in any diseases or disorders? 04/14/2023

ANXA3 has been implicated in several diseases and disorders. For instance, it has been identified as a potential biomarker for lung cancer and colorectal cancer. Additionally, ANXA3 may play a role in inflammation, atherosclerosis, and neuronal development.

Does ANXA3 have any role in inflammation? 04/07/2022

Yes, ANXA3 has been implicated in the regulation of inflammation. It has been shown to interact with other proteins involved in the inflammatory response and can modulate the production of pro-inflammatory molecules. ANXA3 may also contribute to the resolution of inflammation by promoting anti-inflammatory processes.

Are there any known genetic variations or mutations in the ANXA3 gene? 10/12/2020

Yes, genetic variations and mutations in the ANXA3 gene have been reported. Some of these variations have been associated with certain diseases or traits, such as a higher risk of atherosclerosis or altered red blood cell morphology. However, the functional implications of these variations and their precise connection to disease development are still being investigated.

Are there any known interactions of ANXA3 with other proteins? 09/05/2020

Yes, ANXA3 can interact with various proteins to regulate specific cellular processes. For example, it can bind to actin and contribute to cell migration and membrane repair. It can also interact with other annexins or phospholipids to mediate membrane organization and vesicular trafficking.

Are there any known regulatory mechanisms that control ANXA3 expression? 08/24/2020

Yes, ANXA3 expression can be regulated by various factors. For example, certain transcription factors, such as SP1 and NF-κB, can bind to the promoter region of ANXA3 and regulate its transcription. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, can also influence ANXA3 expression levels.

Is ANXA3 associated with any other diseases or conditions? 01/13/2020

Besides cancer, ANXA3 has been implicated in the pathogenesis of other diseases and conditions, including autoimmune disorders, cardiovascular diseases, and neurological disorders. However, further research is needed to fully understand the mechanisms by which ANXA3 contributes to these conditions.

Does ANXA3 have any role in cancer progression? 08/08/2019

Yes, ANXA3 has been implicated in cancer progression. It is often overexpressed in various cancer types, including breast, lung, colon, and pancreatic cancer. ANXA3 can promote tumor growth, angiogenesis, and metastasis by modulating cell survival, proliferation, and invasion pathways. It has also been associated with chemoresistance in certain cancers.

Where is the ANXA3 protein located within the cell? 04/26/2019

ANXA3 is primarily localized in the cytoplasm of cells, but it can also be found associated with the plasma membrane or in the nucleus.

Does ANXA3 have any role in cell proliferation or apoptosis? 11/17/2018

While ANXA3 is primarily known for its involvement in membrane organization and cellular processes, it has also been implicated in regulating cell proliferation and apoptosis. Studies have suggested that ANXA3 can modulate cell growth and survival by influencing various signaling pathways and interacting with other proteins involved in these processes.

Can ANXA3 influence cell migration and invasion? 09/10/2018

Yes, ANXA3 has been found to be involved in cell migration and invasion, particularly in cancer cells. It can interact with proteins associated with cytoskeletal rearrangement and cell adhesion, facilitating the movement and invasion of cells in various biological processes, including cancer metastasis.

Is ANXA3 involved in any signaling pathways? 08/12/2018

ANXA3 has been reported to interact with certain signaling pathways. It can modulate the activity of the Wnt/β-catenin pathway, which is implicated in cell proliferation and tissue homeostasis. ANXA3 may also be involved in the regulation of calcium signaling pathways.

Can ANXA3 be used as a diagnostic marker for cancer? 08/05/2018

ANXA3 has shown promise as a potential diagnostic marker for certain types of cancer, including lung cancer and colorectal cancer. Elevated levels of ANXA3 have been observed in the blood or tissue samples of patients with these cancers. However, further research is needed to validate its diagnostic utility.

Is ANXA3 involved in cellular signaling pathways? 05/20/2018

Yes, ANXA3 has been found to interact with several signaling molecules and participate in various signaling pathways. It can activate the Akt/mTOR pathway, MAPK/ERK pathway, and PI3K/Akt pathway, among others. These interactions indicate that ANXA3 plays a role in cell signaling and can influence cell survival, proliferation, and differentiation.

Is ANXA3 targeted by any drugs or therapies? 07/12/2017

Currently, there are no specific drugs or therapies that directly target ANXA3. However, given its potential involvement in cancer and other diseases, it is an area of ongoing research and may become a target for future therapeutic interventions.

Does ANXA3 have diagnostic or prognostic potential in cancer? 03/18/2017

ANXA3 has been proposed as a potential biomarker for cancer diagnosis and prognosis. Elevated levels of ANXA3 have been associated with poor prognosis in several cancer types, suggesting that it could serve as a prognostic indicator. ANXA3 expression levels in blood or tissue samples can also be used to distinguish cancer patients from healthy individuals.

Can ANXA3 serve as a therapeutic target? 10/15/2016

The potential therapeutic targeting of ANXA3 is currently under investigation. Understanding its precise role and interactions in different diseases could help in developing targeted therapies. However, more research is needed to determine the feasibility and efficacy of targeting ANXA3 for therapeutic purposes.

What are the tissue distribution patterns of ANXA3 protein? 05/05/2016

ANXA3 protein is found in various tissues of the body, including the gastrointestinal tract, lungs, kidneys, and reproductive organs. It is also detected in certain cancers such as lung cancer and colorectal cancer.

Is ANXA3 involved in any other biological processes? 02/14/2016

Yes, ANXA3 is involved in various biological processes beyond cancer. It has been implicated in cell apoptosis, calcium ion regulation, membrane repair, exocytosis, and cellular differentiation. Further research is needed to fully elucidate the precise roles and functions of ANXA3 in these processes.

Customer Reviews (5)

Write a review

    The manufacturer's outstanding technical support serves as a valuable resource, providing prompt and knowledgeable assistance whenever I encounter difficulties or require guidance.


      the ANXA3 protein's well-documented properties and thoroughly tested functionality give me the confidence to integrate it seamlessly into my experimental setup.


        Its consistent performance and remarkable stability make it a reliable tool in studying various cellular processes and signaling pathways.


          the ANXA3 protein's exceptional quality and purity guarantee its suitability for a wide range of experimental applications.


            Their expertise and commitment to customer satisfaction are truly commendable, ensuring that I have access to the necessary resources to overcome any experimental hurdles that may arise.

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