ANXA13
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Official Full Name
annexin A13
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Background
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family;play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this;gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated,;proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants;encoding different isoforms have been identified. -
Synonyms
ANXA13; annexin A13; ANX13; Annexin XIII; Annexin, intestine-specific; Annexin-13; ANX 13; ANX A13; ANX13_HUMAN; Intestine Specific Annexin; Intestine-specific annexin; ISA; MGC150460;
- Involved Pathway
- Protein Function
- Interacting Protein
ANXA13 involved in several pathways and played different roles in them. We selected most pathways ANXA13 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ANXA13 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, NOT phosphatidylcholine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA13 itself. We selected most functions ANXA13 had, and list some proteins which have the same functions with ANXA13. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CD97;MYL9A;F9B;PVALB4;OCM2;ANXA13L;PADI3;MMP12;PCDHB2 |
| calcium-dependent phospholipid binding | CPNE3;ANXA3A;SYT5;PCLO;ANXA2B;SYT17;SYT1A;SYT5B;AP1S2 |
| NOT phosphatidylcholine binding | ANXA13;SESTD1 |
| phosphatidylglycerol binding | |
| phosphatidylserine binding | SYT4;MARK1;OSBPL8;THBS1;TRIM72;SDPR;JPH2;RS1;AXL |
ANXA13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA13 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA13.
- Q&As
- Reviews
Q&As (7)
Ask a questionCurrently, there are no known mutations in the ANXA13 gene that have been directly linked to any specific diseases. However, genetic variations in the ANXA13 gene may exist and could potentially contribute to disease susceptibility or affect ANXA13 function. Further studies are needed to explore the genetic variability of ANXA13 and its potential implications in various diseases.
ANXA13, like other annexin proteins, can be found in various cellular compartments or organelles. Annexin proteins have been detected on the plasma membrane, as well as in the cytoplasm, nucleus, mitochondria, endoplasmic reticulum, and lysosomes. The precise subcellular localization of ANXA13 may depend on the specific cell type and experimental conditions.
Mutations in the ANXA13 gene have been associated with certain diseases, such as amyloidosis. Amyloidosis is a disorder characterized by the abnormal accumulation of proteins in various tissues and organs, leading to organ dysfunction. However, research into the specific role of ANXA13 mutations in the development of amyloidosis is still ongoing.
Mutations in the ANXA13 gene have been associated with certain diseases, such as amyloidosis. Amyloidosis is a disorder characterized by the abnormal accumulation of proteins in various tissues and organs, leading to organ dysfunction. However, research into the specific role of ANXA13 mutations in the development of amyloidosis is still ongoing.
ANXA13 has been implicated in certain cancers. For example, studies have suggested that ANXA13 may promote gastric cancer progression by influencing tumor cell growth and metastasis. However, the exact mechanisms and extent of ANXA13 involvement in cancer development and progression are not fully understood and require further investigation.
While the specific physiological processes involving ANXA13 are not well defined, annexins, in general, have been implicated in various cellular functions. Annexin proteins are known to be involved in membrane repair, membrane trafficking, regulation of ion channels, cell signaling, and apoptosis. It is possible that ANXA13 may have similar roles, but further research is needed to determine its specific functions.
ANXA13 is known to be expressed in various tissues, including the brain, kidney, liver, lung, and pancreas, among others. Its expression pattern may vary depending on the cell type and developmental stage.
Customer Reviews (4)
Write a reviewResearchers can rely on the ANXA13 protein's specificity and sensitivity to obtain accurate and reliable results. -
the ANXA13 protein's versatility allows it to be effectively employed in various experimental designs, further enhancing its suitability for diverse research needs. -
The ANXA13 protein comes highly recommended for a variety of applications, particularly in ELISA and protein electron microscopy structure analysis. -
In protein electron microscopy structure analysis, the ANXA13 protein demonstrates outstanding performance. -
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