ANXA4

  • Official Full Name

    annexin A4

  • Background

    Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways.ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization.Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity.ANX4 is almost exclusively expressed in epithelial cells.
  • Synonyms

    ANXA4; annexin A4; ANX4; P32.5; PP4-X; PAP-II; annexin-4; protein II; endonexin I; lipocortin IV; chromobindin-4; 35-beta calcimedin; proliferation-inducing gene 28; proliferation-inducing protein 28; placental anticoagulant protein II; carbohydrate-bindi;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Antibody
    • Species :
    • Cattle
    • Dog
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • HIS
    • His (Fc)
    • Avi
    • Myc
    • His|T7
    • SUMO
    • MYC
    • DDK
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cattle ANXA4-1331C Recombinant Cattle ANXA4 protein, His & T7-tagged E.coli His/T7
    Dog ANXA4-2518D Recombinant Dog ANXA4 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc
    Dog ANXA4-1332D Recombinant Dog ANXA4 protein, His-tagged E.coli His
    Human ANXA4-1842 Recombinant Human Annexin A4 E.coli N/A
    Human ANXA4-8831HCL Recombinant Human ANXA4 293 Cell Lysate HEK293 N/A
    Human ANXA4-2519H Recombinant Human ANXA4 protein, His-SUMO & Myc-tagged E.coli His-SUMO & Myc
    Human ANXA4-1334H Recombinant Human ANXA4 protein, His-tagged E.coli His
    Human ANXA4-0432H Recombinant Human ANXA4 Protein (Met1-Asp319), N-His-tagged E.coli N-His
    Human ANXA4-634H Recombinant Human ANXA4 protein, GST-tagged Wheat Germ GST
    Human ANXA4-167H Recombinant Human ANXA4 Protein, His-tagged E.coli N-His
    Human ANXA4-346H Recombinant Human ANXA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human ANXA4-9697H Recombinant Human ANXA4, GST-tagged E.coli GST
    Human ANXA4-346H-B Recombinant Human ANXA4 Protein Pre-coupled Magnetic Beads HEK293
    Human ANXA4-26597TH Recombinant Human ANXA4, His-tagged HIS
    Human ANXA4-0431H Recombinant Human ANXA4 Protein (Ala2-Asp319), His-tagged E.coli His
    Human ANXA4-18H Recombinant Human ANXA4 protein, His-tagged HEK293 His
    Human ANXA4-001H Recombinant Human ANXA4 Protein, His-tagged E.coli His
    Mouse ANXA4-584M Recombinant Mouse ANXA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Anxa4-1336M Recombinant Mouse Anxa4 protein, His-tagged E.coli His
    Mouse Anxa4-2520M Recombinant Mouse Anxa4 protein, His&Myc-tagged E.coli His&Myc
    Mouse Anxa4-608M Recombinant Mouse Anxa4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse ANXA4-1716M Recombinant Mouse ANXA4 Protein Mammalian Cell His
    Mouse ANXA4-584M-B Recombinant Mouse ANXA4 Protein Pre-coupled Magnetic Beads HEK293
    Pig ANXA4-1338P Recombinant Pig ANXA4 protein, His-tagged E.coli His
    Rat Anxa4-1340R Recombinant Rat Anxa4 protein, His-tagged E.coli His
    Rat Anxa4-3496R Recombinant Rat Anxa4, His-tagged E.Coli or Yeast His
    Rhesus Macaque ANXA4-167R-B Recombinant Rhesus Macaque ANXA4 Protein Pre-coupled Magnetic Beads HEK293
    Rhesus Macaque ANXA4-339R Recombinant Rhesus monkey ANXA4 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque ANXA4-167R Recombinant Rhesus Macaque ANXA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Zebrafish ANXA4-9640Z Recombinant Zebrafish ANXA4 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • ANXA4 Related Research Area

    ANXA4 involved in several pathways and played different roles in them. We selected most pathways ANXA4 participated on our site, such as Prostaglandin Synthesis and Regulation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Prostaglandin Synthesis and RegulationANXA6;ANXA4;S100A6;ANXA2;ANXA5;CC10;S100A10;ANXA3

    ANXA4 has several biochemical functions, for example, NF-kappaB binding, calcium ion binding, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA4 itself. We selected most functions ANXA4 had, and list some proteins which have the same functions with ANXA4. You can find most of the proteins on our site.

    Function Related Protein
    NF-kappaB bindingANXA4;BRMS1;HDAC1;TAF4B;PSMA6;GSK3B;AP1S2;SNAI1A;BCL10
    calcium ion bindingRCVRN;EPS15L1;CELSR1;ANXA1A;PLA2G2A;PLA2G10;FREM2B;PCDH1G11;EFHA2
    calcium-dependent phospholipid bindingCPNE3;ANXA11B;SYTL2;SYT9B;ANXA1;RPH3A;ANXA11;TC2N;ANXA5A
    calcium-dependent protein bindingPDCD6;S100PBP;RBM22;CALM2;CHP;TNNC1;STX1A;S100B;MBL1
    identical protein bindingTRA@;DPP4;SIAH1;PSME3;RIPK3;MYOM1;KDM6A;SERPINA1;CLDN11
    phospholipase inhibitor activityANXA5;ANXA3B;ANXA2A;SNCB;ANXA2B;ANXA1B;ANGPTL3;ANXA3A;ANXA1C
    protein bindingSPG21;TUFT1;PPP2R5B;SLC9A7;FIP1L1;HELZ;CBX3;STAMBPL1;BTK

    ANXA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA4.

    TINF2; Cdk1; NMT2; SMPD1; POT1; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; GABARAPL1

    • Q&As
    • Reviews

    Q&As (17)

    Ask a question
    Does ANXA4 have any interaction partners or binding proteins? 07/23/2022

    Yes, ANXA4 has been shown to interact with several proteins and lipids. It can bind to phospholipids such as phosphatidylserine and phosphatidylinositol, which are important for its membrane association. ANXA4 can also interact with other annexin proteins or cytoskeletal proteins, potentially contributing to its diverse cellular functions.

    How is the expression of the ANXA4 protein regulated? 03/17/2022

    The expression of ANXA4 can be regulated by various factors, including cellular differentiation, hormones, and cytokines. Additionally, it can be influenced by environmental factors, such as changes in calcium levels and cellular stress.

    Are there any known post-translational modifications of the ANXA4 protein? 12/14/2021

    Yes, ANXA4 can undergo post-translational modifications such as phosphorylation and acetylation. These modifications can affect the protein's stability, subcellular localization, and interactions with other molecules, potentially modulating its cellular functions.

    Are there any diseases or conditions associated with ANXA4 protein? 09/03/2021

    ANXA4 has been implicated in several diseases and conditions. It has been linked to the pathogenesis of atherosclerosis, where it plays a role in lipid metabolism and plaque formation. ANXA4 has also been associated with certain cancers, such as gastric cancer and breast cancer, where it may influence tumor growth and metastasis.

    Are there any known genetic variants or mutations in the ANXA4 gene? 01/12/2020

    Genetic variants and mutations in the ANXA4 gene have been identified in some studies. These genetic alterations may contribute to individual differences in ANXA4 expression or function, potentially impacting disease susceptibility or progression. Further research is needed to fully understand the significance of these genetic variations.

    Can ANXA4 influence cell adhesion and migration? 11/28/2019

    Yes, ANXA4 appears to play a role in cell adhesion and migration. It has been associated with the regulation of focal adhesions and actin cytoskeleton dynamics, processes crucial for cell movement and tissue remodeling. ANXA4 may modulate these processes through its interaction with cytoskeletal components and signaling pathways.

    Can ANXA4 be used as a diagnostic or prognostic marker? 10/27/2019

    ANXA4 has shown potential as a diagnostic or prognostic marker in certain diseases. For example, its expression levels have been correlated with clinical outcomes in breast cancer and ovarian cancer. However, more research is needed to validate its utility and establish standardized protocols for its use as a diagnostic or prognostic marker in different contexts.

    Are there any known genetic variants or mutations in ANXA4? 10/19/2018

    Genetic variants and mutations in ANXA4 have been reported in certain individuals. These variants can occur in the coding sequence of the gene and may lead to alterations in the protein structure or function. Studies investigating the functional impact of these genetic variants and their association with specific diseases are still ongoing.

    How is the ANXA4 protein involved in calcium-dependent processes? 09/30/2018

    ANXA4 has the ability to bind calcium ions, and this binding triggers conformational changes in the protein that allow it to interact with other molecules or membranes. These calcium-dependent interactions are essential for the regulation of various cellular processes, including vesicle fusion, exocytosis, and intracellular signaling.

    Is ANXA4 conserved across different species? 08/04/2018

    Yes, the ANXA4 protein is evolutionarily conserved and found in many species, including mammals, birds, reptiles, and fish. The high degree of conservation suggests its important biological functions across different organisms.

    Is ANXA4 involved in any physiological processes? 07/19/2018

    Yes, ANXA4 is involved in several physiological processes. It has been implicated in the regulation of oocyte maturation, sperm function, and embryonic development. ANXA4 also plays a role in the physiology of the female reproductive tract, including endometrial receptivity and embryo implantation.

    Can ANXA4 be detected or measured in biological samples? 05/21/2018

    Yes, ANXA4 can be detected in various biological samples, including blood, tissues, and cell culture supernatants. Detection methods like immunohistochemistry, Western blotting, and enzyme-linked immunosorbent assays (ELISA) can be used to quantify ANXA4 levels. However, the specific method of detection may vary depending on the research or diagnostic context.

    How is the expression of ANXA4 regulated? 02/20/2018

    The expression of ANXA4 can be regulated at multiple levels, including transcriptional, post-transcriptional, and post-translational mechanisms. Transcriptional regulation can be influenced by various factors and signaling pathways, such as hormones, growth factors, and inflammatory mediators. Post-transcriptional regulation can occur through mechanisms like mRNA stability, alternative splicing, and microRNA-mediated regulation. Post-translational modifications, as mentioned earlier, can also impact ANXA4 expression by affecting its stability and activity.

    What diseases or conditions are associated with ANXA4 dysregulation? 01/14/2018

    Dysregulation of ANXA4 has been implicated in various diseases and conditions. For example, altered ANXA4 expression has been observed in cancers, including breast cancer, ovarian cancer, and lung cancer, where it can contribute to tumor progression and metastasis. ANXA4 dysregulation has also been associated with cardiovascular diseases, inflammation, and autoimmune conditions, highlighting its involvement in diverse pathophysiological processes.

    Are there any ongoing studies or research areas focused on ANXA4? 06/10/2017

    Ongoing studies and research areas related to ANXA4 include investigating its role in cancer biology, understanding its functions in reproductive physiology and fertility, exploring its involvement in cardiovascular diseases and inflammation, and exploring its potential as a therapeutic target. Researchers are also investigating the mechanisms of ANXA4 regulation and its interactions with other molecules.

    Is ANXA4 used as a biomarker or therapeutic target for any diseases? 01/26/2017

    ANXA4 has shown potential as a biomarker in certain diseases, including gastric cancer and atherosclerosis. It may serve as an indicator of disease progression or prognosis. As for therapeutic targeting, the specific role of ANXA4 in disease pathogenesis is still being investigated, and it has not yet emerged as a primary target for therapy.

    Are there any therapeutic implications or potential targets related to ANXA4? 12/23/2016

    The dysregulation of ANXA4 in certain diseases suggests that it could be a potential therapeutic target. Modulating ANXA4 expression or activity may offer opportunities for developing novel treatments. Additionally, ANXA4 itself could serve as a therapeutic agent or biomarker for specific conditions. However, further research is needed to better understand the precise mechanisms of ANXA4 and its therapeutic potential.

    Customer Reviews (4)

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    Reviews
    09/13/2022

      They are readily available to address any concerns or questions and supply valuable resources to assist in experimental design and optimization. -

      04/24/2021

        Their expertise in protein production and purification ensures the delivery of a high-quality product that consistently performs well in my experiments. -

        01/15/2019

          Should I encounter any challenges or require technical assistance, the manufacturer provides prompt and knowledgeable support. -

          12/10/2018

            the manufacturer offers a wide range of ANXA4 protein variants, including recombinant or native forms, as well as different conjugates and modifications. -

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