ANXA7
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Official Full Name
annexin A7
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Background
Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. -
Synonyms
ANXA7; annexin A7; ANX7; SNX; Synexin; annexin-7; annexin VII;
- Involved Pathway
- Protein Function
- Interacting Protein
ANXA7 involved in several pathways and played different roles in them. We selected most pathways ANXA7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ANXA7 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA7 itself. We selected most functions ANXA7 had, and list some proteins which have the same functions with ANXA7. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | EFEMP2A;PCDH1G11;LETM1;HPCAL1;PLCB4;PCDHB7;MAN1C1;PCDH2G10;FAT1A |
calcium-dependent phospholipid binding | SYT1B;ANXA4;SYTL2;ANXA8;C2CD4B;SYT9B;DOC2D;SYT2;ANXA5 |
calcium-dependent protein binding | S100A11;ANXA2;S100B;C9orf9;NRXN1;CCDC167;ANXA3;TSG101;SELP |
integrin binding | KDR;CYR61;CXADR;ADAM2;AMICA1;TGFBI;VCAM1;ADAM15;ACTN1 |
poly(A) RNA binding | HNRNPUL1;RPL32;CDC42EP4;SERBP1;KIAA1967;RBM8A;HERC5;HNRPLL;RBFOX2 |
protein binding | GALNT3;NECAB3;ATRX;RPLP1;SULT1B1;KAT7;PSMA3;LINC00482;IL2RG |
ANXA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA7.
SRI; PDCD6; PAX8; q81y32_bacan; DYNC1I1; DVL1; GNB5; ANGPT2; MPPED1; GDF9; NMT2; TAF5L; ACTL6B; CPNE6; DDAH2; F13A1; A2M
- Q&As
- Reviews
Q&As (26)
Ask a questionBesides its involvement in cancer and spinocerebellar ataxia, ANXA7 has also been implicated in other diseases and conditions. It has been associated with diabetes, where altered ANXA7 expression or function may contribute to insulin resistance and impaired glucose metabolism. ANXA7 dysregulation has also been observed in neurodegenerative diseases like Alzheimer's and Parkinson's.
Yes, ANXA7 can undergo several post-translational modifications, including phosphorylation, acetylation, and sumoylation. These modifications can affect its stability, subcellular localization, and protein-protein interactions. Phosphorylation, in particular, has been implicated in the regulation of ANXA7 function and its involvement in various cellular processes.
Although there are no specific drugs targeting ANXA7 currently available, identifying small molecules or compounds that can modulate ANXA7 activity or stability may have therapeutic implications in diseases where ANXA7 dysregulation is involved.
Yes, ANXA7 has been shown to regulate calcium signaling by interacting with proteins involved in calcium transport and release. It can modulate intracellular calcium levels and contribute to cellular responses dependent on calcium signaling.
ANXA7 can interact with phospholipids, calcium, and other proteins to help regulate membrane dynamics, lipid metabolism, and vesicular transport.
ANXA7 interacts with a variety of proteins involved in different cellular processes. Some of its known interacting partners include proteins involved in calcium signaling, such as inositol triphosphate receptor (IP3R) and S100 proteins. ANXA7 also interacts with proteins involved in exocytosis and vesicle trafficking, such as synaptotagmin and various Rab GTPases. Additionally, ANXA7 can interact with components of the cell cycle machinery and other regulatory proteins.
ANXA7 has been implicated in multiple pathways, including Wnt/β-catenin signaling, PI3K/Akt signaling, and cellular calcium homeostasis.
Yes, ANXA7 has several isoforms resulting from alternative splicing. These isoforms can have different subcellular localizations and may play distinct roles in cellular processes.
ANXA7 has been found in diverse subcellular compartments, including the cytoplasm, nucleus, plasma membrane, and intracellular vesicles. Its distribution can vary depending on cell type and specific cellular processes. For example, in neurons, ANXA7 has been observed in synaptic terminals and dendritic spines.
Yes, ANXA7 has been shown to modulate the activity of certain ion channels. It can interact with and regulate the function of calcium channels, such as the inositol triphosphate receptor (IP3R) and voltage-gated calcium channels (VGCCs). ANXA7 can also modulate the activity of potassium channels, including the inwardly rectifying potassium channel Kir6.2.
ANXA7 has been associated with several diseases, including cancer, cardiovascular disorders, and neurological conditions. Altered expression or mutations in the ANXA7 gene may contribute to the development and progression of these diseases.
Yes, certain genetic mutations in ANXA7 have been associated with disease. For example, a repeat expansion in the exon 4 region of ANXA7 has been linked to spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder characterized by progressive loss of coordination and balance. Other genetic mutations in ANXA7 have been reported in various cancer types, although more research is needed to fully understand their functional significance.
Yes, ANXA7 has been implicated in immune cell function. It has been shown to regulate lymphocyte activation, T cell receptor signaling, and the release of immune mediators, such as cytokines. ANXA7 can also modulate macrophage polarization and phagocytosis. Its involvement in immune cell function suggests a potential role in immune responses and inflammatory processes.
Yes, ANXA7 expression can be regulated by microRNAs (miRNAs). Several miRNAs have been identified that can target the ANXA7 mRNA and suppress its translation or induce mRNA degradation. The dysregulation of these miRNAs can lead to altered expression levels of ANXA7.
While ANXA7 is primarily intracellular, there is evidence to suggest that it can be secreted in certain cellular contexts. Extracellular ANXA7 may have immunomodulatory functions, but further research is needed to fully understand its extracellular roles.
There is emerging evidence suggesting that ANXA7 may play a role in membrane repair mechanisms. It has been implicated in repairing plasma membrane disruptions caused by mechanical stress or pore-forming toxins. ANXA7 interaction with intracellular membranes, calcium-dependent processes, and cytoskeletal elements may contribute to its involvement in membrane repair.
Yes, ANXA7 can interact with several proteins involved in various cellular processes, including S100 proteins, protein kinases (PKC, Akt), ion channels (TRPV5, TRPV6), and components of the exocyst complex.
Yes, ANXA7 can be regulated by intracellular calcium levels. Changes in calcium concentrations can modulate ANXA7 binding to phospholipids and its interactions with other proteins. ANXA7 has been proposed to act as a calcium sensor that can translocate to specific cellular compartments in response to calcium signals.
ANXA7 alterations have been proposed as potential diagnostic and prognostic markers in certain cancers. Furthermore, the restoration of ANXA7 expression or its manipulation as a therapeutic target is being explored in preclinical studies.
Yes, ANXA7 has been implicated in the regulation of apoptosis, particularly through interactions with Bcl-2 family proteins and the modulation of calcium signaling within cells.
Yes, mutations in the ANXA7 gene have been linked to a rare autosomal dominant form of spinocerebellar ataxia, a neurological disorder characterized by progressive degeneration of the cerebellum.
ANXA7 has shown potential as a diagnostic or prognostic biomarker for various cancers. Altered expression levels of ANXA7 have been observed in several cancer types, and its downregulation or loss of expression has been associated with poorer prognosis and aggressive tumor behavior. However, further studies are needed to validate its utility as a biomarker and determine its clinical applicability.
ANXA7 has been shown to interact with proteins involved in vesicle trafficking and exocytosis, such as synaptotagmin. It can modulate the fusion of synaptic vesicles with the plasma membrane, thus regulating neurotransmitter release. ANXA7 may also play a role in recycling and reformation of synaptic vesicles.
ANXA7 has been implicated in tumor suppression through multiple mechanisms. It can inhibit cell proliferation by regulating the cell cycle and inducing cell cycle arrest. ANXA7 can also promote apoptosis by enhancing the activation of pro-apoptotic factors or suppressing anti-apoptotic factors. Additionally, ANXA7 can regulate cell adhesion, migration, and invasion by interacting with proteins involved in cytoskeletal organization and cell signaling pathways.
ANXA7 has been implicated in synaptic plasticity, neurotransmitter release, and neuronal survival. It interacts with proteins involved in synaptic vesicle trafficking and calcium signaling, suggesting its involvement in neuronal function.
Targeting ANXA7 holds therapeutic potential for various diseases. In cancer, strategies aimed at restoring or enhancing ANXA7 expression or function could potentially inhibit tumor growth and metastasis. Therapeutic approaches targeting ANXA7 could also be explored for neurodegenerative diseases, diabetes, and other conditions where ANXA7 dysregulation is implicated. However, more research is needed to develop specific and effective therapeutic strategies targeting ANXA7.
Customer Reviews (5)
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Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments. -
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This flexibility enables researchers like myself to tailor ANXA7 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results. -
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