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  • Official Full Name

    annexin A7

  • Overview

    Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.
  • Synonyms

    ANXA7; annexin A7; ANX7; SNX; Synexin; annexin-7; annexin VII;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • T7
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANXA7-7106H Recombinant Human ANXA7, His-tagged E.coli His 1-466aa
Human ANXA7-5540H Recombinant Human Annexin A7, His-tagged His
Human ANXA7-9700H Recombinant Human ANXA7, GST-tagged E.coli GST 236-466a.a.
Human ANXA7-637H Recombinant Human ANXA7 protein, GST-tagged Wheat Germ GST
Human ANXA7-27324TH Recombinant Human ANXA7, T7 -tagged E.coli T7
Human ANXA7-68H Recombinant Human Annexin A7, T7-tagged E.coli T7
Human ANXA7-8827HCL Recombinant Human ANXA7 293 Cell Lysate HEK293 N/A
Human ANXA7-8826HCL Recombinant Human ANXA7 293 Cell Lysate HEK293 N/A
Human ANXA7-0424H Recombinant Human ANXA7 Protein (Met1-Gln466), Tag Free E.coli Tag Free Met1-Gln466
Human ANXA7-2023H Recombinant Human ANXA7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANXA7-172H Recombinant Human ANXA7 Protein, His-tagged E.coli N-His Met1-Lys309
Human ANXA7-0425H Recombinant Human ANXA7 Protein (Met1-Lys287), N-His-tagged E.coli N-His Met1-Lys287
Human ANXA7-1046HF Recombinant Full Length Human ANXA7 Protein, GST-tagged In Vitro Cell Free System GST 488 amino acids
Human ANXA7-005H Recombinant Human ANXA7 Protein, N-His-tagged E.coli N-His 488
Mouse ANXA7-1719M Recombinant Mouse ANXA7 Protein Mammalian Cell His
Mouse ANXA7-586M Recombinant Mouse ANXA7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Anxa7-610M Recombinant Mouse Anxa7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ANXA7-586M-B Recombinant Mouse ANXA7 Protein Pre-coupled Magnetic Beads HEK293
Mouse Anxa7-173M Recombinant Mouse Anxa7 Protein, His-tagged E.coli N-His Met1-Arg309
Cynomolgus Monkey ANXA7-299C Recombinant Cynomolgus ANXA7 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey ANXA7-49C-B Recombinant Cynomolgus Monkey ANXA7 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey ANXA7-49C Recombinant Cynomolgus Monkey ANXA7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ANXA7-340R Recombinant Rhesus monkey ANXA7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ANXA7-168R-B Recombinant Rhesus Macaque ANXA7 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque ANXA7-168R Recombinant Rhesus Macaque ANXA7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken ANXA7-4766C Recombinant Chicken ANXA7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

ANXA7 involved in several pathways and played different roles in them. We selected most pathways ANXA7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ANXA7 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipid binding, calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA7 itself. We selected most functions ANXA7 had, and list some proteins which have the same functions with ANXA7. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCLO;CAPN11;SPOCK1;CDH23;EGFL7;ELTD1;PCDH2AB5;MMP1A;DSG1A
calcium-dependent phospholipid bindingANXA6;CPNE1;SYT9;ANXA9;SYTL1;RPH3A;CPNE3;ANXA3B;ANXA11A
calcium-dependent protein bindingCHP1;A2M;MMP13;RBM22;ANXA4;RAC3;VPS37B;C9orf9;SNAP25
protein bindingTGM1;TWIST2;PIP5K1C;PPP1R2P3;TSC1;SCYL3;ELP4;TRPC7;NUP54

ANXA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA7.

SRI; PDCD6; PAX8; q81y32_bacan; DYNC1I1; DVL1; GNB5; ANGPT2; MPPED1; GDF9; NMT2; TAF5L; ACTL6B; CPNE6; DDAH2; F13A1; A2M

  • Q&As
  • Reviews

Q&As (26)

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Is ANXA7 associated with any other diseases or conditions? 03/31/2023

Besides its involvement in cancer and spinocerebellar ataxia, ANXA7 has also been implicated in other diseases and conditions. It has been associated with diabetes, where altered ANXA7 expression or function may contribute to insulin resistance and impaired glucose metabolism. ANXA7 dysregulation has also been observed in neurodegenerative diseases like Alzheimer's and Parkinson's.

Are there any known post-translational modifications of ANXA7? 03/25/2023

Yes, ANXA7 can undergo several post-translational modifications, including phosphorylation, acetylation, and sumoylation. These modifications can affect its stability, subcellular localization, and protein-protein interactions. Phosphorylation, in particular, has been implicated in the regulation of ANXA7 function and its involvement in various cellular processes.

Are there any therapeutic implications or potential drugs targeting ANXA7? 12/16/2022

Although there are no specific drugs targeting ANXA7 currently available, identifying small molecules or compounds that can modulate ANXA7 activity or stability may have therapeutic implications in diseases where ANXA7 dysregulation is involved.

Can ANXA7 be involved in calcium homeostasis? 11/30/2022

Yes, ANXA7 has been shown to regulate calcium signaling by interacting with proteins involved in calcium transport and release. It can modulate intracellular calcium levels and contribute to cellular responses dependent on calcium signaling.

How does ANXA7 contribute to membrane organization? 07/28/2022

ANXA7 can interact with phospholipids, calcium, and other proteins to help regulate membrane dynamics, lipid metabolism, and vesicular transport.

Are there any known interacting partners of ANXA7? 07/15/2022

ANXA7 interacts with a variety of proteins involved in different cellular processes. Some of its known interacting partners include proteins involved in calcium signaling, such as inositol triphosphate receptor (IP3R) and S100 proteins. ANXA7 also interacts with proteins involved in exocytosis and vesicle trafficking, such as synaptotagmin and various Rab GTPases. Additionally, ANXA7 can interact with components of the cell cycle machinery and other regulatory proteins.

Is ANXA7 involved in any specific cellular pathways? 05/09/2022

ANXA7 has been implicated in multiple pathways, including Wnt/β-catenin signaling, PI3K/Akt signaling, and cellular calcium homeostasis.

Does ANXA7 have any isoforms? 04/02/2022

Yes, ANXA7 has several isoforms resulting from alternative splicing. These isoforms can have different subcellular localizations and may play distinct roles in cellular processes.

Is ANXA7 localized to specific cellular compartments? 03/28/2022

ANXA7 has been found in diverse subcellular compartments, including the cytoplasm, nucleus, plasma membrane, and intracellular vesicles. Its distribution can vary depending on cell type and specific cellular processes. For example, in neurons, ANXA7 has been observed in synaptic terminals and dendritic spines.

Can ANXA7 affect the activity of ion channels? 11/18/2021

Yes, ANXA7 has been shown to modulate the activity of certain ion channels. It can interact with and regulate the function of calcium channels, such as the inositol triphosphate receptor (IP3R) and voltage-gated calcium channels (VGCCs). ANXA7 can also modulate the activity of potassium channels, including the inwardly rectifying potassium channel Kir6.2.

Does ANXA7 have any clinical significance? 09/23/2021

ANXA7 has been associated with several diseases, including cancer, cardiovascular disorders, and neurological conditions. Altered expression or mutations in the ANXA7 gene may contribute to the development and progression of these diseases.

Are there any known genetic mutations in ANXA7 associated with disease? 06/19/2021

Yes, certain genetic mutations in ANXA7 have been associated with disease. For example, a repeat expansion in the exon 4 region of ANXA7 has been linked to spinocerebellar ataxia type 1 (SCA1), a neurodegenerative disorder characterized by progressive loss of coordination and balance. Other genetic mutations in ANXA7 have been reported in various cancer types, although more research is needed to fully understand their functional significance.

Is ANXA7 involved in immune cell function? 02/20/2021

Yes, ANXA7 has been implicated in immune cell function. It has been shown to regulate lymphocyte activation, T cell receptor signaling, and the release of immune mediators, such as cytokines. ANXA7 can also modulate macrophage polarization and phagocytosis. Its involvement in immune cell function suggests a potential role in immune responses and inflammatory processes.

Can ANXA7 be regulated by microRNAs? 10/04/2020

Yes, ANXA7 expression can be regulated by microRNAs (miRNAs). Several miRNAs have been identified that can target the ANXA7 mRNA and suppress its translation or induce mRNA degradation. The dysregulation of these miRNAs can lead to altered expression levels of ANXA7.

Can ANXA7 be secreted from cells? 09/18/2019

While ANXA7 is primarily intracellular, there is evidence to suggest that it can be secreted in certain cellular contexts. Extracellular ANXA7 may have immunomodulatory functions, but further research is needed to fully understand its extracellular roles.

Is ANXA7 involved in membrane repair mechanisms? 09/17/2019

There is emerging evidence suggesting that ANXA7 may play a role in membrane repair mechanisms. It has been implicated in repairing plasma membrane disruptions caused by mechanical stress or pore-forming toxins. ANXA7 interaction with intracellular membranes, calcium-dependent processes, and cytoskeletal elements may contribute to its involvement in membrane repair.

Are there any known ANXA7 protein interactors? 05/17/2019

Yes, ANXA7 can interact with several proteins involved in various cellular processes, including S100 proteins, protein kinases (PKC, Akt), ion channels (TRPV5, TRPV6), and components of the exocyst complex.

Can ANXA7 be regulated by intracellular calcium levels? 05/14/2019

Yes, ANXA7 can be regulated by intracellular calcium levels. Changes in calcium concentrations can modulate ANXA7 binding to phospholipids and its interactions with other proteins. ANXA7 has been proposed to act as a calcium sensor that can translocate to specific cellular compartments in response to calcium signals.

Can ANXA7 be used as a diagnostic marker or therapeutic target in cancer? 12/15/2018

ANXA7 alterations have been proposed as potential diagnostic and prognostic markers in certain cancers. Furthermore, the restoration of ANXA7 expression or its manipulation as a therapeutic target is being explored in preclinical studies.

Can ANXA7 regulate apoptosis? 10/29/2018

Yes, ANXA7 has been implicated in the regulation of apoptosis, particularly through interactions with Bcl-2 family proteins and the modulation of calcium signaling within cells.

Are there any genetic diseases associated with ANXA7 mutations? 09/10/2018

Yes, mutations in the ANXA7 gene have been linked to a rare autosomal dominant form of spinocerebellar ataxia, a neurological disorder characterized by progressive degeneration of the cerebellum.

Can ANXA7 be used as a diagnostic or prognostic biomarker for cancer? 12/24/2017

ANXA7 has shown potential as a diagnostic or prognostic biomarker for various cancers. Altered expression levels of ANXA7 have been observed in several cancer types, and its downregulation or loss of expression has been associated with poorer prognosis and aggressive tumor behavior. However, further studies are needed to validate its utility as a biomarker and determine its clinical applicability.

How is ANXA7 involved in exocytosis and neurotransmitter release? 03/23/2017

ANXA7 has been shown to interact with proteins involved in vesicle trafficking and exocytosis, such as synaptotagmin. It can modulate the fusion of synaptic vesicles with the plasma membrane, thus regulating neurotransmitter release. ANXA7 may also play a role in recycling and reformation of synaptic vesicles.

What are the potential mechanisms by which ANXA7 exerts its tumor suppressive functions? 10/04/2016

ANXA7 has been implicated in tumor suppression through multiple mechanisms. It can inhibit cell proliferation by regulating the cell cycle and inducing cell cycle arrest. ANXA7 can also promote apoptosis by enhancing the activation of pro-apoptotic factors or suppressing anti-apoptotic factors. Additionally, ANXA7 can regulate cell adhesion, migration, and invasion by interacting with proteins involved in cytoskeletal organization and cell signaling pathways.

Does ANXA7 have any physiological roles in the nervous system? 05/21/2016

ANXA7 has been implicated in synaptic plasticity, neurotransmitter release, and neuronal survival. It interacts with proteins involved in synaptic vesicle trafficking and calcium signaling, suggesting its involvement in neuronal function.

Are there any therapeutic implications of targeting ANXA7? 04/24/2016

Targeting ANXA7 holds therapeutic potential for various diseases. In cancer, strategies aimed at restoring or enhancing ANXA7 expression or function could potentially inhibit tumor growth and metastasis. Therapeutic approaches targeting ANXA7 could also be explored for neurodegenerative diseases, diabetes, and other conditions where ANXA7 dysregulation is implicated. However, more research is needed to develop specific and effective therapeutic strategies targeting ANXA7.

Customer Reviews (5)

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    Its purity, integrity, and consistency ensure reliable and reproducible results, which are essential for meaningful scientific discoveries.


      Their in-depth understanding of the protein's characteristics, applications, and potential limitations allows for valuable insights and recommendations, ensuring the success of my experiments.


        Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.


          This flexibility enables researchers like myself to tailor ANXA7 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.


            Whether it's troubleshooting, protocol optimization, or general inquiries, their knowledgeable and responsive team is readily available to assist and solve any problems that may arise during the experimental process.

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