anxa1
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  • Official Full Name
  • annexin A1
  • Background
  • Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ANXA1; annexin A1; ANX1; LPC1; p35; annexin-1; calpactin-2; calpactin II; lipocortin I; chromobindin-9; annexin I (lipocortin I); phospholipase A2 inhibitory protein;
Cat.#:Anxa1-1122MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Anxa1 Protein, His-tagged
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Cat.#:Anxa1-1713MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Anxa1 Protein, His-tagged
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Cat.#:Anxa1-1714MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Anxa1 Protein, His-tagged
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Cat.#:ANXA1-133PTag:His
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig ANXA1 Protein, His-tagged
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Cat.#:ANXA1-26347THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA1, His-tagged
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Cat.#:ANXA1-26594THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA1
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Cat.#:ANXA1-33HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA1 protein, His-tagged
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Cat.#:ANXA1-627HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ANXA1 protein, GST-tagged
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Cat.#:ANXA1-9159HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA1 protein
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Cat.#:ANXA1-1710MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ANXA1 Protein
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Cat.#:Anxa1-1712MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Anxa1 protein, His/S-tagged
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Cat.#:Anxa1-1345RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Anxa1 protein, His & S-tagged
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Cat.#:ANXA1-688RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ANXA1 Protein
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Cat.#:ANXA1-1346RTag:His/S
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit ANXA1 protein, His & S-tagged
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Cat.#:ANXA1-1347RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit ANXA1 protein, His-tagged
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Cat.#:ANXA1-7094CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ANXA1
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Cat.#:ANXA1-1344PTag:His/S
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig ANXA1 protein, His & S-tagged
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Cat.#:ANXA1-3491CTag:His
Source (Host):Mammalian CellsSpecies:Guinea pig
Product nameRecombinant Cavia cutleri (Guinea pig) ANXA1, His-tagged
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Cat.#:ANXA1-3492CTag:His/S
Source (Host):E. coliSpecies:Guinea pig
Product nameRecombinant Cavia (Guinea pig) ANXA1, His-tagged, S tagged
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Cat.#:ANXA1-5257HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Annexin A1, His-tagged
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Cat.#:ANXA1-5277HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Annexin A1, T7-tagged
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Cat.#:ANXA1-504HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human annexin A1
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Cat.#:ANXA1-8839HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ANXA1 293 Cell Lysate
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Involved Pathway

ANXA1 involved in several pathways and played different roles in them. We selected most pathways ANXA1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Class A/1 (Rhodopsin-like receptors)
RLN3A; CCL35.2; AMCF-II; GPR77; GPR65; HCAR1-2; ADRB1; S1PR1; CYSLTR1; RLN2
Formyl peptide receptors bind formyl peptides and many other ligands
FPR-RS4; FPR-RS6; FPR-RS3; HEBP1; ANXA1
G alpha (i) signalling events
OXGR1A.2; PYY; GPR55A; S1PR3; S1PR5B; SOUL3; CCR7; OXGR1; CXCL13; ANXA1A
G alpha (q) signalling events
OPN4.1; TRPC7; PROKR2; NTS; TAC1; PROKR1; CCK; TAE1; NMBA; NPFFR2
GPCR downstream signaling
CNR1; GCGA; ARHGEF18; AGT; CCL35.2; TAC3; CHRM4; OR4D2; ARHGEF1B; SOUL3
GPCR ligand binding
CYSLTR1; HCAR1-2; SETD6; ACKR4; GNB5B; EMR4; OPN4B; SSTR2; ADORA2A; OXER1
Gastrin-CREB signalling pathway via PKC and MAPK
FPR-RS4; ABHD12; DGKA; DGKB; TRIO; ABHD6B; PROK1; OPN4.1; GPR4; EDN1
Integrated Breast Cancer Pathway
CYP19A1; USP15; USP16; AHR; C21orf7; ZMIZ1; GRN; LGALS13; GDI1; DAG1

Protein Function

ANXA1 has several biochemical functions, for example, annealing helicase activity, calcium ion binding, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA1 itself. We selected most functions ANXA1 had, and list some proteins which have the same functions with ANXA1. You can find most of the proteins on our site.
Function
Related Protein
Function annealing helicase activity
Related Protein ANXA1; BLM; ZRANB3; RECQL4; SMARCAL1; RAD54L; RECQL
Function calcium ion binding
Related Protein EDEM2; TTN; CALUB; PRKCSH; DSG3; LTBP4; PCDH1G11; PLA2G1B; KCNIP3; DOC2B
Function calcium-dependent phospholipid binding
Related Protein ANXA1; TC2N; SYT9; SYT12; ANXA13; PCLO; SYT2; ANXA1A; ANXA2B; SYT5
Function calcium-dependent protein binding
Related Protein S100PBP; VLDLR; MBL2; CCDC167; CALM2; CHP; STMN2; CLEC4M; ANXA7; TNNT3
Function double-stranded DNA-dependent ATPase activity
Related Protein ANXA1
Function helicase activity
Related Protein SMARCAD1; EP400; PL10; CHD1L; HLTF; GTF2F2B; RTEL1; CHD6; HELZ2; TDRD9
Function phospholipase A2 inhibitor activity
Related Protein ANXA2; CC10; ANXA3; ANXA1
Function phospholipid binding
Related Protein WDFY4; SHC1; PSD4; OSBPL1A; ANXA9; NSMAF; APOM; NUP35; MTAP1B; SPTBN1
Function protein binding
Related Protein NUBP2; RAB3B; MORN2; MYOCD; ERC1; MED18; ORAI2; SIKE1; CALU; FAM53C
Function protein binding, bridging
Related Protein FSCN2; DDX20; CAV1; ANK2; FGG; FRMD4A; IVL; DSP; STX1A; SH2D1B
Function protein homodimerization activity
Related Protein GPD1; PDCD6IP; PDGFA; HNF1A; TKT; SLC30A8; MYH7; GIMAP7; FGFR1OP2; TYR
Function receptor binding
Related Protein FGG; PGR; ANGPTL2; ITGA1; PTK6B; UFD1L; PTK2B; CCDC129; PTK6; PSPN
Function single-stranded DNA binding
Related Protein HNRNPK; XPC; SSBP4; C10orf2; CTC1; POLR2GL; NABP2; MCM6; SSBP2; MCM10
Function single-stranded RNA binding
Related Protein STRBP; SNRPC; EIF2C3; LSM14A; DDX58; NXF1; A1CF; CBX4; TLR8; JMJD6
Function structural molecule activity
Related Protein KRT71; KRT72-PS; NPHP1; INAA; LCE1D; CLDN3; MATR3; KRTAP11-1; LAMA3; COL15A1B

Interacting Protein

ANXA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA1.
EGFR; RIPK1; IKBKG; STK4; PPM1B; NFKBIA; ACTB

ANXA1 Related Articles

Belvedere, R; Bizzarro, V; et al. Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells. BMC CANCER 14:-(2014).
Wang, WL; Guan, SL; et al. Detection of circulating antibodies to linear peptide antigens derived from ANXA1 and DDX53 in lung cancer. TUMOR BIOLOGY 35:4901-4905(2014).