• Official Full Name

    annexin A1

  • Background

    Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008]
  • Synonyms

    ANXA1; annexin A1; ANX1; LPC1; p35; annexin-1; calpactin-2; calpactin II; lipocortin I; chromobindin-9; annexin I (lipocortin I); phospholipase A2 inhibitory protein;
    • Type:
    • Recombinant Proteins
    • Antibody
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Guinea pig
    • Human
    • Mouse
    • Pig
    • Rabbit
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • C
    • Avi
    • 6His
    • GST
    • His
    • His (Fc)
    • His\Avi
    • His|S
    • Myc
    • DDK
    • MYC
    • N/A
    • N
    • T7
    • Tag Free
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken ANXA1-7094C Recombinant Chicken ANXA1 Mammalian Cell His
    Guinea pig ANXA1-3491C Recombinant Cavia cutleri (Guinea pig) ANXA1, His-tagged E.Coli or Yeast His
    Guinea pig ANXA1-3492C Recombinant Cavia (Guinea pig) ANXA1, His-tagged, S tagged E.coli His/S
    Human ANXA1-627H Recombinant Human ANXA1 protein, GST-tagged Wheat Germ GST
    Human ANXA1-26348TH Recombinant Human ANXA1 N/A
    Human ANXA1-504H Recombinant Human annexin A1 E.coli N/A
    Human ANXA1-0553H Recombinant Human ANXA1 Protein (Met1-Asn346), N-His-tagged E.coli N-His
    Human ANXA1-004H Recombinant Human ANXA1 Protein E.coli
    Human ANXA1-8839HCL Recombinant Human ANXA1 293 Cell Lysate HEK293 N/A
    Human ANXA1-5277H Recombinant Human Annexin A1, T7-tagged E.coli T7
    Human ANXA1-5257H Recombinant Human ANXA1 protein, His-tagged E.coli His
    Human ANXA1-342H-B Recombinant Human ANXA1 Protein Pre-coupled Magnetic Beads HEK293
    Human ANXA1-26347TH Recombinant Human ANXA1, His-tagged E.coli His
    Human ANXA1-33H Active Recombinant Human ANXA1 protein, His-tagged E.coli His
    Human ANXA1-26594TH Recombinant Human ANXA1 E.coli N/A
    Human ANXA1-342H Recombinant Human ANXA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human ANXA1-9159H Recombinant Human ANXA1 protein E.coli His
    Human ANXA1-0552H Recombinant Human ANXA1 Protein (Ala2-Asn346), Tag Free E.coli Tag Free
    Human ANXA1-001H Recombinant Human ANXA1 Protein, His-tagged E.coli His
    Human ANXA1-1725H Recombinant Human ANXA1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ANXA1-40H Recombinant Human ANXA1 Protein, C-Avi&6His tagged, Biotinylated E.coli C-Avi&6His
    Human ANXA1-213H Recombinant Human ANXA1 Protein, His\Avi-tagged E.coli His\Avi
    Mouse Anxa1-1713M Recombinant Mouse Anxa1 Protein, His-tagged E.coli His
    Mouse ANXA1-1710M Recombinant Mouse ANXA1 Protein Mammalian Cell His
    Mouse ANXA1-578M-B Recombinant Mouse ANXA1 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Anxa1-1712M Recombinant Mouse Anxa1 protein, His/S-tagged E.coli His/S
    Mouse Anxa1-1714M Recombinant Mouse Anxa1 Protein, His-tagged Yeast His
    Mouse Anxa1-1122M Recombinant Mouse Anxa1 Protein, His-tagged E.coli His
    Mouse Anxa1-7269M Recombinant Mouse Anxa1 Protein, His-tagged E.coli His
    Mouse Anxa1-1334M Recombinant Mouse Anxa1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse ANXA1-578M Recombinant Mouse ANXA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Pig ANXA1-133P Recombinant Pig ANXA1 Protein, His-tagged E.coli His
    Pig ANXA1-1344P Recombinant Pig ANXA1 protein, His & S-tagged E.coli His/S
    Rabbit ANXA1-1346R Recombinant Rabbit ANXA1 protein, His & S-tagged E.coli His/S
    Rabbit ANXA1-1347R Recombinant Rabbit ANXA1 protein, His-tagged E.coli His
    Rat ANXA1-688R Recombinant Rat ANXA1 Protein Mammalian Cell His
    Rat ANXA1-344R Recombinant Rat ANXA1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat ANXA1-344R-B Recombinant Rat ANXA1 Protein Pre-coupled Magnetic Beads HEK293
    Rat Anxa1-1345R Recombinant Rat Anxa1 protein, His & S-tagged E.coli His/S
    Rat Anxa1-161R Recombinant Rat Anxa1 Protein, His-tagged E.coli N-His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • ANXA1 Related Articles

    ANXA1 involved in several pathways and played different roles in them. We selected most pathways ANXA1 participated on our site, such as Class A/1 (Rhodopsin-like receptors), Formyl peptide receptors bind formyl peptides and many other ligands, G alpha (i) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class A/1 (Rhodopsin-like receptors)RHOL;GPR37B;SSTR5;OPN1SW1;ADRA1B;OXGR1A.3;OPN1LW;KISS1;INSL3
    Formyl peptide receptors bind formyl peptides and many other ligandsHEBP1;FPR-RS6;FPR-RS4;ANXA1;FPR-RS3
    G alpha (i) signalling eventsRGR;RGS1;HCAR1-2;CCR1;CXCL11.8;CASR;PTGDR2;RGS21;TAS2R13
    G alpha (q) signalling eventsOXTRL;TAC2;EDNRA;GPR65;DGKB;PROK1;NMBB;ANXA1;CASR
    GPCR downstream signalingOR56A1;GPR4;ARHGEF1A;ANXA1;OR4D2;PTH2;UTS2;CALCRL;RAMP2
    Gastrin-CREB signalling pathway via PKC and MAPKFPR-RS3;DGKG;UTS2;OPN4;PRKCHB;TRIO;TRPC7;LPAR2A;TRPC6A
    Integrated Breast Cancer PathwayNOXA1;CYP19A1;PLK3;DAG1;ANXA1;C21orf7;JAKMIP1;SELK;ALKBH1

    ANXA1 has several biochemical functions, for example, annealing helicase activity, calcium ion binding, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA1 itself. We selected most functions ANXA1 had, and list some proteins which have the same functions with ANXA1. You can find most of the proteins on our site.

    Function Related Protein
    annealing helicase activitySMARCAL1;BLM;ANXA1;RECQL4;RAD54L;RECQL;ZRANB3
    calcium ion bindingFSTL5;PITPNM2;EFHC1;MMP11;PLA2G12A;PCDH2G9;MMP3;EFCAB12;PCDHB11
    calcium-dependent phospholipid bindingTC2N;ANXA6;SYTL1;SYT5B;SYTL3;DOC2B;ANXA5;AP1S2;SYT9B
    calcium-dependent protein bindingKOP;SNAP25;STMN2;PDCD6IP;SELP;CCDC167;VPS37C;CLEC4M;NRXN1
    double-stranded DNA-dependent ATPase activity
    phospholipase A2 inhibitor activityANXA1;ANXA3;ANXA2;CC10
    phospholipid bindingNBEA;SPTB;PTAFR;PLA2G2A;LRBA;GLTPD1;PON1;APOA1;APOC3
    protein bindingCALCOCO1;PRKAB1;RUNX1T1;TEX13A;EVL;STX2;ABI1;TCF12;NOC2L
    protein binding, bridgingFLRT2;CRADD;FLRT1;FGG;FSCN1A;ST13;NMD3;TCAP;FSCN2B
    protein homodimerization activityHINT2;TGFB1;ASNSD1;GJC3;GYS2;ASGR1;RPE;CD8A;BOKA
    receptor bindingH2-Q10;FGG;NPPC;Fert2;PLG;PPY;RCHY1;IDUA;TNFSF10
    single-stranded DNA bindingTREX1;MCM10;LUZP4;DMC1;SETMAR;DDX11;RBMS1;PMS1;SSBP3
    single-stranded RNA bindingENDOV;LSM14A;CBX6;ANXA1;TLR7;AGO1;TLR8;HMGB1;JMJD6
    structural molecule activityKRT93;EVPL;CLDNI;KRT77;NEFLB;KRT4;KRT84;PRPH;IVL

    ANXA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA1.


    Belvedere, R; Bizzarro, V; et al. Role of intracellular and extracellular annexin A1 in migration and invasion of human pancreatic carcinoma cells. BMC CANCER 14:-(2014).
    Wang, WL; Guan, SL; et al. Detection of circulating antibodies to linear peptide antigens derived from ANXA1 and DDX53 in lung cancer. TUMOR BIOLOGY 35:4901-4905(2014).
    • Q&As
    • Reviews

    Q&As (13)

    Ask a question
    How is the expression of ANXA1 protein regulated? 04/29/2023

    The expression of ANXA1 protein can be regulated at the transcriptional and post-transcriptional levels. Transcriptional regulation involves the binding of transcription factors to specific regions of the ANXA1 gene promoter, which can either promote or inhibit its expression. Post-transcriptional regulation includes processes such as mRNA stability, alternative splicing, and microRNA-mediated regulation.

    What are the clinical implications of ANXA1 protein? 04/02/2023

    ANXA1 protein has been associated with various diseases and conditions. It has been found to play a role in cancer development and progression, inflammation-related disorders, cardiovascular diseases, and neurodegenerative diseases. It is also being investigated as a potential therapeutic target in these conditions.

    Can ANXA1 protein be secreted from cells? 02/23/2023

    Yes, ANXA1 can be secreted from cells. It is typically localized in the cytoplasm and can be translocated to the cell membrane in response to various stimuli. Upon activation, ANXA1 can undergo acetylation and be released from the cell, either as a free protein or associated with membrane-derived vesicles called exosomes.

    Is ANXA1 protein used as a diagnostic marker? 02/22/2023

    ANXA1 protein has been explored as a potential diagnostic marker for certain diseases. It has been studied as a biomarker for oral squamous cell carcinoma, breast cancer, and gastric cancer, among others. However, further research is needed to fully establish its diagnostic utility.

    What are the cellular functions of ANXA1 protein? 03/13/2022

    ANXA1 protein has diverse cellular functions. It is primarily known for its role in the resolution of inflammation. ANXA1 inhibits phospholipase A2 activity, leading to a decrease in prostaglandin and leukotriene synthesis, thereby suppressing inflammation. It also has anti-inflammatory effects by promoting neutrophil apoptosis and phagocytosis of apoptotic neutrophils by macrophages.

    Are there any drugs targeting ANXA1 protein? 08/06/2020

    Currently, there are no drugs specifically targeting ANXA1 protein approved for clinical use. However, ANXA1 has been considered as a potential target for the development of therapeutic agents. Various approaches have been explored, including the use of small molecule inhibitors, peptide analogs, and antibodies that can modulate ANXA1 function or its downstream signaling pathways. These strategies aim to exploit the role of ANXA1 in diseases such as inflammation, cancer, and cardiovascular disorders.

    What are the interacting partners of ANXA1 protein? 03/19/2020

    ANXA1 protein interacts with various proteins and molecules in the cell. Some of its interacting partners include actin, S100A11, S100A6, p11, p53, and integrins. These interactions are important for its cellular functions and signaling pathways.

    How is ANXA1 protein involved in cancer progression and metastasis? 12/29/2018

    ANXA1 protein has been implicated in cancer progression and metastasis through various mechanisms. It promotes tumor cell migration and invasion by modulating actin cytoskeletal dynamics and facilitating adhesion to extracellular matrix proteins. ANXA1 can also enhance tumor angiogenesis by promoting endothelial cell migration and tube formation.

    Are there any genetic mutations or polymorphisms associated with ANXA1 protein? 05/21/2018

    Yes, genetic mutations and polymorphisms in the ANXA1 gene have been reported in certain diseases, including certain types of cancer and autoimmune disorders. These genetic variations can affect the expression, structure, and function of the ANXA1 protein.

    How is ANXA1 protein regulated? 03/28/2018

    ANXA1 protein expression and activity can be regulated by various factors and signaling pathways. It can be upregulated by anti-inflammatory molecules, glucocorticoids, and certain growth factors. Conversely, it can be downregulated by pro-inflammatory cytokines and oxidative stress.

    Are there any diseases associated with ANXA1 protein dysfunction? 03/22/2018

    Dysregulation of ANXA1 protein has been implicated in several diseases. It has been associated with inflammation-related disorders such as asthma, inflammatory bowel disease, and rheumatoid arthritis. Alterations in ANXA1 expression and function have also been linked to cancer development, metastasis, and drug resistance. Additionally, ANXA1 dysfunction has been implicated in cardiovascular diseases, neurodegenerative disorders, and autoimmune diseases.

    Can ANXA1 protein be a therapeutic target? 04/17/2017

    ANXA1 protein is considered a potential therapeutic target due to its involvement in various disease processes. Targeting ANXA1 or its downstream signaling pathways could have therapeutic implications for inflammatory diseases, cancer treatment, and other disorders where its dysregulation is associated. However, more research is required to develop effective therapies targeting ANXA1.

    Are there any therapeutic implications of ANXA1 protein? 02/05/2017

    ANXA1 protein has potential therapeutic implications. It is being studied as a target for the development of anti-inflammatory drugs and cancer therapies. Additionally, ANXA1-based therapies, such as ANXA1 mimetics or ANXA1-derived peptides, are also being investigated for their therapeutic potential in various diseases and conditions. However, more research is needed in this area.

    Customer Reviews (4)

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      Its purity and reliability ensure reliable and reproducible results in a variety of research applications. -


        Its high quality greatly enhances the reliability and reproducibility of experimental data. -


          ANXA1 protein is known for its versatility and functionality, enabling researchers to explore various biological processes and molecular interactions. -


            Whether I need expertise in experimental optimization or troubleshooting, I can rely on the manufacturer's support to promptly address any concerns or queries. -

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