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  • Official Full Name

    annexin A2

  • Overview

    This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    ANXA2; annexin A2; ANX2ANX2L4; CAL1H; LPC2D; LIP2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36; LPC2; chromobindin 8; OTTHUMP00000163650; calpactin I heavy polypeptide;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E. coli
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANXA2-5278H Recombinant Human Annexin A2, His-tagged E.coli His
Human ANXA2-1846H Recombinant Human ANXA2 protein E.coli N/A Ser2-Asp339
Human ANXA2-1845H Recombinant Human Annexin A2, His-tagged E.coli His
Human ANXA2-9695H Recombinant Human ANXA2, GST-tagged E.coli GST 1-339a.a.
Human ANXA2-631H Recombinant Human ANXA2 protein, GST-tagged Wheat Germ GST
Human ANXA2-26598TH Recombinant Human ANXA2, His-tagged E.coli His
Human ANXA2-8833HCL Recombinant Human ANXA2 293 Cell Lysate HEK293 N/A
Human ANXA2-8834HCL Recombinant Human ANXA2 293 Cell Lysate HEK293 N/A
Human ANXA2-001H Active Recombinant Human ANXA2 Protein, His-tagged E.coli His
Human ANXA2-357H Recombinant Human ANXA2 Protein, Flag-tagged HEK293T Flag
Human ANXA2-0544H Recombinant Human ANXA2 Protein (Met1-Asp339), N-His-tagged E.coli N-His Met1-Asp339
Human ANXA2-4987H Recombinant Human ANXA2 protein, His-tagged HEK293 His 2-339aa
Human ANXA2-1086H Recombinant Human ANXA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANXA2-359H Recombinant Human ANXA2 Protein, Flag-tagged HEK293T Flag
Human ANXA2-356H Recombinant Human ANXA2 Protein, Flag-tagged HEK293T Flag
Human ANXA2-344H-B Recombinant Human ANXA2 Protein Pre-coupled Magnetic Beads HEK293
Human ANXA2-2516H Recombinant Human ANXA2 protein, His-SUMO-tagged E.coli His-SUMO 2-339aa
Human ANXA2-2515H Recombinant Human ANXA2 protein, His-SUMO-tagged E.coli His-SUMO 2-339aa
Human ANXA2-358H Recombinant Human ANXA2 Protein, Flag-tagged HEK293T Flag
Human ANXA2-163H Recombinant Human ANXA2 Protein, His-tagged E.coli N-His Met1-Asp339
Human ANXA2-2517H Recombinant Human ANXA2 protein, GST-tagged E.coli GST 2-339aa
Human ANXA2-1041HF Recombinant Full Length Human ANXA2 Protein, GST-tagged In Vitro Cell Free System GST 339 amino acids
Human ANXA2-6281H Recombinant Human ANXA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANXA2-591HFL Recombinant Full Length Human ANXA2 Protein, C-Flag-tagged Mammalian cells Flag
Human ANXA2-164H Recombinant Human ANXA2 Protein, His-tagged E.coli N-His Met1-Asp339
Human ANXA2-2583H Recombinant Human ANXA2 protein(111-210 aa), C-His-tagged E. coli C-His 111-210 aa
Human ANXA2-344H Recombinant Human ANXA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Anxa2-3495M Recombinant Mouse Anxa2 protein, His/T7-tagged E.coli His/T7 Val46~Glu181
Mouse Anxa2-3494M Recombinant Mouse Anxa2, His-tagged E.Coli or Yeast His 339
Mouse ANXA2-1714M Recombinant Mouse ANXA2 Protein Mammalian Cell His
Mouse ANXA2-582M-B Recombinant Mouse ANXA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Anxa2-742M Recombinant Mouse Anxa2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse ANXA2-582M Recombinant Mouse ANXA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ANXA2-689R Recombinant Rat ANXA2 Protein Mammalian Cell His
Rat ANXA2-345R Recombinant Rat ANXA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ANXA2-345R-B Recombinant Rat ANXA2 Protein Pre-coupled Magnetic Beads HEK293
Rat Anxa2-165R Recombinant Rat Anxa2 Protein, His-tagged E.coli N-His Asn41-Asp182
Chicken ANXA2-6903C Recombinant Chicken ANXA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ANXA2 Related Articles
  • ANXA2 Related Research Area

ANXA2 involved in several pathways and played different roles in them. We selected most pathways ANXA2 participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, Muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Dissolution of Fibrin ClotSERPINF2B;ANXA2A;HRG;SERPINB8;S100A10;ANXA2B;S100A10A;SERPINE2;S100A10B
Prostaglandin Synthesis and RegulationS100A10;CC10;S100A6;ANXA5;ANXA2;ANXA3;ANXA6;ANXA4

ANXA2 has several biochemical functions, for example, Rab GTPase binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA2 itself. We selected most functions ANXA2 had, and list some proteins which have the same functions with ANXA2. You can find most of the proteins on our site.

Function Related Protein
S100 protein bindingFGF1A;ATP2A2;S100A11;EZR;FGF1;AGER;DDX1;ANXA2;ANXA11
calcium-dependent phospholipid bindingANXA1;SYT5A;ANXA1A;SYT15;ANXA5;PLA2G4B;SYT1A;ANXA11A;SYT12
calcium-dependent protein bindingC9orf9;ANXA11;DDX5;CD209A;VLDLR;ANXA3;MMP13;PDCD6;SNAP25
cytoskeletal protein bindingRPH3AL;EPB41L5;DES;EZRA;PKD2;ABI1;CAPN2;FABP3;PTPN4A
phosphatidylinositol-4,5-bisphosphate bindingEXOC1;LDLRAP1;FAM123A;COMMD1;SNX21;SYTL2;SESTD1;KCNJ1;RS1
phospholipase A2 inhibitor activityANXA1;ANXA2;CC10;ANXA3
contributes_to receptor activator activity

ANXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA2.

PCSK9; MLH1; q99ib8-pro_0000045602; ns3_ns4a_hcvco

Canas, F; Simonin, L; et al. Annexin A2 autoantibodies in thrombosis and autoimmune diseases. THROMBOSIS RESEARCH 135:226-230(2015).
Chaudhary, P; Thamake, SI; et al. Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. BRITISH JOURNAL OF CANCER 111:2328-2341(2014).
  • Q&As
  • Reviews

Q&As (16)

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Is ANXA2 used as a biomarker or therapeutic target? 12/03/2022

ANXA2 has been investigated as a potential biomarker and therapeutic target in various diseases. Its overexpression or altered expression levels have been detected in certain cancers, making it a potential diagnostic or prognostic biomarker. In addition, ANXA2-targeted therapies, such as antibodies or small molecules, are being explored for cancer treatment, particularly in inhibiting tumor metastasis. However, further research is needed to fully establish its clinical utility as a biomarker or target.

What are the potential implications of ANXA2 in cardiovascular diseases? 10/18/2022

ANXA2 has been implicated in cardiovascular diseases, particularly in atherosclerosis and thrombosis. It can regulate processes such as platelet aggregation, coagulation, and inflammation, which are key factors in the development of cardiovascular diseases. ANXA2 has been found to interact with components of the clotting cascade and endothelial cells, suggesting its involvement in thrombus formation and vascular inflammation. Further research is needed to better understand its exact role and potential therapeutic implications in these diseases.

Can ANXA2 be used as a diagnostic or prognostic marker in cancer? 12/16/2021

ANXA2 expression levels have been investigated as potential diagnostic and prognostic markers in various types of cancer. Increased ANXA2 expression has been associated with poor prognosis and aggressiveness in several cancer types, including breast, lung, colorectal, and pancreatic cancer. Additionally, ANXA2 levels in patient samples, such as blood or tissue, can be measured and may provide valuable information for cancer diagnosis, prognosis, and treatment response. However, further validation and standardized protocols are needed before it can be widely implemented in clinical practice.

How is ANXA2 involved in cancer progression and metastasis? 10/24/2021

ANXA2 has been implicated in promoting cancer progression and metastasis. It can facilitate cell migration and invasion through its interaction with actin cytoskeleton and integrins, which are involved in adhesion and movement. ANXA2 also regulates the trafficking and localization of membrane receptors involved in metastasis, such as urokinase plasminogen activator receptor (uPAR) and matrix metalloproteinase-2 (MMP-2), facilitating the degradation of extracellular matrix and tumor cell invasion.

Are there any other functions or roles of ANXA2? 04/03/2021

Besides its known functions in membrane trafficking, cell adhesion, and migration, ANXA2 has been implicated in other processes. It has been suggested to have a role in DNA repair, cell proliferation, immune response regulation, and viral replication. Additional research is needed to fully understand the extent of ANXA2's functions in these areas.

Are there any known genetic mutations or alterations in the ANXA2 gene associated with diseases? 02/08/2021

Yes, there have been several genetic mutations and alterations in the ANXA2 gene that have been associated with various diseases. For example, mutations in the ANXA2 gene have been reported in a rare condition called type 2A congenital dysfibrinogenemia, which is characterized by abnormal clotting and bleeding tendencies. Additionally, alterations in the ANXA2 gene have been found in certain cancers, such as lung cancer and prostate cancer, although the exact implications of these alterations are still being explored.

What are the potential side effects of targeting ANXA2 for therapeutic purposes? 02/03/2021

As targeting ANXA2 is still in the early stages of development, the potential side effects of such therapies are not yet fully known. However, it is important to consider the possible off-target effects and unintended consequences of inhibiting ANXA2, as it plays multiple roles in various physiological processes. Additionally, careful consideration should be given to the delivery methods, dosages, and potential toxicities associated with any targeted therapies. Extensive preclinical and clinical studies are necessary to assess the safety and efficacy of ANXA2-targeted treatments.

Can ANXA2 be detected or measured in clinical settings? 11/23/2020

Yes, ANXA2 can be detected and measured in clinical settings. Various methods, such as enzyme-linked immunosorbent assays (ELISA) and immunohistochemistry (IHC), can be used to detect ANXA2 protein levels in patient samples, including blood, tissue, or other bodily fluids.

What other functions besides clotting and cell membrane organization does ANXA2 have? 01/11/2020

In addition to its roles in clotting and cell membrane organization, ANXA2 has been implicated in various cellular processes. It is involved in cell migration, invasion, and adhesion, playing a role in cancer metastasis. ANXA2 also plays a role in exocytosis, contributing to the release of certain molecules from cells. Furthermore, ANXA2 has been shown to participate in RNA processing and transcription regulation, suggesting its involvement in gene expression. It is important to note that these functions can vary depending on the cellular context and the specific binding partners of ANXA2.

Are there any diseases or conditions associated with ANXA2? 10/06/2019

ANXA2 has been implicated in several diseases and conditions. It has been associated with cancer progression and metastasis, as it plays a role in promoting cell migration, invasion, and angiogenesis. It is also involved in thrombosis and fibrinolysis disorders. Furthermore, ANXA2 has been linked to autoimmune diseases, neurodegenerative disorders, and viral infections.

Does ANXA2 have any known binding partners? 07/17/2019

Yes, ANXA2 interacts with different proteins to carry out its functions. It can bind to a variety of molecules including actin, S100 proteins, plasminogen, tissue-type plasminogen activator (tPA), and some receptors such as integrins and the LDL receptor-related protein 1 (LRP1).

Are there any genetic variations or mutations in ANXA2 associated with diseases? 02/26/2018

Yes, some genetic variations in the ANXA2 gene have been reported and associated with certain diseases. For example, single nucleotide polymorphisms (SNPs) in ANXA2 have been linked to an increased risk of developing Alzheimer's disease, while some mutations in ANXA2 have been found in patients with a rare autosomal-dominant form of amyotrophic lateral sclerosis (ALS).

Is ANXA2 involved in neurodegenerative diseases? 01/31/2017

ANXA2 has been implicated in neurodegenerative diseases, although its exact role is not yet fully understood. Studies have shown that ANXA2 is often upregulated in the brains of patients with Alzheimer's disease and Parkinson's disease, suggesting its involvement in the pathological processes of these conditions. ANXA2 may contribute to neuroinflammation, amyloid-beta deposition, and tau protein pathology, which are hallmarks of Alzheimer's disease. Further research is needed to better understand the specific mechanisms by which ANXA2 is involved in neurodegenerative diseases and its potential as a therapeutic target.

Are there any known interactions or partnerships between ANXA2 and other proteins? 05/27/2016

Yes, ANXA2 interacts with various proteins and molecules to carry out its functions. One of its well-known partnerships is with tissue plasminogen activator (tPA), a protein involved in the breakdown of blood clots. ANXA2 acts as a cofactor for tPA, facilitating its binding to plasminogen and enhancing its enzymatic activity. ANXA2 also interacts with other clotting factors, integrins, and extracellular matrix proteins. Additionally, ANXA2 has been found to interact with viral proteins, such as those from HIV, influenza A virus, and SARS-CoV-2 (the virus causing COVID-19), suggesting its involvement in viral entry and infection.

Can ANXA2 be used as a therapeutic target for cancer or other diseases? 03/12/2016

ANXA2 is being explored as a potential therapeutic target for cancer due to its involvement in tumor progression and metastasis. Several approaches have been investigated, including the use of ANXA2-targeted antibodies, peptides, or small molecules to inhibit its function. However, more research is needed to determine the efficacy and safety of these targeting strategies.

Are there any drugs or therapies that target ANXA2? 01/01/2016

While there are no specific drugs targeting ANXA2 currently approved for clinical use, research is ongoing to develop targeted therapies. Some studies have explored the use of ANXA2-targeting agents, such as monoclonal antibodies or small molecule inhibitors, to disrupt its function and potentially inhibit cancer progression or metastasis. However, more research and clinical trials are needed to determine their efficacy and safety.

Customer Reviews (4)

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    The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.


      Their team of technical experts possess deep knowledge and expertise regarding the protein, ensuring that researchers receive accurate and timely assistance.


        Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the ANXA2 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.


          They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the ANXA2 protein.

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