ANXA2 Protein

ANXA2

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ANXA2

Official Full Name annexin A2
Background This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms ANXA2; annexin A2; ANX2ANX2L4; CAL1H; LPC2D; LIP2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36; LPC2; chromobindin 8; OTTHUMP00000163650; calpactin I heavy polypeptide
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Flag
    • GST
    • His
    • T7
    • His-SUMO
    • MYC/DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ANXA2-1846H Recombinant Human ANXA2 protein E.coli N/A
    Human ANXA2-1845H Recombinant Human Annexin A2, His-tagged E.coli His
    Human ANXA2-26598TH Recombinant Human ANXA2, His-tagged E.coli His
    Human ANXA2-5278H Recombinant Human Annexin A2, His-tagged E.coli His
    Human ANXA2-631H Recombinant Human ANXA2 protein, GST-tagged Wheat Germ GST
    Human ANXA2-9695H Recombinant Human ANXA2, GST-tagged E.coli GST
    Mouse ANXA2-1714M Recombinant Mouse ANXA2 Protein Mammalian Cell His
    Mouse Anxa2-3494M Recombinant Mouse Anxa2, His-tagged E.Coli or Yeast His
    Mouse Anxa2-3495M Recombinant Mouse Anxa2 protein, His/T7-tagged E.coli His/T7
    Rat ANXA2-689R Recombinant Rat ANXA2 Protein Mammalian Cell His
    Chicken ANXA2-6903C Recombinant Chicken ANXA2 Mammalian Cell His
    Human ANXA2-8833HCL Recombinant Human ANXA2 293 Cell Lysate HEK293 N/A
    Human ANXA2-8834HCL Recombinant Human ANXA2 293 Cell Lysate HEK293 N/A
    Human ANXA2-163H Recombinant Human ANXA2 Protein, His-tagged E.coli N-His
    Human ANXA2-164H Recombinant Human ANXA2 Protein, His-tagged E.coli N-His
    Rat Anxa2-165R Recombinant Rat Anxa2 Protein, His-tagged E.coli N-His
    Human ANXA2-2515H Recombinant Human ANXA2 protein, His-SUMO-tagged E.coli His-SUMO
    Human ANXA2-2516H Recombinant Human ANXA2 protein, His-SUMO-tagged E.coli His-SUMO
    Human ANXA2-2517H Recombinant Human ANXA2 protein, GST-tagged E.coli GST
    Human ANXA2-4987H Recombinant Human ANXA2 protein, His-tagged HEK293 His
    Human ANXA2-001H Recombinant Human ANXA2 Protein, His-tagged E.coli His
    Human ANXA2-1086H Recombinant Human ANXA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ANXA2-356H Recombinant Human ANXA2 Protein, Flag-tagged HEK293T Flag
    Human ANXA2-357H Recombinant Human ANXA2 Protein, Flag-tagged HEK293T Flag
    Human ANXA2-358H Recombinant Human ANXA2 Protein, Flag-tagged HEK293T Flag
    Human ANXA2-359H Recombinant Human ANXA2 Protein, Flag-tagged HEK293T Flag
    Human ANXA2-6281H Recombinant Human ANXA2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Anxa2-742M Recombinant Mouse Anxa2 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    ANXA2 involved in several pathways and played different roles in them. We selected most pathways ANXA2 participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, Muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Dissolution of Fibrin Clot SERPINE2; ANXA2B; S100A10; S100A10A; S100A10B; SERPINB8; ANXA2A; HRG; ANXA2; SERPINF2B
    Hemostasis KCNMA1; F9B; CABLES2; KIFC1; SLC7A6; NFE2; ITGB3A; IRF2; KIF4A; GNA13B
    Muscle contraction VIML; TNNI2A.4; TNNT1; ANXA2; SMYHC3; MYL9; TNNI2A.1; TNNI1B; DESMA; MYL1
    Prostaglandin Synthesis and Regulation ANXA4; S100A6; ANXA3; CC10; ANXA5; ANXA2; ANXA6; S100A10

    ANXA2 has several biochemical functions, for example, Rab GTPase binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA2 itself. We selected most functions ANXA2 had, and list some proteins which have the same functions with ANXA2. You can find most of the proteins on our site.

    Function Related Protein
    Rab GTPase binding Fert2; TBC1D30; RABGGTA; RABGEF1; HPS6; NGFR; ULK1; GAS8; KIF16B; FER
    S100 protein binding S100A1; EZR; FGF1; S100A6; ATP2A2; KCNK3; DDX1; FGF1A; ANXA11; AHNAK
    calcium ion binding SLC24A5; DHH; JAG2; CLEC3B; CABS1; LTBP2; CDHR1A; PKD2L2; FKBP14; PADI1
    calcium-dependent phospholipid binding ANXA3B; ANXA1B; SYT5A; ANXA11B; SYT1; SYT5B; ANXA11; SYT9B; ANXA2A; SYTL3
    calcium-dependent protein binding SYT8; PDCD6IP; ANXA1; MYO5A; CCDC167; S100P; STX2; ANXA11; VPS37B; SLC9A1
    cytoskeletal protein binding ALDOC; DYNLL2; EPB41L3B; B4GALT1; PKD2L1; CAPN1; ANXA2A; TNNT2A; ABI1; CORO1A
    phosphatidylinositol-4,5-bisphosphate binding SYT1; MAPKAP1; PHLDA3; FAM21C; FAM123A; TULP1; PARD3; SNX20; RS1; ALOX15
    phospholipase A2 inhibitor activity ANXA3; ANXA2; CC10; ANXA1
    poly(A) RNA binding MKI67IP; ZYX; HUWE1; DHX35; MKI67; ETF1B; TRMT2A; HSPA9; PDAP1; MTERF
    protease binding UBC; TYSND1; POLG; PINK1; TIMP2; A2M; CHL1; TNFAIP3; INSL3; CFLAR
    protein binding ALK; LYVE1; PELI2; ATXN7; HTR1A; MYD88; SETDB1; TBC1D10A; NUF2; RLN3
    contributes_to receptor activator activity ANXA2

    ANXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA2.

    PCSK9; MLH1; q99ib8-pro_0000045602; ns3_ns4a_hcvco

    Canas, F; Simonin, L; et al. Annexin A2 autoantibodies in thrombosis and autoimmune diseases. THROMBOSIS RESEARCH 135:226-230(2015).
    Chaudhary, P; Thamake, SI; et al. Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. BRITISH JOURNAL OF CANCER 111:2328-2341(2014).

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