anxa2
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  • Official Full Name
  • annexin A2
  • Background
  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ANXA2; annexin A2; ANX2ANX2L4; CAL1H; LPC2D; LIP2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36; LPC2; chromobindin 8; OTTHUMP00000163650; calpactin I heavy polypeptide
Cat.#:ANXA2-26598THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA2, His-tagged
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Cat.#:ANXA2-1846HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA2 protein
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Cat.#:ANXA2-631HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ANXA2 protein, GST-tagged
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Cat.#:ANXA2-9695HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA2, GST-tagged
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Cat.#:ANXA2-1714MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ANXA2 Protein
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Cat.#:Anxa2-3494MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Anxa2, His-tagged
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Cat.#:Anxa2-3495MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Anxa2 protein, His/T7-tagged
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Cat.#:ANXA2-689RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ANXA2 Protein
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Cat.#:ANXA2-6903CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ANXA2
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Cat.#:ANXA2-5278HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Annexin A2, His-tagged
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Cat.#:ANXA2-1845HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Annexin A2, His-tagged
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Cat.#:ANXA2-8833HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ANXA2 293 Cell Lysate
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Cat.#:ANXA2-8834HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ANXA2 293 Cell Lysate
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Involved Pathway

ANXA2 involved in several pathways and played different roles in them. We selected most pathways ANXA2 participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, Muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dissolution of Fibrin Clot
SERPINB8; HRG; S100A10A; SERPINE2; S100A10B; SERPINF2B; ANXA2B; ANXA2A; S100A10; ANXA2
Hemostasis
RACGAP1; ANXA2B; SLC7A8A; RAPGEF4; IRF2A; BA1L; KIFAP3; MAFGB; F13A1B; SERPINB8
Muscle contraction
TNNI1; MYL12B; SMYHC3; MYL6B; SMYHC2; TNNT3B; MYBPC2A; LMOD1; MYLZ3; ANXA6
Prostaglandin Synthesis and Regulation
ANXA3; ANXA5; ANXA2; ANXA6; S100A10; CC10; S100A6; ANXA4

Protein Function

ANXA2 has several biochemical functions, for example, Rab GTPase binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA2 itself. We selected most functions ANXA2 had, and list some proteins which have the same functions with ANXA2. You can find most of the proteins on our site.
Function
Related Protein
Function Rab GTPase binding
Related Protein ERC1; CHML; KIF16B; ODF2; ULK1; RPH3A; STXBP5A; RILP; HACE1; ZFP652
Function S100 protein binding
Related Protein FGF1A; ANXA2; EZR; DDX1; KCNK3; AGER; S100B; ANXA11; S100A6; ATP2A2
Function calcium ion binding
Related Protein MACF1; FREM2; NUCB2A; CASQ1B; FSTL1; CBLC; ESYT2; PVALB4; S100T; DSG4
Function calcium-dependent phospholipid binding
Related Protein ANXA9; PCLO; SYTL3; ANXA1C; AP1S2; PLA2G4A; DOC2D; ANXA3B; ANXA8; ANXA1
Function calcium-dependent protein binding
Related Protein STX2; SLC9A1; S100A4; ANXA2; DDX5; CPNE3; ANXA6; ANXA1; FCN2; CALM2
Function cytoskeletal protein binding
Related Protein CDK5; PACSIN1; EPB41B; TPM1; CORO1A; PTPN4; NF2A; TNNT2A; ANXA2A; PTPN3
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein MAPKAP1; SYTL2; RAG2; TTPA; PFN1; AMER2; PFN2; RAB35; TIRAP; EXOC1
Function phospholipase A2 inhibitor activity
Related Protein ANXA2; ANXA1; ANXA3; CC10
Function poly(A) RNA binding
Related Protein CAST; DNTTIP2; TBL3; RPL5B; DHX9; SRP54; RPL21; CS; TDRD9; POLR2B
Function protease binding
Related Protein IL1R1; CRADD; RFFL; DERL1; BCL10; CCBE1; RNF139; SERPINA1; TIMP3; DVL3
Function protein binding
Related Protein DPP4; TOB1; TGS1; Mill2; ITGB1BP2; SELENBP1; RAPGEF4; DYDC1; REXO1L1; EPCAM
Function contributes_to receptor activator activity
Related Protein ANXA2

Interacting Protein

ANXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA2.
PCSK9; MLH1; q99ib8-pro_0000045602; ns3_ns4a_hcvco

ANXA2 Related Articles

Canas, F; Simonin, L; et al. Annexin A2 autoantibodies in thrombosis and autoimmune diseases. THROMBOSIS RESEARCH 135:226-230(2015).
Chaudhary, P; Thamake, SI; et al. Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. BRITISH JOURNAL OF CANCER 111:2328-2341(2014).