ANXA8

  • Official Full Name

    annexin A8

  • Synonyms

    ANXA8;annexin A8;ANX8;VAC-beta;annexin-8;annexin VIII;vascular anticoagulant-beta;FLJ53095;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ANXA8-2798H Recombinant Human Annexin A8, His-tagged E.coli His
Human ANXA8-638H Recombinant Human ANXA8 protein, GST-tagged Wheat Germ GST
Human ANXA8-222H Recombinant Human ANXA8 protein, His-tagged E.coli His Met1-Pro327
Human ANXA8-27322TH Recombinant Human ANXA8, His-tagged E.coli His 327 amino acids
Human ANXA8-1023HCL Recombinant Human ANXA8 cell lysate N/A
Human ANXA8-0517H Recombinant Human ANXA8 Protein (Met1-Pro327), Tag Free E.coli Tag Free Met1-Pro327
Human ANXA8-5770H Recombinant Human ANXA8 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ANXA8-174H Recombinant Human ANXA8 Protein, His-tagged E.coli N-His Ala2-Val323
Human ANXA8-2319H Recombinant Human ANXA8 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human ANXA8-1324HF Recombinant Full Length Human ANXA8 Protein, GST-tagged In Vitro Cell Free System GST 327 amino acids
Mouse Anxa8-3499M Recombinant Mouse Anxa8, His-tagged E.Coli or Yeast His 327
Mouse ANXA8-1720M Recombinant Mouse ANXA8 Protein Mammalian Cell His
Mouse ANXA8-587M Recombinant Mouse ANXA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Anxa8-175M Recombinant Mouse Anxa8 Protein, His&GST-tagged E.coli N-His&GST Met1-Leu327
Mouse ANXA8-587M-B Recombinant Mouse ANXA8 Protein Pre-coupled Magnetic Beads HEK293
Rat ANXA8-692R Recombinant Rat ANXA8 Protein Mammalian Cell His
Rat ANXA8-348R Recombinant Rat ANXA8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat ANXA8-348R-B Recombinant Rat ANXA8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ANXA8 involved in several pathways and played different roles in them. We selected most pathways ANXA8 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ANXA8 has several biochemical functions, for example, actin filament binding, calcium ion binding, calcium-dependent phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA8 itself. We selected most functions ANXA8 had, and list some proteins which have the same functions with ANXA8. You can find most of the proteins on our site.

Function Related Protein
actin filament bindingTAGLN3B;FMNL1;MYH9;SVIL;WIPF1;AIF1L;TULP1;ACTN2B;CAPZB
calcium ion bindingRASGRP1;SULF2A;NOTCH3;PKD1L3;PCDH2AB6;EGFL7;EMR2;FSTL1B;HPGDS
calcium-dependent phospholipid bindingANXA2B;ANXA3B;CPNE1;ANXA4;ANXA8;ANXA11;ANXA3A;ESYT2;CCDC167
phosphatidylinositol-3,4,5-trisphosphate bindingINPPL1;CYTH3;FERMT2;COMMD1;FAM21C;ARHGAP9;JPH2;ARAP3;BTK
phosphatidylinositol-3,4-bisphosphate bindingRS1;ADAP2;KIF16B;GAB2;ARAP3;COMMD1;RAG2;PLEKHA1;TTPA
phosphatidylinositol-4,5-bisphosphate bindingSTXBP6;ADAP2;PFN1;SLC9A1;ALOX15;TIRAP;SNX20;ASAP1;KRIT1

ANXA8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA8 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA8.

Cdk1; TERF1; ACD; RDH12; TINF2; TERF2IP; ACTA1

Research Area

Related articles

Almatroodi, SA; McDonald, CF; et al. Quantitative Proteomics of Bronchoalveolar Lavage Fluid in Lung Adenocarcinoma. CANCER GENOMICS & PROTEOMICS 12:39-48(2015).
Pimiento, JM; Chen, DT; et al. Annexin A8 Is a Prognostic Marker and Potential Therapeutic Target for Pancreatic Cancer. PANCREAS 44:122-127(2015).
  • Q&As
  • Reviews

Q&As (16)

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Can ANXA8 be targeted for therapeutic purposes? 11/26/2022

Targeting ANXA8 could potentially have therapeutic implications, especially in cancer treatment. Modulating ANXA8 expression or function might be explored as a strategy to suppress tumor growth, metastasis, or enhance chemotherapeutic responses. However, more studies are required to evaluate the feasibility and effectiveness of targeting ANXA8 for specific therapeutic interventions.

Are there any known ANXA8 polymorphisms or genetic variants associated with diseases? 07/03/2022

ANXA8 polymorphisms and genetic variants have been identified, but their associations with diseases are still limited and require further investigation. Some studies have reported the presence of ANXA8 polymorphisms in different populations, but their functional implications or associations with specific diseases are not well-characterized. However, as research progresses, it is possible that specific ANXA8 variants may be identified as potential genetic markers or contributors to certain diseases.

Is ANXA8 associated with any diseases? 06/24/2022

ANXA8 has been linked to certain diseases. Abnormal expression or dysregulation of ANXA8 has been observed in different types of cancer, including breast, ovarian, pancreatic, and lung cancers. It has also been implicated in autoimmune diseases, neurodegenerative disorders, and cardiovascular diseases, although further research is needed to elucidate its precise involvement in these conditions.

Can ANXA8 be used as a therapeutic target or biomarker? 06/14/2022

The potential of ANXA8 as a therapeutic target or biomarker is still under investigation. Its involvement in various cellular processes and its dysregulation in diseases suggest that it could be a target for therapeutic interventions. Additionally, its association with disease progression and prognosis in certain cancers indicates its potential as a biomarker. However, more research is needed to fully understand its clinical significance and its potential as a target for therapeutic interventions.

Can you provide more information about ANXA8 expression patterns in different tissues? 04/20/2022

ANXA8 expression patterns can vary across different tissues. It is generally expressed in a wide range of tissues, including the brain, liver, lung, kidney, heart, and intestine. However, the expression levels may differ, and certain tissues may exhibit higher expression than others. For example, ANXA8 has been reported to be highly expressed in the brain, specifically in the hippocampus, cortex, and Purkinje cells of the cerebellum. In the liver, ANXA8 expression has been observed in hepatocytes. Additionally, ANXA8 expression has been detected in various cell types of the reproductive system, such as ovarian granulosa cells and Leydig cells in the testes. Overall, the expression patterns of ANXA8 suggest its involvement in multiple biological processes and cellular functions throughout the body.

Are there any known post-translational modifications of ANXA8? 11/11/2021

Yes, ANXA8 can undergo various post-translational modifications (PTMs). These modifications can regulate its cellular localization, interactions, and functions. Some known PTMs of ANXA8 include phosphorylation, acetylation, ubiquitination, and sumoylation. Phosphorylation of ANXA8 by different kinases can modulate its binding to other proteins or cellular membranes. Acetylation can similarly affect ANXA8's activity and interactions. Ubiquitination and sumoylation can regulate ANXA8's stability and degradation. These PTMs play critical roles in fine-tuning the functions and regulation of ANXA8 in different cellular contexts.

Are there any known cellular or physiological processes regulated by ANXA8? 03/24/2021

ANXA8 is involved in various cellular and physiological processes. It has been implicated in calcium signaling and ion transport, membrane dynamics, exocytosis, endocytosis, and vesicle trafficking. ANXA8 may also play a role in cell adhesion, migration, and cytoskeletal organization.

Are there any known binding partners or interactors of ANXA8? 03/10/2020

Yes, ANXA8 has been found to interact with several proteins and molecules. Some known binding partners include membrane proteins such as S100A10, S100A11, and S100A13, which are involved in calcium signaling and cytoskeletal organization. ANXA8 has also been shown to interact with vesicle-associated proteins like clathrin, dynamin, and endophilin, suggesting a role in vesicle trafficking and membrane dynamics. Other interactors include protein kinases, phosphatases, and cytoskeletal proteins such as actin and tubulin.

Are there any known post-translational modifications of ANXA8? 01/26/2020

Yes, ANXA8 undergoes various post-translational modifications. It can be phosphorylated, acetylated, ubiquitinated, and undergo proteolytic cleavage. These modifications can regulate its stability, localization, and interaction with other proteins, thereby influencing its cellular functions.

Is ANXA8 expressed in specific cell types or organs? 07/22/2019

ANXA8 is expressed in various tissues and cell types. It has been detected in the brain, heart, liver, kidneys, lungs, gastrointestinal tract, and reproductive organs. Its expression levels may vary in different cell types and can be influenced by developmental stage, physiological conditions, and disease states.

Can ANXA8 regulate cell migration and invasion? 04/27/2018

Yes, ANXA8 has been reported to have a role in cell migration and invasion. It can promote or inhibit these processes depending on the cellular context and other interacting proteins. ANXA8 has been shown to interact with components of the actin cytoskeleton and affect cell adhesion, which are crucial for cell motility and migration.

Is ANXA8 involved in any diseases or pathological conditions? 04/04/2018

ANXA8 has been implicated in various diseases and pathological conditions. It has been associated with cancer, where its expression levels and functions can impact tumor growth, invasion, and metastasis. ANXA8 dysregulation has also been observed in autoimmune diseases, such as systemic lupus erythematosus (SLE), and neurodegenerative disorders, including Alzheimer's disease. Its involvement in inflammation, immunity, and oxidative stress pathways suggests its potential relevance to several disease processes.

Can ANXA8 be used as a diagnostic or prognostic marker for cancer? 01/05/2018

ANXA8 has shown potential as a diagnostic or prognostic marker for certain types of cancers. Altered expression levels of ANXA8 have been observed in cancer tissues compared to normal tissues, and its overexpression or downregulation has been associated with different clinical outcomes. However, more research is required to establish its reliability and clinical utility as a biomarker.

Are there any known ANXA8 knockout or transgenic animal models? 10/15/2016

While ANXA8 knockout or transgenic animal models have not been extensively reported, there are a few studies that have utilized ANXA8 knockout or overexpression in cell culture or animal models. These studies have provided insights into the functions and roles of ANXA8 in specific cellular processes, such as cell migration, adhesion, and calcium signaling. However, further research is needed to understand the full impact of ANXA8 dysregulation in vivo.

Are there any known genetic mutations in ANXA8 associated with disease? 07/15/2016

Currently, there is limited information about genetic mutations specifically in ANXA8 that are associated with disease. However, mutations in other annexin family members have been reported in certain disorders, highlighting the potential relevance of ANXA8 mutations in disease development. Further research is needed to investigate this aspect comprehensively.

Does ANXA8 have any known interacting partners? 01/20/2016

Yes, ANXA8 has been found to interact with various proteins. It can associate with other annexin family members, as well as several cytoskeletal proteins, ion channels, and membrane receptors. These interactions suggest that ANXA8 may participate in protein-protein complexes involved in cellular processes and signaling pathways.

Customer Reviews (5)

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Reviews
01/12/2023

    The manufacturer's extensive experience and expertise in the field of ANXA8 protein research make them a trusted partner.

    12/07/2022

      The manufacturer's commitment to providing excellent technical support is highly valuable.

      10/29/2022

        The ANXA8 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.

        10/03/2022

          The combination of high-quality ANXA8 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.

          08/30/2018

            The manufacturer's commitment to customer satisfaction and their willingness to customize solutions based on specific experimental requirements is commendable.

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