Recombinant Human TNFSF4 Protein, MYC/DDK-tagged, C13 and N15-labeled

• Cat.No.: TNFSF4-086H
• Product Overview: TNFSF4 MS Standard C13 and N15-labeled recombinant protein (NP_003317) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 20.9 kDa
• AA Sequence: MERVQPLEENVGNAARPRFERNKLL LVASVIQGLGLLLCFTYICLHFSAL QVSHRYPRIQSIKVQFTEYKKEKGF ILTSQKEDEIMKVQNNSVIINCDGF YLISLKGYFSQEVNISLHYQKDEEP LFQLKKVRSVNSLMVASLTYKDKVY LNVTTDNTSLDDFHVNGGELILIHQ NPGEFCVLTRTRPLEQKLISEEDLA ANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: TNFSF4 TNF superfamily member 4 [ Homo sapiens (human) ]
• Official Symbol: TNFSF4
• Synonyms: TNFSF4; TNF superfamily member 4; CD134L; CD252; GP34; OX-40L; OX4OL; TNLG2B; TXGP1; tumor necrosis factor ligand superfamily member 4; CD134 ligand; OX40 antigen ligand; glycoprotein Gp34; tax-transcriptionally activated glycoprotein 1 (34kD); tumor necrosis factor (ligand) superfamily member 4; tumor necrosis factor ligand 2B; tumor necrosis factor superfamily member 4
• Gene ID: 7292
• mRNA Refseq: NM_003326
• Protein Refseq: NP_003317
• MIM: 603594
• UniProt ID: P23510

Reviews

12/28/2022

Efficient service, accelerates research productivity.

05/13/2018

Outstanding accuracy, essential for research quality.

02/12/2018

Trusted for research integrity, a critical research asset.

Q&As

How do genetic variations in TNFSF4 affect immune function?

Genetic changes in TNFSF4 affect immune regulation and autoimmune disease susceptibility.

What is the primary role of TNFSF4 in immune system regulation?

TNFSF4 (OX40L) regulates immune responses and T-cell activation.

How does TNFSF4 contribute to inflammatory responses?

It activates T-cells, stimulating inflammatory cytokine production.

What role does TNFSF4 play in autoimmune disorders?

TNFSF4 is implicated in autoimmune disease development by promoting immune cell activation.

How does TNFSF4 interact with other cytokines and receptors in the immune system?

TNFSF4 interacts with OX40 and other receptors, influencing immune signaling.

What potential therapeutic applications arise from targeting TNFSF4 in immune-related diseases?

Targeting TNFSF4 could treat autoimmune and inflammatory diseases by modulating the immune system.

What is the impact of altered TNFSF4 activity on chronic inflammation?

Altered TNFSF4 activity contributes to chronic inflammation.