Description : |
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
104.6 kDa |
AA Sequence : |
MTDSKYFTTTKKGEIFELKAELNSD KKEKKKEAVKKVIASMTVGKDVSAL FPDVVNCMQTDNLELKKLVYLYLMN YAKSQPDMAIMAVNTFVKDCEDPNP LIRALAVRTMGCIRVDKITEYLCEP LRKCLKDEDPYVRKTAAVCVAKLHD INAQLVEDQGFLDTLKDLISDSNPM VVANAVAALSEIAESHPSSNLLDLN PQSINKLLTALNECTEWGQIFILDC LANYMPKDDREAQSICERVTPRLSH ANSAVVLSAVKVLMKFMEMLSKDLD YYGTLLKKLAPPLVTLLSAEPELQY VALRNINLIVQKRPEILKHEMKVFF VKYNDPIYVKLEKLDIMIRLASQAN IAQVLAELKEYATEVDVDFVRKAVR AIGRCAIKVEQSAERCVSTLLDLIQ TKVNYVVQEAIVVIKDIFRKYPNKY ESVIATLCENLDSLDEPEARAAMIW IVGEYAERIDNADELLESFLEGFHD ESTQVQLQLLTAIVKLFLKKPTETQ ELVQQVLSLATQDSDNPDLRDRGYI YWRLLSTDPVAAKEVVLAEKPLISE ETDLIEPTLLDELICYIGTLASVYH KPPSAFVEGGRGVVHKSLPPRTASS ESAESPETAPTGAPPGEQPDVIPAQ GDLLGDLLNLDLGPPVSGPPLATSS VQMGAVDLLGGGLDSLMGDEPEGIG GTNFVAPPTAAVPANLGAPIGSGLS DLFDLTSGVGTLSGSYVAPKAVWLP AMKAKGLEISGTFTRQVGSISMDLQ LTNKALQVMTDFAIQFNRNSFGLAP AAPLQVHAPLSPNQTVEISLPLSTV GSVMKMEPLNNLQVAVKNNIDVFYF STLYPLHILFVEDGKMDRQMFLATW KDIPNENEAQFQIRDCPLNAEAASS KLQSSNIFTVAKRNVEGQDMLYQSL KLTNGIWVLAELRIQPGNPSCTDLE LSLKCRAPEVSQHVYQAYETILKNT RTRPLEQKLISEEDLAANDILDYKD DDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |