AP2A1
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Official Full Name
adaptor-related protein complex 2, alpha 1 subunit
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Overview
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined -
Synonyms
AP2A1; adaptor-related protein complex 2, alpha 1 subunit; AP-2 complex subunit alpha-1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | AP2A1-27357TH | Recombinant Human AP2A1, His-tagged | E.coli | His | 734-950 | |
Human | AP2A1-651H | Recombinant Human AP2A1 protein, GST-tagged | Wheat Germ | GST | ||
Human | AP2A1-185H | Recombinant Human AP2A1 Protein, His-tagged | E.coli | His | Pro2-Pro253 | |
Mouse | Ap2a1-3530M | Recombinant Mouse Ap2a1, His-tagged | E.Coli or Yeast | His | 955 | |
Mouse | AP2A1-1738M | Recombinant Mouse AP2A1 Protein | Mammalian Cell | His | ||
Mouse | AP2A1-600M | Recombinant Mouse AP2A1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi | ||
Mouse | AP2A1-600M-B | Recombinant Mouse AP2A1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | AP2A1-347R | Recombinant Rhesus monkey AP2A1 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | AP2A1-175R | Recombinant Rhesus Macaque AP2A1 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi | ||
Rhesus Macaque | AP2A1-175R-B | Recombinant Rhesus Macaque AP2A1 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- AP2A1 Related Signal Pathway
AP2A1 involved in several pathways and played different roles in them. We selected most pathways AP2A1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | UBE2L6;KIF4;KIF15;ATG7;ITGB1B.1;RNF182;CDKN1B;DCTN6;CTSLL |
Arf1 pathway | CLTA;USO1;AP2A1;ARF1;CLTB;ARFIP2;AP2M1 |
Axon guidance | RGMA;DCX;RGS3;SRGAP3;EFNB2;ACTR2;GNAI2;SCN9A;GFRA4 |
Beta-catenin independent WNT signaling | ITPR2;DVL2;GNB5;AGO3;CLTB;DVL3;CLTA;AGO2;RYK |
Developmental Biology | ARPC2;ARPC5;ADAM22;MED25;EFNA1A;EBF1;ADAM23;PLXNC1;DPYSL5B |
Disease | CUX1;FGFR1OP2;CDC37;TTR;OPN1SW;PPIA;KPNA3;DERL2;VPS37A |
EGFR downregulation | AP2S1;STAM2;PTPRK;SPRY2;AP2M1;AP2A2;AP2B1;SPRY1;AP2A1 |
EGFR1 Signaling Pathway | PLSCR1;WNK1;EPS8;MAP3K2;DOK2;RALBB;EEF1A1;ELF3;DNM1 |
AP2A1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2A1 itself. We selected most functions AP2A1 had, and list some proteins which have the same functions with AP2A1. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to clathrin adaptor activity | AP2A2;AP2M1;AP2A1;AP2S1;AP2B1 |
protein C-terminus binding | PEX5;TBL1X;EFHC1;ITGB3BP;RAD51;PDZD11;STIP1;HESX1;BAIAP2 |
protein binding | PTGDS;PTPN11A;FYCO1;GSK3B;TSPAN4;LEPR;LBX1;MAP4K1;ADD1 |
protein complex binding | MAPK8IP2;AKAP5;ITPR1;ADRB2;PPFIA2;STRN;TELO2;DRD1A;THRA |
protein kinase binding | SMAD1;DNAJC3;SPRED1;PARN;H2AFY;B4GALT1;DBF4B;RACGAP1;JAK2 |
protein transporter activity | RUFY1;CALCRL;COG2;AP2B1;IPO5;ZFYVE16;COX18;VPS26B;MLC1 |
AP2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2A1.
HIP1; EGFR; SHC1; FCHO2; ATG9A; MYC; RNPS1; Edc4
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewThe short half-life and high clearance characteristics make it have greater potential in the treatment of tumors, infections and other diseases, and is expected to become a new generation of therapeutic drugs.
Stability is very high and it can maintain stable performance even in extreme environments, which shows its excellent adaptability and reliability.
Production process uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, and has a positive impact on the environment.
Activity is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.
Q&As (18)
Ask a questionThe AP2A1 has the function of regulating intracellular molecular transport, so it has potential application value in drug delivery, gene therapy and cancer therapy.
The study of AP2A1 is still in its infancy, but some interesting results have been achieved. Future studies will further explore its potential for clinical and scientific applications and improve its efficacy and safety.
AP2A1 has been widely used in neuroscience research to study the important processes of endocytosis, synaptic formation and synaptic plasticity of nerve cells.
The biosynthesis of AP2A1 is the process of synthesis into protein according to the encoded mRNA sequence by the cellular transcription and translation mechanism.
AP2A1 can inhibit the proliferation and metastasis of tumor cells and promote the apoptosis of tumor cells by regulating the signaling pathway, so as to achieve the purpose of anticancer.
AP2A1 can usually be synthesized in large quantities in the expressing host through genetic engineering technology, and then purified protein can be prepared through purification and structural identification.
The commonly used validation methods include intracellular localization, protein expression level detection and functional experimental proof.
At present, there are no clear studies showing a direct association between AP2A1 and cardiovascular disease, and further empirical studies are needed to explore.
AP2A1 can be used for high-throughput screening and gene function analysis in genetic studies to study the relationship between genes and phenotypes.
Studies have shown that recombinant AP2A1 protein may improve insulin sensitivity in diabetic patients by regulating pathways such as glucose transport, but relevant research is still in the early stages.
AP2A1 is not currently widely used in the treatment of infectious diseases, but researchers are exploring its potential vaccine and therapeutic value.
Studies have shown that recombinant AP2A1 protein may play a certain role in inhibiting the development of obesity by regulating molecular transport and metabolism in adipocytes.
The current study shows that the AP2A1 may have some potential in the treatment of neurodegenerative diseases, but more research is still needed to verify its true efficacy.
The role of AP2A1 in the signal transduction pathway is to participate in endocytosis, thereby regulating the interaction and signal transduction between intracellular molecules and membrane proteins.
No significant side effects of recombinant AP2A1 have been reported, but its safety needs to be carefully evaluated in application.
The recombinant AP2A1 protein may be relevant for immunotherapy because it can affect cellular endocytosis and antigen processing, which in turn affects immune cell function.
The recombinant AP2A1 protein can be used for stem cell differentiation and targeted induction to promote the production and maintenance of specific cell lines.
At present, there are no clear results showing that the AP2A1 can directly block tumor angiogenesis, but relevant studies are ongoing.
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