• Official Full Name

    adaptor-related protein complex 2, alpha 1 subunit

  • Overview

    This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined
  • Synonyms

    AP2A1; adaptor-related protein complex 2, alpha 1 subunit; AP-2 complex subunit alpha-1;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP2A1-27357TH Recombinant Human AP2A1, His-tagged E.coli His
Human AP2A1-651H Recombinant Human AP2A1 protein, GST-tagged Wheat Germ GST
Human AP2A1-185H Recombinant Human AP2A1 Protein, His-tagged E.coli N-His Pro2-Pro253
Mouse Ap2a1-3530M Recombinant Mouse Ap2a1, His-tagged E.Coli or Yeast His 955
Mouse AP2A1-1738M Recombinant Mouse AP2A1 Protein Mammalian Cell His
Mouse AP2A1-600M Recombinant Mouse AP2A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AP2A1-600M-B Recombinant Mouse AP2A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AP2A1-347R Recombinant Rhesus monkey AP2A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AP2A1-175R Recombinant Rhesus Macaque AP2A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AP2A1-175R-B Recombinant Rhesus Macaque AP2A1 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • AP2A1 Related Signal Pathway

AP2A1 involved in several pathways and played different roles in them. We selected most pathways AP2A1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemASB8;KLRB1B;CD300LB;NRG3;ACTR1B;CREB1;CD300C;RNF220;TREML2
Beta-catenin independent WNT signalingAP2A1;RYK;MOV10;AGO2;GNB5;PRICKLE1B;AP2A2;CTNNB2;ITPR2
EGFR downregulationAP2M1;PTPRK;AP2A1;AP2S1;AP2B1;SPRY1;AP2A2;STAM2;SPRY2

AP2A1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2A1 itself. We selected most functions AP2A1 had, and list some proteins which have the same functions with AP2A1. You can find most of the proteins on our site.

Function Related Protein
contributes_to clathrin adaptor activityAP2A1;AP2B1;AP2M1;AP2S1;AP2A2
protein C-terminus bindingBLOC1S2A;SDCBP2;HAND2;NCF2;JAK2;ERCC6;TJP2;FIGN;DAB2
protein bindingRG9MTD1;BMPR1B;ZNF543;CYTH1;CDA;CEP164;CXCL2;TCF25;OGFR
protein complex bindingAP2A1;SLC25A3;SHANK1;BAX;CDK5RAP2;COG2;GRIN2A;RELA;RNF40
protein kinase bindingPRKAG3;DNM2;PFKFB2;CCNT2B;NEK6;FBXO7;NPM1;MAPK8IP2;POLA1
protein transporter activityRAMP3;DPY19L2;VPS26A;KPNA7;RAMP2;TMCO6;KPNB1;SNUPN;PGAP2

AP2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2A1.


Research Area

Related articles

Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
Upadhyay, RD; Kumar, AV; et al. Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes. REPRODUCTIVE SCIENCES 20:1162-1174(2013).
  • Q&As
  • Reviews

Q&As (18)

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What are the clinical applications of AP2A1 ? 11/21/2022

The AP2A1 has the function of regulating intracellular molecular transport, so it has potential application value in drug delivery, gene therapy and cancer therapy.

What is the research progress and prospect of AP2A1 ? 07/25/2022

The study of AP2A1 is still in its infancy, but some interesting results have been achieved. Future studies will further explore its potential for clinical and scientific applications and improve its efficacy and safety.

What is the important role of AP2A1 in neuroscience research? 09/05/2021

AP2A1 has been widely used in neuroscience research to study the important processes of endocytosis, synaptic formation and synaptic plasticity of nerve cells.

What is the biosynthesis mechanism of AP2A1 ? 07/10/2021

The biosynthesis of AP2A1 is the process of synthesis into protein according to the encoded mRNA sequence by the cellular transcription and translation mechanism.

What is the mechanism of action of AP2A1 in tumor therapy? 05/16/2021

AP2A1 can inhibit the proliferation and metastasis of tumor cells and promote the apoptosis of tumor cells by regulating the signaling pathway, so as to achieve the purpose of anticancer.

How to prepare AP2A1 ? 04/14/2021

AP2A1 can usually be synthesized in large quantities in the expressing host through genetic engineering technology, and then purified protein can be prepared through purification and structural identification.

How to verify the biological activity of AP2A1 ? 12/19/2020

The commonly used validation methods include intracellular localization, protein expression level detection and functional experimental proof.

Is there any relevant study that shows the relationship between AP2A1 and cardiovascular disease? 10/02/2020

At present, there are no clear studies showing a direct association between AP2A1 and cardiovascular disease, and further empirical studies are needed to explore.

What is the application of recombinant AP2A1 in genetic research? 08/17/2020

AP2A1 can be used for high-throughput screening and gene function analysis in genetic studies to study the relationship between genes and phenotypes.

Can AP2A1 improve insulin sensitivity in diabetic patients? 04/27/2020

Studies have shown that recombinant AP2A1 protein may improve insulin sensitivity in diabetic patients by regulating pathways such as glucose transport, but relevant research is still in the early stages.

Can AP2A1 be used as a vaccine or therapy to treat infectious diseases? 01/18/2020

AP2A1 is not currently widely used in the treatment of infectious diseases, but researchers are exploring its potential vaccine and therapeutic value.

What is the potential of recombinant AP2A1 in the treatment of obesity? 01/08/2020

Studies have shown that recombinant AP2A1 protein may play a certain role in inhibiting the development of obesity by regulating molecular transport and metabolism in adipocytes.

Can recombinant AP2A1 be used to treat neurodegenerative diseases? 11/27/2019

The current study shows that the AP2A1 may have some potential in the treatment of neurodegenerative diseases, but more research is still needed to verify its true efficacy.

What is the role of AP2A1 in the signaling pathway? 09/12/2019

The role of AP2A1 in the signal transduction pathway is to participate in endocytosis, thereby regulating the interaction and signal transduction between intracellular molecules and membrane proteins.

Are there side effects of AP2A1 ? 08/18/2019

No significant side effects of recombinant AP2A1 have been reported, but its safety needs to be carefully evaluated in application.

What is the relevance of recombinant AP2A1 protein to immunotherapy? 07/12/2019

The recombinant AP2A1 protein may be relevant for immunotherapy because it can affect cellular endocytosis and antigen processing, which in turn affects immune cell function.

What is the application of AP2A1 in stem cell research? 03/30/2019

The recombinant AP2A1 protein can be used for stem cell differentiation and targeted induction to promote the production and maintenance of specific cell lines.

Can AP2A1 be used to block tumor angiogenesis? 01/13/2019

At present, there are no clear results showing that the AP2A1 can directly block tumor angiogenesis, but relevant studies are ongoing.

Customer Reviews (4)

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    The short half-life and high clearance characteristics make it have greater potential in the treatment of tumors, infections and other diseases, and is expected to become a new generation of therapeutic drugs.


      Stability is very high and it can maintain stable performance even in extreme environments, which shows its excellent adaptability and reliability.


        Production process uses advanced biotechnology, which makes the production process more efficient and environmentally friendly, and has a positive impact on the environment.


          Activity is very powerful and can effectively accelerate the process of chemical reactions, which brings great convenience to our experiments.

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