AP2A1

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AP2A1

Official Full Name adaptor-related protein complex 2, alpha 1 subunit
Background This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined
Synonyms AP2A1; adaptor-related protein complex 2, alpha 1 subunit; AP-2 complex subunit alpha-1
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.Coli or Yeast
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AP2A1-27357TH Recombinant Human AP2A1, His-tagged E.coli His
    Human AP2A1-651H Recombinant Human AP2A1 protein, GST-tagged Wheat Germ GST
    Mouse AP2A1-1738M Recombinant Mouse AP2A1 Protein Mammalian Cell His
    Mouse Ap2a1-3530M Recombinant Mouse Ap2a1, His-tagged E.Coli or Yeast His
    Rhesus Macaque AP2A1-347R Recombinant Rhesus monkey AP2A1 Protein, His-tagged Mammalian Cell His

    AP2A1 involved in several pathways and played different roles in them. We selected most pathways AP2A1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System LILRB4; SIGLEC11; KIF3B; IGKC; NA; OSBPL1A; SRMS; KIF22; CTSS; FGFR1B
    Arf1 pathway AP2A1; CLTA; CLTB; AP2M1; ARF1; USO1; ARFIP2
    Axon guidance FGF10B; NCK2; JAK2; SCN9A; EFNB2A; CLASP1; SPTA1; NCK1; PAQR3A; SEMA3AA
    Beta-catenin independent WNT signaling GNB5; AP2A1; CLTC; AP2S1; MOV10; AP2A2; RYK; PRICKLE1B; AGO2; DVL3
    Developmental Biology SCN2B; DCX; DUSP10; NR6A1; CFC1; MEF2AA; DUSP2; ST8SIA2; SHB; SEMA3A
    Disease FDX1; NUPL2; FGFR1OP; KPNA5; RNF43; KREMEN2; CYP11A1; PRELP; PDCD6IP; MIB1
    EGFR downregulation AP2B1; SPRY1; SPRY2; AP2M1; STAM2; AP2A1; AP2A2; AP2S1; PTPRK
    EGFR1 Signaling Pathway DNM1; CEBPA; EPPK1; PITPNA; GRB10; CRKL; PITPNAA; RGS16; REPS1; WNK1

    AP2A1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2A1 itself. We selected most functions AP2A1 had, and list some proteins which have the same functions with AP2A1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to clathrin adaptor activity AP2A1; AP2M1; AP2A2; AP2S1; AP2B1
    protein C-terminus binding YWHAB; HIC2; ATF4; PHB; SIAH1A; XRCC6; YEATS4; DST; PEX1; DGKZ
    protein binding SNX6; SUMO3; CASC3; ANKMY2; LDLRAD1; CRYBB3; FLCN; TMSB4X; CLDN16; MSH6
    protein complex binding DISC1; CDK2; FGFR1; BAX; ERCC6; RPAIN; UGT1A6A; ST13; LRP2; PEX26
    protein kinase binding DOK7; SPDYB; PTPN1; YWHAZ; PTPN23; PRKRIP1; VRK1; CALM3; PARP1; TRIB3
    protein transporter activity TNPO1; CHMP7; AP1S1; VPS26BL; MLC1; USO1; TNPO3; RAMP3; AP1S3A; AP2B1

    AP2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2A1.

    HIP1; EGFR; SHC1; FCHO2; ATG9A; MYC; RNPS1; Edc4

    Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
    Upadhyay, RD; Kumar, AV; et al. Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes. REPRODUCTIVE SCIENCES 20:1162-1174(2013).

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