AP2A1 Protein

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AP2A1

Official Full Name	adaptor-related protein complex 2, alpha 1 subunit
Background	This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined
Synonyms	AP2A1; adaptor-related protein complex 2, alpha 1 subunit; AP-2 complex subunit alpha-1

Type:
Recombinant Proteins

Species :
Human
Mouse
Rhesus Macaque

Source :
E.coli
E.Coli or Yeast
Mammalian Cell
Wheat Germ

Tag :
GST
His
N-His

Species	Cat.#	Product name	Source (Host)	Tag
Human	AP2A1-27357TH	Recombinant Human AP2A1, His-tagged	E.coli	His
Human	AP2A1-651H	Recombinant Human AP2A1 protein, GST-tagged	Wheat Germ	GST
Mouse	AP2A1-1738M	Recombinant Mouse AP2A1 Protein	Mammalian Cell	His
Mouse	Ap2a1-3530M	Recombinant Mouse Ap2a1, His-tagged	E.Coli or Yeast	His
Rhesus Macaque	AP2A1-347R	Recombinant Rhesus monkey AP2A1 Protein, His-tagged	Mammalian Cell	His
Human	AP2A1-185H	Recombinant Human AP2A1 Protein, His-tagged	E.coli	N-His

Involved Pathway Protein Function Interacting Protein AP2A1 Related Articles

AP2A1 involved in several pathways and played different roles in them. We selected most pathways AP2A1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	AP2A2; RNF34; ERAP1; KIF3A; TRIM11; CD200R3; RAP1GAP2B; CD300LD; ACTR1B; TRIM9
Arf1 pathway	ARFIP2; CLTB; AP2M1; ARF1; AP2A1; USO1; CLTA
Axon guidance	ARPC3; EVL; FES; SEMA3C; RAC2; CSK; SEMA6C; CSNK2A2; SEMA6A; CAP1
Beta-catenin independent WNT signaling	CLTB; DVL2; DVL1; CLTC; RYK; CTNNB2; DVL3; MOV10; ROR2; AGO1
Developmental Biology	NADL1.1; UNC5D; DAB2IPB; DPYSL3; SCN8A; ITSN1; EPHA4A; SCN9A; EPHA2A; SCN4A
Disease	AP2A2; KERA; JAG2; ARF1; KPNA4; SUPT4H1; CDK9; CPSF4; MMAA; CDK8
EGFR downregulation	PTPRK; STAM2; SPRY1; AP2S1; AP2B1; AP2A2; SPRY2; AP2M1; AP2A1
EGFR1 Signaling Pathway	DOK2; WNK1; RALBP1; ARF4; REPS2; PTK6; SPRY2; ZPR1; TNK2; DNM1

AP2A1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2A1 itself. We selected most functions AP2A1 had, and list some proteins which have the same functions with AP2A1. You can find most of the proteins on our site.

Function	Related Protein
contributes_to clathrin adaptor activity	AP2A2; AP2B1; AP2M1; AP2S1; AP2A1
protein C-terminus binding	OPRL1; PRDX3; BLOC1S2A; MAP3K7; HRAS; DYNLL1; SDCBP; SREBF2; PEX16; SNX17
protein binding	EXOSC3; CX3CR1; TSHR; CRYBB3; PFKFB1; NUDT18; IL13RA1; GPR85; GHRL; NUBP1
protein complex binding	SLC9A3R1; KHDRBS1; PTCH1; RNF40; C8A; GNB2; WASF1; DLG4; HNF1B; PGAM5
protein kinase binding	GSK3B; MAPT; PFKFB2; EPHA1; PTEN; TPX2; MS4A2; RHEB; RAB11FIP2; BAD
protein transporter activity	KPNA2; KPNA7; COG3; AP2A2; TNPO2; COX18; CALCRL; CALCR; TIMM10; VPS26BL

AP2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2A1.

HIP1; EGFR; SHC1; FCHO2; ATG9A; MYC; RNPS1; Edc4

Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).

Upadhyay, RD; Kumar, AV; et al. Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes. REPRODUCTIVE SCIENCES 20:1162-1174(2013).

AP2A1

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AP2A1

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