AP3S1

  • Official Full Name

    adaptor-related protein complex 3, sigma 1 subunit

  • Overview

    AP-3 complex subunit sigma-1 is a protein that in humans is encoded by the AP3S1 gene.
  • Synonyms

    AP3S1; adaptor-related protein complex 3, sigma 1 subunit; CLAPS3; AP-3 complex subunit sigma-1; small 3; Adapter-related protein complex 3 sigma-1 subunit; Adaptor-related protein complex 3; AP-3 complex sigma-3A subunit; AP-3 complex subunit sigma-3A; AP3S1_HUMAN; Clathrin associated/assembly/adapter protein small 3; Clathrin-associated/assembly/adapter protein; Sigma-3A-adaptin; Sigma-adaptin 3a; Sigma3A; Sigma3A-adaptin; clathrin-associated/assembly/adapter protein, small 3; clathrin-associated/assembly/adaptor protein, small 3 (22kD);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP3S1-364H Recombinant Human adaptor-related protein complex 3, sigma 1 subunit, His-tagged E.coli His
Human AP3S1-659H Recombinant Human AP3S1 protein, GST-tagged Wheat Germ GST
Human AP3S1-8808HCL Recombinant Human AP3S1 293 Cell Lysate HEK293 N/A
Human AP3S1-191H Recombinant Human AP3S1 Protein, His-tagged E.coli N-His
Human AP3S1-1043HF Recombinant Full Length Human AP3S1 Protein, GST-tagged In Vitro Cell Free System GST
Rat Ap3s1-192R Recombinant Rat Ap3s1 Protein, His-tagged E.coli N-His
Zebrafish AP3S1-1494Z Recombinant Zebrafish AP3S1 Mammalian Cell His
Chicken AP3S1-1723C Recombinant Chicken AP3S1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AP3S1 Related Articles

AP3S1 involved in several pathways and played different roles in them. We selected most pathways AP3S1 participated on our site, such as Clathrin derived vesicle budding, Golgi Associated Vesicle Biogenesis, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP3S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Clathrin derived vesicle buddingSNAPIN;FTH1B;PICALM;CLVS1;SNX9B;TGOLN2;ARF1;AP1S3A;NECAP1
Golgi Associated Vesicle BiogenesisAP4B1;SNX9B;TGOLN2;DTNBP1B;BLOC1S4;NECAP1;PICALM;SNAPIN;HIP1RB
LysosomeCTSM;LAPTM5;ENTPD4;GUSB;ATP6V0C;ATP6V0A2;CTSW;LAMP2;CLN5
Membrane TraffickingNAPAB;MYO1C;BLOC1S4;GJB3;MIA3;COPB2;COPG;DNASE2;AP1S3A
Vesicle-mediated transportANKRD28;CLVS1;PICALM;SCGB3A2;TRAPPC2;YIPF6;DTNBP1B;HIP1RB;STAB2
trans-Golgi Network Vesicle BuddingCLVS1;PICALMA;FTH1B;SNX9A;TFR1B;DTNBP1B;TBC1D8B;NECAP1;SH3D19

AP3S1 has several biochemical functions, for example, protein binding, protein transporter activity, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP3S1 itself. We selected most functions AP3S1 had, and list some proteins which have the same functions with AP3S1. You can find most of the proteins on our site.

Function Related Protein
protein bindingFAM167A;MTA3;KLHL2;IL1A;GJB6;RAB11FIP2;TTC32;KHK;TSG101
protein transporter activityAP2A1;AP1S1;COG2;RANGRF;FRAG1;AP1G1;IPO11;AP2S1;COX18
transporter activitySLC13A5A;ABCA6;FABP7B;SV2C;NUP88;FABP5;PBSN;SLCO2B1;SLC51B

AP3S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP3S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP3S1.

pi3p; Mast3; ZWINT; CD14; Cdk1; Kif4; EMC2; Tmed10; KIAA1107; EPB41L3; PCDHB15

Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the research prospect of AP3S1 ? 10/26/2022

Based on the results and therapeutic potential of existing studies, the AP3S1 is promising, but further experiments are needed to confirm its efficacy and safety.

Are there indications to restrict the use of AP3S1 ? 06/21/2022

There are currently no reports of indications restricting the use of AP3S1 , but specific treatment options need to be determined based on the characteristics of the disease.

What is the dose and route of administration of AP3S1 ? 06/20/2022

The specific choice of dose and route of administration depends on the specific disease and treatment regimen, and further research is needed to determine the optimal dose and method of administration.

Which diseases are associated with recombinant AP3S1? 02/10/2022

AP3S1 has been implicated in the repair of error damage, immune regulation and anti-tumor response.

Are there side effects of AP3S1 treatment? 03/08/2021

There have been no definitive reports of side effects, but more clinical trials are needed to assess the potential risks.

How does the efficacy of recombinant AP3S1 compare with other treatments? 12/19/2020

There is a lack of large-scale clinical trial results compared to other treatments, so it is not possible to definitively assess their relative effectiveness.

Which companies or research institutions are currently developing AP3S1 ? 04/04/2020

A number of companies and research institutions are currently conducting research related to AP3S1 s, including pharmaceutical companies, university laboratories and scientific research institutions.

What are the applications of AP3S1 in clinical treatment? 12/11/2019

AP3S1 has potential applications in immunotherapy, DNA repair therapy and tumor targeting therapy.

How to evaluate the therapeutic effect of AP3S1 ? 07/17/2019

Clinical trials, cell culture experiments, animal models, and molecular biological methods can be used to evaluate the therapeutic effect of AP3S1 .

How is the research progress of AP3S1 ? 02/13/2019

Current studies have shown that the AP3S1 has a potentially important role in the treatment of many diseases, and further studies are currently being conducted to explore its mechanisms and applications.

Customer Reviews (4)

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Reviews
01/24/2022

    Reproducibility of AP3S1 is very good, which greatly reduces experimental error and allows me to evaluate experimental results more accurately.

    11/12/2021

      With short half-life and high clearance characteristics, it has higher potential in drug development and is expected to become a new generation of therapeutic drugs.

      05/01/2021

        Stability of AP3S1 is very good, and a variety of experimental operations can be performed without worrying about changes and effects on its performance.

        11/27/2019

          Resolution in Western blot is high, which can distinguish similar protein molecular weights.

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