AP4M1

  • Official Full Name

    adaptor-related protein complex 4, mu 1 subunit

  • Overview

    This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system.
  • Synonyms

    AP4M1; adaptor-related protein complex 4, mu 1 subunit; AP-4 complex subunit mu-1; adaptor related protein complex AP 4 mu4 subunit; AP 4 adapter complex mu subunit; mu subunit of AP 4; MU 4; mu adaptin related protein 2; MU ARP2; Adaptor related protein complex 4 mu 1 subunit; Adaptor related protein complex AP4 mu4 subunit; Adaptor-related protein complex AP-4, mu 1; AP 4 complex subunit mu 1; AP4 adapter complex mu subunit; AP4 complex subunit mu 1; Ap4m4; CPSQ3; MU4; Mu4-adaptin; MUARP 2; MUARP2; OTTHUMP00000206506; OTTHUMP00000206588; OTTHUMP00000206591; OTTHUMP00000206630; OTTHUMP00000206943; OTTHUMP00000206944; mu subunit of AP-4; mu-adaptin-related protein 2; mu-adaptin-related protein-2; adapter-related protei; MU-4; MU-ARP2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP4M1-3544H Recombinant Human AP4M1, His-tagged E.Coli or Yeast His
Human AP4M1-663H Recombinant Human AP4M1 protein, GST-tagged Wheat Germ GST
Human AP4M1-88HCL Recombinant Human AP4M1 cell lysate N/A
Human AP4M1-1095HF Recombinant Full Length Human AP4M1 Protein, GST-tagged In Vitro Cell Free System GST
Mouse AP4M1-1752M Recombinant Mouse AP4M1 Protein Mammalian Cell His
Mouse Ap4m1-196M Recombinant Mouse Ap4m1 Protein, His-tagged E.coli N-His
Mouse AP4M1-609M-B Recombinant Mouse AP4M1 Protein Pre-coupled Magnetic Beads HEK293
Mouse AP4M1-609M Recombinant Mouse AP4M1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AP4M1-704R Recombinant Rat AP4M1 Protein Mammalian Cell His
Rat AP4M1-360R Recombinant Rat AP4M1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AP4M1-360R-B Recombinant Rat AP4M1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish AP4M1-779Z Recombinant Zebrafish AP4M1 Mammalian Cell His
Chicken AP4M1-6698C Recombinant Chicken AP4M1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AP4M1 Related Articles

AP4M1 involved in several pathways and played different roles in them. We selected most pathways AP4M1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP4M1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeMCOLN1;ARSG;AP1M3;HYAL1;GLB1;ASAH1;PPT1;AP3B2;AP4S1

AP4M1 has several biochemical functions, for example, protein binding, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP4M1 itself. We selected most functions AP4M1 had, and list some proteins which have the same functions with AP4M1. You can find most of the proteins on our site.

Function Related Protein
protein bindingIGHMBP2;NEU2;LSM11;FAM20A;TRIM44;SIAH1;FIG4;DUSP14;FGD5
transporter activitySLCO2B1;ATP6AP1;SLC4A1B;RLBP1B;ABCA4;SLC4A2B;SLC25A13;SLCO4C1;ATP6V0B

AP4M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP4M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP4M1.

USP47; tax; ZBTB22; CHTF8; DDX52; b4dnw0_human; SF3B2; H3F3B; CBX4; LCMT2; RALA; IMPDH2; HMGA1; CDK11B; AKT2; GALNT2; NPAT

Abdollahpour, H; Alawi, M; et al. An AP4B1 frameshift mutation in siblings with intellectual disability and spastic tetraplegia further delineates the AP-4 deficiency syndrome. EUROPEAN JOURNAL OF HUMAN GENETICS 23:256-259(2015).
Jameel, M; Klar, J; et al. A novel AP4M1 mutation in autosomal recessive cerebral palsy syndrome and clinical expansion of AP-4 deficiency. BMC MEDICAL GENETICS 15:-(2014).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
How can AP4M1 protein be delivered to specific tissues or organs in the body? 11/02/2022

Delivery systems, such as targeted nanoparticles or viral vectors, can potentially be used to specifically deliver AP4M1 protein to desired tissues or organs.

What is the current understanding of the structure of AP4M1 protein? 08/30/2022

The structure of AP4M1 protein has been studied using techniques like X-ray crystallography, revealing important insights into its function.

How can the effects of AP4M1 protein be studied in animal models? 07/26/2022

Animal models, such as mice with genetic modifications or knockouts, can help researchers investigate the role and impact of AP4M1 protein in various disease contexts.

Can AP4M1 be used for therapeutic purposes? 07/19/2022

It is possible that AP4M1 could be used as a therapeutic agent in the future, but more research is needed.

How can AP4M1 protein expression be regulated within cells? 06/30/2022

Various cellular mechanisms, such as transcription factors and signaling pathways, may regulate AP4M1 protein expression.

Are there any ongoing clinical trials involving AP4M1 protein? 06/22/2022

At the moment, there are no known ongoing clinical trials involving AP4M1 protein, but it is an area of active research.

Can AP4M1 protein be used in combination with other therapeutic agents? 03/05/2022

The possibility of combining AP4M1 protein with other therapeutic agents for synergistic effects could be explored in future studies.

Can AP4M1 protein be used for diagnostic purposes? 01/13/2022

Detecting AP4M1 protein levels or mutations could potentially be used as a diagnostic tool for certain diseases or genetic disorders.

What are the potential applications of AP4M1 in cancer research? 09/30/2021

AP4M1 protein may play a role in cancer cell migration and invasion, making it a potential target for cancer therapeutics or biomarkers.

What are the major challenges in producing AP4M1 at large scale? 09/29/2021

Challenges may include optimizing protein purification methods, ensuring proper folding and functionality, and maintaining stability during production.

How can AP4M1 protein be effectively delivered to the brain for neurological disorders? 04/05/2021

Strategies like using blood-brain barrier-penetrating nanoparticles or viral vectors could potentially enable the delivery of AP4M1 protein to the brain for neurological disorders.

What are the potential future directions for AP4M1 research? 03/27/2021

Future research may focus on elucidating the molecular mechanisms of AP4M1, exploring its role in different diseases, and developing therapeutic strategies.

How is AP4M1 related to clinical conditions or diseases? 02/13/2021

Mutations in the AP4M1 gene have been associated with a rare genetic disorder called AP-4 deficiency syndrome.

Are there any known natural compounds that can modulate AP4M1 protein activity? 11/13/2020

Currently, there are no known natural compounds that have been identified as direct modulators of AP4M1 protein activity.

What is the function of AP4M1 protein in the human body? 10/24/2020

AP4M1 is a subunit of the AP-4 complex, which plays a role in protein trafficking within cells.

How can AP4M1 protein be effectively targeted for drug development? 03/19/2020

Understanding the three-dimensional structure of AP4M1 could provide valuable information for designing drugs that specifically target this protein.

How can the effects of AP4M1 protein be studied at the cellular level? 03/12/2020

Techniques like CRISPR-Cas9 gene editing or siRNA knockdown can be employed to study the cellular effects of AP4M1 protein.

What are the potential side effects or risks associated with AP4M1 protein therapy? 02/27/2019

As AP4M1 protein therapy is still in the early stages of research, potential side effects and risks are not yet fully understood and need further investigation.

Are there any known interactions between AP4M1 protein and other cellular proteins? 01/31/2019

Yes, AP4M1 has been found to interact with other proteins within the AP-4 complex and in other cellular processes.

Are there any known inhibitors or activators of AP4M1 protein? 01/08/2019

Currently, there are no known specific inhibitors or activators of AP4M1 protein, but research is ongoing in this area.

Customer Reviews (3)

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Reviews
04/12/2022

    The short half-life and high clearance characteristics of AP4M1 enable it to better control the concentration and duration of action of the drug in the body, so as to better grasp the therapeutic effect.

    11/20/2021

      High band strength of this protein in Western blot improves the signal-to-noise ratio of the experiment.

      04/11/2021

        After a long period of storage or repeated use, the stability of AP4M1 is still very good, indicating its high reliability and trustworthiness.

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