AP4M1
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Official Full Name
adaptor-related protein complex 4, mu 1 subunit
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Overview
This gene encodes a subunit of the heterotetrameric AP-4 complex. The encoded protein belongs to the adaptor complexes medium subunits family. This AP-4 complex is involved in the recognition and sorting of cargo proteins with tyrosine-based motifs from the trans-golgi network to the endosomal-lysosomal system. -
Synonyms
AP4M1; adaptor-related protein complex 4, mu 1 subunit; AP-4 complex subunit mu-1; adaptor related protein complex AP 4 mu4 subunit; AP 4 adapter complex mu subunit; mu subunit of AP 4; MU 4; mu adaptin related protein 2; MU ARP2; Adaptor related protein complex 4 mu 1 subunit; Adaptor related protein complex AP4 mu4 subunit; Adaptor-related protein complex AP-4, mu 1; AP 4 complex subunit mu 1; AP4 adapter complex mu subunit; AP4 complex subunit mu 1; Ap4m4; CPSQ3; MU4; Mu4-adaptin; MUARP 2; MUARP2; OTTHUMP00000206506; OTTHUMP00000206588; OTTHUMP00000206591; OTTHUMP00000206630; OTTHUMP00000206943; OTTHUMP00000206944; mu subunit of AP-4; mu-adaptin-related protein 2; mu-adaptin-related protein-2; adapter-related protei; MU-4; MU-ARP2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AP4M1-3544H | Recombinant Human AP4M1, His-tagged | E.Coli or Yeast | His | 453 |
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| Human | AP4M1-663H | Recombinant Human AP4M1 protein, GST-tagged | Wheat Germ | GST |
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| Human | AP4M1-88HCL | Recombinant Human AP4M1 cell lysate | N/A |
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| Human | AP4M1-1095HF | Recombinant Full Length Human AP4M1 Protein, GST-tagged | In Vitro Cell Free System | GST | 453 amino acids |
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| Mouse | AP4M1-1752M | Recombinant Mouse AP4M1 Protein | Mammalian Cell | His |
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| Mouse | Ap4m1-196M | Recombinant Mouse Ap4m1 Protein, His-tagged | E.coli | N-His | Met1-Val208 |
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| Mouse | AP4M1-609M-B | Recombinant Mouse AP4M1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | AP4M1-609M | Recombinant Mouse AP4M1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | AP4M1-704R | Recombinant Rat AP4M1 Protein | Mammalian Cell | His |
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| Rat | AP4M1-360R | Recombinant Rat AP4M1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | AP4M1-360R-B | Recombinant Rat AP4M1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | AP4M1-779Z | Recombinant Zebrafish AP4M1 | Mammalian Cell | His |
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| Chicken | AP4M1-6698C | Recombinant Chicken AP4M1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- AP4M1 Related Articles
AP4M1 involved in several pathways and played different roles in them. We selected most pathways AP4M1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP4M1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | AP4M1;M6PR;DNASE2A;IDS;CTSG;GLA;LAPTM4B;CTSL1B;CTSA |
AP4M1 has several biochemical functions, for example, protein binding, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP4M1 itself. We selected most functions AP4M1 had, and list some proteins which have the same functions with AP4M1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RPRD1B;TMEM8A;HNRNPUL1;IL23;DDX11;FAM167A;NOS1;SUMO2;ARL4C |
| transporter activity | LBFABP;PTGDSB;STEAP1;AQP1A.2;SLCO2B1;AP2M1;FABP11A;ABCA7;ABCB11 |
AP4M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP4M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP4M1.
USP47; tax; ZBTB22; CHTF8; DDX52; b4dnw0_human; SF3B2; H3F3B; CBX4; LCMT2; RALA; IMPDH2; HMGA1; CDK11B; AKT2; GALNT2; NPAT
- Q&As
- Reviews
Q&As (20)
Ask a questionDelivery systems, such as targeted nanoparticles or viral vectors, can potentially be used to specifically deliver AP4M1 protein to desired tissues or organs.
The structure of AP4M1 protein has been studied using techniques like X-ray crystallography, revealing important insights into its function.
Animal models, such as mice with genetic modifications or knockouts, can help researchers investigate the role and impact of AP4M1 protein in various disease contexts.
It is possible that AP4M1 could be used as a therapeutic agent in the future, but more research is needed.
Various cellular mechanisms, such as transcription factors and signaling pathways, may regulate AP4M1 protein expression.
At the moment, there are no known ongoing clinical trials involving AP4M1 protein, but it is an area of active research.
The possibility of combining AP4M1 protein with other therapeutic agents for synergistic effects could be explored in future studies.
Detecting AP4M1 protein levels or mutations could potentially be used as a diagnostic tool for certain diseases or genetic disorders.
AP4M1 protein may play a role in cancer cell migration and invasion, making it a potential target for cancer therapeutics or biomarkers.
Challenges may include optimizing protein purification methods, ensuring proper folding and functionality, and maintaining stability during production.
Strategies like using blood-brain barrier-penetrating nanoparticles or viral vectors could potentially enable the delivery of AP4M1 protein to the brain for neurological disorders.
Future research may focus on elucidating the molecular mechanisms of AP4M1, exploring its role in different diseases, and developing therapeutic strategies.
Mutations in the AP4M1 gene have been associated with a rare genetic disorder called AP-4 deficiency syndrome.
Currently, there are no known natural compounds that have been identified as direct modulators of AP4M1 protein activity.
AP4M1 is a subunit of the AP-4 complex, which plays a role in protein trafficking within cells.
Understanding the three-dimensional structure of AP4M1 could provide valuable information for designing drugs that specifically target this protein.
Techniques like CRISPR-Cas9 gene editing or siRNA knockdown can be employed to study the cellular effects of AP4M1 protein.
As AP4M1 protein therapy is still in the early stages of research, potential side effects and risks are not yet fully understood and need further investigation.
Yes, AP4M1 has been found to interact with other proteins within the AP-4 complex and in other cellular processes.
Currently, there are no known specific inhibitors or activators of AP4M1 protein, but research is ongoing in this area.
Customer Reviews (3)
Write a reviewThe short half-life and high clearance characteristics of AP4M1 enable it to better control the concentration and duration of action of the drug in the body, so as to better grasp the therapeutic effect.
High band strength of this protein in Western blot improves the signal-to-noise ratio of the experiment.
After a long period of storage or repeated use, the stability of AP4M1 is still very good, indicating its high reliability and trustworthiness.
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