AP2A2 involved in several pathways and played different roles in them. We selected most pathways AP2A2 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Adaptive Immune System |
NPEPPS; UBE2J2; RNF4; UBE2L6; CTSH; CTS7; AGO2; TRIM11; KIF4; KIF5B |
| Axon guidance |
FGFR1B; MAPK1; SPRED2; DAB2IPB; Ntng2; CSF2; NTN4; PAK4; SEMA3D; FRS3 |
| Beta-catenin independent WNT signaling |
ITPR2; DVL2; CLTB; CLTC; AGO2; PRICKLE1B; DVL1; AP2S1; PRICKLE1; AP2A1 |
| Developmental Biology |
CFL1; KALRN; PLXNC1; ACVR1C; CNKSR1; NRG4; MEF2B; PTPRA; KCNQ3; CD24 |
| Disease |
GYG2; JAG2; NA; PSTPIP2; CDC37; PDCD6IP; CHMP4B; PACS1; AP2A1; CCNC |
| EGFR downregulation |
AP2A2; AP2M1; STAM2; AP2S1; SPRY2; SPRY1; PTPRK; AP2B1; AP2A1 |
| EPH-Ephrin signaling |
AP2M1; ARPC4; EFNA1B; EPHB3A; EFNA4; ARPC5; ARPC1B; EFNA1; KALRN; ACTR2 |
| EPH-ephrin mediated repulsion of cells |
EFNB3; EFNB1; EPHA2; EFNA2A; AP2S1; EFNB2; EFNA5; AP2B1; EPHA2A; EFNA3 |
AP2A2 has several biochemical functions, for example, contributes_to clathrin adaptor activity, lipid binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2A2 itself. We selected most functions AP2A2 had, and list some proteins which have the same functions with AP2A2. You can find most of the proteins on our site.
| Function |
Related Protein |
| contributes_to clathrin adaptor activity |
AP2A1; AP2M1; AP2S1; AP2B1; AP2A2 |
| lipid binding |
APOE; UNC119; PLUNC; BPIFA3; PITPNB; BPIFB6; OSBPL6; AP2A2; DOK7; UNC119.1 |
| molecular_function |
ASB18; CRYGMXL1; FAM65C; WBP1LB; RSPH4A; BTN2A1; NIPAL2; LIPK; ACBD5; TPRN |
| protein binding |
RAB3C; ABCD2; ZBTB9; ITSN2; LASP1; HMOX1; MT2A; CISH; NMUR2; DDX19B |
| protein complex binding |
RBM10; CRIPT; KRIT1; AKAP5; CASP8; MLC1; RAP1B; ATF1; NFKBIA; PPARA |
| protein kinase binding |
CCNK; ACSL3; ILK; USP37; FBXW5; PARP1; EMP2; SKI; AP2A2; PARK2 |
| protein transporter activity |
CALCR; L7RN6; VPS26BL; SEC61G; CCT6B; AP1S1; KPNA7; XPO1; FRAG1; TIMM10 |
AP2A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2A2.
SHC1; AP2M1; Dab2; Kcnj11; HTT; SMAD1; katG; hflK; q81lw1_bacan; y2173_bacan; vacB; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; EGFR
Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
Upadhyay, RD; Kumar, AV; et al. Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes. REPRODUCTIVE SCIENCES 20:1162-1174(2013).
