AP2A2
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Official Full Name
adaptor-related protein complex 2, alpha 2 subunit
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Synonyms
AP2A2;adaptor-related protein complex 2, alpha 2 subunit;ADTAB, CLAPA2;AP-2 complex subunit alpha-2;adaptin;alpha B;alpha adaptin C;Huntingtin interacting protein J;clathrin associated/assembly/adaptor protein;large;alpha 2;DKFZP564D1864;HIP9;HYPJ;KIAA0899;alpha2-adaptin;adaptin, alpha B;huntingtin yeast partner J;100 kDa coated vesicle protein C;huntingtin-interacting protein 9;alpha-adaptin C;Huntingtin interacting protein J;clathrin assembly protein complex 2 alpha-C large chain;plasma membrane adaptor HA2/AP2 adaptin alpha C subunit;clathrin-associated/assembly/adaptor protein, large, alpha 2;ADTAB;HIP-9;CLAPA2;FLJ37177;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- Mammalian Cell
- His
- Fc
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AP2A2-9715H | Recombinant Human AP2A2, His-tagged | E.coli | His | 590-939a.a. | |
| Human | AP2A2-3532H | Recombinant Human AP2A2, His-tagged | E.Coli or Yeast | His | 940 |
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| Human | AP2A2-8816HCL | Recombinant Human AP2A2 293 Cell Lysate | HEK293 | Non |
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| Mouse | AP2A2-1739M | Recombinant Mouse AP2A2 Protein | Mammalian Cell | His |
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| Mouse | AP2A2-601M | Recombinant Mouse AP2A2 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | AP2A2-601M-B | Recombinant Mouse AP2A2 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | Ap2a2-3531R | Recombinant Rat Ap2a2, His-tagged | E.Coli or Yeast | His | 938 |
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| Chicken | AP2A2-2111C | Recombinant Chicken AP2A2 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
- AP2A2 Related Signal Pathway
AP2A2 involved in several pathways and played different roles in them. We selected most pathways AP2A2 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | B2ML;EGF;AGO2;OSCAR;DZIP3;KLHL21;MGC174857;UBE2E3;RAPGEF4 |
| Axon guidance | LRRC4;FRS2A;EPHA5;SLIT1;CSK;Plxna2;EPHA1;SLIT3;CNTN6 |
| Beta-catenin independent WNT signaling | CTNNB2;AGO3;AP2A1;AP2M1;DVL1;AP2B1;RYK;MOV10;AGO1 |
| Developmental Biology | CCNC;CEBPB;NKX2.2A;SEMA3AB;SEMA3AA;ARPC4;EVL;MYL9;PCSK6 |
| Disease | CTBP2;TCEB3;MYO18A;DERL2;PSTPIP2;OS9;SSRP1;ARF1;TH1L |
| EGFR downregulation | AP2A1;AP2A2;AP2S1;SPRY2;STAM2;SPRY1;AP2M1;PTPRK;AP2B1 |
| EPH-Ephrin signaling | DNM1;ARPC5;ARPC4;EFNB2A;EPHB3A;EPHA2;CLTC;MYL12A;AP2B1 |
| EPH-ephrin mediated repulsion of cells | EFNA1B;EFNA3;EFNB2A;EPHB4B;EPHB4A;EFNB3B;EPHA4A;EFNA2A;EFNA1 |
AP2A2 has several biochemical functions, for example, contributes_to clathrin adaptor activity, lipid binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2A2 itself. We selected most functions AP2A2 had, and list some proteins which have the same functions with AP2A2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to clathrin adaptor activity | AP2B1;AP2A1;AP2S1;AP2A2;AP2M1 |
| lipid binding | EPN3;UNC119;MAL;BPIFB6;FABP10A;PLEKHA2;APOEA;LPAR3;APOA4A |
| molecular_function | NKX2-4;ESPNL;TMEM30AB;PRPF38A;LRRC45;LEPROTL1;DNALC1;REEP5;TMEM230A |
| protein binding | MAPRE3;MYLIPA;METTL17;KCNH1;RPL11;DRD4;LYSMD1;PLSCR1;AIFM1 |
| protein complex binding | NDUFA8;ABI1;SHANK1;ITPR1;NDUFA4;VDAC1;CPD;IGBP1;SLC27A5 |
| protein kinase binding | SYN1;MEF2A;PPME1;VRK1;PARK2;PDGFRB;LCK;TCTN2;YWHAZ |
| protein transporter activity | RAMP2;KPNA2;RAB4A;AP1S3B;ITGB1BP1;PPIAL4A;ARFGAP3;VPS26BL;RANBP6 |
AP2A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2A2.
SHC1; AP2M1; Dab2; Kcnj11; HTT; SMAD1; katG; hflK; q81lw1_bacan; y2173_bacan; vacB; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; EGFR
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewThe sensitivity of AP2A2 in Western blot is very high, and low concentrations of the target protein can be detected.
I appreciate the production process of AP2A2, every step is strictly controlled to ensure the quality and repeatability of the product.
Under different pH conditions, the stability of this protein is still very good, indicating that it has excellent acid-base stability.
AP2A2 are structurally stable and not prone to mutation.
Q&As (19)
Ask a questionRecombinant AP2A2 may play an antitumor role by inhibiting tumor growth and promoting autoimmunity.
Normally, AP2A2 injections should be stored in the refrigerator at a temperature of 2-8 ° C.
Recombinant AP2A2 therapy can be administered intravenously or intramuscularly.
Generally, the preparation methods of AP2A2 include recombinant DNA technology and protein expression and purification technology.
At present, the recombinant AP2A2 protein is still in clinical trials, and researchers are evaluating its safety and efficacy.
There are no clear studies showing that the AP2A2 improves patients' quality of life, but its therapeutic effect may vary for individuals.
Recombinant AP2A2 protein may regulate immune cell activity and enhance immune response, but the specific mechanism still needs to be further studied.
While some studies have shown that recombinant AP2A2 has a preventive effect, more research is needed to confirm its effectiveness.
The study of AP2A2 still faces challenges in terms of safety, efficacy and stability.
Although some preliminary studies suggest that recombinant AP2A2 may have a therapeutic effect on autoimmune diseases, more clinical trials are needed to determine its efficacy.
Evaluation of the effectiveness of AP2A2 therapy usually includes clinical symptom improvement, biomarker level detection, etc.
No definite side effects have been reported, but please consult your doctor before receiving treatment.
The indication for the treatment of AP2A2 needs to be determined based on the specific disease and individual patient situation. Consult your doctor for more accurate advice.
The duration of treatment for AP2A2 varies according to the purpose of treatment and individual differences, please consult your doctor for details.
Currently, the AP2A2 shows potential in the treatment of certain cancers and autoimmune diseases.
There is no clear clinical limit to its use, but different diseases and individual conditions may affect its therapeutic effectiveness.
There are no clear studies showing that recombinant AP2A2 has a therapeutic effect on non-immune-related diseases.
Recombinant protein AP2A2 is mainly involved in intracellular material transport and endocytosis.
Some studies have shown that recombinant AP2A2 can inhibit the growth and spread of certain cancer cells, but further clinical studies are needed to verify its therapeutic effect.
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