• Official Full Name

    adaptor-related protein complex 2, alpha 2 subunit

  • Synonyms

    AP2A2;adaptor-related protein complex 2, alpha 2 subunit;ADTAB, CLAPA2;AP-2 complex subunit alpha-2;adaptin;alpha B;alpha adaptin C;Huntingtin interacting protein J;clathrin associated/assembly/adaptor protein;large;alpha 2;DKFZP564D1864;HIP9;HYPJ;KIAA0899;alpha2-adaptin;adaptin, alpha B;huntingtin yeast partner J;100 kDa coated vesicle protein C;huntingtin-interacting protein 9;alpha-adaptin C;Huntingtin interacting protein J;clathrin assembly protein complex 2 alpha-C large chain;plasma membrane adaptor HA2/AP2 adaptin alpha C subunit;clathrin-associated/assembly/adaptor protein, large, alpha 2;ADTAB;HIP-9;CLAPA2;FLJ37177;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP2A2-9715H Recombinant Human AP2A2, His-tagged E.coli His 590-939a.a.
Human AP2A2-3532H Recombinant Human AP2A2, His-tagged E.Coli or Yeast His 940
Human AP2A2-8816HCL Recombinant Human AP2A2 293 Cell Lysate HEK293 N/A
Mouse AP2A2-1739M Recombinant Mouse AP2A2 Protein Mammalian Cell His
Mouse AP2A2-601M Recombinant Mouse AP2A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse AP2A2-601M-B Recombinant Mouse AP2A2 Protein Pre-coupled Magnetic Beads HEK293
Rat Ap2a2-3531R Recombinant Rat Ap2a2, His-tagged E.Coli or Yeast His 938
Chicken AP2A2-2111C Recombinant Chicken AP2A2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • AP2A2 Related Signal Pathway

AP2A2 involved in several pathways and played different roles in them. We selected most pathways AP2A2 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemUBR1;THEM4;KIF4A;LRRC41;CD200R4;PAG1;LAIR1;RNF123;ASB11
Beta-catenin independent WNT signalingAP2M1;AP2B1;CTNNB2;CLTA;AP2S1;AGO1;DVL1;DVL2;ROR1
Developmental BiologyDLG3;GFRA4;NRG4;TCF12;MARK3;ADAM23;INSM1B;MEF2B;SEMA3AA
EGFR downregulationAP2S1;AP2A2;STAM2;AP2M1;SPRY2;PTPRK;SPRY1;AP2A1;AP2B1
EPH-ephrin mediated repulsion of cellsAP2S1;EFNA5;EFNB3B;EFNA1;EFNB2A;EPHB4B;EFNA3B;EFNA1A;CLTB

AP2A2 has several biochemical functions, for example, contributes_to clathrin adaptor activity, lipid binding, molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2A2 itself. We selected most functions AP2A2 had, and list some proteins which have the same functions with AP2A2. You can find most of the proteins on our site.

Function Related Protein
contributes_to clathrin adaptor activityAP2A2;AP2B1;AP2A1;AP2M1;AP2S1
protein bindingRIPK4;LAT;KCNA3;FAM59A;DRD2;KIAA1267;PKMYT1;FAM113A;STRA13
protein complex bindingPPIB;COG2;PGAM5;CCNE1;SH2B3;ABI1;LCK;AP2B1;ST13
protein kinase bindingPDGFRB;CCNE2;SMAD3;AXIN2;CAMK2N2;GDF3;MAML1;SV2A;TCF7L2
protein transporter activityVPS26BL;KPNA3;SEC62;RUFY1;SNUPN;COX18;AP1G2;AP1B1;KPNA7

AP2A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2A2.

SHC1; AP2M1; Dab2; Kcnj11; HTT; SMAD1; katG; hflK; q81lw1_bacan; y2173_bacan; vacB; pi3p; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; EGFR

Research Area

Related articles

Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
Upadhyay, RD; Kumar, AV; et al. Estrogen Effects on Actin Cytoskeletal and Endocytic Proteins Associated With Tubulobulbar Complex Disruption in Rat Testes. REPRODUCTIVE SCIENCES 20:1162-1174(2013).
  • Q&As
  • Reviews

Q&As (19)

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What is the mechanism of AP2A2 in antitumor therapy? 12/25/2022

Recombinant AP2A2 may play an antitumor role by inhibiting tumor growth and promoting autoimmunity.

What are the storage conditions of AP2A2 injection? 11/28/2022

Normally, AP2A2 injections should be stored in the refrigerator at a temperature of 2-8 ° C.

By what means can AP2A2 therapy be delivered to patients? 10/18/2022

Recombinant AP2A2 therapy can be administered intravenously or intramuscularly.

What are the preparation methods of AP2A2 ? 09/08/2022

Generally, the preparation methods of AP2A2 include recombinant DNA technology and protein expression and purification technology.

What is the progress of recombinant AP2A2 in clinical trials? 05/15/2022

At present, the recombinant AP2A2 protein is still in clinical trials, and researchers are evaluating its safety and efficacy.

Is there any research showing that recombinant AP2A2 can improve patients' quality of life? 03/23/2022

There are no clear studies showing that the AP2A2 improves patients' quality of life, but its therapeutic effect may vary for individuals.

What are the effects of recombinant AP2A2 on the immune system? 01/29/2022

Recombinant AP2A2 protein may regulate immune cell activity and enhance immune response, but the specific mechanism still needs to be further studied.

Is there any research showing that recombinant AP2A2 can prevent certain diseases? 05/07/2021

While some studies have shown that recombinant AP2A2 has a preventive effect, more research is needed to confirm its effectiveness.

What are the remaining challenges in the research of AP2A2 ? 04/27/2021

The study of AP2A2 still faces challenges in terms of safety, efficacy and stability.

Is there any research showing that recombinant AP2A2 is effective in the treatment of autoimmune diseases? 12/27/2020

Although some preliminary studies suggest that recombinant AP2A2 may have a therapeutic effect on autoimmune diseases, more clinical trials are needed to determine its efficacy.

How to evaluate the effectiveness of AP2A2 therapy? 07/31/2020

Evaluation of the effectiveness of AP2A2 therapy usually includes clinical symptom improvement, biomarker level detection, etc.

Are there side effects of recombinant AP2A2? 06/13/2020

No definite side effects have been reported, but please consult your doctor before receiving treatment.

Is AP2A2 therapy suitable for everyone? 05/12/2020

The indication for the treatment of AP2A2 needs to be determined based on the specific disease and individual patient situation. Consult your doctor for more accurate advice.

How long is the usual course of treatment for AP2A2 ? 04/03/2020

The duration of treatment for AP2A2 varies according to the purpose of treatment and individual differences, please consult your doctor for details.

In what diseases is recombinant AP2A2 used? 03/08/2020

Currently, the AP2A2 shows potential in the treatment of certain cancers and autoimmune diseases.

Are there any limitations to the clinical use of recombinant AP2A2? 01/04/2020

There is no clear clinical limit to its use, but different diseases and individual conditions may affect its therapeutic effectiveness.

Can recombinant AP2A2 be used to treat other non-immune-related diseases? 08/24/2019

There are no clear studies showing that recombinant AP2A2 has a therapeutic effect on non-immune-related diseases.

What is the main function of AP2A2 ? 06/27/2019

Recombinant protein AP2A2 is mainly involved in intracellular material transport and endocytosis.

What is the therapeutic effect of recombinant AP2A2 on certain cancers? 03/17/2019

Some studies have shown that recombinant AP2A2 can inhibit the growth and spread of certain cancer cells, but further clinical studies are needed to verify its therapeutic effect.

Customer Reviews (4)

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    The sensitivity of AP2A2 in Western blot is very high, and low concentrations of the target protein can be detected.


      I appreciate the production process of AP2A2, every step is strictly controlled to ensure the quality and repeatability of the product.


        Under different pH conditions, the stability of this protein is still very good, indicating that it has excellent acid-base stability.


          AP2A2 are structurally stable and not prone to mutation.

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