AP2B1
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Official Full Name
adaptor-related protein complex 2, beta 1 subunit
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Background
Subunit of clathrin associated adaptor protein complex 1 that plays a role in protein sorting in the late Golgi/trans Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 (AP1) is an heterotetramer composed of two large adaptins (gamma type subunit AP1G1 and beta type subunit AP1B1), a medium adaptin (mu type subunit AP1M1 or AP1M2) and a small adaptin (sigma type subunit AP1S1 or AP1S2 or AP1S3). -
Synonyms
AP2B1; adaptor-related protein complex 2, beta 1 subunit; AP-2 complex subunit beta; AP105B; beta1-adaptin; beta2-adaptin; beta-1-adaptin; beta-2-adaptin; beta-adaptin 1; AP-1 complex subunit beta-1; adaptor protein complex AP-2 subunit beta; golgi adapto;
- Involved Pathway
- Protein Function
- Interacting Protein
- AP2B1 Related Articles
AP2B1 involved in several pathways and played different roles in them. We selected most pathways AP2B1 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | FBXO17;NRG4;ASB6;KLRB1A;CD96;RNF6;ASB8;CTSLL;LRSAM1 |
| Axon guidance | AKAP9;RAC3;HFE2;SCN2B;PPP3R1;PAK4;COL9A1B;DPYSL3;GFRA2 |
| Beta-catenin independent WNT signaling | DVL2;MOV10;DVL1;PRICKLE1;CLTC;CLTB;AP2A2;CTNNB2;ROR1 |
| Developmental Biology | SALL4;RHOC;DUSP6;MYF6;SEMA3AA;LAMTOR2;ITGB1B.1;RASGRP4;HIF3A |
| Disease | MIB1;BANF1;TLR10;AP2B1;PDCD6IP;TICAM1;TNKS2;HEY2;TH1L |
| EGFR downregulation | SPRY2;SPRY1;AP2A2;AP2A1;PTPRK;AP2S1;AP2B1;AP2M1;STAM2 |
| EPH-Ephrin signaling | EPHA2A;EFNB1;ARPC1B;EFNB2A;KDR;EFNB3;ARPC3;EFNB3B;MYL12B |
| EPH-ephrin mediated repulsion of cells | EFNB3B;AP2B1;EFNB2A;EPHA10;EFNA3B;EPHB3A;EFNA2;EFNB1;EFNA1B |
AP2B1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, clathrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2B1 itself. We selected most functions AP2B1 had, and list some proteins which have the same functions with AP2B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to clathrin adaptor activity | AP2B1;AP2M1;AP2A2;AP2S1;AP2A1 |
| clathrin binding | SYT1A;SYT5A;AFTPH;DNER;TOM1L1;SYT10;SYT7;RPH3AL;SYT13 |
| protein binding | DSTN;FGFRL1B;IL17RE;CCDC28A;STAT4;GRB7;TSPAN4;UNC13B;NEDD4L |
| protein complex binding | FADD;CDK4;ANKRD32;STRN4;STK11;RNF40;ULK1;HSPD1;NASP |
| protein transporter activity | VPS26BL;IPO7;AP1S3A;IPO13;VPS26A;IPO8;KPNA3;VPS35;ITGB1BP1 |
| signal sequence binding | AP2M1;AP2B1;SRP68 |
AP2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2B1.
LDLRAP1; THAP1; AP1M2; Ap2m1; 10411; SLC25A6
- Q&As
- Reviews
Q&As (20)
Ask a questionAP2B1 s belong to the chaperone family and contain several domains, the main one being the C-glycosyltransferase domain.
The main difference between AP2B1 and other molecular chaperones is that AP2B1 participates in different biological processes, and its structure and function are also different.
Recombinant AP2B1 protein may be a therapeutic target for some diseases, but further research and experimental validation are needed.
The AP2B1 exists primarily as a molecular chaperone and part of a signaling pathway in protein complexes.
The expression of recombinant AP2B1 protein is influenced by genetic and environmental factors, such as certain gene mutations, drugs, etc.
The AP2B1 is mainly located in the cytoplasm and endoplasmic reticulum.
The biological function of AP2B1 may be influenced by its expression level, but the specific details need to be further studied.
The AP2B1 is associated with a variety of diseases, including cancer, neurodegenerative diseases, and genetic diseases.
Recombinant AP2B1 protein may be involved in tumor growth and metastasis in tumor cells, but further experimental verification is needed.
The role of AP2B1 in cell proliferation and apoptosis still needs further research.
The biosynthesis of recombinant AP2B1 requires participation in multiple protein synthesis pathways, including translation, transport, shearing, modification, etc.
There are many interactions between AP2B1 and other molecules, such as protein-protein interactions, biochemical reactions, etc.
Recombinant AP2B1 protein may be involved in a variety of metabolic, signal transduction and other biological processes in genetic diseases, but the specific role needs to be further studied.
The regulatory mechanism of AP2B1 includes regulation of many signaling pathways and regulatory elements such as transcription factors.
The recombinant AP2B1 protein is a molecular chaperone involved in biological processes such as regulating internal cellular secretion pathways and endoplasmic reticulum function.
The structure, function and regulation of AP2B1 are similar to other proteins in some respects, but the specific differences need to be further studied.
AP2B1 is widely present in various tissues of the human body, including liver, lung, gastrointestinal tract, kidney and so on.
The AP2B1 may have certain research and therapeutic value for the treatment of some neurological diseases.
AP2B1 may be used as a drug, which has certain application value in tumor therapy, nerve cell protection, genetic therapy and so on.
The study of AP2B1 will be helpful in understanding the pathogenesis of the disease and developing treatments.
Customer Reviews (3)
Write a reviewThe performance of AP2B1 recombinant protein was evaluated by measuring its functional activity in the cell, such as interaction with other proteins and efficiency of endocytosis. -
Excellent protein properties also need to be pure enough to play a role, so it is necessary to measure the purity and expression level of AP2B1 recombinant protein. -
The structural stability of proteins can be studied through spectral technology, thermodynamic experiments and other methods to see whether it is easy to denaturate or aggregate. -
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