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AP2B1

  • Official Full Name

    adaptor-related protein complex 2, beta 1 subunit

  • Overview

    Subunit of clathrin associated adaptor protein complex 1 that plays a role in protein sorting in the late Golgi/trans Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 (AP1) is an heterotetramer composed of two large adaptins (gamma type subunit AP1G1 and beta type subunit AP1B1), a medium adaptin (mu type subunit AP1M1 or AP1M2) and a small adaptin (sigma type subunit AP1S1 or AP1S2 or AP1S3).
  • Synonyms

    AP2B1; adaptor-related protein complex 2, beta 1 subunit; AP-2 complex subunit beta; AP105B; beta1-adaptin; beta2-adaptin; beta-1-adaptin; beta-2-adaptin; beta-adaptin 1; AP-1 complex subunit beta-1; adaptor protein complex AP-2 subunit beta; golgi adapto;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP2B1-652H Recombinant Human AP2B1 protein, GST-tagged Wheat Germ GST
Human AP2B1-8815HCL Recombinant Human AP2B1 293 Cell Lysate HEK293 N/A
Human AP2B1-6159H Recombinant Human AP2B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AP2B1-2317H Recombinant Human AP2B1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AP2B1-1014HF Recombinant Full Length Human AP2B1 Protein, GST-tagged In Vitro Cell Free System GST 951 amino acids
Human AP2B1-186H Recombinant Human AP2B1 Protein, His-tagged E.coli N-His Thr2-Phe266
Human AP2B1-350H-B Recombinant Human AP2B1 Protein Pre-coupled Magnetic Beads HEK293
Human AP2B1-476HFL Recombinant Full Length Human AP2B1 Protein, C-Flag-tagged Mammalian cells Flag
Human AP2B1-350H Recombinant Human AP2B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AP2B1-0528H Recombinant Human AP2B1 Protein (Met1-Phe266), N-His-tagged E.coli N-His Met1-Phe266
Mouse Ap2b1-1653M Recombinant Mouse Ap2b1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat AP2B1-700R Recombinant Rat AP2B1 Protein Mammalian Cell His
Rat Ap2b1-3534R Recombinant Rat Ap2b1, His-tagged E.Coli or Yeast His 951
Rat AP2B1-356R Recombinant Rat AP2B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AP2B1-356R-B Recombinant Rat AP2B1 Protein Pre-coupled Magnetic Beads HEK293
Bovine AP2B1-3533B Recombinant Bovine AP2B1, His-tagged E.Coli or Yeast His 937
Zebrafish AP2B1-10288Z Recombinant Zebrafish AP2B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

AP2B1 involved in several pathways and played different roles in them. We selected most pathways AP2B1 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemTREML1;LRR1;AGO1;DCTN3;SIGLEC7;ASB2;KIF20A;Mill2;GRAP2B
Axon guidancePLXNA1;SLIT1;CLTC;EPHB2;COL6A1;EPHA8;CHL1;ARHGEF28;DAB2IPB
Beta-catenin independent WNT signalingRYK;AP2M1;PRICKLE1B;DVL1;CLTB;PRICKLE1;AP2S1;AGO1;GNB5
Developmental BiologyDAB2IPB;TDGF1;BNIP2;DOCK1;KBTBD7;SCN3B;AP2A2;DPYSL5B;SPTA1
DiseaseKREMEN1;SFTPB;AP1S1;COBRA1;CCDC59;ARF1;SFTPC;TRIM24;NPM1
EGFR downregulationSTAM2;AP2A1;AP2B1;AP2S1;AP2A2;SPRY2;SPRY1;AP2M1;PTPRK
EPH-Ephrin signalingMYL9;EPHB4A;EFNA3;ARPC4;EFNB3B;ARPC3;EFNB1;EFNB2A;AP2S1
EPH-ephrin mediated repulsion of cellsEPHA4A;EPHA2A;EFNB1;EPHA10;EFNA3;EFNB2A;EFNB2;EPHA2;AP2S1

AP2B1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, clathrin binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2B1 itself. We selected most functions AP2B1 had, and list some proteins which have the same functions with AP2B1. You can find most of the proteins on our site.

Function Related Protein
contributes_to clathrin adaptor activityAP2M1;AP2B1;AP2A1;AP2A2;AP2S1
clathrin bindingHIP1;CCDC167;SYT13;SYT4;SYT3;SYT16;SYT15;SYT1;SYT1A
protein bindingMR1;GRID2IP;JUNB;ZC3HC1;KRT25;PTRH2;BLOC1S3;RPL39L;MBD4
protein complex bindingPRMT5;WRN;INS2;FBN1;NSF;KRAS;VHLL;RANBP2;ERCC6
protein transporter activityRANBP6;ARFGAP3;AP1G2;TNPO3;RANGRF;XPO1;KPNB3;VPS35;CCT6B
signal sequence bindingAP2M1;AP2B1;SRP68

AP2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2B1.

LDLRAP1; THAP1; AP1M2; Ap2m1; 10411; SLC25A6

Research Area

Related articles

Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).
Jones, ML; Murden, SL; et al. Disruption of AP3B1 by a chromosome 5 inversion: a new disease mechanism in Hermansky-Pudlak syndrome type 2. BMC MEDICAL GENETICS 14:-(2013).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
What are the structural characteristics of AP2B1 ? 12/02/2022

AP2B1 s belong to the chaperone family and contain several domains, the main one being the C-glycosyltransferase domain.

What is the difference between AP2B1 and other molecular chaperones? 06/05/2022

The main difference between AP2B1 and other molecular chaperones is that AP2B1 participates in different biological processes, and its structure and function are also different.

Can AP2B1 be used in clinical treatment? 04/25/2022

Recombinant AP2B1 protein may be a therapeutic target for some diseases, but further research and experimental validation are needed.

What is the role of AP2B1 in protein complex? 02/20/2022

The AP2B1 exists primarily as a molecular chaperone and part of a signaling pathway in protein complexes.

What factors affect the expression of AP2B1 ? 11/15/2021

The expression of recombinant AP2B1 protein is influenced by genetic and environmental factors, such as certain gene mutations, drugs, etc.

What is the localization of AP2B1 in the cell? 10/23/2021

The AP2B1 is mainly located in the cytoplasm and endoplasmic reticulum.

Is the biological function of recombinant AP2B1 affected by its expression level? 09/04/2021

The biological function of AP2B1 may be influenced by its expression level, but the specific details need to be further studied.

Which diseases are associated with recombinant AP2B1? 08/30/2021

The AP2B1 is associated with a variety of diseases, including cancer, neurodegenerative diseases, and genetic diseases.

What is the role of AP2B1 in tumor cells? 07/05/2021

Recombinant AP2B1 protein may be involved in tumor growth and metastasis in tumor cells, but further experimental verification is needed.

What is the role of AP2B1 in cell proliferation and apoptosis? 06/02/2021

The role of AP2B1 in cell proliferation and apoptosis still needs further research.

What is the biosynthetic pathway of AP2B1 ? 04/11/2021

The biosynthesis of recombinant AP2B1 requires participation in multiple protein synthesis pathways, including translation, transport, shearing, modification, etc.

What is the interaction of AP2B1 with other molecules? 01/05/2021

There are many interactions between AP2B1 and other molecules, such as protein-protein interactions, biochemical reactions, etc.

What is the role of recombinant AP2B1 in genetic diseases? 06/02/2020

Recombinant AP2B1 protein may be involved in a variety of metabolic, signal transduction and other biological processes in genetic diseases, but the specific role needs to be further studied.

What is the regulatory mechanism of AP2B1 ? 02/06/2020

The regulatory mechanism of AP2B1 includes regulation of many signaling pathways and regulatory elements such as transcription factors.

What is the function of AP2B1 ? 10/26/2019

The recombinant AP2B1 protein is a molecular chaperone involved in biological processes such as regulating internal cellular secretion pathways and endoplasmic reticulum function.

Is the structure, function and regulation of recombinant AP2B1 similar to other proteins? 09/15/2019

The structure, function and regulation of AP2B1 are similar to other proteins in some respects, but the specific differences need to be further studied.

In which tissues is recombinant AP2B1 expressed? 07/22/2019

AP2B1 is widely present in various tissues of the human body, including liver, lung, gastrointestinal tract, kidney and so on.

What is the help of AP2B1 in the treatment of neurological diseases? 06/29/2019

The AP2B1 may have certain research and therapeutic value for the treatment of some neurological diseases.

Can AP2B1 be used as a drug? 06/27/2019

AP2B1 may be used as a drug, which has certain application value in tumor therapy, nerve cell protection, genetic therapy and so on.

Is the study of recombinant AP2B1 meaningful for the treatment of diseases? 03/21/2019

The study of AP2B1 will be helpful in understanding the pathogenesis of the disease and developing treatments.

Customer Reviews (3)

Write a review
Reviews
09/27/2022

    Convenient storage, whether it is multiple use or long-term storage, its structure and function have always remained stable, providing great convenience for scientific research work.

    02/04/2022

      Green production process of AP2B1 pays attention to harmonious symbiosis with nature, realizes zero pollution in the production process, and has no negative impact on the environment.

      08/19/2019

        The high activity greatly reduces the time and energy required for chemical reactions, and its economic value is immeasurable.

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