AP2B1
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Official Full Name
adaptor-related protein complex 2, beta 1 subunit -
Overview
Subunit of clathrin associated adaptor protein complex 1 that plays a role in protein sorting in the late Golgi/trans Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 1 (AP1) is an heterotetramer composed of two large adaptins (gamma type subunit AP1G1 and beta type subunit AP1B1), a medium adaptin (mu type subunit AP1M1 or AP1M2) and a small adaptin (sigma type subunit AP1S1 or AP1S2 or AP1S3). -
Synonyms
AP2B1;adaptor-related protein complex 2, beta 1 subunit;AP-2 complex subunit beta;AP105B;beta1-adaptin;beta2-adaptin;beta-1-adaptin;beta-2-adaptin;beta-adaptin 1;AP-1 complex subunit beta-1;adaptor protein complex AP-2 subunit beta;golgi adapto
Recombinant Proteins
- Zebrafish
- Bovine
- Rat
- Human
- Mouse
- Mammalian Cells
- E.Coli/Yeast
- Wheat Germ
- HEK293
- E.coli
- In Vitro Cell Free System
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
AP2B1 involved in several pathways and played different roles in them. We selected most pathways AP2B1 participated on our site, such as Adaptive Immune System,Axon guidance,Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EPH-Ephrin signaling | ARPC2,KALRN,ARPC1B,CLTC,EFNB2A,EPHA4A,KALRNB,ARPC3,ARHGEF28,AP2M1 |
| EPH-ephrin mediated repulsion of cells | EFNB2A,EFNA1B,CLTB,EFNA1A,EPHA4A,EPHB4A,EPHB3A,AP2S1,EFNB1,EPHA2 |
| Axon guidance | DPYSL5A,ACTR3,SPTBN2,Unc5b,CNKSR1,HRAS,SEMA3B,COL4A3,EPHA2A,PPP3CC |
| Developmental Biology | DUSP5,POU5F3,EPHB4A,CHL1,DPYSL5B,KIF4A,DUSP9,MED20,DAB2IPB,EFNA5 |
| Disease | ARF1,OGN,NUPL2,KPNA4,KREMEN1,SFTPC,ANTXR2,CTDP1,SUPT4H1,GYG2 |
| EGFR downregulation | STAM2,PTPRK,AP2A2,SPRY2,SPRY1,AP2M1,AP2A1,AP2S1 |
| Beta-catenin independent WNT signaling | ITPR2,PRICKLE1,DVL1,DVL3,AP2S1,ROR1,CLTB,CLTA,AGO2,CTNNB2 |
| Adaptive Immune System | RASGRP1,ITPR2,TRAT1,GAN,RACGAP1,OSBPL1A,ASB18,CD300E,ATG7,HUWE1 |
Protein Function
AP2B1 has several biochemical functions, for example, contributes_to clathrin adaptor activity,clathrin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2B1 itself. We selected most functions AP2B1 had, and list some proteins which have the same functions with AP2B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein complex binding | PRKACA,CTSL2,RPAIN,DAG1,PDCL,GIT1,CDK4,DRD1,SKAP1,TAPBPL |
| signal sequence binding | AP2M1,SRP68 |
| protein transporter activity | AP1S3,VPS26BL,XPO1,IPO13,AP2A2,MLC1,AP2S1,KPNB3,RAB4A,IPO7 |
| protein binding | RQCD1,LRP12,CLCNKB,RHOB,S100A16,CLDN16,TRAF2,MAP1LC3B,STX12,SENP3 |
| contributes_to clathrin adaptor activity | AP2M1,AP2A2,AP2S1,AP2A1 |
| clathrin binding | SYT11B,SYT1B,LDLRAP1,SNAP91,HIP1,SYTL4,SYT13,RPH3AL,SYT16,HIP1R |
Interacting Protein
AP2B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2B1.
LDLRAP1;THAP1;AP1M2;Ap2m1;10411;SLC25A6
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References
- Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).
- Jones, ML; Murden, SL; et al. Disruption of AP3B1 by a chromosome 5 inversion: a new disease mechanism in Hermansky-Pudlak syndrome type 2. BMC MEDICAL GENETICS 14:-(2013).
