AP2M1 Protein


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Official Full Name adaptor-related protein complex 2, mu 1 subunit
Background This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms AP2M1; adaptor-related protein complex 2, mu 1 subunit; CLAPM1; AP-2 complex subunit mu; AP 2 mu 2 chain; AP50; clathrin adaptor complex AP2; mu subunit; clathrin assembly protein complex 2 medium chain; clathrin coat adaptor protein AP50; clathrin associ
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • His-SUMO
    • MYC/DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AP2M1-27356TH Recombinant Human AP2M1, T7 -tagged E.coli T7
    Human AP2M1-653H Recombinant Human AP2M1 protein, GST-tagged Wheat Germ GST
    Human AP2M1-70H Recombinant Human AP2M1, T7-tagged E.coli T7
    Human AP2M1-9717H Recombinant Human AP2M1, GST-tagged E.coli GST
    Mouse AP2M1-1741M Recombinant Mouse AP2M1 Protein Mammalian Cell His
    Rat Ap2m1-3535R Recombinant Rat Ap2m1, His-tagged E.Coli or Yeast His
    Rat AP2M1-701R Recombinant Rat AP2M1 Protein Mammalian Cell His
    Cynomolgus Monkey AP2M1-301C Recombinant Cynomolgus AP2M1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque AP2M1-348R Recombinant Rhesus monkey AP2M1 Protein, His-tagged Mammalian Cell His
    Chicken AP2M1-3533C Recombinant Chicken AP2M1 Mammalian Cell His
    Human AP2M1-8813HCL Recombinant Human AP2M1 293 Cell Lysate HEK293 N/A
    Human AP2M1-8814HCL Recombinant Human AP2M1 293 Cell Lysate HEK293 N/A
    Human AP2M1-1035HF Recombinant Full Length Human AP2M1 Protein, GST-tagged In Vitro Cell Free System GST
    Human AP2M1-1173H Recombinant Human AP2M1 protein, His-tagged E.coli His
    Human AP2M1-2524H Recombinant Human AP2M1 protein, His-SUMO-tagged E.coli His-SUMO
    Human AP2M1-2694H Recombinant Human AP2M1 protein, His-tagged E.coli His
    Human AP2M1-1328H Recombinant Human AP2M1 Protein (1-435 aa), His-tagged Yeast His
    Human AP2M1-393H Recombinant Human AP2M1 Protein, His-tagged E.coli His
    Human AP2M1-5692H Recombinant Human AP2M1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Ap2m1-621M Recombinant Mouse Ap2m1 Protein, MYC/DDK-tagged HEK293T MYC/DDK

    AP2M1 involved in several pathways and played different roles in them. We selected most pathways AP2M1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2M1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System LILRA3; RNF41; CTSK; UBE2J2; AGO3; SRMS; AKT3; SIGLEC5; RAP1GAP2B; NCR3LG1
    Arf1 pathway ARF1; AP2M1; AP2A1; CLTB; ARFIP2; CLTA; USO1
    Axon guidance Sema3f; FRS2A; SEMA5B; RHOAE; CXCR4; EPHB3; COL9A3; EPHA7; NRG3; RND1L
    Beta-catenin independent WNT signaling ROR2; GNB5; ITPR2; PRICKLE1B; AP2S1; DVL3; CLTC; CTNNB2; ROR1; AGO1
    Developmental Biology MED22; CACNG8A; CDON; MYL9; MED16; MYOD1; PAK4; TRIO; DCC; PLXNC1
    Disease PDCD6IP; NMT2; OGN; MMADHC; RCC1; STRA6; VPS37A; TLR10; HEY2; CDK9
    EGFR downregulation AP2S1; SPRY2; STAM2; PTPRK; SPRY1; AP2M1; AP2A1; AP2A2; AP2B1
    EPH-Ephrin signaling EFNB1; AP2M1; ARPC2; ACTR2B; MYL12A; KALRN; ARPC1A; SHB; EFNB2A; EFNB3

    AP2M1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, ion channel binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2M1 itself. We selected most functions AP2M1 had, and list some proteins which have the same functions with AP2M1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to clathrin adaptor activity AP2B1; AP2M1; AP2A1; AP2A2; AP2S1
    ion channel binding PANX1; TCAP; DLG1; PDE4B; TRAPPC2; GPD1L; KCNC1; PDE4D; CALM3; CAV1
    lipid binding APOA1A; STARD8; ANXA6; S100A13; SH3GL3; FABP1A; CADPS; PLEKHA2; MARK2; TRIP10
    low-density lipoprotein particle receptor binding DNAJA1; HSP90B1; SLC9A3R2; CCDC167; APOE; SYT1; DKK1; SACS; CRP; APOEB
    protein binding SMCO4; BTF3; SLAMF1; TCTE3; KLRB1F; HOOK2; ENOX2; CAMK2B; SLU7; HOXB5
    signal sequence binding AP2B1; AP2M1; SRP68
    transporter activity AP3B2; PTGDSA; ATP6V0E1; SEC14L2; AQP3B; LCN9; SYPL2A; SLC12A10.2; ABCC6; SLC12A10.3

    AP2M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2M1.

    TBC1D5; AAK1; RALBP1; EGFR; AP2B1; p27958-pro_0000037566; AP2A2

    Huang, X; Dai, FF; et al. The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity. MOLECULAR ENDOCRINOLOGY 27:1550-1563(2013).
    Dadlchah, E; Naseh, H; et al. A Cancer-Array Approach Elucidates the Immune Escape Mechanism and Defects in the DNA Repair System in Esophageal Squamous Cell Carcinoma. ARCHIVES OF IRANIAN MEDICINE 16:463-470(2013).

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