AP2M1

  • Official Full Name

    adaptor-related protein complex 2, mu 1 subunit

  • Overview

    This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    AP2M1; adaptor-related protein complex 2, mu 1 subunit; CLAPM1; AP-2 complex subunit mu; AP 2 mu 2 chain; AP50; clathrin adaptor complex AP2; mu subunit; clathrin assembly protein complex 2 medium chain; clathrin coat adaptor protein AP50; clathrin associ;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • MYC
  • N/A
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP2M1-27356TH Recombinant Human AP2M1, T7 -tagged E.coli T7
Human AP2M1-9717H Recombinant Human AP2M1, GST-tagged E.coli GST C-term-269a.a.
Human AP2M1-653H Recombinant Human AP2M1 protein, GST-tagged Wheat Germ GST
Human AP2M1-70H Recombinant Human AP2M1, T7-tagged E.coli T7
Human AP2M1-8813HCL Recombinant Human AP2M1 293 Cell Lysate HEK293 N/A
Human AP2M1-8814HCL Recombinant Human AP2M1 293 Cell Lysate HEK293 N/A
Human AP2M1-1328H Recombinant Human AP2M1 Protein (1-435 aa), His-tagged Yeast His 1-435 aa
Human AP2M1-2694H Recombinant Human AP2M1 protein, His-tagged E.coli His 1-108 aa
Human AP2M1-1375HFL Recombinant Full Length Human AP2M1 Protein, C-Flag-tagged Mammalian cells Flag
Human AP2M1-393H Recombinant Human AP2M1 Protein, His-tagged E.coli His Arg170~Cys435
Human AP2M1-5692H Recombinant Human AP2M1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AP2M1-1173H Recombinant Human AP2M1 protein, His-tagged E.coli His 1-435aa
Human AP2M1-2524H Recombinant Human AP2M1 protein, His-SUMO-tagged E.coli His-SUMO 1-435aa
Human AP2M1-351H Recombinant Human AP2M1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human AP2M1-1035HF Recombinant Full Length Human AP2M1 Protein, GST-tagged In Vitro Cell Free System GST 435 amino acids
Human AP2M1-351H-B Recombinant Human AP2M1 Protein Pre-coupled Magnetic Beads HEK293
Mouse AP2M1-1741M Recombinant Mouse AP2M1 Protein Mammalian Cell His
Mouse AP2M1-602M Recombinant Mouse AP2M1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ap2m1-621M Recombinant Mouse Ap2m1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse AP2M1-602M-B Recombinant Mouse AP2M1 Protein Pre-coupled Magnetic Beads HEK293
Rat AP2M1-701R Recombinant Rat AP2M1 Protein Mammalian Cell His
Rat Ap2m1-3535R Recombinant Rat Ap2m1, His-tagged E.Coli or Yeast His 435
Rat AP2M1-357R-B Recombinant Rat AP2M1 Protein Pre-coupled Magnetic Beads HEK293
Rat AP2M1-357R Recombinant Rat AP2M1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey AP2M1-301C Recombinant Cynomolgus AP2M1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey AP2M1-51C-B Recombinant Cynomolgus Monkey AP2M1 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey AP2M1-51C Recombinant Cynomolgus Monkey AP2M1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AP2M1-348R Recombinant Rhesus monkey AP2M1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AP2M1-176R Recombinant Rhesus Macaque AP2M1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AP2M1-176R-B Recombinant Rhesus Macaque AP2M1 Protein Pre-coupled Magnetic Beads HEK293
Chicken AP2M1-3533C Recombinant Chicken AP2M1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AP2M1 Related Articles

AP2M1 involved in several pathways and played different roles in them. We selected most pathways AP2M1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2M1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemLRSAM1;NCR3LG1;ACTR1B;MGC174857;CLTA;PAG1;RAPGEF4;FBXO17;SEC24A
Arf1 pathwayARF1;CLTA;USO1;CLTB;ARFIP2;AP2M1;AP2A1
Axon guidanceSEMA4B;PEA15A;SCN4A;EFNA4;ROBO2;RASGEF1A;AP2B1;PEBP1;RHOGA
Beta-catenin independent WNT signalingDVL1;ITPR2;AGO3;AP2A1;CLTC;PRICKLE1;AP2S1;RYK;ROR1
Developmental BiologyMYL9;GDF1;BOC;COL4A4;JAK1;CDK8;SPTB;CACNG2B;CNTN1
DiseaseAMN;PSTPIP2;STX1B;NMT1;CCNC;DPF1;FKBP1A;TCEA1;PACS1
EGFR downregulationPTPRK;AP2M1;AP2A2;AP2A1;SPRY2;SPRY1;AP2S1;AP2B1;STAM2
EPH-Ephrin signalingAP2S1;EFNB2A;KALRN;EFNB1;EFNA1B;MYL12A;ACTR2B;EFNB3;EFNA1

AP2M1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, ion channel binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2M1 itself. We selected most functions AP2M1 had, and list some proteins which have the same functions with AP2M1. You can find most of the proteins on our site.

Function Related Protein
contributes_to clathrin adaptor activityAP2A1;AP2M1;AP2A2;AP2S1;AP2B1
ion channel bindingPKD2;RIMS1;KCNQ1;FAM115C;CALM2;CALM3;SCN5A;RNF207;PKP2
lipid bindingATP5G3;GPIHBP1;ESYT3;PLEKHA2;APOA5;PTEN;APODA.2;PITPNM3;APOA4B.2
low-density lipoprotein particle receptor bindingLDLRAP1;LRPAP1;APOEB;APOEA;SYT1;HSP90B1;DKK1;ARRB2;CCDC167
protein bindingRIT1;CHAC1;KCNJ10;C16orf59;BAG3;FXYD7;LIN28B;TRIM23;MAT2B
signal sequence bindingSRP68;AP2B1;AP2M1
transporter activitySLCO1F4;RBP2;CRABP2;CRABP2A;RLBP1B;ABCD1;SLCO4C1;CRABP1A;Abca2

AP2M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2M1.

TBC1D5; AAK1; RALBP1; EGFR; AP2B1; p27958-pro_0000037566; AP2A2

Huang, X; Dai, FF; et al. The Identification of Novel Proteins That Interact With the GLP-1 Receptor and Restrain its Activity. MOLECULAR ENDOCRINOLOGY 27:1550-1563(2013).
Dadlchah, E; Naseh, H; et al. A Cancer-Array Approach Elucidates the Immune Escape Mechanism and Defects in the DNA Repair System in Esophageal Squamous Cell Carcinoma. ARCHIVES OF IRANIAN MEDICINE 16:463-470(2013).
  • Q&As
  • Reviews

Q&As (20)

Ask a question
What are the applications of AP2M1 in scientific research? 12/05/2022

AP2M1 can be used in scientific research to study the regulation mechanism of intracellular protein and the pathogenesis of disease.

What are the mechanisms of recombinant AP2M1 in cancer therapy? 06/13/2022

AP2M1 can interfere with tumor cell signaling pathways, thereby inhibiting tumor growth and spread.

What are the remaining challenges in the research of AP2M1 ? 05/23/2022

AP2M1 research still needs to address safety, preparation methods and dosage challenges.

Can AP2M1 be used in personalized medicine? 05/15/2022

The personalized medicine is the development trend in the future, and we can expect the application prospect of AP2M1 in this field.

Does AP2M1 have side effects? 09/20/2021

The side effects of recombinant AP2M1 are not known and further studies are needed to evaluate its safety.

Can AP2M1 be applied through gene therapy? 06/07/2021

It is theoretically possible to apply recombinant AP2M1 with gene therapy, but more research is needed to confirm this.

What animal model can be used for the study of AP2M1 ? 06/04/2021

Mouse models are currently available to further understand the pharmacological properties of AP2M1 .

Can AP2M1 be administered orally? 12/21/2020

There are no results of studies on oral administration, but attempts to develop the pathway could be made.

What are the advantages of AP2M1 compared with drug therapy? 08/10/2020

AP2M1 can play a therapeutic role by interfering with intracellular signaling pathways, sometimes avoiding adverse drug reactions.

What is the dosage and use of AP2M1 ? 06/28/2020

The current dosage and mode of use are still under investigation, and further clinical trials are needed to determine the best use.

What is the future development direction of AP2M1 research? 03/10/2020

Future studies could focus on optimizing the preparation method, study dose and safety, and further evaluate the clinical prospects of AP2M1 .

How does AP2M1 act on human cells? 03/06/2020

AP2M1 can bind to specific receptors in human cells to regulate signaling pathways.

Can recombinant AP2M1 be used for drug delivery? 02/27/2020

AP2M1 may be used as part of the drug delivery system to achieve targeted drug delivery by regulating intracellular delivery mechanisms.

Does AP2M1 interact with other proteins? 12/02/2019

Yes, the recombinant AP2M1 protein can interact with other proteins to affect cell function.

How is the research progress of AP2M1 ? 11/10/2019

AP2M1 research is still in its infancy, but there have been some promising discoveries.

What is the preparation method of AP2M1 ? 09/30/2019

AP2M1 is generally expressed and purified in cells by genetic engineering technology.

What is the stability of AP2M1 ? 07/19/2019

The stability of AP2M1 may be affected by a variety of factors and needs to be optimized through further research.

Does AP2M1 have antiviral activity? 04/28/2019

AP2M1 may have antiviral activity, but further validation and research is needed.

Can recombinant AP2M1 be used to treat clinical diseases? 03/28/2019

It is not currently in clinical use, but one can expect its potential in treating diseases such as cancer.

What are the advantages of AP2M1 in treatment? 02/26/2019

AP2M1 has high specificity and selectivity, and can be targeted for treatment.

Customer Reviews (4)

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Reviews
02/24/2022

    The reproducibility of AP2M1 is very good, and the results remain consistent even after repeated experiments, which makes me more confident in the experimental results.

    04/05/2021

      The short half-life and high clearance characteristics of AP2M1 enable it to reach the therapeutic concentration quickly and maintain a stable blood concentration, thus improving the therapeutic effect.

      12/14/2019

        In the case of adding different chemicals or drugs, the stability of this protein is still very good, indicating that it has excellent anti-interference ability and stability.

        11/24/2019

          AP2M1 in Western blot is very good, even if it is stored for a long time, it will not affect its performance.

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