AP2M1
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Official Full Name
adaptor-related protein complex 2, mu 1 subunit
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Overview
This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
AP2M1; adaptor-related protein complex 2, mu 1 subunit; CLAPM1; AP-2 complex subunit mu; AP 2 mu 2 chain; AP50; clathrin adaptor complex AP2; mu subunit; clathrin assembly protein complex 2 medium chain; clathrin coat adaptor protein AP50; clathrin associ;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- Fc
- Avi
- SUMO
- Myc
- DDK
- Non
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
AP2M1 involved in several pathways and played different roles in them. We selected most pathways AP2M1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2M1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | KIF2A;HUWE1;SH3RF1;ACTR1B;CTS7;ICAM4;CD300A;DCTN6;MKRN1 |
Arf1 pathway | AP2A1;CLTB;AP2M1;USO1;ARF1;ARFIP2;CLTA |
Axon guidance | CFL1;AGRN;MYL9;PLXNC1;KALRN;DLG4;PAK3;EPHA7;DNM1 |
Beta-catenin independent WNT signaling | AP2A2;CLTB;RYK;CLTC;AP2A1;AP2M1;MOV10;AGO3;DVL2 |
Developmental Biology | NRP2;SEMA3AA;DUSP1;PEA15A;NR2F2;ST8SIA2;SCN8A;SEMA4D;GPC1A |
Disease | LTF;ANTXR1;TH1L;CCNC;SFTPB;NA;CDK8;OPN1MW;MMAA |
EGFR downregulation | PTPRK;SPRY2;STAM2;AP2A2;AP2S1;SPRY1;AP2B1;AP2M1;AP2A1 |
EPH-Ephrin signaling | EFNB3;EFNB3B;ACTR2B;EFNA2;CFL1;EPHA2A;EFNA5;EPHB4B;MYL12A |
AP2M1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, ion channel binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2M1 itself. We selected most functions AP2M1 had, and list some proteins which have the same functions with AP2M1. You can find most of the proteins on our site.
Function | Related Protein |
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contributes_to clathrin adaptor activity | AP2M1;AP2S1;AP2A2;AP2B1;AP2A1 |
ion channel binding | KCND3;PRKCSH;CAMK2D;CAV3;PACS2;ABCC9;ASPH;PIRT;RNF207 |
lipid binding | IQSEC1;ACBD6;OSBPL6;MARK2;C3;CHMP4A;EPN3;APOL3;EPN1 |
low-density lipoprotein particle receptor binding | AP2M1;APOE;LRP2;CCDC167;LRPAP1;CRP;APOA5;SACS;MESDC2 |
protein binding | ESRRG;ZAP70;CD81;APOB;PIK3CD;NCF2;SMCO4;SLC30A3;RAVER2 |
signal sequence binding | SRP68;AP2M1;AP2B1 |
transporter activity | AQP1A.1;SLC2A13B;SLC6A20B;SLC4A11;SLC22A1;ATP6V0B;SLC26A3;ATP6AP1;AQP11 |
AP2M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2M1.
TBC1D5; AAK1; RALBP1; EGFR; AP2B1; p27958-pro_0000037566; AP2A2
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewThe reproducibility of AP2M1 is very good, and the results remain consistent even after repeated experiments, which makes me more confident in the experimental results.
The short half-life and high clearance characteristics of AP2M1 enable it to reach the therapeutic concentration quickly and maintain a stable blood concentration, thus improving the therapeutic effect.
In the case of adding different chemicals or drugs, the stability of this protein is still very good, indicating that it has excellent anti-interference ability and stability.
AP2M1 in Western blot is very good, even if it is stored for a long time, it will not affect its performance.
Q&As (20)
Ask a questionAP2M1 can be used in scientific research to study the regulation mechanism of intracellular protein and the pathogenesis of disease.
AP2M1 can interfere with tumor cell signaling pathways, thereby inhibiting tumor growth and spread.
AP2M1 research still needs to address safety, preparation methods and dosage challenges.
The personalized medicine is the development trend in the future, and we can expect the application prospect of AP2M1 in this field.
The side effects of recombinant AP2M1 are not known and further studies are needed to evaluate its safety.
It is theoretically possible to apply recombinant AP2M1 with gene therapy, but more research is needed to confirm this.
Mouse models are currently available to further understand the pharmacological properties of AP2M1 .
There are no results of studies on oral administration, but attempts to develop the pathway could be made.
AP2M1 can play a therapeutic role by interfering with intracellular signaling pathways, sometimes avoiding adverse drug reactions.
The current dosage and mode of use are still under investigation, and further clinical trials are needed to determine the best use.
Future studies could focus on optimizing the preparation method, study dose and safety, and further evaluate the clinical prospects of AP2M1 .
AP2M1 can bind to specific receptors in human cells to regulate signaling pathways.
AP2M1 may be used as part of the drug delivery system to achieve targeted drug delivery by regulating intracellular delivery mechanisms.
Yes, the recombinant AP2M1 protein can interact with other proteins to affect cell function.
AP2M1 research is still in its infancy, but there have been some promising discoveries.
AP2M1 is generally expressed and purified in cells by genetic engineering technology.
The stability of AP2M1 may be affected by a variety of factors and needs to be optimized through further research.
AP2M1 may have antiviral activity, but further validation and research is needed.
It is not currently in clinical use, but one can expect its potential in treating diseases such as cancer.
AP2M1 has high specificity and selectivity, and can be targeted for treatment.
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