| Official Full Name | adaptor-related protein complex 2, mu 1 subunit |
| Background | This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. |
| Synonyms | AP2M1; adaptor-related protein complex 2, mu 1 subunit; CLAPM1; AP-2 complex subunit mu; AP 2 mu 2 chain; AP50; clathrin adaptor complex AP2; mu subunit; clathrin assembly protein complex 2 medium chain; clathrin coat adaptor protein AP50; clathrin associ |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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AP2M1 involved in several pathways and played different roles in them. We selected most pathways AP2M1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2M1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | B2ML; KIF3B; FGF8B; IGKC; ARIH2; TREML2; KIF2C; UBR1; ARF1; CYBB |
| Arf1 pathway | AP2M1; ARF1; USO1; AP2A1; CLTA; CLTB; ARFIP2 |
| Axon guidance | RASA1; ABLIM1; PLXNA3; SDCBP; PAK1; EPHB3A; AP2A2; DUSP1; SCN2A; KALRN |
| Beta-catenin independent WNT signaling | AGO2; PRICKLE1B; AP2A1; CTNNB2; GNB5; CLTA; CLTB; DVL2; AGO3; PRICKLE1 |
| Developmental Biology | SPRED1; MYOG; SCN8A; SPRED2; ST8SIA2; SEMA3AB; SPRED3; LAMTOR2; EFNA1B; TCF12 |
| Disease | JAG1; OPN1SW; CTBP2; APOBEC3G; CPSF4; OPN1LW; BANF1; AP1S1; STRA6; TCEB3 |
| EGFR downregulation | STAM2; AP2M1; AP2B1; SPRY1; AP2S1; AP2A1; PTPRK; AP2A2; SPRY2 |
| EPH-Ephrin signaling | EPHB4B; EFNA3B; EFNB3B; ACTR2; EFNB3; AP2B1; ACTR2B; KALRN; ARPC2; AP2S1 |
AP2M1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, ion channel binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2M1 itself. We selected most functions AP2M1 had, and list some proteins which have the same functions with AP2M1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to clathrin adaptor activity | AP2B1; AP2M1; AP2A2; AP2A1; AP2S1 |
| ion channel binding | TRPC1; YWHAH; ACTN2; KCND3; PHPT1; SNTA1; LYN; PPP1R9B; YES1; YWHAQ |
| lipid binding | APODA.2; C3; DBI; FABP6; FABP1B.1; GLTP; MAL; SNX10B; CLINT1; SH3GL2 |
| low-density lipoprotein particle receptor binding | APOA5; MMP13; DNAJA1; HSP90B1; LRP2; SYT1; LDLRAP1; MESDC2; AP2M1; PCSK9 |
| protein binding | HTR3C; TTC12; TTYH2; GRIFIN; PIH1D2; PPP2R3A; FOXC2; POLR2E; ELP3; UBE2G2 |
| signal sequence binding | SRP68; AP2B1; AP2M1 |
| transporter activity | Abcb1b; UCP3; SEC14L4; SLC5A6A; SEC14L3; AQP1A.2; SLC37A4; SLC22A13; SLC15A5; CLVS2 |
AP2M1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2M1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2M1.
TBC1D5; AAK1; RALBP1; EGFR; AP2B1; p27958-pro_0000037566; AP2A2
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