AP1B1
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Official Full Name
adaptor-related protein complex 1, beta 1 subunit
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Overview
Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants. -
Synonyms
AP1B1; adaptor-related protein complex 1, beta 1 subunit; ADTB1, CLAPB2; AP-1 complex subunit beta-1; AP105A; BAM22; beta1-adaptin; beta-1-adaptin; beta-adaptin 1; beta-prime-adaptin; Golgi adaptor HA1/AP1 adaptin beta subunit; adaptor protein complex AP-;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
AP1B1 involved in several pathways and played different roles in them. We selected most pathways AP1B1 participated on our site, such as Adaptive Immune System, Clathrin derived vesicle budding, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adaptive Immune System | HLA-DQB2;FBXO27;AGO3;RNF138;LAIR2;AP2A2;RNF123;SPSB1;RAP1GAP2 |
Clathrin derived vesicle budding | NECAP1;TPD52;PICALM;TPD52L1;SNX9A;AP3S1;TFR1B;BLOC1S3;DNM2 |
Disease | TRAT1;FGFR1OP2;RPL35;CDK8;TTR;JAG2;CPSF4;RBP4;WHSC2 |
FOXA1 transcription factor network | DSCAM;CYP2C18;AP1B1;CC10;NRIP1;NFIC;NFIA;TFF1;CEBPB |
Golgi Associated Vesicle Biogenesis | AP1G1;CLINT1;FTH1A;AP4B1;AP1M2;FTH1B;AP1S3A;SNX9B;DTNBP1 |
HIV Infection | DOCK2;ELL;VPS37A;RCC1;SSRP1;CHMP4B;AP1M2;PACS1;PSIP1 |
Host Interactions of HIV factors | PPIAL4A;PACS1;PSIP1;AP1G1;RCC1;DOCK2;AP1S1;APOBEC3G;AP1B1 |
Immune System | TRIM26;DYNC1H1;TRAF7;DHX9;DCTN3;PAG1;PPAPDC1A;LILRA2;FCN1 |
AP1B1 has several biochemical functions, for example, protein binding, protein kinase binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP1B1 itself. We selected most functions AP1B1 had, and list some proteins which have the same functions with AP1B1. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | CNOT3;C11orf46;TUBA3D;ARSI;CDX4;IL23;WWP1;GCKR;ARHGEF7 |
protein kinase binding | NEFH;CCNA2;KCNQ3;TRIM5;CCNE2;PRC1;CD24;PRKRIP1;PKD1 |
protein transporter activity | SNUPN;IPO9;IPO5;RANGRF;DPY19L2;KPNA2;AP1G1;AP1B1;EIF4ENIF1 |
transporter activity | SLCO1F1;FABP10A;NUP98;RASSF9;ABCA6;SLC4A1A;SLC15A3;SLC16A10;FABP2 |
AP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP1B1.
Ap1g1; Ap1m1; nef; AP1S1; AP1S3; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (4)
Write a reviewReproducibility of the AP1B1 is very good, which can reduce the error in the experiment and improve the repeatability of the experiment.
AP1B1 labeling effect is very good, can be used for fluorescence labeling, etc., which is very suitable for our research.
It is very stable, even after multiple uses or storage, its structure and function remain stable, providing strong support for long-term experiments and applications.
Catalytic activity of this protein is very strong, which can make chemical reactions that are difficult to carry out easy to achieve, and has high application potential.
Q&As (14)
Ask a questionAP1B1 mutations may be associated with retinal diseases, but there are relatively few studies directly related to vision problems.
Some studies have shown that the AP1B1 gene mutation may be associated with some mental diseases such as schizophrenia.
AP1B1 mutation may affect intracellular vesicle transport and membrane protein localization, thus affecting the efficacy of therapy and the action of drugs.
Some studies have shown that mutations in the AP1B1 gene may be associated with diseases related to intellectual development.
AP1B1 mutations may be associated with a variety of diseases, including congenital retinitis pigmentosa and neurodegenerative diseases.
Gene-editing techniques such as CRISPR-Cas9 could potentially be used to fix AP1B1 mutations, but they are still in the laboratory stage and require further research and trials.
AP1B1 mutation may be hereditary, and the specific inheritance pattern may be related to each specific mutation.
There is currently no specific treatment for diseases caused by AP1B1 mutations, but the quality of life of patients can be improved through symptom relief treatment and rehabilitation training.
AP1B1 plays an important role in cell regulation by participating in intracellular vesicle transport and cell membrane protein localization.
AP1B1 mutation may lead to the abnormality of intracellular signal transduction pathway and affect the normal process of various biochemical reactions in the cell.
There is currently no direct way to prevent AP1B1 mutations, but a healthy lifestyle and genetic counseling may help reduce the risk of certain genetic diseases.
Recent studies have shown that AP1B1 plays an important role in intracellular vesicle transport and neuronal development.
It is unclear whether AP1B1 mutations directly affect longevity.
AP1B1 gene mutation can be detected by molecular biological methods such as gene sequencing.
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