AP1B1

  • Official Full Name

    adaptor-related protein complex 1, beta 1 subunit

  • Overview

    Adaptor protein complex 1 is found at the cytoplasmic face of coated vesicles located at the Golgi complex, where it mediates both the recruitment of clathrin to the membrane and the recognition of sorting signals within the cytosolic tails of transmembrane receptors. This complex is a heterotetramer composed of two large, one medium, and one small adaptin subunit. The protein encoded by this gene serves as one of the large subunits of this complex and is a member of the adaptin protein family. This gene is a candidate meningioma gene. Alternative splicing results in multiple transcript variants.
  • Synonyms

    AP1B1; adaptor-related protein complex 1, beta 1 subunit; ADTB1, CLAPB2; AP-1 complex subunit beta-1; AP105A; BAM22; beta1-adaptin; beta-1-adaptin; beta-adaptin 1; beta-prime-adaptin; Golgi adaptor HA1/AP1 adaptin beta subunit; adaptor protein complex AP-;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP1B1-9707H Recombinant Human AP1B1, His-tagged E.coli His 671-919a.a.
Human AP1B1-644H Recombinant Human AP1B1 protein, GST-tagged Wheat Germ GST
Human AP1B1-1261H Recombinant Human AP1B1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human AP1B1-2318H Recombinant Human AP1B1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human AP1B1-4359H Recombinant Human AP1B1 protein, His&Myc-tagged E.coli His&Myc 1-584aa
Human AP1B1-4360H Recombinant Human AP1B1 protein, His&Myc-tagged E.coli His&Myc 1-584aa
Human AP1B1-178H Recombinant Human AP1B1 Protein, His-tagged E.coli N-His Thr2-Val255
Human AP1B1-1013HF Recombinant Full Length Human AP1B1 Protein, GST-tagged In Vitro Cell Free System GST 939 amino acids
Mouse Ap1b1-618M Recombinant Mouse Ap1b1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat AP1B1-698R Recombinant Rat AP1B1 Protein Mammalian Cell His
Rat Ap1b1-3523R Recombinant Rat Ap1b1, His-tagged E.Coli or Yeast His 949
Rat AP1B1-354R Recombinant Rat AP1B1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AP1B1-354R-B Recombinant Rat AP1B1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish AP1B1-6919Z Recombinant Zebrafish AP1B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AP1B1 Related Articles

AP1B1 involved in several pathways and played different roles in them. We selected most pathways AP1B1 participated on our site, such as Adaptive Immune System, Clathrin derived vesicle budding, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemKIF26A;CD300LF;KIF2C;LILRB2;UBE2J2;DYNLL2;CTSL1;PIK3AP1;FRS2B
Clathrin derived vesicle buddingNAPAA;BLOC1S1;SNX9;DNM2;GAK;AP1S1;PICALM;PLDN;DNASE2
DiseaseOPN1MW;NUP50;CTDP1;RPL35;PACS1;CHMP4B;AMN;SSRP1;AP2S1
FOXA1 transcription factor networkTFF1;AP1B1;NR2F2;NFIC;FOXA1;DSCAM;CC10;CYP2C18;NRIP1
Golgi Associated Vesicle BiogenesisAP3S1;GAK;SNX9A;NECAP1;FTH1B;PICALMA;AP1M2;TPD52L1;PICALM
HIV InfectionNMT2;PDCD6IP;AP1M2;PPIAL4A;APOBEC3G;CDK9;PSTPIP2;TAF1L;AP1G1
Host Interactions of HIV factorsRCC1;AP1M2;PPIAL4A;AP1B1;PACS1;DOCK2;AP1G1;AP1S1;APOBEC3G
Immune SystemUBR1;LAT2;CSH1;RNF123;ASB2;POLR3GLA;CD300LH;TLR10;TRIM46

AP1B1 has several biochemical functions, for example, protein binding, protein kinase binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP1B1 itself. We selected most functions AP1B1 had, and list some proteins which have the same functions with AP1B1. You can find most of the proteins on our site.

Function Related Protein
protein bindingC11orf49;MED14;DENR;RNF165;BLVRA;CTBP2;DHX36;ADRA2A;Chrng
protein kinase bindingCDC25B;ADCY6;FZD5;TRIM22;PARK2;KCNH1;RPS3;CDKN2C;PTPRR
protein transporter activityIPO5;C11orf73;AP4S1;AP2A2;KPNA1;TNPO1;XPO6;IPO9;AP1G2
transporter activityFABP2;ABCA13;SLC2A11L;AQP3B;AQP8B;SLC22A13;SEC14L3;AQP11;SLC12A3

AP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP1B1.

Ap1g1; Ap1m1; nef; AP1S1; AP1S3; 1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate

Saito, T; Ji, G; et al. Genetic variations in humans associated with differences in the course of hepatitis C. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 317:335-341(2004).
  • Q&As
  • Reviews

Q&As (14)

Ask a question
Does AP1B1 mutation cause vision problems? 08/27/2022

AP1B1 mutations may be associated with retinal diseases, but there are relatively few studies directly related to vision problems.

Is AP1B1 mutation associated with mental illness? 06/28/2022

Some studies have shown that the AP1B1 gene mutation may be associated with some mental diseases such as schizophrenia.

What is the effect of AP1B1 mutation on treatment? 04/27/2022

AP1B1 mutation may affect intracellular vesicle transport and membrane protein localization, thus affecting the efficacy of therapy and the action of drugs.

Is AP1B1 mutation related to intelligence development? 04/08/2022

Some studies have shown that mutations in the AP1B1 gene may be associated with diseases related to intellectual development.

What diseases are associated with AP1B1 mutations? 09/07/2021

AP1B1 mutations may be associated with a variety of diseases, including congenital retinitis pigmentosa and neurodegenerative diseases.

Can AP1B1 mutation be repaired by gene editing? 09/07/2021

Gene-editing techniques such as CRISPR-Cas9 could potentially be used to fix AP1B1 mutations, but they are still in the laboratory stage and require further research and trials.

Can AP1B1 mutations be inherited? 05/24/2021

AP1B1 mutation may be hereditary, and the specific inheritance pattern may be related to each specific mutation.

How to treat diseases caused by AP1B1 mutations? 09/17/2020

There is currently no specific treatment for diseases caused by AP1B1 mutations, but the quality of life of patients can be improved through symptom relief treatment and rehabilitation training.

What is the function of AP1B1? 08/22/2020

AP1B1 plays an important role in cell regulation by participating in intracellular vesicle transport and cell membrane protein localization.

How does AP1B1 mutation affect intracellular signaling? 06/09/2020

AP1B1 mutation may lead to the abnormality of intracellular signal transduction pathway and affect the normal process of various biochemical reactions in the cell.

How can AP1B1 mutation be prevented? 06/05/2020

There is currently no direct way to prevent AP1B1 mutations, but a healthy lifestyle and genetic counseling may help reduce the risk of certain genetic diseases.

What is the latest progress of AP1B1 research? 12/03/2019

Recent studies have shown that AP1B1 plays an important role in intracellular vesicle transport and neuronal development.

Does AP1B1 mutation affect life span? 05/16/2019

It is unclear whether AP1B1 mutations directly affect longevity.

How to detect AP1B1 gene mutation? 02/13/2019

AP1B1 gene mutation can be detected by molecular biological methods such as gene sequencing.

Customer Reviews (4)

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Reviews
10/11/2022

    Reproducibility of the AP1B1 is very good, which can reduce the error in the experiment and improve the repeatability of the experiment.

    11/07/2020

      AP1B1 labeling effect is very good, can be used for fluorescence labeling, etc., which is very suitable for our research.

      03/30/2020

        It is very stable, even after multiple uses or storage, its structure and function remain stable, providing strong support for long-term experiments and applications.

        05/21/2019

          Catalytic activity of this protein is very strong, which can make chemical reactions that are difficult to carry out easy to achieve, and has high application potential.

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