• Official Full Name

    adaptor-related protein complex 1, sigma 1 subunit

  • Overview

    The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle.
  • Synonyms

    AP1S1; adaptor-related protein complex 1, sigma 1 subunit; CLAPS1; AP-1 complex subunit sigma-1A; AP 1 complex subunit sigma 1A; AP19; clathrin assembly protein complex 1 sigma 1A small chain; clathrin coat assembly protein AP19; clathrin associated/assembly/adaptor protein; small 1 (19kD); golgi adaptor HA1/AP1 adaptin sigma 1A subunit; HA1 19 kDa subunit; SIGMA1A; sigma1A subunit of AP 1 clathrin adaptor complex; sigma1A adaptin; WUGSC:H_DJ0747G18.2; Adapter related protein complex 1 sigma 1A subunit; Adapter-related protein complex 1 sigma-1A subunit; Adaptor protein complex AP-1 sigma-1A subunit; Adaptor protein complex AP1 sigma 1A subunit; AP1 complex subunit sigma 1A; AP1S1_HUMAN; Clathrin assembly protein complex 1 sigma-1A small chain; Golgi adaptor HA1/AP1 adaptin sigma-1A subunit; Sigma 1a subunit of AP-1 clathrin; Sigma 1a subunit of AP1 clathrin; Sigma adaptin 1A; Sigma-adaptin 1A; Sigma1A-adaptin; sigma1A subunit of AP-1 clathrin adaptor complex; clathrin-associated/assembly/adaptor protein, small 1 (19kD);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP1S1-649H Recombinant Human AP1S1 protein, GST-tagged Wheat Germ GST
Human AP1S1-8817HCL Recombinant Human AP1S1 293 Cell Lysate HEK293 N/A
Human AP1S1-184H Recombinant Human AP1S1 Protein, His-tagged E.coli N-His Met1-Ala158
Human AP1S1-24HF Recombinant Full Length Human AP1S1 Protein In Vitro Cell Free System 133 amino acids
Human AP1S1-27354TH Recombinant Human AP1S1 Wheat Germ N/A 133 amino acids
Human AP1S1-1036HF Recombinant Full Length Human AP1S1 Protein, GST-tagged In Vitro Cell Free System GST 133 amino acids
Mouse AP1S1-1735M Recombinant Mouse AP1S1 Protein Mammalian Cell His
Mouse Ap1s1-3529M Recombinant Mouse Ap1s1, His-tagged E.Coli or Yeast His 158
Mouse AP1S1-598M-B Recombinant Mouse AP1S1 Protein Pre-coupled Magnetic Beads HEK293
Mouse AP1S1-598M Recombinant Mouse AP1S1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish AP1S1-10638Z Recombinant Zebrafish AP1S1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

AP1S1 involved in several pathways and played different roles in them. We selected most pathways AP1S1 participated on our site, such as Adaptive Immune System, Clathrin derived vesicle budding, Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP1S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemCD200;SLAMF6;SPTBN2;BLMH;RNF4;HCST;SH3RF1;STIM1B;GM11711
Clathrin derived vesicle buddingAP1G1;APPA;SNAPIN;AP1S3A;CLTB;PLDN;AP4B1;FTH1B;BLOC1S4
Golgi Associated Vesicle BiogenesisPLDN;TCEAL4;SNX9B;BLOC1S3;NECAP1;DTNBP1B;YIPF6;NAPAB;CNO
Host Interactions of HIV factorsPPIAL4A;AP1G1;AP1S1;APOBEC3G;PSIP1;DOCK2;AP1B1;PACS1;AP1M2
Immune SystemKLC3;FCGR1B;S100B;RNF216;HUWE1;CR1;TREX1;CD300C;TRIM39

AP1S1 has several biochemical functions, for example, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP1S1 itself. We selected most functions AP1S1 had, and list some proteins which have the same functions with AP1S1. You can find most of the proteins on our site.

Function Related Protein
protein transporter activityCHMP7;IPO7;ARFGAP3;KPNA5;RUFY1;CCT6B;TIMM9;AP2A2;AP3S2

AP1S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP1S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP1S1.

AP1B1; Ap1g1; SLC16A1; AP1S2; RAB10; SEC61A1; IKBKE; ARMC6; EBLN2; pi3p; GTSE1

Research Area

Related articles

Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).
  • Q&As
  • Reviews

Q&As (19)

Ask a question
Which diagnostic reagents can AP1S1 be used to prepare? 04/26/2022

At present, AP1S1 is mainly used in the therapeutic field, and has not been widely used in the preparation of diagnostic reagents.

Can AP1S1 be used in the treatment of tumor? 07/10/2021

Previous studies have shown that AP1S1 has potential application value in tumor therapy, and the specific application needs further study.

What is the relationship between AP1S1 and immunotherapy? 06/21/2021

As an immunomodulator, AP1S1 is expected to become a new immunotherapy strategy to help patients fight cancer, viruses and other diseases.

Can AP1S1 be used in combination with other treatments? 04/20/2021

Yes, AP1S1 can be used as an adjunct therapeutic means, combined with radiotherapy, chemotherapy and other therapeutic means to improve the therapeutic effect.

Does AP1S1 gene have an effect on tumor invasion and metastasis? 04/15/2021

AP1S1 gene is involved in important biological processes such as intracellular signaling and cargo transport, and has a certain relationship with tumor invasion and metastasis.

What are the new ideas of recombinant AP1S1 in the treatment of viral infection? 02/03/2021

The AP1S1 can enhance the immune response of the body and has a good therapeutic potential for viral infection.

What is the effect of AP1S1 on tumor microenvironment? 10/10/2020

Recombinant protein AP1S1 can regulate the immune response in the tumor microenvironment and play an anti-tumor role.

Is the production technology of AP1S1 mature? 08/03/2020

The production technology of AP1S1 has been relatively mature, and some pharmaceutical companies have begun large-scale production.

In which diseases does AP1S1 have application prospects? 02/10/2020

According to existing studies, AP1S1 may have application prospects in tumor, autoimmune disease, viral infection, etc.

Can AP1S1 be administered orally? 11/25/2019

AP1S1 as a protein drug needs to be injected, and oral method is not practical.

What is the quality control standard of AP1S1 ? 08/14/2019

The quality of AP1S1 should meet certain standards of purity, activity, stability, non-toxicity, no bacterial contamination and so on.

What is the role of AP1S1 in clinical medicine? 08/08/2019

AP1S1 can play an important role in antiviral, anti-tumor and immune response regulation by interfering with intracellular cargo transport mechanisms, and is expected to become a new therapeutic means.

What is the biological function of AP1S1 ? 07/18/2019

AP1S1 is involved in the transport of substances between the endoplasmic reticulum and the Golgi apparatus, intracellular signaling and cytoskeleton formation and other biological processes.

Can recombinant AP1S1 be used as a cancer prevention tool? 04/10/2019

Recombinant AP1S1 has not been shown to have a tumor preventive effect.

What is the role of recombinant AP1S1 in the treatment of autoimmune diseases? 03/31/2019

Recombinant AP1S1 can regulate the overactivation of the immune response in patients with autoimmune disease and reduce symptoms.

Does AP1S1 have immunovirulence enhancement effect? 03/27/2019

Recombinant AP1S1 protein can enhance immune response and enhance immunovirulence by interfering with cargo transport and other mechanisms.

What is the preparation method of AP1S1 ? 03/25/2019

There are two common methods for preparing AP1S1 : prokaryotic expression system and mammalian expression system.

What are the similarities and differences between antibody gene therapy and AP1S1 ? 02/09/2019

Antibody gene therapy targets specific tumor targets, while recombinant AP1S1 exerts its role by regulating immune responses and interfering with cargo transport.

What is the effect of AP1S1 on proinflammatory cytokines? 01/27/2019

Recombinant AP1S1 can inhibit the expression of a series of pro-inflammatory cytokines and play an anti-inflammatory role.

Customer Reviews (6)

Write a review

    The production process focuses on the recycling of resources, and the waste is reused, reducing the consumption of natural resources.


      Background of AP1S1 in Western blot was very clean and showed good antibody specificity.


        Under different experimental conditions, the stability of AP1S is still very good, indicating that it has a wide range of applications and adaptability.


          Reproducibility of AP1S1 is very good, and I can get consistent results from each experiment, which makes me more confident in the experimental results.


            The short half-life and high clearance characteristics of AP1S1 make it better adapted to the needs of clinical treatment, and provide patients with safer and more effective treatment options.


              The short half-life and high clearance characteristics of AP1S make it able to effectively avoid drug accumulation and side effects, and provide a strong guarantee for the health of patients.

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