AP2S1 Protein

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AP2S1

Official Full Name	adaptor-related protein complex 2, sigma 1 subunit
Background	One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.
Synonyms	AP2S1; adaptor-related protein complex 2, sigma 1 subunit; CLAPS2; AP-2 complex subunit sigma; Adapter-related protein complex 2 sigma subunit; Adaptor protein complex AP2 subunit sigma; Adaptor related protein complex 2 sigma 1 subunit; AI043088; AP 17; AP 2 complex subunit sigma 1; AP17; AP17 delta; AP2 complex subunit sigma 1; CLAPS 2; Clathrin adaptor complex AP2, sigma subunit; Clathrin adaptor protein AP17; Clathrin assembly protein 2 small chain; Clathrin associated/assembly/adaptor protein small 2; Clathrin associated/assembly/adaptor protein small 2, 17-KD; Clathrin coat assembly protein AP17; Clathrin coat associated protein AP17; HA2 17 kDa subunit; MGC62945; Plasma membrane adaptor AP 2 17 kDa protein; Plasma membrane adaptor AP-2 17 kDa protein; Plasma membrane adaptor AP2 17 kDa protein; Sigma adaptin 3b; Sigma2 adaptin; sigma2-adaptin; clathrin coat-associated protein AP17; adaptor protein complex AP-2 subunit sigma; plasma membrane adaptor AP-2 17 kDa p; AP17-DELTA

Species :
Human
Mouse
Rat
Rhesus Macaque
Zebrafish

Source :
E.coli
E.Coli or Yeast
HEK293
HEK293T
Mammalian Cell
Wheat Germ

Tag :
GST
His
Myc/DDK
N/A
N-His

Species	Cat.#	Product name	Source (Host)	Tag
Human	AP2S1-3537H	Recombinant Human AP2S1, His-tagged	E.Coli or Yeast	His
Human	AP2S1-654H	Recombinant Human AP2S1 protein, GST-tagged	Wheat Germ	GST
Mouse	AP2S1-1742M	Recombinant Mouse AP2S1 Protein	Mammalian Cell	His
Rat	Ap2s1-3536R	Recombinant Rat Ap2s1, His-tagged	E.Coli or Yeast	His
Rat	AP2S1-702R	Recombinant Rat AP2S1 Protein	Mammalian Cell	His
Rhesus Macaque	AP2S1-349R	Recombinant Rhesus monkey AP2S1 Protein, His-tagged	Mammalian Cell	His
Zebrafish	AP2S1-12371Z	Recombinant Zebrafish AP2S1	Mammalian Cell	His
Human	AP2S1-8811HCL	Recombinant Human AP2S1 293 Cell Lysate	HEK293	N/A
Human	AP2S1-8812HCL	Recombinant Human AP2S1 293 Cell Lysate	HEK293	N/A
Human	AP2S1-187H	Recombinant Human AP2S1 Protein, His-tagged	E.coli	N-His
Mouse	Ap2s1-1654M	Recombinant Mouse Ap2s1 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK

Involved Pathway Protein Function Interacting Protein AP2S1 Related Articles

AP2S1 involved in several pathways and played different roles in them. We selected most pathways AP2S1 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	DYNC1LI2; FRS2; CTLA4; DYNC1H1; AGO3; ASB17; AMICA1; RASGRP1; KIF15; LCP2A
Axon guidance	EPHA1; CNTN6; CSNK2B; RHOB; MYL12B; NTNG1; RASA1; RASGEF1A; EFNB2A; PPP3R2
Beta-catenin independent WNT signaling	CLTB; CLTA; AP2A1; ITPR2; ROR1; DVL2; DVL3; PRICKLE1; DVL1; AGO3
Developmental Biology	ARPC4; EFNA3B; MARK3; PLXNC1; CD24; RANBP9; MYL12B; TCF3B; FRS2A; SIAH2
Disease	EPM2A; BANF1; OPN1MW; NA; TLR6; KPNA3; ELL; VPS37A; CPSF4; HEY1
EGFR downregulation	AP2A2; AP2M1; PTPRK; SPRY1; STAM2; SPRY2; AP2A1; AP2B1; AP2S1
EPH-Ephrin signaling	EFNA1B; DNM1; SDCBP; ITSN1; AP2A2; AP2M1; ARPC1B; KDR; ARHGEF28; EFNB1
EPH-ephrin mediated repulsion of cells	EFNA5; EPHA2; AP2A2; EFNA1B; EFNB3B; EFNA2; EFNB2; EFNB3; EPHB4B; EFNA3

AP2S1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2S1 itself. We selected most functions AP2S1 had, and list some proteins which have the same functions with AP2S1. You can find most of the proteins on our site.

Function	Related Protein
contributes_to clathrin adaptor activity	AP2S1; AP2A2; AP2A1; AP2M1; AP2B1
protein binding	TRAF7; RYR1B; FYTTD1; IL6; VAMP8; KCNJ15; ICK; TNFSF12; SRPK3; SLC16A3
protein transporter activity	COG2; KPNA1; VPS26B; MLC1; AP3S1; AP1S3A; XPO5; SNUPN; KPNA2; KPNB3
transporter activity	SLC4A11; AP4B1; CSN1S1; AQP9A; SLC26A3; ATP5D; SLC6A20B; SLC5A11; AQP12B; SYPL2

AP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2S1.

AAGAB; VCAM1; Ap2a1; vpu; TDGF1; EGFR; CLTB; EPS15; NUMB; Smo; GRB2; AP2M1

Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).

Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).

AP2S1

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AP2S1

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