AP2S1 involved in several pathways and played different roles in them. We selected most pathways AP2S1 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Adaptive Immune System |
LRR1; RACGAP1; NCR3LG1; LILRA3; RBCK1; DYNC1LI2; AP2A2; ARIH2; Mill2; CDKN1B |
| Axon guidance |
EPHA5; EPHB3A; PPP3CC; COL9A1B; AKAP9; EFNA2; COL9A1; RAC1; EPHA2; COL4A5 |
| Beta-catenin independent WNT signaling |
ROR1; DVL1; CTNNB2; AGO3; AP2S1; AGO1; CLTC; AGO2; AP2A1; AP2M1 |
| Developmental Biology |
HELZ2; COL6A2; TCF3B; LEFTY1; CACNG8A; INSM1A; PLXNC1; CARM1; NRG4; EFNA3B |
| Disease |
FDX1L; HDAC5; NMT2; AP2B1; TCEA1; OPN1MW; CCNC; CTDP1; CUX1; TIRAP |
| EGFR downregulation |
SPRY1; AP2M1; SPRY2; AP2A2; AP2B1; AP2S1; AP2A1; STAM2; PTPRK |
| EPH-Ephrin signaling |
EFNA3; AP2M1; ACTR3; EPHA4A; EFNA2A; EPHB3A; ARPC4; SHB; CFL1; EFNA3B |
| EPH-ephrin mediated repulsion of cells |
EFNA1; CLTB; EFNA3; EFNA1A; AP2B1; EFNB2; EFNB1; EFNA2A; EFNB3B; EPHA2 |
AP2S1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2S1 itself. We selected most functions AP2S1 had, and list some proteins which have the same functions with AP2S1. You can find most of the proteins on our site.
| Function |
Related Protein |
| contributes_to clathrin adaptor activity |
AP2A2; AP2A1; AP2S1; AP2B1; AP2M1 |
| protein binding |
FAM72A; SOD1; CD80; TNS3; SPDYE2; SYNJ2; DHH; PIK3IP1; EPB41L1; MARCKSL1 |
| protein transporter activity |
IPO5; RAB4A; DPY19L2; SOSTDC1B; AP1S3B; TIMM10; AP1G1; VPS26A; RAMP1; MLC1 |
| transporter activity |
PBSN; NUP153; SLC15A2; XK; CPNE7; AQP8B; RBP7; SLC2A15A; CHP1; SLC2A11L |
AP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2S1.
AAGAB; VCAM1; Ap2a1; vpu; TDGF1; EGFR; CLTB; EPS15; NUMB; Smo; GRB2; AP2M1
Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).
