AP2S1

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AP2S1

Official Full Name adaptor-related protein complex 2, sigma 1 subunit
Background One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.
Synonyms AP2S1; adaptor-related protein complex 2, sigma 1 subunit; CLAPS2; AP-2 complex subunit sigma; Adapter-related protein complex 2 sigma subunit; Adaptor protein complex AP2 subunit sigma; Adaptor related protein complex 2 sigma 1 subunit; AI043088; AP 17; AP 2 complex subunit sigma 1; AP17; AP17 delta; AP2 complex subunit sigma 1; CLAPS 2; Clathrin adaptor complex AP2, sigma subunit; Clathrin adaptor protein AP17; Clathrin assembly protein 2 small chain; Clathrin associated/assembly/adaptor protein small 2; Clathrin associated/assembly/adaptor protein small 2, 17-KD; Clathrin coat assembly protein AP17; Clathrin coat associated protein AP17; HA2 17 kDa subunit; MGC62945; Plasma membrane adaptor AP 2 17 kDa protein; Plasma membrane adaptor AP-2 17 kDa protein; Plasma membrane adaptor AP2 17 kDa protein; Sigma adaptin 3b; Sigma2 adaptin; sigma2-adaptin; clathrin coat-associated protein AP17; adaptor protein complex AP-2 subunit sigma; plasma membrane adaptor AP-2 17 kDa p; AP17-DELTA
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AP2S1-3537H Recombinant Human AP2S1, His-tagged E.Coli or Yeast His
    Human AP2S1-654H Recombinant Human AP2S1 protein, GST-tagged Wheat Germ GST
    Human AP2S1-8811HCL Recombinant Human AP2S1 293 Cell Lysate HEK293 N/A
    Human AP2S1-8812HCL Recombinant Human AP2S1 293 Cell Lysate HEK293 N/A
    Mouse Ap2s1-1654M Recombinant Mouse Ap2s1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse AP2S1-1742M Recombinant Mouse AP2S1 Protein Mammalian Cell His
    Rat Ap2s1-3536R Recombinant Rat Ap2s1, His-tagged E.Coli or Yeast His
    Rat AP2S1-702R Recombinant Rat AP2S1 Protein Mammalian Cell His
    Rhesus Macaque AP2S1-349R Recombinant Rhesus monkey AP2S1 Protein, His-tagged Mammalian Cell His
    Zebrafish AP2S1-12371Z Recombinant Zebrafish AP2S1 Mammalian Cell His

    AP2S1 involved in several pathways and played different roles in them. We selected most pathways AP2S1 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System TRIM50; RNF4; AP1G1; LILRA2; OSCAR; CTLA4; HBEGF; LILRB2; KLHL21; KIF3C
    Axon guidance FYN; NRP1A; FES; ABL1; EFNA1A; TRPC4; RND1; NRG2A; EPHA4; DPYSL2
    Beta-catenin independent WNT signaling AP2A2; CLTA; ROR1; CLTB; CLTC; AGO3; AP2A1; MOV10; DVL2; ROR2
    Developmental Biology CNTN6; KLB; RASGEF1A; PHB; EFNA4; DUSP9; EPHB3A; CTNNA2; LEFTY1; UNC5D
    Disease FGFR1OP; SFTPB; KPNA5; DERL2; KPNA3; AP2S1; LRRFIP1; AMN; PSTPIP2; NMT2
    EGFR downregulation AP2A1; AP2M1; AP2B1; STAM2; AP2S1; PTPRK; AP2A2; SPRY2; SPRY1
    EPH-Ephrin signaling EFNA3; KALRN; ARPC1A; EFNA1B; ARPC1B; EFNA5; EFNB2A; EFNB1; EPHB4B; ARHGEF28
    EPH-ephrin mediated repulsion of cells AP2B1; EFNA1A; EPHB4B; EFNA3; EPHA10; EFNA5; EFNA4; EPHB3A; EFNB2; EFNA2

    AP2S1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2S1 itself. We selected most functions AP2S1 had, and list some proteins which have the same functions with AP2S1. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to clathrin adaptor activity AP2B1; AP2A2; AP2S1; AP2A1; AP2M1
    protein binding TRIP13; CLIC3; MOBP; NUFIP2; TLE2; NF1; ZBTB17; SEC22C; HDGFRP2; CCDC60
    protein transporter activity RAMP1; RAB4A; ZFYVE16; AP2A1; AP1G1; AP1B1; TSNAX; CALCRL; KPNA6; ARFGAP3
    transporter activity SLC22A1; TCIRG1; SCARB1; ABCA1B; SYPL1; PTGDSB; ABCF2; APODA.2; CRABP2; SYPL2

    AP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2S1.

    AAGAB; VCAM1; Ap2a1; vpu; TDGF1; EGFR; CLTB; EPS15; NUMB; Smo; GRB2; AP2M1

    Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
    Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).

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