• Official Full Name

    adaptor-related protein complex 2, sigma 1 subunit

  • Overview

    One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing has been observed in this gene and results in two known transcripts.
  • Synonyms

    AP2S1; adaptor-related protein complex 2, sigma 1 subunit; CLAPS2; AP-2 complex subunit sigma; Adapter-related protein complex 2 sigma subunit; Adaptor protein complex AP2 subunit sigma; Adaptor related protein complex 2 sigma 1 subunit; AI043088; AP 17; AP 2 complex subunit sigma 1; AP17; AP17 delta; AP2 complex subunit sigma 1; CLAPS 2; Clathrin adaptor complex AP2, sigma subunit; Clathrin adaptor protein AP17; Clathrin assembly protein 2 small chain; Clathrin associated/assembly/adaptor protein small 2; Clathrin associated/assembly/adaptor protein small 2, 17-KD; Clathrin coat assembly protein AP17; Clathrin coat associated protein AP17; HA2 17 kDa subunit; MGC62945; Plasma membrane adaptor AP 2 17 kDa protein; Plasma membrane adaptor AP-2 17 kDa protein; Plasma membrane adaptor AP2 17 kDa protein; Sigma adaptin 3b; Sigma2 adaptin; sigma2-adaptin; clathrin coat-associated protein AP17; adaptor protein complex AP-2 subunit sigma; plasma membrane adaptor AP-2 17 kDa p; AP17-DELTA;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.Coli or Yeast
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP2S1-654H Recombinant Human AP2S1 protein, GST-tagged Wheat Germ GST
Human AP2S1-3537H Recombinant Human AP2S1, His-tagged E.Coli or Yeast His 142
Human AP2S1-8811HCL Recombinant Human AP2S1 293 Cell Lysate HEK293 N/A
Human AP2S1-8812HCL Recombinant Human AP2S1 293 Cell Lysate HEK293 N/A
Human AP2S1-187H Recombinant Human AP2S1 Protein, His-tagged E.coli N-His Met1-Glu142
Human AP2S1-1040HF Recombinant Full Length Human AP2S1 Protein, GST-tagged In Vitro Cell Free System GST 142 amino acids
Mouse AP2S1-1742M Recombinant Mouse AP2S1 Protein Mammalian Cell His
Mouse AP2S1-603M-B Recombinant Mouse AP2S1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ap2s1-1654M Recombinant Mouse Ap2s1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse AP2S1-603M Recombinant Mouse AP2S1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AP2S1-702R Recombinant Rat AP2S1 Protein Mammalian Cell His
Rat Ap2s1-3536R Recombinant Rat Ap2s1, His-tagged E.Coli or Yeast His 142
Rat AP2S1-358R-B Recombinant Rat AP2S1 Protein Pre-coupled Magnetic Beads HEK293
Rat AP2S1-358R Recombinant Rat AP2S1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque AP2S1-349R Recombinant Rhesus monkey AP2S1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AP2S1-177R-B Recombinant Rhesus Macaque AP2S1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AP2S1-177R Recombinant Rhesus Macaque AP2S1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish AP2S1-12371Z Recombinant Zebrafish AP2S1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • AP2S1 Related Articles

AP2S1 involved in several pathways and played different roles in them. We selected most pathways AP2S1 participated on our site, such as Adaptive Immune System, Axon guidance, Beta-catenin independent WNT signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP2S1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Beta-catenin independent WNT signalingCLTA;CLTB;AP2A1;ROR2;DVL3;AP2B1;AP2S1;AP2M1;CLTC
EGFR downregulationSTAM2;PTPRK;SPRY2;AP2A2;SPRY1;AP2A1;AP2M1;AP2B1;AP2S1
EPH-ephrin mediated repulsion of cellsAP2A2;EPHA10;EFNB2;EFNA5;AP2B1;EFNA4;EFNB3;EFNA3B;CLTB

AP2S1 has several biochemical functions, for example, contributes_to clathrin adaptor activity, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP2S1 itself. We selected most functions AP2S1 had, and list some proteins which have the same functions with AP2S1. You can find most of the proteins on our site.

Function Related Protein
contributes_to clathrin adaptor activityAP2B1;AP2S1;AP2A1;AP2A2;AP2M1
protein transporter activityEIF4ENIF1;AP1S3;RAB4A;CALCR;AP2A1;AP1B1;XPO5;SEC61G;C11orf73
transporter activitySLC5A8L;SYPL;CLVS2;CRABP1A;SLC2A9L1;AQP9B;MFSD10;ABCA9;SLC25A13

AP2S1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP2S1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP2S1.

AAGAB; VCAM1; Ap2a1; vpu; TDGF1; EGFR; CLTB; EPS15; NUMB; Smo; GRB2; AP2M1

Stratta, P; Merlotti, G; et al. Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population. NEPHROLOGY DIALYSIS TRANSPLANTATION 29:1902-1909(2014).
Kim, YA; Choi, HJ; et al. Replication of Caucasian loci associated with bone mineral density in Koreans. OSTEOPOROSIS INTERNATIONAL 24:2603-2610(2013).
  • Q&As
  • Reviews

Q&As (19)

Ask a question
Is the mutation of AP2S1 gene associated with hereditary diseases? 09/02/2022

Genetic mutations in the AP2S1 have been shown to be associated with certain genetic diseases.

What is the structure of AP2S1 ? 08/30/2022

The AP2S1 is a three-dimensional structure composed of multiple amino acid residues.

Which signaling pathways are associated with recombinant AP2S1? 06/29/2022

AP2S1 is associated with various signaling pathways, such as EGFR signaling pathway and Notch signaling pathway.

Can AP2S1 be used as a diagnostic marker for tumors? 04/09/2022

There is currently insufficient evidence to support recombinant AP2S1 as a diagnostic marker for tumors.

What is the function of AP2S1 ? 03/28/2022

The AP2S1 is involved in protein breakdown and transport in the cell.

What is the significance of the research of AP2S1 for the development of new drugs? 03/16/2022

The study of AP2S1 is of great significance for the research and development of new drugs, which can provide new ideas and directions for the discovery of drug targets.

How to detect the expression level of AP2S1 ? 03/14/2022

Immunohistochemistry, Western blot and other methods can be used to detect the expression level of AP2S1 .

Is there any research on the mechanism of action of AP2S1 in tumorigenesis? 02/27/2022

Some studies have shown that AP2S1 may play a role in tumorgenesis by influencing cell proliferation and metastasis.

Does the study of recombinant AP2S1 involve gene therapy? 11/17/2021

There are currently no gene therapy studies involving recombinant AP2S1.

What is the application prospect of AP2S1 in tumor therapy? 10/09/2021

Recombinant protein AP2S1 may be a potential target for tumor therapy, but further research and validation are needed.

Is there any research on the interaction of AP2S1 with drugs? 07/26/2021

There has not been much research on the interaction of AP2S1 with drugs.

Can AP2S1 be used as a drug target? 05/01/2021

The AP2S1 may be one of the targets for drug development, but further studies are needed to confirm it.

What is the distribution of AP2S1 in human body? 02/26/2021

The AP2S1 is widely distributed in the human body, including the nervous system and several organs.

In what diseases does recombinant AP2S1 play a key role? 02/01/2021

The AP2S1 plays a key role in many diseases such as nervous system diseases and tumors.

What is the progress of drug development targeting AP2S1 ? 07/01/2020

The current drug development targeting AP2S1 is still in the preliminary stage, and further research and development is needed.

Is the association between recombinant AP2S1 and disease genetic? 05/07/2020

The association of recombinant AP2S1 with certain diseases may have genetic characteristics.

In which cell types is AP2S1 expressed? 12/22/2019

Recombinant AP2S1 protein is expressed in a variety of cell types.

Is there any research on the function of AP2S1 in neurological diseases? 06/30/2019

Some studies have shown that recombinant AP2S1 may be involved in regulating synaptic transmission and other functions in nervous system diseases.

Can recombinant AP2S1 be used as a therapeutic target for this disease? 03/06/2019

The AP2S1 may be a potential target for the treatment of this disease, but further studies are needed to confirm it.

Customer Reviews (4)

Write a review

    Catalytic activity of AP2S1 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and its application potential is huge.


      Experimenting with this recombinant protein allows me to focus more on experimental design and data analysis without worrying about the reproducibility of experimental results.


        Quality of AP2S1 is consistent, and we're reassured.


          Stability of AP2S1 is highly praised, and it can maintain its structural and functional stability even under various extreme environments, which is really impressive.

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