AP4B1
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Official Full Name
adaptor-related protein complex 4, beta 1 subunit
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Overview
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; MIM 607244), a medium chain, mu-4 (AP4M1; MIM 602296), and a small chain, sigma-4 (AP4S1; MIM 607243). -
Synonyms
AP4B1; adaptor-related protein complex 4, beta 1 subunit; AP-4 complex subunit beta-1; beta 4 subunit of AP 4; BETA 4; Adapter related protein complex 4 beta 1 subunit; AP 4 adapter complex subunit beta; AP 4 complex subunit beta 1; Beta subunit of AP 4; beta4-adaptin; OTTHUMP00000013725; OTTHUMP00000013726; OTTHUMP00000013730; beta subunit of AP-4; beta 4 subunit of AP-4; AP-4 adapter complex subunit beta; adapter-related protein complex 4 subunit beta-1; CPSQ5; BETA-4;
- Recombinant Proteins
- Cell & Tissue Lysates
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- N/A
- N
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | AP4B1-9725H | Recombinant Human AP4B1, GST-tagged | E.coli | GST | 1-351a.a. | |
| Human | AP4B1-661H | Recombinant Human AP4B1 protein, GST-tagged | Wheat Germ | GST |
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| Human | AP4B1-8806HCL | Recombinant Human AP4B1 293 Cell Lysate | HEK293 | N/A |
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| Human | AP4B1-194H | Recombinant Human AP4B1 Protein, His-tagged | E.coli | N-His | Met1-Arg276 |
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| Human | AP4B1-1138HF | Recombinant Full Length Human AP4B1 Protein, GST-tagged | In Vitro Cell Free System | GST | 739 amino acids |
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| Mouse | Ap4b1-195M | Recombinant Mouse Ap4b1 Protein, His-tagged | E.coli | N-His | Met1-Ile261 |
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| Zebrafish | AP4B1-10662Z | Recombinant Zebrafish AP4B1 | Mammalian Cell | His |
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| Chicken | AP4B1-2606C | Recombinant Chicken AP4B1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
AP4B1 involved in several pathways and played different roles in them. We selected most pathways AP4B1 participated on our site, such as Clathrin derived vesicle budding, Golgi Associated Vesicle Biogenesis, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP4B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Clathrin derived vesicle budding | CLTA;NECAP1;APPB;AP1B1;TGOLN2;CLVS2;DNM2;CPD;BLOC1S4 |
| Golgi Associated Vesicle Biogenesis | CLINT1;AP3S1;BLOC1S3;AP1G1;AP1B1;TGOLN2;HIP1RB;BLOC1S6;DTNBP1B |
| Lysosome | CTSG;GNSA;SORT1B;LITAF;AP1S3B;CTSK;CTPS1B;ATP6V0A2;HEXA |
| Lysosome Vesicle Biogenesis | CLVS2;BLOC1S1;AP4B1;AP1S3A;DNASE2;CTSZ;CLVS1 |
| Membrane Trafficking | TFG;NECAP1;DTNBP1;AP4B1;CNIH3;YIPF6;TRAPPC5;MYO6A;CX27.5 |
| Vesicle-mediated transport | PPP6R1;TGOLN2;SNX9;SNAPIN;GJB5;MYO6B;AP3S1;GJA8;SNX9B |
| trans-Golgi Network Vesicle Budding | CLVS1;CPD;TPD52;GAK;AP4B1;TPD52L1;TBC1D8B;CLINT1;DTNBP1 |
AP4B1 has several biochemical functions, for example, protein binding, protein transporter activity, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP4B1 itself. We selected most functions AP4B1 had, and list some proteins which have the same functions with AP4B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RPS3A;CD3E;MZB1;CCND1;DDX3X;IRS2;ASB6;RAB11FIP3;CHD8 |
| protein transporter activity | USO1;IPO7;TNPO3;KPNA6;SOSTDC1B;KPNA1;VPS26BL;AP1S3A;KPNB3 |
| transporter activity | CRABP2B;SLC5A12;CDH17;XPO1;NUP153;FLR;SEC22A;SLCO1F4;SLC22A13 |
AP4B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP4B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP4B1.
ZNF576; FIBP; MYC; AP4E1; AP4S1
- Q&As
- Reviews
Q&As (19)
Ask a questionAP4B1 is involved in intracellular protein transport and transport, and plays an important role in maintaining cell function.
Studies targeting the AP4B1 are actively underway to explore its function, mechanism of action, and potential therapeutic applications.
A number of related research projects have been carried out targeting the AP4B1 to understand its role in disease and potential therapeutic strategies.
Because there are currently no approved drugs, the side effects of AP4B1 are not fully understood.
At present, there are no reports on the crystal structure analysis of AP4B1 , which needs future research efforts.
The AP4B1 can interact with other proteins to form complexes that regulate cellular function.
There are currently no approved drugs targeting the AP4B1, but research is ongoing.
At present, there are no published clinical trial results on AP4B1 , which is the focus of future research.
As no related drugs have been approved yet, the feasibility of oral administration of AP4B1 needs to be further investigated.
Gene editing technology can be used to regulate the expression of AP4B1 , but further studies are needed to verify its feasibility and effect.
The recombinant AP4B1 protein has been implicated in several neurological diseases, such as neurodegenerative diseases and epilepsy.
At present, there are no reports on the application of AP4B1 in clinical cases, which is an area to be studied and developed.
The AP4B1 has a specific three-dimensional structure, including helix and folding, which plays an important role in its function.
Drugs targeting the AP4B1 are expected to take a long time to become available, as related research and clinical trials are still ongoing.
No clear studies have been reported on the relationship between AP4B1 and the immune system, which is an area of further study and we can look forward to future discoveries.
The recombinant AP4B1 protein has the potential to be used as a novel drug target in the clinical treatment of its related diseases.
Recombinant protein AP4B1 plays an important role in regulating nervous system function and cell signaling, and may be related to the occurrence and development of nervous system diseases.
At present, there are no reports on the development of specific antibodies against AP4B1 , which is the future research direction.
Recombinant AP4B1 proteins are usually synthesized using genetic engineering techniques to produce s by expressing the AP4B1 gene in cells.
Customer Reviews (4)
Write a reviewUnder different environmental conditions, the stability of AP4B1 is still very good, indicating that it has a wide range of applicability and stability.
AP4B1 showed good solubility in Western blot and can be easily dissolved in various buffers.
Short half-life and high clearance of AP4B1 make its effect more rapid and short, and can quickly achieve the therapeutic effect.
Experimenting with this AP4B1 allows me to more easily perform experimental operations without having to worry about reproducibility of experimental results.
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