AP4B1

  • Official Full Name

    adaptor-related protein complex 4, beta 1 subunit

  • Overview

    The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1) and epsilon-4 (AP4E1; MIM 607244), a medium chain, mu-4 (AP4M1; MIM 602296), and a small chain, sigma-4 (AP4S1; MIM 607243).
  • Synonyms

    AP4B1; adaptor-related protein complex 4, beta 1 subunit; AP-4 complex subunit beta-1; beta 4 subunit of AP 4; BETA 4; Adapter related protein complex 4 beta 1 subunit; AP 4 adapter complex subunit beta; AP 4 complex subunit beta 1; Beta subunit of AP 4; beta4-adaptin; OTTHUMP00000013725; OTTHUMP00000013726; OTTHUMP00000013730; beta subunit of AP-4; beta 4 subunit of AP-4; AP-4 adapter complex subunit beta; adapter-related protein complex 4 subunit beta-1; CPSQ5; BETA-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP4B1-9725H Recombinant Human AP4B1, GST-tagged E.coli GST 1-351a.a.
Human AP4B1-661H Recombinant Human AP4B1 protein, GST-tagged Wheat Germ GST
Human AP4B1-8806HCL Recombinant Human AP4B1 293 Cell Lysate HEK293 N/A
Human AP4B1-194H Recombinant Human AP4B1 Protein, His-tagged E.coli N-His Met1-Arg276
Human AP4B1-1138HF Recombinant Full Length Human AP4B1 Protein, GST-tagged In Vitro Cell Free System GST 739 amino acids
Mouse Ap4b1-195M Recombinant Mouse Ap4b1 Protein, His-tagged E.coli N-His Met1-Ile261
Zebrafish AP4B1-10662Z Recombinant Zebrafish AP4B1 Mammalian Cell His
Chicken AP4B1-2606C Recombinant Chicken AP4B1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AP4B1 involved in several pathways and played different roles in them. We selected most pathways AP4B1 participated on our site, such as Clathrin derived vesicle budding, Golgi Associated Vesicle Biogenesis, Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP4B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Clathrin derived vesicle buddingSNAPIN;DNM2;TCEAL4;BLOC1S1;YIPF6;FTH1A;TPD52L1;SNX9B;TGOLN2
Golgi Associated Vesicle BiogenesisTGOLN2;BLOC1S4;TBC1D8B;AP1S3A;HIP1RB;AP1B1;CLINT1;YIPF6;TCEAL4
LysosomeCTSG;ARSA;Ctsl;SMPD1;CLN5;CD68;CTSH;CTSSA;CTSC
Lysosome Vesicle BiogenesisCLVS2;CLVS1;AP1S3A;CTSZ;AP4B1;BLOC1S1;DNASE2
Membrane TraffickingSTAM2;AP4B1;PREB;COPG;GJA5;TRAPPC6B;CNO;SEC22C;SNF8
Vesicle-mediated transportTPD52L1;HP;AMBP;YIPF6;NAPB;TERFA;TRAPPC6B;TCEAL4;FTH1B
trans-Golgi Network Vesicle BuddingTCEAL4;TPD52L1;CLVS2;TPD52;AP3S1;SNX9B;DNASE2;SNX9A;BLOC1S3

AP4B1 has several biochemical functions, for example, protein binding, protein transporter activity, transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AP4B1 itself. We selected most functions AP4B1 had, and list some proteins which have the same functions with AP4B1. You can find most of the proteins on our site.

Function Related Protein
protein bindingC1orf116;TFRC;TICAM1;CYTH2;TEF;RXFP4;DNPEP;ESYT2;XAGE2
protein transporter activityRAMP2;AP4S1;IPO8;VPS35;IPO7;IPO13;KPNA6;XPO5;AP1B1
transporter activityRBP4L;NUP88;ABCF2;PMP2;ABCA7;SLC5A11;ATP6V0B;SLC4A4A;STEAP2

AP4B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP4B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP4B1.

ZNF576; FIBP; MYC; AP4E1; AP4S1

  • Q&As
  • Reviews

Q&As (19)

Ask a question
How does AP4B1 participate in cellular processes? 10/11/2022

AP4B1 is involved in intracellular protein transport and transport, and plays an important role in maintaining cell function.

What is the research progress on AP4B1? 07/20/2022

Studies targeting the AP4B1 are actively underway to explore its function, mechanism of action, and potential therapeutic applications.

Are there any existing research projects related to AP4B1 ? 05/29/2022

A number of related research projects have been carried out targeting the AP4B1 to understand its role in disease and potential therapeutic strategies.

May AP4B1 have side effects? 04/14/2022

Because there are currently no approved drugs, the side effects of AP4B1 are not fully understood.

Is there any crystal structure analysis of AP4B1 ? 03/09/2022

At present, there are no reports on the crystal structure analysis of AP4B1 , which needs future research efforts.

How does AP4B1 interact with other proteins? 01/06/2022

The AP4B1 can interact with other proteins to form complexes that regulate cellular function.

Are there any drugs that target recombinant AP4B1 that have been approved? 11/23/2021

There are currently no approved drugs targeting the AP4B1, but research is ongoing.

Are there any clinical trial results on recombinant AP4B1? 10/16/2021

At present, there are no published clinical trial results on AP4B1 , which is the focus of future research.

Can AP4B1 be used by oral administration? 05/31/2021

As no related drugs have been approved yet, the feasibility of oral administration of AP4B1 needs to be further investigated.

Can the expression of AP4B1 be regulated by gene editing technology? 05/17/2021

Gene editing technology can be used to regulate the expression of AP4B1 , but further studies are needed to verify its feasibility and effect.

Which diseases are associated with recombinant AP4B1? 03/12/2021

The recombinant AP4B1 protein has been implicated in several neurological diseases, such as neurodegenerative diseases and epilepsy.

Has AP4B1 been used in clinical cases? 01/16/2021

At present, there are no reports on the application of AP4B1 in clinical cases, which is an area to be studied and developed.

What are the structural properties of AP4B1 ? 08/12/2020

The AP4B1 has a specific three-dimensional structure, including helix and folding, which plays an important role in its function.

How soon can drugs targeting recombinant AP4B1 be available? 02/28/2020

Drugs targeting the AP4B1 are expected to take a long time to become available, as related research and clinical trials are still ongoing.

What is the relationship between AP4B1 and immune system? 12/22/2019

No clear studies have been reported on the relationship between AP4B1 and the immune system, which is an area of further study and we can look forward to future discoveries.

What is the clinical application value of AP4B1 ? 12/20/2019

The recombinant AP4B1 protein has the potential to be used as a novel drug target in the clinical treatment of its related diseases.

What is the role of AP4B1 in neurological diseases? 03/15/2019

Recombinant protein AP4B1 plays an important role in regulating nervous system function and cell signaling, and may be related to the occurrence and development of nervous system diseases.

Have specific antibodies against AP4B1 been developed? 01/29/2019

At present, there are no reports on the development of specific antibodies against AP4B1 , which is the future research direction.

What is the synthesis method of AP4B1 ? 01/11/2019

Recombinant AP4B1 proteins are usually synthesized using genetic engineering techniques to produce s by expressing the AP4B1 gene in cells.

Customer Reviews (4)

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Reviews
09/11/2021

    Under different environmental conditions, the stability of AP4B1 is still very good, indicating that it has a wide range of applicability and stability.

    11/21/2020

      AP4B1 showed good solubility in Western blot and can be easily dissolved in various buffers.

      08/30/2019

        Short half-life and high clearance of AP4B1 make its effect more rapid and short, and can quickly achieve the therapeutic effect.

        05/31/2019

          Experimenting with this AP4B1 allows me to more easily perform experimental operations without having to worry about reproducibility of experimental results.

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