AP3B1

  • Official Full Name

    adaptor-related protein complex 3, beta 1 subunit

  • Overview

    This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
  • Synonyms

    AP3B1; adaptor-related protein complex 3, beta 1 subunit; PE; HPS; HPS2; ADTB3; ADTB3A; AP-3 complex subunit beta-1; beta-3A-adaptin; AP-3 complex beta-3A subunit; adaptor protein complex AP-3 subunit beta-1; clathrin assembly protein complex 3 beta-1 large chain;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AP3B1-3538H Recombinant Human AP3B1, His-tagged E.Coli or Yeast His 1094
Human AP3B1-9719H Recombinant Human AP3B1, GST-tagged E.coli GST 763-1094a.a.
Human AP3B1-655H Recombinant Human AP3B1 protein, GST-tagged Wheat Germ GST
Human AP3B1-8810HCL Recombinant Human AP3B1 293 Cell Lysate HEK293 N/A
Human AP3B1-188H Recombinant Human AP3B1 Protein, His-tagged E.coli N-His Met1-Leu233
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AP3B1 involved in several pathways and played different roles in them. We selected most pathways AP3B1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP3B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
LysosomeAP1S3;AP3M2;ATP6V0A1A;GNS;HGSNAT;IGF2R;SUMF1;AP3B2;AP1M3

AP3B1 has several biochemical functions, for example, GTP-dependent protein binding, protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP3B1 itself. We selected most functions AP3B1 had, and list some proteins which have the same functions with AP3B1. You can find most of the proteins on our site.

Function Related Protein
GTP-dependent protein bindingRAB32;RAPGEF5;PPIAL4A;EEA1;RAB38;GCHFR;CDC42;ARFIP2;MRAS
protein phosphatase bindingEGFR;CDKN1B;PIK3R2;STAT6;KCNN4;CSK;PARD3;JAK3;GRB2

AP3B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP3B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP3B1.

ARRB2; ARRB1; pmbA; pi3p; 15-deoxy-delta(12,14; Lyplal1; PTBP3; YWHAZ; SNW1; LRRK2; SKA3; DLG3; NLRP3; Nup155; EPB41L3

  • Reviews
  • Q&As

Customer Reviews (4)

Write a review
Reviews
10/10/2022

    In the case of repeated experiments, the stability of this protein is still very good, indicating that it has high repeatability and reproducibility.

    02/04/2022

      Strip location in the Western blot was accurate and showed good specificity.

      11/21/2021

        Green production process of AP3B1 focuses on sustainable development and maximizes the utilization of energy and resources by optimizing the production process and equipment.

        01/17/2019

          The short half-life and high clearance properties of AP3B1 allow it to act quickly in the body and be cleared quickly, reducing the risk of side effects.

          Q&As (10)

          Ask a question
          What is the association between recombinant AP3B1 and intracellular transport abnormalities? 12/21/2022

          The study of recombinant AP3B1 may help us better understand and treat diseases associated with abnormal intracellular vesicle transport.

          What are the long-term preservation conditions of AP3B1 ? 12/03/2022

          The AP3B1 should be frozen at -80°C to ensure its long-term stability.

          Does AP3B1 have anti-tumor effects? 11/28/2022

          At present, there is no clear evidence that the AP3B1 has anti-tumor effect, but it may have a certain application prospect in the field of tumor therapy.

          What is the relationship between recombinant AP3B1 and drug delivery? 04/27/2022

          The recombinant AP3B1 protein can be used as a carrier to help transport drugs to specific organelles or tissues, thereby improving the efficiency of drug delivery.

          How to prepare AP3B1 ? 04/15/2022

          AP3B1 can be expressed, extracted and purified in cells by genetic engineering technology.

          Is the recombinant AP3B1 immunogenic? 06/16/2021

          The current study shows that the AP3B1 does not cause a significant immune response in most people.

          What is the association between AP3B1 and genetic diseases? 08/08/2020

          Mutations in the AP3B1 gene can lead to an inherited neurodevelopmental disorder, AP-3 associated intracellular transport deficiency. AP3B1 research may contribute to the treatment and understanding of related diseases.

          What is the clinical application prospect of AP3B1 ? 11/10/2019

          AP3B1 has potential application in disease treatment, drug delivery and other fields, but it is still in the research stage.

          What is the targeting effect of AP3B1 ? 05/27/2019

          AP3B1 can bind to specific cell membrane proteins, and has certain targeting effects in vitro and in vivo.

          Is AP3B1 toxic? 01/21/2019

          The current study shows that the AP3B1 is safe at appropriate doses. Of course, further confirmation is needed before clinical application.

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