AP3B1
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Official Full Name
adaptor-related protein complex 3, beta 1 subunit
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Background
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012] -
Synonyms
AP3B1; adaptor-related protein complex 3, beta 1 subunit; PE; HPS; HPS2; ADTB3; ADTB3A; AP-3 complex subunit beta-1; beta-3A-adaptin; AP-3 complex beta-3A subunit; adaptor protein complex AP-3 subunit beta-1; clathrin assembly protein complex 3 beta-1 large chain;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | AP3B1-8810HCL | Recombinant Human AP3B1 293 Cell Lysate | HEK293 | N/A |
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| Human | AP3B1-188H | Recombinant Human AP3B1 Protein, His-tagged | E.coli | N-His |
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| Human | AP3B1-3538H | Recombinant Human AP3B1, His-tagged | E.Coli or Yeast | His |
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| Human | AP3B1-9719H | Recombinant Human AP3B1, GST-tagged | E.coli | GST |
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| Human | AP3B1-655H | Recombinant Human AP3B1 protein, GST-tagged | Wheat Germ | GST |
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- Involved Pathway
- Protein Function
- Interacting Protein
AP3B1 involved in several pathways and played different roles in them. We selected most pathways AP3B1 participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with AP3B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | PLA2G15;ATP6V0A1B;SUMF1;ATP6AP1;AP4S1;CLN3;LAPTM5;CTSC;GUSB |
AP3B1 has several biochemical functions, for example, GTP-dependent protein binding, protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AP3B1 itself. We selected most functions AP3B1 had, and list some proteins which have the same functions with AP3B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP-dependent protein binding | HPS6;GCHFR;RASGRP4;MRAS;GCH1;RAPGEF5;RAPGEF6;RAB38;ARFIP2 |
| protein phosphatase binding | JUPA;Itga10&Itgb1;STAT6;JAK1;GNB2L1;PPP1R3C;MAP3K5;PIK3R1;STAT3 |
AP3B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AP3B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AP3B1.
ARRB2; ARRB1; pmbA; pi3p; 15-deoxy-delta(12,14; Lyplal1; PTBP3; YWHAZ; SNW1; LRRK2; SKA3; DLG3; NLRP3; Nup155; EPB41L3
- Q&As
- Reviews
Q&As (10)
Ask a questionThe study of recombinant AP3B1 may help us better understand and treat diseases associated with abnormal intracellular vesicle transport.
The AP3B1 should be frozen at -80°C to ensure its long-term stability.
At present, there is no clear evidence that the AP3B1 has anti-tumor effect, but it may have a certain application prospect in the field of tumor therapy.
The recombinant AP3B1 protein can be used as a carrier to help transport drugs to specific organelles or tissues, thereby improving the efficiency of drug delivery.
AP3B1 can be expressed, extracted and purified in cells by genetic engineering technology.
The current study shows that the AP3B1 does not cause a significant immune response in most people.
Mutations in the AP3B1 gene can lead to an inherited neurodevelopmental disorder, AP-3 associated intracellular transport deficiency. AP3B1 research may contribute to the treatment and understanding of related diseases.
AP3B1 has potential application in disease treatment, drug delivery and other fields, but it is still in the research stage.
AP3B1 can bind to specific cell membrane proteins, and has certain targeting effects in vitro and in vivo.
The current study shows that the AP3B1 is safe at appropriate doses. Of course, further confirmation is needed before clinical application.
Customer Reviews (4)
Write a reviewThe stability of the protein is tested by long-term storage or storage under different conditions, such as temperature, pH value, etc. -
The cytotoxicity of the protein is detected through the effect on cells to ensure the safety of the protein. -
The molecular weight of the protein and whether there are impurities were detected by SDS-PAGE, Western blot and other methods. -
The activity of protein, such as enzyme activity and binding activity, was detected by functional experiments. -
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