Recombinant Mouse Ppp1r15a Protein, Myc/DDK-tagged

• Cat.No.: Ppp1r15a-5064M
• Product Overview: Purified recombinant protein of mouse full-length protein phosphatase 1, regulatory subunit 15A (Ppp1r15a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'. In case of infection with vesicular stomatitis virus (VSV), impairs viral replication.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 71.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ppp1r15a protein phosphatase 1, regulatory subunit 15A [ Mus musculus (house mouse) ]
• Official Symbol: Ppp1r15a
• Synonyms: Ppp1r15a; protein phosphatase 1, regulatory subunit 15A; Gadd3; Gadd34; Myd116; 9630030H21; protein phosphatase 1 regulatory subunit 15A; growth arrest and DNA damage-inducible protein GADD34; growth arrest and DNA-damage-inducible 34; myeloid differentiation primary response gene 116; myeloid differentiation primary response protein MyD116; protein phosphatase 1, regulatory (inhibitor) subunit 15A
• Gene ID: 17872
• mRNA Refseq: NM_008654
• Protein Refseq: NP_032680
• UniProt ID: P17564