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PPP2R3A

Official Full Name

protein phosphatase 2, regulatory subunit B, alpha
Overview

This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B/PR61, and B/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B family. The B family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms

PPP2R3A; protein phosphatase 2, regulatory subunit B, alpha; PPP2R3, protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 72), alpha isoform and (PR 130), beta isoform , protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha; serine/t;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N/A
N
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PPP2R3A-1918H	Recombinant Human PPP2R3A, His-tagged	E.coli	His	801-1150aa	$319 / 25ug
Human	PPP2R3A-2921HCL	Recombinant Human PPP2R3A 293 Cell Lysate	HEK293	N/A		Inquiry
Human	PPP2R3A-1254H	Recombinant Human PPP2R3A Protein (M786-F1070), Tag Free	E.coli	No tag	M786-F1070	Inquiry
Human	PPP2R3A-2621H	Recombinant Human PPP2R3A Protein, His-tagged	E.coli	N-His	Asp827-Glu1150	Inquiry
Human	PPP2R3A-1255H	Recombinant Human PPP2R3A Protein (M786-F1070), His tagged	E.coli	His	M786-F1070	Inquiry
Rhesus Macaque	PPP2R3A-3573R	Recombinant Rhesus monkey PPP2R3A Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	PPP2R3A-3391R	Recombinant Rhesus Macaque PPP2R3A Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	PPP2R3A-3391R-B	Recombinant Rhesus Macaque PPP2R3A Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
PPP2R3A Related Articles

PPP2R3A involved in several pathways and played different roles in them. We selected most pathways PPP2R3A participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R3A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
mRNA surveillance pathway	NCBP1;PPP2CB;NXT2;PABPC5;PPP2R5E;PPP2R5EA;DDX39B;WIBG;GSPT1L
Sphingolipid signaling pathway	PPP2R2B;MAPK13;GNAI1;TNFRSF1A;PLD2;GNAI2;PPP2R5A;LASS1;NRAS
PIK-Akt signaling pathway	PIK3R5;YWHAZ;RBL2;CCND3;TCL1B;NFKB1;NOS3;BCL2;CCNE1
AMPK signaling pathway	IGF1;PRKAG3;PFKL;RAB10;INS2;INS;PPP2R5C;RAB2A;CREB3L1
Adrenergic signaling in cardiomyocytes	SCN4BA;SCN1B;PPP1R1A;ATP1B2B;ATP1A3A;CALM2;MAPK12A;ATP1B3;PPP2R2BB
Dopaminergic synapse	TH;GNG2;PRKCG;GNAO1;SLC18A2;KIF5C;GNAL;PPP2R5B;GNB1

PPP2R3A has several biochemical functions, for example, calcium ion binding, protein binding, protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R3A itself. We selected most functions PPP2R3A had, and list some proteins which have the same functions with PPP2R3A. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	EPDL1;EPS15L1;EMR1;SYT15;MMP13A;DHH;BGLAP2;TNNC1B;PLA2G2F
protein binding	LNX2;PVRL3;EPOR;THRA;ZCCHC10;BAP1;SHKBP1;USP4;EIF2S2
protein binding, bridging	FRMD4A;STX1A;COL8A2;RBM14;NMD3;WWC1;TRIM5;PPP4R2;TNNT2A
protein phosphatase type 2A regulator activity	ENSAA;PPP2R5EA;pab1;PPP2R2D;EIF2AK2;PPP2R5B;PPP2R2CA;PPP2R2BB;PPP2R4

PPP2R3A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R3A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R3A.

PPP2R1A; PPP2R1B; PPP5C; ATXN7L2; Ppp2r1a; SLX4

Becsi, B; Dedinszki, D; et al. Identification of protein phosphatase interacting proteins from normal and UVA-irradiated HaCaT cell lysates by surface plasmon resonance based binding technique using biotin-microcystin-LR as phosphatase capturing molecule. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 138:240-248(2014).

Peng, HY; Chen, GD; et al. Spinal SIRP alpha 1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. PAIN 153:1042-1053(2012).