PPP2R4
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Official Full Name
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
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Overview
Type 2 protein serine/threonine phosphatase (PP2A) is a trimer composed of a catalytic C subunit and two regulatory (A and B) subunits; many isoforms for the A and B subunits have been found. PP2A has a high specific activity against the alpha subunit of phosphorylase kinase and is insensitive to Inhibitor-2. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and by its high sensitivity to inhibition by okadaic acid. It is also thought to be the principal downmodulator of serine/threonine kinase cascades. PP2B requires Ca2+/calmodulin for activity, and is an activator of NFAT transcription factors. PP2C requires Mg2+, but is insensitive to okadaic acid, microcystin LR, or the calmodulin inhibitor trifluoperazine. -
Synonyms
PPP2R4; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A, regulatory subunit B (PR 53); serine/threonine-protein phosphatase 2A activator; phosphotyrosyl phosphatase activator; PP2A phosphatase activator; PR53; PTPA; PP2A subunit B isoform PR53; serine/threonine-protein phosphatase 2A regulatory subunit B; PP2A; MGC2184;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- His
- Fc
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PPP2R4-27572TH | Recombinant Human PPP2R4, His-tagged | E.coli | His | 104-323 |
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| Human | PPP2R4-589H | Recombinant Human PPP2R4 | E.coli | Non |
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| Human | PPP2R4-2919HCL | Recombinant Human PPP2R4 293 Cell Lysate | HEK293 | Non |
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| Mouse | PPP2R4-13260M | Recombinant Mouse PPP2R4 Protein | Mammalian Cell | His |
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| Mouse | PPP2R4-7037M | Recombinant Mouse PPP2R4 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | PPP2R4-7037M-B | Recombinant Mouse PPP2R4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | PPP2R4-878Z | Recombinant Zebrafish PPP2R4 | Mammalian Cell | His |
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| Chicken | PPP2R4-3022C | Recombinant Chicken PPP2R4 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PPP2R4 involved in several pathways and played different roles in them. We selected most pathways PPP2R4 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin resistance | GYS1;CREB3L3A;RPS6KAL;PIK3R1;PPP2R4;PPP1CAB;FOXO1B;IRS2;SLC2A2 |
PPP2R4 has several biochemical functions, for example, ATP binding, contributes_to ATPase activity, peptidyl-prolyl cis-trans isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R4 itself. We selected most functions PPP2R4 had, and list some proteins which have the same functions with PPP2R4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | KIFC1;VPS4B;MAP3K5;SIK2A;SMYHC2;MTOR;DYRK3;PRKAA2;ALPK1 |
| contributes_to ATPase activity | ATP1B1;MSH6;ABCG8;ATP1A2;RFC3;ATP5F1;MSH2;ATP5D;ATP5H |
| peptidyl-prolyl cis-trans isomerase activity | PPIH;FKBP5;PPIFA;FKBP9;PPIAA;TTC9C;PPIAL4C;PPIE;FKBP1AA |
| protein binding | RPS27;HSPA13;NLRP3;KIF3B;DCTN5;PDGFC;PAWR;POLR1C;RHOT2 |
| protein heterodimerization activity | MYF6;CHUK;ALX4;HIST1H2B8;AXL;MEF2C;TAF11;JDP2;NEUROD1 |
| protein homodimerization activity | SPPL2B;CBX1;RIPK2;ZNF174;AGXT;TBC1D22A;NFKB1;AOC3;CCBL2 |
| protein phosphatase 2A binding | TP53;RPS6KB1;FOXO1;ARPP19;GRIN3A;STRN4;ENSAA;PTPN1;SPHK1 |
| protein phosphatase type 2A regulator activity | SET;PPP2R3A;IGBP1;ENSAA;PPP2R2CA;PPP2R5EB;pab1;ARPP19;PPP2R5CB |
| protein tyrosine phosphatase activator activity | PPP2R4;IGFBP3 |
| receptor binding | DDX54;GFRA1;Itga10&Itgb1;MLN;DPP4;NRXN1;CAPRIN2;FGF1B;GFRA3 |
PPP2R4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R4.
AMOT; BRINP1; Kiaa1109; TCP1; CCT6A; CCT5; CCT3; CCT8; CCT4; PPP2CA; CCT2; CCT7; AKT1
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