Ppp2r2a
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Official Full Name
protein phosphatase 2, regulatory subunit B, alpha
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Ppp2r2a Related Articles
Ppp2r2a involved in several pathways and played different roles in them. We selected most pathways Ppp2r2a participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ppp2r2a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | UPF3A;GSPT1;PABPC4;FIP1L1;ETF1;SMG7;PPP2R2BB;PABPC3;PPP2R1A |
| Sphingolipid signaling pathway | PPP2R2D;GAB2;TRAF2;S1PR5;RAC1;PRKCZ;PLCB2;RELA;LASS2 |
| PIK-Akt signaling pathway | TSC1;Ifna15;Fasl;RPS6KB1;CASP9;GNG3;LAMB4;FGF9;FGF8 |
| AMPK signaling pathway | PPARGC1A;RHEB;PRKAB2;INS1;ADIPOQ;PPARG;CCNA1;PDPK1;SIRT1 |
| Adrenergic signaling in cardiomyocytes | ATP1A2;RYR2;PPP2R5CB;ADRA1B;SLC8A1;ATP1B2A;CALM2B;CACNG7A;SLC14A2 |
| Hippo signaling pathway | FGF1;TGFBR1;FZD3;WNT3;BBC3;FZD8;SCRIB;SMAD2;TEAD3 |
| Tight junction | MYH3;CRB3A;RHOAC;CLDNF;PPP2R1A;EPB41L1;PRKCBA;CLDN11;CASK |
| Dopaminergic synapse | GNAQ;KIF5B;GNAL;CALM4;KCNJ5;GNAS;GSK3B;MAOA;CALY |
| Chagas disease (American trypanosomiasis) | IKBKB;ACE;IFNGR2;GNAO1;IL-8;TGFB1;MAPK11;MAPK1;BDKRB2 |
| Hepatitis C | PDPK1;KRAS;CLDN5;BRAF;IFNA14;NRAS;LDLR;TYK2;CLDN22 |
Ppp2r2a has several biochemical functions, for example, protein binding, protein complex binding, protein phosphatase 2A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Ppp2r2a itself. We selected most functions Ppp2r2a had, and list some proteins which have the same functions with Ppp2r2a. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LYAR;MEI4;TXNRD2;CCHCR1;FBXW11;PYROXD1;TAF7L;STXBP3A;MAP4K5 |
| protein complex binding | ATG101;PRMT5;OTOF;CDH2;MYSM1;RANBP2;MAPK8IP2;KAT2B;ULK1 |
| protein phosphatase 2A binding | TP53;FOXO1;TRP53;STRN4;GRIN3A;PPP2R2A;SMG5;IGBP1;ARPP19 |
| protein phosphatase type 2A regulator activity | PPP2R2CA;PPP2R2D;PPP2R3A;EIF2AK2;pab1;ARPP19;ENSAA;PPP2R1B;PPP2R5E |
| protein serine/threonine phosphatase activity | DULLARD;CTDNEP1B;PDP1;DUSP23A;PPM1H;PPP1CC;PPM1DA;PPEF1;PPM1NB |
| tau protein binding | S100B;SERPINB1A;AATF;FKBP4;APOE;SNCA;BIN1;HDAC6;DYRK1A |
Ppp2r2a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ppp2r2a here. Most of them are supplied by our site. Hope this information will be useful for your research of Ppp2r2a.
PPP2R1A; PPP2CA; PPP2CB; PPP2R1B
- Q&As
- Reviews
Q&As (7)
Ask a questionFollowing the downregulation of PPP2R2A using shRNA, a significant increase in GFPT2 phosphorylation levels was observed, while the phosphorylation levels of GFPT1 did not show significant changes.
The study used tandem affinity purification combined with HPLC-Chip-ESI/MS/MS to screen for proteins interacting with PPP2R2A.
The analysis revealed that Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) and Glutamine-fructose-6-phosphate transaminase 2 (GFPT2) are potential binding partners of PPP2R2A.
The interaction between PPP2R2A and GFPT1/GFPT2 was further confirmed through methods such as immunofluorescence co-localization, GST Pull-down, and immunoprecipitation.
PPP2R2A is one of the regulatory subunits of the PP2A phosphatase. Past research reports indicate that PPP2R2A can promote tumor cell survival and growth.
The study used immunofluorescence co-localization, GST Pull-down, and immunoprecipitation methods to further confirm the direct interaction between PPP2R2A and GFPT2.
GFPT2 is a rate-limiting enzyme in the O-GlcNAc glycosylation modification pathway. In breast cancer cells (MDA-MB-231), downregulation of PPP2R2A led to an increase in protein O-GlcNAc glycosylation levels.
Customer Reviews (3)
Write a reviewWe observed remarkable consistency in product performance across multiple batches, reducing variability in our experiments.
The reliability of the product's quality and effectiveness from one batch to another instilled confidence in its usage.
The product's batch-to-batch consistency was a key factor in the success of our long-term research projects.
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